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( Chung Hoon Kim ),( Yong Pil Cheon ),( Kyung Hee Lee ),( Su Kyoung Kwon ),( Sung Hoon Kim ),( Hee Dong Chae ),( Byung Moon Kang ),( Chung Hoon Kim ) 대한산부인과학회 2012 대한산부인과학회 학술대회 Vol.99 No.-
We performed this study to investigate whether GnRH antagonist could affect endometrial receptivity and the addition of GnRH agonist could reverse the impact of GnRH antagonist. In female mice, superovulation was induced by standard protocol using pregnant mare serum gonadotropin (PMSG) and hCG. Female mice were divided into three groups. Group 1 was served as control group. In group 2, GnRH antagonist was injected concomitantly with PMSG. In group 3, GnRH antagonist was injected concomitantly with PMSG and GnRH agonist was added at the time of hCG injection. After hCG injection, the mice were mixed with fertile stud male mice and the copulation plug was checked in the next morning (day 1). Pregnant mice were sacrificed 4 days after hCG injection and their uteri were collected. Total RNA was isolated from endometrial tissue. Reverse transcription and Real-time PCR was performed. The expression of estrogen receptor (ER)α, ERβ, progesterone receptor (PR)α, PRβ, COX2, GnRH receptor (GnRHR)-1, leukemia inhibitory factor (LIF) and HOXA10 mRNAs was analyzed by realtime RT-PCR. There were no significant differences in the relative amounts of PRα, PR β, COX2 and GnRHR-1 mRNAs among three groups. The relative amounts of ERβ and LIF mRNAs were significantly higher in group 1 (p<0.05, p<0.01). On the other hand, the expression of ERα and HOXA10 mRNAs were significantly lower in group 2 (p<0.05, p<0.005) GnRH antagonist can reduce the expression of ERα, ERβ, LIF and HOXA10 mRNAs in murine endometrium, but the addition of GnRH agonist can reverse the amounts of ERα and HOXA10 mRNAs.
Phototrichogram findings in alopecia areata and their relation to disease activity and severity
( Chung Hyeok Lee ),( Jong Won Lee ),( Sang Hoon Lee ),( Won-soo Lee ) 대한피부과학회 2019 대한피부과학회 학술발표대회집 Vol.71 No.2
Background: Phototrichogram is a non-invasive method, which provides an accurate qualitative as well as quantitative assessment of the hair. Furthermore, taking a close-up photograph of a well-defined scalp area can provide sophisticated high-resolution image about scalp, hair shafts and hair follicles. Objectives: Investigate whether hair findings observed in the phototrichogram is related to the activity and severity of alopecia areata. Methods: We retrospectively analyzed 126 patients and 220 AA patches which is taken with a phototrichogram. The magnification of the phototrichogram was 50x to 100x. Using the one-way anova test, correlations between the incidence of each hair findings on phototrichogram and the severity of disease and disease activity were examined Results: A total of 220 AA patches were analyzed. The association between disease severity of AA and clustered white dots (p-value < 0.01, 95% CI: 0.11-0.88) and black dots (p-value < 0.05, 95% CI: 1.13-6.57) showed statistical significance. The association between disease activity of AA and brown dots (p-value< 0.01, 95% CI: 1.10-5.68), exclamation marks hair (p-value <0.05, 95% CI: 1.13-18.27), short vellus hair (p-value < 0.05, 95% CI: 2.11-4.65) and upright regrowth hair (p-value <0.05, 95% CI: 0.35-0.85) showed statistical significance. Conclusion: Phototrichogram findings are related to the activity and severity of alopecia areata.
Evaluation of Daily Intake of $^{238} U$ and $^{232} Th$ in a Korean Mixed Diet Sample Using RNAA
Chung, Yong-Sam,Moon, Jong-Hwa,Kim, Sun-Ha,Park, Kwang-Won,Kang, Sang-Hoon,Cho, Seung-Yeon Korean Nuclear Society 2000 Nuclear Engineering and Technology Vol.32 No.5
To estimate the degree of intake of $^{238}$ U and $^{232}$ Th through daily diet, a Korean mixed diet sample was prepared after the investigation of the amount of consumption of the daily diet which corresponds to the age of 20 to 60 years. For the analysis of U and Th, the RNAA method was applied. Two standard reference materials were used for quality control and assurance and the analytical results were compared with a certified value. The determination of U and Th in the Korean mixed diet sample was carried out under the same analytical conditions and procedures with SRM. It is found that the concentration of U and Th in a Korean mixed diet was about 35.4 ppb and 3.4 ppb. From these results, the daily intake of $^{238}$ U and $^{232}$ Th by diet is evaluated to be 6.98 and 0.67 $\mu\textrm{g}$ per day, respectively. Radioactivities related to the intake of $^{238}$ U and $^{232}$ Th were estimated to be about 86 mBq and 27 mBq per person per day and the annual dose equivalents from $^{238}$ U and $^{232}$ Th revealed as 3.18 $\mu$Sv and 0.29 $\mu$Sv per person, respectively.
