Hepatic Cirrhosis Occurring in a Young Woodchuck(Marmota monax) Due to Vertical Transmission of Woodchuck Hepatitis Virus(WHV)

Kyu-shik Jeong,정원일,Jae-yong Chung,Mi-young An,Chae-yong Jung,Gyoung-jae Lee,Jong-soo Kang,Byeong-cheol Kang,Young-heun Jee,Bruce H Williams,Young-oh Kwon,Da-hee Jeong 대한수의학회 2003 Journal of Veterinary Science Vol.4 No.2

Cirrhosis Occurring in a Young Woodchuck (Marmota monax) Due to Vertical Transmission of Woodchuck Hepatitis Virus (WHV)Da-hee Jeong, Won-il Jeong, Jae-yong Chung, Mi-young An, Chae-yong Jung, Gyoung-jae Lee1, Jong-soo Kang1, Byeong-cheol Kang2, Young-heun Jee3, Bruce H Williams4, Young-oh Kwon5 and Kyu-shik Jeong*College of Veterinary Medicine, Kyungpook National University, Daegu 702-701, Korea1Shinwon Scientific Co., LTD, Research Institute, Suwon, Korea2Clinical Research Institute, Seoul National University, Seoul 110-744, Korea3College of Veterinary Medicine, Jeju National University, Jeju 690-756, Korea

Quantifying and Localizing the Mitochondrial Proteome Across Five Tissues in A Mouse Population

Williams, Evan G.,Wu, Yibo,Wolski, Witold,Kim, Jun Yong,Lan, Jiayi,Hasan, Moaraj,Halter, Christian,Jha, Pooja,Ryu, Dongryeol,Auwerx, Johan,Aebersold, Ruedi American Society for Biochemistry and Molecular Bi 2018 Molecular and Cellular Proteomics Vol.17 No.9

<P>We have used SWATH mass spectrometry to quantify 3648 proteins across 76 proteomes collected from genetically diverse BXD mouse strains in two fractions (mitochondria and total cell) from five tissues: liver, quadriceps, heart, brain, and brown adipose (BAT). Across tissues, expression covariation between genes' proteins and transcripts-measured in the same individuals-broadly aligned. Covariation was however far stronger in certain subsets than others: only 8% of transcripts in the lowest expression and variance quintile covaried with their protein, in contrast to 65% of transcripts in the highest quintiles. Key functional differences among the 3648 genes were also observed across tissues, with electron transport chain (ETC) genes particularly investigated. ETC complex proteins covary and form strong gene networks according to tissue, but their equivalent transcripts do not. Certain physiological consequences, such as the depletion of ATP synthase in BAT, are thus obscured in transcript data. Lastly, we compared the quantitative proteomic measurements between the total cell and mitochondrial fractions for the five tissues. The resulting enrichment score highlighted several hundred proteins which were strongly enriched in mitochondria, which included several dozen proteins were not reported in literature to be mitochondrially localized. Four of these candidates were selected for biochemical validation, where we found MTAP, SOAT2, and IMPDH2 to be localized inside the mitochondria, whereas ABCC6 was in the mitochondria-associated membrane. These findings demonstrate the synergies of a multi-omics approach to study complex metabolic processes, and this provides a resource for further discovery and analysis of proteoforms, modified proteins, and protein localization.</P>

