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Isolation of an Unusual Aloenin-acetal from Aloe
Won Sick Woo,Kuk Hyun Shin,Ha Sook Chung,Jung Mi Lee,Chang Sub Shim 한국생약학회 1995 생약학회지 Vol.25 No.4
A hitherto unknown substance was isolated from the commercial sample of Aloe arborescens, which was shown to be the 4`, 6`-O-ethylidene-aloenin, most likely an artifact caused by hot-air drying procedure for the product preparation.
Coumarin Constituents from the Roos of Angelica koreana Max.
Chung-Kyu Lee(이정규),우원식(Won-Sick Woo) 한국생약학회 1982 생약학회지 Vol.13 No.1
From the ethereal extract of the roots of Angelica koreana Max. (Umbelliferae) two furanocoumarins such as isooxypeucedanin and oxypeucedanin methanolate were newly isolated together with isoimperatorin, osthol, imperatorin, bergapten, oxypeucedanin and β-sitosterol.
정정명,임대건,이원식,최봉기,장윤식,이연재,이상혁,설상명,최하진 인제대학교 1996 仁濟醫學 Vol.17 No.2
1991년 1월부터 1993년 12월까지 인제의대 부산백병원에서 6개월 이상 HBsAg 및 HBeAg 양성이며 간조직 검사상 만성간염을 보인 환자들(활동성;26례, 지속성;3례)을 대상으로 알파 인터페론 치료시 혈청 전환 및 간기능 정상화율과 인터페론 투여에 따른 효과에 대해 분석하여 보았다. In order to evaluate the therapeutic efficacy and safety of recombinent alpha-interferon, we studied 29 patients proven to have chronic hepatitis B(CAH : 26 cases, CPH : 3 cases) through biopsy from January 1991 to December 1993. All patients were seropositive for HBeAg and HBsAg, and recieved alpha-interferon with tonal dosage up to 120 million units. The results were as follows ; 1) HBeAg sero-conversion rate was 51.7%(Total 15 cases including 3 cases in chronic per-sistant hepatitis group), and all these patients have showed normalized transaminase levels continously. 2) In response group, the serum transaminase level began to decrease at average 4.7th week after initiation of interferon. But in non-response group, the serum transaminase level began to decrease at 2nd to 4th week transiently after interferon, and then increased again. 3) Several adverse effects were noted during interferon treatment. General ache and myalgia were most common(65.5%), followed by fever and chillness(37.9%), headache(37.9%), leukopenia(17.2%) etc. But they were relatively tolerable. 4) Peripheral blood leukocyte counts showed slight reduction within 1 week after initiationof interferon treatment but rapidly recovered to normal level within 5 days after temporary withdrawal. And after completion of interferon treatment, no significant differences were remained compared with initial level. With these results, it suggests that α-interferon therapy may be effective and safe in chronic hepatitis B. However, further study will be required in non-responsive group thereafter.
Flavonoids from the Rhizomes of Belamcanda chinensis
Chung, Ha-Sook,Woo, Won-Sick The Pharmaceutical Society of Korea 1991 Archives of Pharmacal Research Vol.14 No.4
Two flavonoids were isolated from the rhizomes of Belamcanda chinensis and identified as kanzakiflavove-2 and 2R:3R-dihydrokaempferol-7-methylether, respectively.
약물대사효소활성에 영향을 주는 한약에 관한 연구(4) : 천연 Coumarin이 약물대사효소활성에 미치는 영향
우원식(Won-Sick Woo),신국현(Kuk-Hyun Shin),지형준(Hyung-Joon Chi),이정규(Chung-Kyu Lee) 한국생약학회 1980 생약학회지 Vol.11 No.1
연자 등은 한방요법의 과학화를 이루기 위한 목적의 일환으로 상용한약을 대상으로 그 알콜 조추출물들의 약물대사효소 유도 및 억제효과를 검토한 결과 산형과 식물생약인 백지, 당귀 및 강활 등에 강력한 작용이 있음을 관찰한 바 있다. 이와같은 산형과 식물에 들어있는 약물대사효소활성에 영향을 주는 성분이 Coumarin계 물질임을 입증 하였으며 단리한 성분들의 작용을 비교 검토한 결과를 보고한다. 체중 20±2g의 웅성 mouse를 실험동물로 하였다. 상법에 의하여 단리한 coumarin 유도체를 중심으로 23종의 성분들을 1% Tween 80∼0.9% NaCl에 현탁하여 사료로 하고 대조약물로 SKF-525A 및 Warfarin을 사용하였다. 약물대사효소활성 억제 및 유도효과는 Hexobarbital 수면시간 및 그 혈중 농도를 지표로 검토하였다. Furocoumarin인 Imperatorin , isoimperatorin, oxypeucedanin (hydrate), Prangolarin 및 bergapten 등은 적은 용량에도 강력한 활성을 나타내었다. Furan핵이 포화된 Nodakenin, Nodakenetin이나 Coumarin, esculin, osthole, Scopolin, 6-methylcoumarin, glabralactone 및 Khellactone과 같은 coumarin 유도체들은 활성이 악하거나 거의 없다. Decursin은 높은 투여량에서 활성을 나타내었다.