Chung, In-Young,Park, Yu-Mi,Lee, Hyun-Jeoung,Kim, Hyuk,Kim, Dong-Hoon,Kim, Il-Gyu,Kim, Sang-Min,Do, Young-Sun,Seok, Kwang-Seol,Kwon, Jung-Hwan Editorial Dept. of Journal of Environmental Scienc 2017 JOURNAL OF ENVIRONMENTAL SCIENCES -BEIJING- Vol.62 No.-
<P>It is thought that there are many unregulated anthropogenic chemicals in the environment. For risk assessment of chemicals, it is essential to estimate the predicted environmental concentrations. As an effort of identifying residual organic contaminants in air and water in Korea, nontarget screening using two-dimensional gas chromatography time-of-flight mass spectrometry (GC x GC-TOFMS) was conducted at 10 sites using polyurethane foam passive air sampler and at 6 sites using polydimethyl siloxane (PDMS) passive water sampler in three different seasons in 2014. More than 600 chemical peaks were identified satisfying the identification criteria in air and water samples, respectively, providing a list for further investigation. Chemical substances with reported national emission rates in 2014 (n = 149) were also screened for potential existence in the environment using a level II fugacity model. Most of chemical substances classified as not detectable were not identified with detection frequency greater than 20% by nontarget screening, indicating that a simple equilibrium model has a strong potential to be used to exclude chemicals that are not likely to remain in the environment after emissions from targeted monitoring. (C) 2017 The Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences. Published by Elsevier B.V.</P>
( Sang-hee Jeong ),( Mi-young Lee ),( Ok-ju Kang ),( Rina Kim ),( Jin-hoon Chung ),( Hye-sung Won ),( Pil-ryang Lee ),( Euiseok Jung ),( Byong Sop Lee ),( Woo-jong Choi ),( Yoon Se Lee ) 대한산부인과학회 2021 Obstetrics & Gynecology Science Vol.64 No.1
Objective To report our experience with management of fetuses with congenital high airway obstruction syndrome (CHAOS). Methods We retrospectively reviewed the cases of fetuses who were prenatally diagnosed and postnatally confirmed with CHAOS between 2010 and 2019 at Asan Medical Center, Seoul, Korea. Results Of 13 fetuses prenatally diagnosed with CHAOS, 7 were lost to follow-up and 6 were postnatally confirmed as having CHAOS. All fetuses, except one were delivered via cesarean section with an ex utero intrapartum treatment (EXIT) procedure. Two patients had coexisting congenital heart diseases requiring several cardiac surgeries following birth. Both of these patients demonstrated developmental delay; however, the remaining 4 had a normal development except for expressive language. Two infants died of respiratory complications, and the remaining 4 were alive at the end of the follow-up period. All 4 live patients underwent tracheostomy with planned reconstruction surgery. Three children are now able to phonate, and 1 can maintain a conservation. Conclusion The proper management of CHAOS using the EXIT procedure results in high survival and low hypoxemia-induced complication rates. Therefore, an accurate prenatal diagnosis is necessary for an appropriate perinatal management.
