Antiulcerogenic effects of Gymnosporia rothiana

Surana, SJ,Jain, AS Kyung Hee Oriental Medicine Research Center 2009 Oriental pharmacy and experimental medicine Vol.9 No.3

Gymnosporia rothiana (walp) Lawson (celastraceae), commonly known as Maytenus rothiana, is used in Indian folk medicine as an antiulcerogenic agent. However, there have been no scientific reports regarding its antiulcer activity. Therefore, this study was intended to evaluate the antiulcer property of petroleum ether, chloroform, and methanolic extract of leaves of Gymnosporia rothiana at different dose levels in ethanol induced and indomethacin induced gastric ulcer models. It was observed that oral administration of all the extract of Gymnosporia rothiana produces significant reduction in ulcer lesion index as well as increase in volume and pH of gastric content in both experimental models, being petroleum ether extract the most effective at dose of 250 mg/kg; it significantly reduced gastric lesion index (70.06%), in comparison to omeprazole (71.20%) and methanolic extract at a dose of 500 mg/kg (67.22%). Increased gastric mucosal defense mechanism by petroleum ether extract is probably due to its high levels of terpenoids like $\beta$ amyrin, lupeol acetate. The present results clearly shows antiulcer effect of Gymnosporia rothiana against various irritants has been mainly due to cytoprotective effect mediated through prostaglandin and partly due to free radical scavenging activity.

Synthesis, characterization and application of CdSe quantum dots

Surana, K.,Singh, P.K.,Rhee, H.W.,Bhattacharya, B. Korean Society of Industrial and Engineering Chemi 2014 Journal of industrial and engineering chemistry Vol.20 No.6

Contrary to popularly prepared cadmium selenide (CdSe) quantum dots (QDs) at temperatures above 200<SUP>o</SUP>C, we here report synthesis of CdSe QDs at room temperature and above using wet-chemical method. Also we have used a much safer binder than the commonly used TOPO/TBPO. Controlling the size and shape of the nanocrystals allows us to control their bandgap over a wide range and thus, QDs can be prepared that can absorb and emit light over the entire frequency range of the solar spectrum. The prepared CdSe QDs were characterized by UV-Vis absorption, PL spectra, XRD and TEM. Particle size was also calculated according to the Brus equation. We have fabricated a dye sensitized solar cell using our CdSe QDs which shows a maximum efficiency of 0.22% at 1Sun condition.

A comprehensive study of chalcogenide quantum dot sensitized solar cells with a new solar cell exceeding 1V output

Surana, Karan,Mehra, R.M.,Bhattacharya, B.,Rhee, Hee-Woo,Polu, Anji Reddy,Singh, Pramod K. Elsevier 2015 RENEWABLE & SUSTAINABLE ENERGY REVIEWS Vol.52 No.-

<P><B>Abstract</B></P> <P>In the last two decades quantum dots (QDs) have attracted research interest all across the globe owing to their unique size-dependent optical and electronic properties. Generally, smaller the size of the crystal, the larger is the energy gap and greater is the difference in energy between the highest valence band and the lowest conduction band. Therefore more energy is needed to excite the dot, and concurrently more energy is released when the crystal returns to its resting state. Chalcogenide QDs have gained worldwide acceptance for their application in quantum dot sensitized solar cells (QDSSC). This review article focuses chiefly on the progress made in chalcogenide QD based solar cells (SC) over the years along with a new type of QDSSC giving an output voltage of over 1V.</P>

A prospective randomized controlled double-blind trial to assess the effects of dexmedetomidine during cleft palate surgery

Priyanka Surana,Devangi A. Parikh,Geeta A. Patkar,Bharati A. Tendolkar 대한마취통증의학회 2017 Korean Journal of Anesthesiology Vol.70 No.6