동아시아 구법승과 상카시야 유적

Williams Joanna G. 미술사와 시각문화학회 2005 미술사와 시각문화 Vol.4 No.-

According to Legge, Faxian wrote: Proceeding 18 yojanas southeast [from Mathurii and 7 yojemas from Kanauj, which he visited next], they found themselves in a kingdom called Sankasya, at the place where the Buddha came down, after ascending to the Trayatrimsa heaven… The bbirsuni Utpalavarna thought in her heart, "Today the kings ... will all be meeting the Buddha. I am but a woman; how shall I succeed in being the first to see him?" Buddha immediately ... changed her into the appearance of a holy cakravartin king, and she was foremost of all in doing reverence to rum. As Buddha descended from his position aloft in the Trayatrimsa heaven, when he was coming down, there were made to appear three flights of precious steps. Buddha was on the middle. composed of the seven precious substances. The king of Brahma-loka also made a flight of silver steps appear on the right side, where he attended with a white chowry in his hand, Sakra, ruler of devas, made steps of purple gold on the left, where he held an umbrella "" When he was come down, the three flights all disappeared in the ground, excepting seven steps ... Afterwards King Asoka, wishing to know where their ends rested, sent men to dig and see, They went down to the yellow springs [the water table] without reaching the bonom of the steps, and from this the king rceived an increase to his reverence"" [Asoka] built a vihara over the steps, with a standing image 16 cubits in height, right over the middle flight. Behind the pillar, he erected a stone pillar, about 50 cubits high, with a lion on the top of it. Let into the pillar, on each of its 4 sides, there is an image of the Buddha, inside and out shining and transparent, and pure as it were of lapis lazuli [which roared in a later monastic debate], Faxian also reported stupas built later where the nun Utpalavarla knelt, where the Buddha cut his hair, where three previous Buddhas sat, as well as offerings made to a white-eared dragon that continued to protect the monastic community, One gets the impression of a crowded, complex site in the early 5th century, with presumably wooden monastic buildings, Over 200 years later, Xuanzang described visiting the site of the descent from Tryatrima named now)iebita (Beal: "written formerly Sengjiashe") and located less than 200 li southeast from Kanauj (in which Beal suggests he is mistaken on the direction), His account reads: Some centuries ago the ladders still existed in their original position, but now they have sunk into the earth and have disappeared. The neighboring princes ... bujlt up of bricks and chased stones, on the ancient foundations 3 ladders resembling the old ones. They are about 70 feet high. Above them they have built a vihara in which is a stone image of Buddha, and on either side of this is a ladder of Brahma and Sma, just as they appeared. On the outside of the vihara, but close by its side, there is a stone column about 70 feet high, which was erected by Asoka-raja, It is of a purple color, and shining as if with moisture. The substance is hard and fmely grained, Above it is a lion sitting on its haunches and facing the ladder. There are carved fig-ures inlaid, of wonderful execution on the four sides of the pillar and around It Xuanzang also records other stupas commemorating Buddhas of the past and the nun Utpalavatma, now eclipsed by Subhoti who had already seen the dharmakaya in the form of the doctrine that all existing things are void of reality, Again, we get a picture of a bustling monastic community in the 7th century. And the resplendent lion pillar with Buddha images stands out in both accounts, On the basis of the name Sankasya, known from the pilgrims and from texts like the Divyavadana, as well as the general location, Cunning-ham identified the modern village Sankfsa in modern Farrukhabad district, up. with the site of the Descent, It lies some 40 km. northeast of Kanauj in the Doab, richly populated with ancient remains, The two Gupta sites Jankhat and Bilsadh took me to this area in 1974, Cunningham included the site in his reports for 1862 and 1876. In the first he recorded the presence of an ASokan capital and worship of a naga named Karewar, which he identified with Faxian's description. In 1876 hecollected objects reproduced on the right. I know these only from this abysmal image and would be delighted to hear that they survive in some museum. Cunningham suggested that #2, a fragment of a tiny soapstone disc, represented the site itself, with a seated Buddha and kneeling Utpalavarna at the top of what survived. The Archaeological Survey of India returned to this site ten years ago and excavated here for at least 2 seasons, as reported in Indian Arcbaeolo-gy, A Review for 1995-96 and 96-97, finding Painted Grey Ware, Northern Black Polished Ware, Sunga, Kushan, and Gupta pottery, pre-Kushan bricks, and terra-conas attributed to the Gupta period, The Aokan capital found here has continued to receive attention. Is this what both Faxian and Xuanzang described as a lion? Cunningham asserted that both were mistaken about the identity of the animal, It might be pointed out that the shorter pillar that stands at the site of the Parinilvana makes some confusion plausible, Xuanzang describes the pillar standing at Sarnath as "bright and shining as a mirror: its surface is glistening and smooth as ice, and on it can be constantly seen the figure of Buddha as a shadow," I. e" he ignored the form of the capital and was mesmerized by the stone's polish, It is also possible that the Buddha figures he mentions here and Sa:nkasya were in fact carved on the pillar like the Gupta pillar at Kahaum, which has four TIrthankaras at the top as well as a single one below. The elephant capital has continued to attract attention for the excep-tional swirls beneath what was long considered a lotiform bottom to the capital, John l1win took these to indicate that the "lotus" in fact originated as a piece of cloth draped over a wood

Application and testing of a triple bubbler sensor in molten salts

Williams A.N.,Shigrekar A.,Galbreth G.G.,Sanders J. 한국원자력학회 2020 Nuclear Engineering and Technology Vol.52 No.7

A triple bubbler sensor was tested in LiCleKCl molten salt from 450 to 525 C in a transparent furnace to validate thermal-expansion corrections and provide additional molten salt data sets for calibration and validation of the sensor. In addition to these tests, a model was identified and further developed to accurately determine the density, surface tension, and depth from the measured bubble pressures. A unique feature of the model is that calibration constants can be estimated using independent depth measurements, which allow calibration and validation of the sensor in an electrorefiner where the salt density and surface tension are largely unknown. This model and approach were tested using the current and previous triple bubbler data sets, and results indicate that accuracies are as high as 0.03%, 4.6%, and 0.15% for density, surface tension, and depth, respectively

Quantification of Capacity Fade Mechanisms in Spinel LiMn₂O₄/Graphite Lithium Ion Cell

( Williams Agyei Appiah ),박주남,변승우,유명현,이용민 한국공업화학회 2018 한국공업화학회 연구논문 초록집 Vol.2018 No.0

To quantify the capacity fade mechanism in lithium ion batteries composed of a spinel-based cathode and an artificial graphite, a comprehensive mathematical model describing the cycling performance of LiMn2O4/graphite lithium ion cell is developed in this work. The developed model is incorporated into the Newman’s Porous Composite Electrode framework (PCE) and implemented in the battery module of COMSOL Multiphysics. The proposed model is used to investigate the effects of variations in the ambient temperature and of voltage range of cycling on the capacity fade. The effect of changes in the volume fraction of cathode active material, resistance in the cell and state of charge are also studied.

