3D micro-CT analysis of void formations and push-out bonding strength of resin cements used for fiber post cementation

İsmail Hakkı Uzun,Meral Arslan Malkoç,Ali Keleş,Ayşe Tuba Öğreten 대한치과보철학회 2016 The Journal of Advanced Prosthodontics Vol.8 No.2

PURPOSE To investigate the void parameters within the resin cements used for fiber post cementation by micro-CT (µCT) and regional push-out bonding strength. MATERIALS AND METHODS Twenty-one, single and round shaped roots were enlarged with a low-speed drill following by endodontic treatment. The roots were divided into three groups (n=7) and fiber posts were cemented with Maxcem Elite, Multilink N and Superbond C&B resin cements. Specimens were scanned using µCT scanner at resolution of 13.7 µm. The number, area, and volume of voids between dentin and post were evaluated. A method of analysis based on the post segmentation was used, and coronal, middle and apical thirds considered separately. After the µCT analysis, roots were embedded in epoxy resin and sectioned into 2 mm thick slices (63 sections in total). Push-out testing was performed with universal testing device at 0.5 mm/min cross-head speed. Data were analyzed with Kruskal–Wallis and Mann–Whitney U tests (α=.05). RESULTS Overall, significant differences between the resin cements and the post level were observed in the void number, area, and volume (P<.05). Super-Bond C&B showed the most void formation (44.86 ± 22.71). Multilink N showed the least void surface (3.51 ± 2.24 mm2) and volume (0.01 ± 0.01 mm3). Regional push-out bond strength of the cements was not different (P>.05). CONCLUSION µCT proved to be a powerful non-destructive 3D analysis tool for visualizing the void parameters. Multilink N had the lowest void parameters. When efficiency of all cements was evaluated, direct relationship between the post region and push-out bonding strength was not observed.

Evaluation Expression of the Caspase-3 and Caspase-9 Apoptotic Genes in Schizophrenia Patients

Ebubekir Dirican(Ebubekir Dirican ),Halil Özcan(Halil Özcan ),Sevgi Karabulut Uzunçakmak(Sevgi Karabulut Uzunçakmak ),Uğur Takım(Uğur Takım ) 대한정신약물학회 2023 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.21 No.1

Objective: Apoptosis is programmed cell death that occurs by several pathways. Caspase-3 is induced by active caspase-9 via the intrinsic pathway. The aim of this research was to explore the expression of caspase-3 and caspase-9 in schizophrenia patients and healthy samples. Methods: RNA was isolated from the peripheral blood of 39 schizophrenia patients’ and healthy samples. After cDNA synthesis, real time PCR (RT-PCR) was used to analyse caspase-3 and caspase-9 gene expression. The severity of psychopathological symptoms of schizophrenia was evaluated using the Positive and Negative Symptoms Scale for schizophrenia (PANSS) and Clinical Global Impressions (CGI). Results: The expression of caspase-3 and caspase-9 genes was higher in schizophrenia patients than in healthy samples (p = 0.012, p = 0.002, respectively). The increase in caspase-3 gene expression was significant with being male, smoking and with a duration of less than 6 years (p = 0.047, p = 0.049, p = 0.034, respectively). On the other hand, the increase in caspase-9 gene expression was significant in patients who is smoke, have children, and are under 33 years old (p = 0.040, p = 0.043, p = 0.045, respectively). A significant positive correlation was detected between the caspase-3 and caspase-9 gene expression (r = 0.3218, p = 0.049). Conclusion: Our findings indicate that caspase-3 and caspase-9 gene expression may activate cell death mechanisms by intrinsic apoptotic genes. Furthermore, caspase-3 and caspase-9 may play essential roles in different ways in schizophrenia. Hence there is a need to further study the apoptotic mechanism with expanded patient populations.

Comments on “The Correlation of Peripapillary and Juxtapapillary Choroidal Thickness in Healthy Subjects”

Salih Uzun(Salih Uzun ),Fatma Uzun(Fatma Uzun ) 대한안과학회 2023 Korean Journal of Ophthalmology Vol.37 No.2

Cardiovascular Disease Risk in Children and Adolescents with Attention Deficit/Hyperactivity Disorder

Necati Uzun(Necati Uzun ),Mehmet Akif Akıncı(Mehmet Akif Akıncı ),Hayrullah Alp(Hayrullah Alp ) 대한정신약물학회 2023 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.21 No.1