Chung, Young-Hoon,Kim, Soo Jin,Chung, Dong Young,Park, Hee Young,Sung, Yung-Eun,Yoo, Sung Jong,Jang, Jong Hyun The Royal Society of Chemistry 2015 Chemical communications Vol.51 No.14
<P>The residual surfactant organic molecules on electrocatalysts are expected to enhance the tolerance to specific anion adsorption, whereas the surfactants have been generally regarded as contaminants that block active surfaces. In this study, the Pt nanoparticles with adsorbed surfactants were prepared, and their electrochemical characteristics at various phosphoric acid concentrations were studied by the half-cell test. The third-body effect was experimentally confirmed by the single-cell test with a phosphoric acid-doped polybenzimidazole membrane.</P> <P>Graphic Abstract</P><P>The third-body effect of oleylamine could enhance the oxygen reduction reaction of Pt nanoparticles in the presence of specifically adsorbed anions despite the quite small electrochemical surface active area. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=c4cc09019e'> </P>
Radioresponse of Hepatocellular Carcinoma-Treatment of Lymph Node Metastasis
Sang Min Yoon,Jong Hoon Kim,Eun Kyung Choi,Seung Do Ahn,Sang-wook Lee,Byong Yong Yi,Young Wha Chung,Young Sang Lee,Dong Jin Seo 대한암학회 2004 Cancer Research and Treatment Vol.36 No.1
PURPOSE: To analyze the radioresponse of hepatocellular carcinomas (HCC), using accurate measurements of the tumor size in extrahepatic lymph node metastasis, and to obtain information for the future treatment of primary intrahepatic lesions. MATERIALS AND METHODS: Fifty-one extrahepatic lymph node metastases from primary HCCs, which could be treated by external radiotherapy alone, were included in this study. The radiation dose ranged from 30 to 51 Gy with fraction sizes of 2.0~3.0 Gy. Responses were determined by measuring the areas on CT scans 0, 1 and 3 months after the completion of radiotherapy. The median follow-up period of the surviving patients was 10 months. RESULTS: The overall response rate was 76%, and the important factors were; total dose of radiation, time dose fractionation (TDF) value and the biologically effective dose (BED). A dose of 45 Gy or higher showed an objective response rate of 93%, and if the TDF value was higher than 90, a similar result was observed. In about half (47%) of the patients the maximum response was observed at 3 months or later. The response duration was observable in 14 patients surviving 12 months or longer. Regrowth of irradiated lesions were observed in 4 (66.7%) patients among those who received less than 45 Gy, and in 4 (50%) among those who were treated with 45 Gy or more. There was a statistically significant difference in the survivals between the responders and non-responders (p=0.008). Gastrointestinal bleeding or ulceration was observed in 8 patients, including 3 with NCI common toxicity criteria grade III or higher. CONCLUSION: Radiotherapy was an effective palliative modality for extrahepatic metastasis in HCCs. A radiation dose of 45 Gy or higher (or a TDF value 〉90), was required for a major response. (Cancer Res Treat. 2004;36:79-84)
Vasoconstriction Potency Induced by Aminoamide Local Anesthetics Correlates with Lipid Solubility
Sung, Hui-Jin,Ok, Seong-Ho,Sohn, Jin-Young,Son, Yong Hyeok,Kim, Jun Kyu,Lee, Soo Hee,Han, Jeong Yeol,Lim, Dong Hoon,Shin, Il-Woo,Lee, Heon-Keun,Chung, Young-Kyun,Choi, Mun-Jeoung,Sohn, Ju-Tae Hindawi Publishing Corporation 2012 Journal of biomedicine & biotechnology Vol.2012 No.-
<P>Aminoamide local anesthetics induce vasoconstriction <I>in vivo</I> and <I>in vitro</I>. The goals of this <I>in vitro</I> study were to investigate the potency of local anesthetic-induced vasoconstriction and to identify the physicochemical property (octanol/buffer partition coefficient, pKa, molecular weight, or potency) of local anesthetics that determines their potency in inducing isolated rat aortic ring contraction. Cumulative concentration-response curves to local anesthetics (levobupivacaine, ropivacaine, lidocaine, and mepivacaine) were obtained from isolated rat aorta. Regression analyses were performed to determine the relationship between the reported physicochemical properties of local anesthetics and the local anesthetic concentration that produced 50% (ED<SUB>50</SUB>) of the local anesthetic-induced maximum vasoconstriction. We determined the order of potency (ED<SUB>50</SUB>) of vasoconstriction among local anesthetics to be levobupivacaine > ropivacaine > lidocaine > mepivacaine. The relative importance of the independent variables that affect the vasoconstriction potency is octanol/buffer partition coefficient > potency > pKa > molecular weight. The ED<SUB>50</SUB> in endothelium-denuded aorta negatively correlated with the octanol/buffer partition coefficient of local anesthetics (<I>r</I><SUP>2</SUP> = 0.9563; <I>P</I> < 0.001). The potency of the vasoconstriction in the endothelium-denuded aorta induced by local anesthetics is determined primarily by lipid solubility and, in part, by other physicochemical properties including potency and pKa.</P>