우원식(Won-Sick Woo),신국현(Kuk-Hyun Shin),이은방(Eun-Bang Lee),이정규(Chung-Kyu Lee) 한국생약학회 1980 생약학회지 Vol.11 No.1
필발의 alkaloiol 성분인 pipeline에 강력한 수면증강 작용이 있으며 중추신경 흥분제인 strychnine의 사망률을 현저히 감소시킴을 보고한 바 있다. 본 실험에서는 piperine의 급성독성 및 중추신경 억제작용을 구체적으로 검토하였다. 체중 27±2g의 웅성 mouse를 실험동물로 하고 상법에 의하여 단리한 pipeline을 1% Tween 80, 0.9% NaCl에 현탁시켜서 시료로 사용하였다. Piperine의 LD_(50)는 복강내 투여시 294.4㎎/㎏, 경구투여시 1636.8㎎/㎏이었다. Piperine은 Rotarod test에서 현저한 진정효과를 나타내어 경구투여시그 ED<sub>50</sub>는 89.1㎎/㎏이었으며 항 pentylenetetrazole 경련작용이 있으며 그 ED<sub>50</sub>는 복강내투여시 22.4㎎/㎏,경구투여시 211.5㎎/㎏이었다. Piperine의 strychine 사망률 억제작용에 대한 ED<sub>50</sub>는 복강내투여시 11.2㎎/㎏이었다. Maximal electroshock seizure에 대한 억제효과는 미약하여 복강내투여시 200㎎/㎏ 이상, 경구투여시 1,300㎎/㎏ 이상에서 억제효과를 나타내었다. Piperine은 5㎎/㎏ 정맥내 주사로 토끼의 호흡 및 혈압에 변동을 초래하지 않았다.
A survey of the response of Korean medicinal plants on drug metabolism
Woo, Won-Sick,Shin, Kuk-Hyun,Kim, In-Chull,Lee, Chung-Kyu The Pharmaceutical Society of Korea 1978 Archives of Pharmacal Research Vol.1 No.1
Alcohol extracts of plants widely used in the traditional medicine have been tested to establish if they affect the metabolism of drug in mice. Forteen of the plants tested exhibited prolonging and/or inhibitory effect on hexobarbital sleeping time. Some of them also showed increasing effect on strychnine mortality, whereas piperis retrofracti Fructus reduced the toxicity of strychnine.
남자 초·중학생의 무산소성 작업능력과 무산소성 파워의 관계
정동식,정덕조,정성태,이병근,전태원,김은혜,이동규,정동춘 師範大學 體育硏究所 1998 서울大學校 體育硏究所論集 Vol.19 No.2
The critical power(CP) is the highest intensity to sustain for a long time without a fatigue. The anaerobic work capacity(AWC) is the highest anaerobic capacity to be provided by anaerobic energy system without the infection of hypoxia. The purpose of this study was to determine the relationship between AWC and AnP and to verify the validity of AWC. The subjects were consisted of 10 elementary and 10 middle school male students(12.8±1.3yrs, 159.3±12.1㎝, 49.4±11.8㎏). The critical power and anaerobic work capacity were calculated by work-time relationship after four cycle ergometry test to fatigue from 1 to 10 minute. The anaerobic power included Margaria-Kalmen test, Sargent jump and Wingate test. The main finding were as follows. The AWC of elementary and middle school students. were 6.47±2.63KJ and 11.10±3.01KJ. The AWC of elementary students was 58.3% of the middle school students's one. The AnP of elementary students were 47.2∼66.5% of the middle school students's one. And there were high correlation between AWC and AnP(0.64∼0.87, P<0.01). This study showed that AWC is useful index on AnP both elementary and middle school students.