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RISS 인기검색어
- 검색키워드
- 저자 : H. S. Mahajan (검색결과 6 건)
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Preparation and evaluation of flutamide mucoadhesive microparticles loaded poloxamer suppositories
B. S. Patil,H. S. Mahajan,S. J. Surana 한국약제학회 2016 Journal of Pharmaceutical Investigation Vol.46 No.2
Flutamide (FLT) is a potent non-steroidal antiandrogen drug primarily used in palliative treatment of prostate cancer that inhibits androgen uptake and/or nuclear binding of androgen in target tissues. The objective of the present study was to prepare FLT mucoadhesive microparticles. FLT mucoadhesive microparticles were developed by ionic gelation technique using hydrophilic polymers such as sodium alginate and Carbopol 971P and optimised by one factorial design of response surface methodology. The optimised microparticles were characterised by zeta potential study, in vitro release study, scanning electron microscopy and X-ray diffraction study. The stability studies performed on the optimized batch at 40 C/75 % RH for 90 days indicated no significant change in the physicochemical properties. Optimised batch of microparticles was further developed as suppository system using different proportions of Poloxamer 407:Poloxamer 188 as suppository base by fusion method.
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Kim, I.,Bong, S.,Woo, S.,Mahajan, R.K.,Kim, H. Pergamon Press ; Elsevier Science Ltd 2011 INTERNATIONAL JOURNAL OF HYDROGEN ENERGY - Vol.36 No.2
Highly active 40 wt.% PtRu/C electrocatalysts that can be used as anode in polymer electrolyte membrane fuel cells (PEMFCs) were fabricated by improved impregnation method that introduced formaldehyde as a reducing agent and HCl as a segmentation agent with heat treatments at various temperatures. The morphology of the prepared catalysts was characterized by transmission electron microscopy (TEM) and X-ray diffraction (XRD), which revealed that the PtRu particles on carbon after heat treatment at 300 <SUP>o</SUP>C had a very narrow size distribution in the range of 1.5-3.4 nm, and that the average size varied between 2.3 and 2.4 nm. The electrochemical active surface area of the prepared PtRu/C catalysts was determined by CO-stripping voltammetry. In particular, the PtRu nanostructure electrodes heat treated at 300 <SUP>o</SUP>C showed an excellent catalytic activity because of the metals' large surface area as well as a sufficient degree of alloy formation for CO tolerance. The unit cell performance of the PtRu/C catalyst with heat treatment at 300 <SUP>o</SUP>C exhibited a power density of 0.67 W cm<SUP>-2</SUP> which was higher than that of a unit cell with a commercial PtRu/C catalyst (E-TEK) with the same metal loadings.
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Fermentation, a feasible strategy for enhancing bioactivity of herbal medicines
Hussain, A.,Bose, S.,Wang, J.H.,Yadav, M.K.,Mahajan, G.B.,Kim, H. Published on behalf of the Canadian Institute of F 2016 Food Research International Vol.81 No.-
<P>Herbal drugs, which possess immunomodulatory, anti-inflammatory, anti-diabetic, anti-infective, and anti-allergic activities, encompass various therapeutic areas, and have been used as traditional medicines for thousands of years. Fermentation is an indispensable traditional technology for the improving the efficacy or reducing adverse effects of herbal medicines. The fermentation process has been shown to improve biological properties of plants, vegetables, and herbs. More specifically, fermentation causes decomposition and/or biotransformation of complex substrates into compatible components, thereby modulating product properties or changing the quantity of certain bioactive compounds. Accumulating evidence indicates the valuable contribution of probiotics and their fermented food products to health. In recent years, considerable attention has been paid to fermentation technology across the globe for improving herbal drugs through production and enrichment of additional bioactive metabolites of medicinal importance including isoflavones, saponins, phytosterols, and phenols. For example, the phenolic contents of the herbal preparation can be increased as a consequence of fermentation and a positive correlation between polyphenols and the anti-oxidant activities of herbs has been well demonstrated. This is in agreement with evidence showing fermentation-mediated enhancement of the pharmacological properties and therapeutic efficacies of herbal formulations against a number of diseases including obesity and inflammation. The subject of fermentation of herbal preparations has been maturing and gaining considerable attention of scientific and technical communities worldwide. In the current review we have addressed these issues in detail with emphasis on understanding the contribution of fermentation-derived bioactive substances to therapies against a number of diseases. (C) 2016 Elsevier Ltd. All rights reserved.</P>
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Edralin A. Lucas,Sachin S. Mahajan,Do Y. Soung,Stanley A. Lightfoot,Brenda J. Smith,Bahram H. Arjmandi 한국식품영양과학회 2011 Journal of medicinal food Vol.14 No.3
This study was designed to investigate whether flaxseed oil (FO) exerts hypocholesterolemic effects similar to ground whole flaxseed (WF) and to gain insight into its hypocholesterolemic mechanism. Forty-eight 6-month-old female Golden Syrian hamsters were either sham-operated (Sham) or ovariectomized (Ovx) and randomly assigned to one of four treatment groups (n = 12/group) for 90 days: Sham, Ovx, Ovx+WF, or Ovx+FO. Hamsters in the Sham and Ovx groups were fed a semipurified diet (control), whereas Ovx+WF and Ovx+FO received the same basic diet supplemented with either WF (15% wt/wt) or FO (amount equivalent to the oil contribution of WF). Ovariectomy significantly (P < .05) increased serum total concentrations by approximately 15%. WF, but not FO, prevented (P < .05) the ovariectomy-induced increase in serum total cholesterol concentration (12% and 4% reduction by WF and FO, respectively). Hamsters fed FO or WF had high-density lipoprotein (HDL)-cholesterol concentrations similar to those of the Ovx hamsters receiving the control diet. Non–HDL-cholesterol concentrations were lowest in the WF group, albeit not statistically different from the other treatment groups. There were no significant differences among groups in serum triglyceride concentration and liver lipids. Both WF and FO more than doubled the hepatic protein levels of 7α-hydroxylase in comparison to the Ovx hamsters receiving the control diet (P < .05). Our findings suggest that increased bile acid synthesis is one of the major cholesterol-lowering mechanisms of flaxseed and that other flaxseed components, aside from its oil, contribute to its hypocholesterolemic property. The cholesterol-lowering effects of other components of flaxseed and their mechanisms of action need to be further explored.
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Badadhe, Pravin V.,Chate, Asha V.,Hingane, Dattatraya G.,Mahajan, Pravin S.,Chavhan, Namdev M.,Gill, Charansingh H. Korean Chemical Society 2011 대한화학회지 Vol.55 No.6
Thiamine hydrochloride (VB1) has been used as an acid catalyst in organic synthesis. One pot three component Biginelli condensation of dimedone, urea/thiourea and substituted aromatic aldehydes catalyzed by 10 mol % of thiamine hydrochloride (VB1) in solvent free condition under microwave irradiation in good to excellent yields has been investigated. Utilization of microwave irradiation, simple reaction conditions, short reaction time, ease of product isolation, and purification makes this manipulation very interesting from an economic and environmental perspective.
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