Background: We investigated whether the intraoperative administration of dexmedetomidine would attenuate the profound sympathoadrenal response associated with cleft palate (CP) surgery. Methods: Sixty children aged 6 months to 12 years undergoing CP surgery under general anesthesia were randomly assigned to the control (C) or dexmedetomidine (D) groups. Group C received benzodiazepine (0.05 mg/kg midazolam followed by infusion of normal saline) fentanyl isoflurane anesthesia, and Group D received dexmedetomidine (loading 1 μg/kg followed by infusion of 0.5 μg/kg/h) fentanyl isoflurane anesthesia. Heart rate (HR), mean blood pressure (MBP), intraoperative fentanyl and isoflurane requirements, recovery scores, emergence agitation, pain scores, time and requirement of rescue analgesic, and surgeon satisfaction were noted. Results: Intraoperative HR and MBP in Group D were significantly lower than the corresponding values in Group C (P < 0.001). HR decreased up to 16% in Group D. By contrast, HR increased up to 20% in Group C. Group D had comparable MBP to its baseline, whereas Group C had higher MBP until extubation (P = 0.015). Two children in Group D developed bradycardia and hypotension, which was successfully treated. The fentanyl and isoflurane requirements decreased by 43% and 30%, respectively, in Group D patients compared to those in Group C (P < 0.001). Group D had lower pain scores and less emergence agitation (P < 0.001). Time until requirement of first rescue analgesic was longer in Group D than that in Group C (P < 0.001). Surgeon satisfaction was higher in Group D than that in Group C. Conclusions: Intravenous dexmedetomidine during CP surgery attenuated hemodynamic responses with excellent surgeon satisfaction. Close monitoring of hemodynamics is recommended.

Antiulcerogenic effects of Gymnosporia rothiana

SJ Surana,AS Jain 경희대학교 융합한의과학연구소 2009 Oriental Pharmacy and Experimental Medicine Vol.9 No.3

Gymnosporia rothiana (walp) Lawson (celastraceae), commonly known as Maytenus rothiana, is used in Indian folk medicine as an antiulcerogenic agent. However, there have been no scientific reports regarding its antiulcer activity. Therefore, this study was intended to evaluate the antiulcer property of petroleum ether, chloroform, and methanolic extract of leaves of Gymnosporia rothiana at different dose levels in ethanol induced and indomethacin induced gastric ulcer models. It was observed that oral administration of all the extract of Gymnosporia rothiana produces significant reduction in ulcer lesion index as well as increase in volume and pH of gastric content in both experimental models, being petroleum ether extract the most effective at dose of 250 mg/kg; it significantly reduced gastric lesion index (70.06%), in comparison to omeprazole (71.20%) and methanolic extract at a dose of 500 mg/kg (67.22%). Increased gastric mucosal defense mechanism by petroleum ether extract is probably due to its high levels of terpenoids like β amyrin, lupeol acetate. The present results clearly shows antiulcer effect of Gymnosporia rothiana against various irritants has been mainly due to cytoprotective effect mediated through prostaglandin and partly due to free radical scavenging activity. Gymnosporia rothiana (walp) Lawson (celastraceae), commonly known as Maytenus rothiana, is used in Indian folk medicine as an antiulcerogenic agent. However, there have been no scientific reports regarding its antiulcer activity. Therefore, this study was intended to evaluate the antiulcer property of petroleum ether, chloroform, and methanolic extract of leaves of Gymnosporia rothiana at different dose levels in ethanol induced and indomethacin induced gastric ulcer models. It was observed that oral administration of all the extract of Gymnosporia rothiana produces significant reduction in ulcer lesion index as well as increase in volume and pH of gastric content in both experimental models, being petroleum ether extract the most effective at dose of 250 mg/kg; it significantly reduced gastric lesion index (70.06%), in comparison to omeprazole (71.20%) and methanolic extract at a dose of 500 mg/kg (67.22%). Increased gastric mucosal defense mechanism by petroleum ether extract is probably due to its high levels of terpenoids like β amyrin, lupeol acetate. The present results clearly shows antiulcer effect of Gymnosporia rothiana against various irritants has been mainly due to cytoprotective effect mediated through prostaglandin and partly due to free radical scavenging activity.

