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- 저자 : Tianwen Wu (검색결과 2 건)
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Xylazole inhibits NO-cGMP pathway in fetal rat nerve cells
Xinyu Wang,Yue Wu,Lin Liu,Hui Bai,Zhiheng Zhang,Mingchao Zhao,Tianwen Ma,Xiaopeng Song,Lina Jia,Liangyu Lv,Yue Yu,Xinyu Xu,Hong Chen,Li Gao 대한수의학회 2022 Journal of Veterinary Science Vol.23 No.1
Background: Xylazole (Xyl) is a veterinary anesthetic that is structurally and functionally similar to xylazine. However, the effects of Xyl in vitro remain unknown. Objectives: This study aimed to investigate the anesthetic mechanism of Xyl using fetal rat nerve cells treated with Xyl. Methods: Fetal rat nerve cells cultured for seven days were treated with 10, 20, 30, and 40 μg/ mL Xyl for 0, 5, 10, 15, 20, 25, 30, 45, 60, 90, and 120 min. Variations of amino acid neurotransmitters (AANTs), Nitric oxide-Cyclic GMP (NO-cGMP) signaling pathway, and ATPase were evaluated. Results: Xyl decreased the levels of cGMP and NO in nerve cells. Furthermore, Xyl affected the AANT content and Na+-K+-ATPase and Ca2+-Mg2+-ATPase activity in nerve cells. These findings suggested that Xyl inhibited the NO-cGMP signaling pathway in nerve cells in vitro. Conclusions: This study provided new evidence that the anesthetic and analgesic effects of Xyl are related to the inhibition of the NO-cGMP signaling pathway.
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Ginsenoside Rb1 ameliorates cisplatin-induced learning and memory impairments
Chen Chen,Haifeng Zhang,Hongliang Xu,Yake Zheng,Tianwen Wu 고려인삼학회 2019 Journal of Ginseng Research Vol.43 No.4
Background: Ginsenoside Rb1 (Rb1), a dominant component from the extract of Panax ginseng root,exhibits neuroprotective functions in many neurological diseases. This study was intended to investigatewhether Rb1 can attenuate cisplatin-induced memory impairments and explore the potentialmechanisms. Methods: Cisplatin was injected intraperitoneally with a dose of 5 mg/kg/wk, and Rb1 was administeredin drinking water at the dose of 2 mg/kg/d to rats for 5 consecutive wk. The novel objects recognition taskand Morris water maze were used to detect the memory of rats. Nissl staining was used to examine theneuron numbers in the hippocampus. The activities of superoxide dismutase, glutathione peroxidase,cholineacetyltransferase, acetylcholinesterase, and the levels of malondialdehyde, reactive oxygen species,acetylcholine, tumor necrosis factor-a, interleukin-1b, and interleukin-10 were measured by ELISAto assay the oxidative stress, cholinergic function, and neuroinflammation in the hippocampus. Results: Rb1 administration effectively ameliorates the memory impairments caused by cisplatin in bothnovel objects recognition task and Morris water maze task. Rb1 also attenuates the neuronal loss inducedby cisplatin in the different regions (CA1, CA3, and dentate gyrus) of the hippocampus. Meanwhile, Rb1 isable to rescue the cholinergic neuron function, inhibit the oxidative stress and neuroinflammation incisplatin-induced rat brain. Conclusion: Rb1 rescues the cisplatin-induced memory impairment via restoring the neuronal loss byreducing oxidative stress and neuroinflammation and recovering the cholinergic neuron functions.
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