Objective: The aim of this case-controlled study is to evaluate chronic inflammation, subclinical atherosclerosis and cardiovascular disease risk in children and adolescents with ADHD. Methods: A total of 51 medication-free children and adolescents with ADHD and 51 healthy controls were included in this study. K-SADS-PL was used to determine the diagnosis of ADHD and other psychiatric disorders. Conners’ Parent Rating Scale-Revised Short Form and the Conners’ Teacher Rating Scale-Revised Short Form severity of ADHD was used to evaluate severity of ADHD. In order to evaluate subclinical atherosclerosis, common carotid intima media thickness (IMT), epicardial adipose tissue thickness (EAT), and periaortic adipose tissue thickness (PAT) were assessed as well as clinical parameters. Results: The IMT (0.037 ± 0.005 cm vs. 0.026 ± 0.003 cm), EAT (0.472 ± 0.076 cm vs. 0.355 ± 0.051 cm), and PAT (0.135 ± 0.016 cm vs. 0.118 ± 0.009 cm) measurements were significantly higher in the ADHD group than in the control group. Additionally, partial correlation analyses revealed that a positive correlation was observed between IMT and EAT, and PAT measurements separately. Multivariate linear regression analysis revealed that, body mass index (BMI) positively predicted IMT. Also, age and BMI positively predicted the EAT levels of the subjects with ADHD. Conclusion: Our results suggest that children and adolescents with ADHD have a risk for cardiovascular disease. For this reason, subclinical atherosclerosis should be taken into consideration in the follow-up and treatment of ADHD for cardiovascular disease risk.

The correlation of linguistic and geographic distance: A sampling of Altaic languages

( Nadir Engin Uzun ),( Kyoo-seok Yeon ) 한국외국어대학교 언어연구소 2021 언어와 언어학 Vol.- No.94

In this paper, a group of languages (Turkish, Mongolian, Evenki, Korean and Japanese in comparison with Arabic, English and Chinese) will be investigated in terms of how linguistically and geographically distant they are according to the related data of these well-defined language samples in WALS. Then, depending on Holman et al. (2007) and applying a counting method offered by Uzun (2012b) we will investigate how much their linguistic differences are in correlation with geographic distances. With reference to the acquired findings, the aim of this study is to discover whether the differentiation of these languages is closer to the related languages or to the unrelated ones, and to make a contribution to the Altaic debates.

Free vibration analysis Silicon nanowires surrounded by elastic matrix by nonlocal finite element method

Uzun, Busra,Civalek, Omer Techno-Press 2019 Advances in nano research Vol.7 No.2

Higher-order theories are very important to investigate the mechanical properties and behaviors of nanoscale structures. In this study, a free vibration behavior of SiNW resting on elastic foundation is investigated via Eringen's nonlocal elasticity theory. Silicon Nanowire (SiNW) is modeled as simply supported both ends and clamped-free Euler-Bernoulli beam. Pasternak two-parameter elastic foundation model is used as foundation. Finite element formulation is obtained nonlocal Euler-Bernoulli beam theory. First, shape function of the Euler-Bernoulli beam is gained and then Galerkin weighted residual method is applied to the governing equations to obtain the stiffness and mass matrices including the foundation parameters and small scale parameter. Frequency values of SiNW is examined according to foundation and small scale parameters and the results are given by tables and graphs. The effects of small scale parameter, boundary conditions, foundation parameters on frequencies are investigated.

Reliability of Corroded Steel Members Subjected to Elastic Lateral Torsional Buckling

Uzun Ertugrul Turker,Engin Aktaş 한국강구조학회 2021 International Journal of Steel Structures Vol.21 No.4

Structural steel members are subjected to corrosion due to environmental condition. As a result, there is decreasing in the cross-section properties of the member. This causes diff erent stability problems and reduction in the load carrying capacity of members. Then, the probability of failure, P f increases due to corrosion. The need arises to determine expected level of safety for such members and systems. Besides, reliability of the steel structure is also eff ected by the structural stability problems that result decreasing in the resistance. Lateral torsional buckling is one of the most encountered problems in steel members and aff ected by the critical moment which is a function of lateral and torsional stiff ness. Critical moment depends on the material properties, boundary conditions, unbraced length, load pattern, and the member’s cross section. Under the corrosion, it is inevitable to observe changing in some of properties. In this study, a damage model to determine the reliability of a corroded I-shape steel member under linear moment gradient is developed considering corrosion exposure time. Uniform and varying thickness loss models are considered to show the corrosion eff ect. Infl uence of environmental condition on the load carrying capacity of the members is considered and their eff ects on member design is evaluated. As a result, it is concluded that load carrying capacity of steel members degrades and safety of them adversely eff ected. With presented formulas, it is ensured that the load carrying capacity and reliability indices of the steel members can be calculated practically under the examined situations

