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( Wataru Ando ),( Hiroaki Yokomori ),( Nobuhiro Tsutsui ),( Eigoro Yamanouchi ),( Yutaka Suzuki ),( Masaya Oda ),( Yutaka Inagaki ),( Katsuya Otori ),( Isao Okazaki ) 대한간학회 2018 Clinical and Molecular Hepatology(대한간학회지) Vol.24 No.1
Background/Aims: Nonalcoholic steatohepatitis (NASH) is prevalent in both economically developed and developing countries. Twenty percent of NASH progresses to cirrhosis with/without hepatocellular carcinoma, and there is an urgent need to find biomarkers for early diagnosis and monitoring progression of the disease. Using immunohistochemical and immunoelectron microscopic examination we previously reported that expression of matrix metalloproteinase-1 (MMP- 1) increased in monocytes, Kupffer cells and hepatic stellate cells in early stage NASH. The present study investigated whether serum MMP-1 levels reflect disease activity and pharmaceutical effects in NASH patients. Methods: We measured the serum levels of MMPs, tissue inhibitors of metalloproteinases (TIMPs), and several cytokines/ chemokines in patients with histologically proven early and advanced stages of NASH and compared them with those in healthy controls. Results: Serum MMP-1 levels in stage 1 fibrosis, but not in the more advanced fibrosis stages, were significantly higher than in healthy controls (P=0.019). There was no correlation between serum MMP-1 level and fibrosis stage. Serum MMP- 1 levels in NASH patients represented disease activity estimated by serum aminotransferase values during the followup period. In contrast, MMP-2, MMP-9 and TIMPs did not change with disease activity. Consistent with the finding that MMP-1 is expressed predominantly in monocytes and Kupffer cells, serum levels of monocyte chemotactic protein-1 and granulocyte-colony stimulating factor were significantly increased in NASH with stage 1 fibrosis. Conclusions: These results suggest that serum MMP-1 levels represent disease activity and may serve as a potential biomarker for monitoring the progression of NASH. (Clin Mol Hepatol 2018;24:61-76)
Toshihiro Suzuki,Ashiq Khan,Motonari Kobayashi,Wataru Takita 보안공학연구지원센터 2008 International Journal of Hybrid Information Techno Vol.1 No.2
The limited battery resource of mobile devices is an endless problem. The conventional solution, improving battery technologies, is insufficient; we need alternative energy sources to enhance mobile lifetimes. One solution is to utilize cars as intermediate nodes in mobile ad hoc networks. However, the high velocities of cars may seriously degrade network quality. To overcome this, we need an efficient routing protocol that can establish stable routes even if moving cars are used as network components. This paper conducts simulations to evaluate the impact of high speed cars and proposes a novel technology that allows routing to consider vehicle velocity. Extensive simulation results are presented to show the efficiency that can be achieved by our proposal.
Ik-Je Choi,Seung-Gyu Lee,Wataru Suzuki,최수빈,임종옥 국립중앙과학관 2019 Journal of Asia-Pacific Biodiversity Vol.12 No.2
We studied the taxonomy of the predatory genus Cryptalaus Ôhira (Coleoptera: Elateridae) in South Korea, including two species, C. berus (Candèze) and C. larvatus pini (Lewis), which have been previously reported from South Korea. In the present study, a rare species, C. yamato (Nakane), which had been regarded as endemic to Japan, is discovered in the central region of South Korea for the first time with a DNA barcode (COI) sequence. A key, redescription, distribution map of three Korean species in Asia, and illustrations of the diagnostic characters of the Korean Cryptalaus species are provided.
Makoto Fujimoto,Koichi Tsuneyama,Yuko Nakanishi,Thucydides L. Salunga,Kazuhiro Nomoto,Yoshiyuki Sasaki,Seiichi Iizuka,Mitsunobu Nagata,Wataru Suzuki,Tsutomu Shimada,Masaki Aburada,Yutaka Shimada,M. Er 한국식품영양과학회 2014 Journal of medicinal food Vol.17 No.3
The metabolic syndrome is a major worldwide health care issue and a dominant risk factor for cardiovascular disease. The liver manifestations of this syndrome include nonalcoholic fatty liver disease (NAFLD) and its progressive variant nonalcoholic steatohepatitis (NASH). Although significant research has been performed, the basic pathogenesis of NAFLD/NASH remains controversial and effective treatments are still unavailable. We have previously reported on a murine model of NASH induced by the neonatal injection of monosodium glutamate (MSG), which includes the clinical manifestations of central obesity, diabetes, hyperlipidemia, and ultimately liver inflammation, fibrosis, and cancer. Although MSG is considered a safe food additive, its administration to pregnant rats increases the voracity and growth hormone levels in the offspring. To further understand the biology of this model, we have investigated the influence of the calorie intake on these clinical manifestations by feeding animals a restrictive diet. MSG-treated animals fed a restrictive diet continue to manifest obesity and early stage NASH but have improvements in serum lipid profiles. At 12 months of age, mice had manifestations of obesity, whether animals were fed a restricted or control diet, but animals fed a restrictive diet had a reduction in the progression of NASH. In conclusion, MSG appears to be a critical factor in the initiation of obesity, whereas calorie intake may modulate the progression of disease.