EPRI의 사용후연료 저장방안

Williams, R. F.,Lambert, R. W.,Stahlkopf, K. E. 한국원자력산업회의 1992 원자력산업 Vol.12 No.1

Historical reconstruction of anthropogenic mercury input from sedimentary records: Yeongsan Estuary, South Korea

Williams, J.,Dellapenna, T.,Louchouarn, P.,Lee, G.h. Academic Press in association with the Estuarine a 2015 Estuarine, coastal and shelf science Vol.167 No.2

The rapid economic growth of the Republic of Korea (S. Korea) within the last half-century has resulted in a pronounced increase in anthropogenic Hg emission from coal combustion, oil refining, cement production, and waste incineration. The record of increasing atmospheric sources have been investigated with a historical reconstruction of Hg accumulation in 30 sediment cores collected from the Yeongsan Estuary. Within the last several decades, this region has undergone severe anthropogenic alteration, including the construction of an estuarine dam forming the Yeongsan Lake, and installation of numerous seawalls that eliminated vast tidal flats and restricted estuarine circulation. Total mercury concentrations (T-Hg) measured in sediments deposited after 1980 (23.2 +/- 9.6 ng g<SUP>-1</SUP>; n = 273), were significantly higher than those reported for pre-industrial sediments (i.e. background values: 8.6 +/- 2.7 ng g<SUP>-1</SUP>; n = 274). An extensive survey of surface samples show that T-Hg concentrations are highest above the dam, with a gradient to lower values further offshore. The concomitant timing of enrichment of T-Hg within the sedimentary record and increased National emissions in Korea suggests that regional sources dominate the input to the Yeongsan Estuary. This indicates that with sufficient regional historic emission data, T-Hg might be utilized as a geochronologic tool to aid in corroborating traditional radioisotopic methods.

Thermoneutrality but Not UCP1 Deficiency Suppresses Monocyte Mobilization Into Blood

Williams, Jesse W.,Elvington, Andrew,Ivanov, Stoyan,Kessler, Skyler,Luehmann, Hannah,Baba, Osamu,Saunders, Brian T.,Kim, Ki-Wook,Johnson, Michael W.,Craft, Clarissa S.,Choi, Jae-Hoon,Sorci-Thomas, Mar Grune & Stratton 2017 Circulation research Vol.121 No.6

<P>Conclusions: Warm ambient temperature is, like UCP1 deficiency, atheroprotective, but the mechanisms of action differ. Thermoneutrality associates with reduced monocyte egress from the bone marrow in a UCP1-dependent manner in mice and likewise may also suppress blood monocyte counts in man.</P>

Synergetic effects of blended cathode active materials: Simulation and Experiment

( Williams Agyei Appiah ),박주남,변승우,유명현,이용민 한국공업화학회 2017 한국공업화학회 연구논문 초록집 Vol.2017 No.1

In the quest to achieve a higher capacity electrode materials for lithium ion batteries, different active materials for both cathode and anode are being studied. However, the available electrode materials which have been discovered have both good and bad sides. Hence, the electrochemical characteristics of Li-ion cells made of blended cathode material composed of LiMn2O4 and LiNi0.6Co0.2Mn0.2O2 and an artificial graphite anode are being studied via both experiments and simulation. The cycle performance of the two pure cell chemistries we modelled by considering Mn2+ dissolution in the cathode and solid electrolyte interphase information in the anode. By fitting our model predictions to the experimental data, the percentage of each contributing factor to the total capacity fade was determined. Ragone plots were used to study the correlation between the energy density and average specific power of the two pure chemistries and their blends.

Art as Peace Education at ‘Dark’ Museums and Sites in the United Kingdom, Europe, and Southeast Asia

Williams, Christopher 서울대학교 통일평화연구원 2018 Asian Journal of Peacebuilding Vol.6 No.1

Art increasingly appears at “dark” museums and related formal sites to balance the traditional exhibits of war. This article explores how art might contribute a peace education perceptive in differing countries and a globalizing context. Case studies from the United Kingdom, Europe (West and East), and Southeast Asia (Cambodia and Vietnam) are analyzed. The former deploys new technologies and supports wellknown artists who appeal to art markets. Asian curation relies more on creativity, including children’s and victim’s art. Both deploy artistic devices to symbolize the scale of atrocities and create aesthetic depth-juxtaposition, prominence, perspective, repetition, patterning, and soundscapes. The analysis provides tools and checklists to assist curation and inform artists, and concludes that critical educational processes are as important as the art.