Synthesis, characterization and application of CdSe quantum dots

Karan Surana,Pramod K. Singh,이희우,B. Bhattacharya 한국공업화학회 2014 Journal of Industrial and Engineering Chemistry Vol.20 No.6

Contrary to popularly prepared cadmium selenide (CdSe) quantum dots (QDs) at temperatures above200 8C, we here report synthesis of CdSe QDs at room temperature and above using wet-chemicalmethod. Also we have used a much safer binder than the commonly used TOPO/TBPO. Controlling thesize and shape of the nanocrystals allows us to control their bandgap over a wide range and thus, QDs canbe prepared that can absorb and emit light over the entire frequency range of the solar spectrum. Theprepared CdSe QDs were characterized by UV–Vis absorption, PL spectra, XRD and TEM. Particle size wasalso calculated according to the Brus equation. We have fabricated a dye sensitized solar cell using ourCdSe QDs which shows a maximum efficiency of 0.22% at 1 Sun condition.

New polymer electrolyte for electrochemical application

Singh, M.,Singh, V.K.,Surana, K.,Bhattacharya, B.,Singh, P.K.,Rhee, H.W. Korean Society of Industrial and Engineering Chemi 2013 Journal of industrial and engineering chemistry Vol.19 No.3

A solid polymer electrolyte consisting of poly vinylpyrrolidone (PVP) and potassium iodide (KI) were developed, characterized for possible application in dye sensitized solar cell (DSSC) as an electrolyte. Complex impedance spectroscopy revealed the enhancement in electrical conductivity (σ) by salt doping and a conductivity maximum was obtained at 30wt% KI concentration. Dielectric phenomena also support the σ data. Fourier transform infrared spectroscopy (FTIR) confirmed the composite nature of polymer electrolyte film. Using maximum electrical conductivity film we have fabricated a DSSC which shows 0.14% efficiency at 1 sun condition.

Suppression of essential pro-inflammatory signaling pathways by natural agents for the therapy of Multiple Myeloma

Sikka, Sakshi,Shanmugam, Muthu K.,Kannaiyan, Radhamani,Surana, Rohit,Shin, Eun Myoung,Kumar, Alan Prem,Sethi, Gautam,Ahn, Kwang Seok Springer-Verlag 2014 Phytochemistry reviews Vol.13 No.1

Preparation and evaluation of flutamide mucoadhesive microparticles loaded poloxamer suppositories

B. S. Patil,H. S. Mahajan,S. J. Surana 한국약제학회 2016 Journal of Pharmaceutical Investigation Vol.46 No.2

Flutamide (FLT) is a potent non-steroidal antiandrogen drug primarily used in palliative treatment of prostate cancer that inhibits androgen uptake and/or nuclear binding of androgen in target tissues. The objective of the present study was to prepare FLT mucoadhesive microparticles. FLT mucoadhesive microparticles were developed by ionic gelation technique using hydrophilic polymers such as sodium alginate and Carbopol 971P and optimised by one factorial design of response surface methodology. The optimised microparticles were characterised by zeta potential study, in vitro release study, scanning electron microscopy and X-ray diffraction study. The stability studies performed on the optimized batch at 40 C/75 % RH for 90 days indicated no significant change in the physicochemical properties. Optimised batch of microparticles was further developed as suppository system using different proportions of Poloxamer 407:Poloxamer 188 as suppository base by fusion method.

New polymer electrolyte for electrochemical application

Pramod K. Singh,이희우,Manjeet Singh,Vivek K. Singh,Karan Surana,B. Bhattacharya 한국공업화학회 2013 Journal of Industrial and Engineering Chemistry Vol.19 No.3

A solid polymer electrolyte consisting of poly vinylpyrrolidone (PVP) and potassium iodide (KI) were developed, characterized for possible application in dye sensitized solar cell (DSSC) as an electrolyte. Complex impedance spectroscopy revealed the enhancement in electrical conductivity (s) by salt doping and a conductivity maximum was obtained at 30 wt% KI concentration. Dielectric phenomena also support the s data. Fourier transform infrared spectroscopy (FTIR) confirmed the composite nature of polymer electrolyte film. Using maximum electrical conductivity film we have fabricated a DSSC which shows 0.14% efficiency at 1 sun condition.