Narrative differences between Orkhon inscriptions

Uzun, Gülsün Leylâ 한국이슬람학회 2010 한국이슬람학회논총 Vol.20 No.2

This study aims to demonstrate some of the discourse features of Tunyukuk scripts, a part of Orkhon inscriptions and compare it to the other parts, which are Bilge Kagan and Kül Tigin, in terms of its basic narrative discourse. The data will be analyzed using descriptive tools provided by narrative analysis and the rhetorical structure theory with a synchronic point of view. Tunyukuk will be the main text to be analyzed. and it will be compared to Kül Tigin to specify the discursive differences among them. Since Kül Tigin and Bilge Kagan have similar contents, Bilge Kagan will be excluded from this analysis. This study claims that even though these two scripts seem to report the same sequence of events, there is a drastic difference between them in terms of the presentation of their macro structures. This study aims to demonstrate some of the discourse features of Tunyukuk scripts, a part of Orkhon inscriptions and compare it to the other parts, which are Bilge Kagan and Kül Tigin, in terms of its basic narrative discourse. The data will be analyzed using descriptive tools provided by narrative analysis and the rhetorical structure theory with a synchronic point of view. Tunyukuk will be the main text to be analyzed. and it will be compared to Kül Tigin to specify the discursive differences among them. Since Kül Tigin and Bilge Kagan have similar contents, Bilge Kagan will be excluded from this analysis. This study claims that even though these two scripts seem to report the same sequence of events, there is a drastic difference between them in terms of the presentation of their macro structures.

Increased Bladder Wall Thickness in Diabetic and Nondiabetic Women With Overactive Bladder

Hakkı Uzun,Sabri Ogullar,Serap Baydur Şahin,Orhan Ünal Zorba,Görkem Akça,Fatih Sümer,Ülkü Mete Güney,Gülşah Balık 대한배뇨장애요실금학회 2013 International Neurourology Journal Vol.17 No.2

Purpose: Bladder wall thickness has been reported to be associated with overactive bladder (OAB) in women. Diabetic women have an increased risk for OAB syndrome and may have an increased risk for bladder wall thickness. Methods: A total of 235 female patients aged 40 to 75 years were categorized into four groups. The first group consisted of women free of urgency or urge urinary incontinence. The second group included nondiabetic women with idiopathic OAB. The third group consisted of women with diabetes and clinical OAB, and women with diabetes but without OAB constituted the fourth group. Bladder wall thickness at the anterior wall was measured by ultrasound by the suprapubic approach with bladder filling over 250 mL. Results: The diabetic (third group) and nondiabetic (second group) women with OAB had significantly greater bladder wall thickness at the anterior bladder wall than did the controls. However, the difference was not significant between the diabetic (third group) and the nondiabetic (second group) women with OAB. Women with diabetes but without OAB (fourth group) had greater bladder wall thickness than did the controls but this difference was not significant. Additionally, the difference in bladder wall thickness between diabetic women with (third group) and without (fourth group) OAB was not significant. Conclusions: This is the first study to show that bladder wall thickness is increased in diabetic women with and without OAB. Additionally, nondiabetic women with OAB had increased bladder wall thickness. Further studies may provide additional information for diabetic and nondiabetic women with OAB, in whom the etiopathogenesis of the disease may be similar.

Oxytocin and Vasopressin Levels and Related Factors in Adolescents with Social Phobia and Other Anxiety Disorders

Necati Uzun,Ö,mer Faruk Akç,a,İ,brahim Kılınç,Tevfik Balcı 대한정신약물학회 2022 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.20 No.2

Objective: This study aimed to determine whether a difference exists in plasma oxytocin and vasopressin levels among social anxiety disorder, other anxiety disorders, and healthy control groups in adolescents. The relationship between several psychiatric variables (i.e., state and trait anxiety, social anxiety, childhood trauma, and behavioral inhibition) and oxytocin or vasopressin levels were also investigated in adolescents with anxiety disorders. Methods: The study included three groups of adolescents: social anxiety disorder (n = 29), those with other anxiety disorders (n = 27), and the control group (n = 28). The participants filled out self-report scales to determine various psychological variables. Oxytocin and vasopressin levels were determined from the blood samples of the participants. Results: The oxytocin levels did not show a significant difference between the social anxiety disorder group and the other anxiety disorders group. However, the oxytocin levels were significantly higher in the social anxiety disorder and other anxiety disorders groups than in the control group. The vasopressin levels did not show a significant difference among the groups. According to the hierarchical regression analysis, the state and trait anxiety levels predicted oxytocin in opposite directions. Oxytocin showed positive and negative relationship with trait and state anxiety respectively. No predictive factors were found for the vasopressin levels. Conclusion: We found that the oxytocin levels of adolescents with social anxiety disorder were not different from those of adolescents with other anxiety disorders. Further studies can improve our knowledge of the relationship among anxiety disorders and oxytocin or vasopressin.