A comparison of survival outcome of open, total laparoscopic and laparoscopy-assisted vaginal radical hysterectomy in patients with early cervical cancer of stage IB2

( Sul Lee ),( Hyung Joon Yoon ),( Eun Hye Jeon ),( Juseok Yang ),( Yong Jung Song ),( Hyun Jin Roh ),( Sang Hun Lee ),( Byung Su Kwon ),( Ki Hyung Kim ),( Dong Soo Suh ) 대한산부인과학회 2019 대한산부인과학회 학술대회 Vol.105 No.-

Objective: The aim of this study is to evaluate oncologic outcomes of total abdominal radical hysterectomy (TARH), total laparoscopic radical hysterectomy (TLRH) and laparoscopic-assisted radical vaginal hysterectomy (LARVH) in early cervical cancer patients (stage IB2-3, tumor size≥2cm), analyzing the risk factors that may affect the clinical results. Methods: A total of 756 patients underwent radical hysterectomy between 2000 and 2019 from three university hospitals (Pusan National University Hospital, Yang-san Pusan National University Hospital, Ulsan University Hospital) were enrolled. Among them, 172 patients with stage IB2-3 were analyzed retrospectively. Results: Seventy-seven patients were treated with TARH, and 95 were managed via minimally invasive surgery (MIS), consisting of 35 with TLRH and 60 with LARVH. TARH group had better disease five-year disease free survival (DFS) and overall survival (OS) compared with MIS group (86.4% vs. 73.4 for DFS and 91.7 vs. 82.2 for OS), but not statistically significant in both (p=0.058 for DFS and p=0.119 for OS). When TARH and the LARVH group were compared, both five-year DFS and OS were not significant different (86.4 vs 82.2%; p=0.288 for DFS and 91.7 vs 84.4%; p=0.206 for OS). However, when TARH and the TLRH group were compared, TLRH group had significantly worse five-year DFS than TARH (86.4 vs 54.5%; p=0.008), but five-year OS was not significant different (91.7 vs 77.5%; p=0.127). Multivariate analysis showed that LN metastasis and TLRH surgical approaches were an independent prognostic factor for DFS in IB2-3 cervical cancers. Conclusion: Our findings provided the evidence that TLRH surgical approach was associated with worse DFS in IB2-3 cervical cancers but that of LARVH was not. Such results may have important implications of colpotomy method for MIS in cervical cancer.

Changes in Ginsenoside Composition of White Ginseng by Fermentation

Sung Kwon Ko,Ok Sun Cho,Hye Min Bae,Byung Wook Yang,Byung-Ok Im,Young Tae Hahm,Kyung Nam Kim,Soon Hyun Cho,Jae Young Kim,Sung Hyun Chung,Boo Yong Lee 한국식품과학회 2009 Food Science and Biotechnology Vol.18 No.1

The purpose of the study was to develop a new process to manufacture ginseng extract containing saponin aglycon of high concentration. The process to transform saponin glycosides to saponin aglycon was analyzed by high performance liquid chromatography (HPLC). GCK-1 (open cultured mixture for 1 day at 42℃) had the highest content of protopanaxadiol (0.662%). However, other mixtures (GCK-2, 3, 4, 5, and 6) had less than 0.152% in the content of protopanaxadiol. In case of fermentation by inoculation of Bacillus natto, BNG-5 (B. natto inoculated mixture for 5 days at 42℃) showed the highest content of protopanaxadiol (0.364%). Other mixtures (BNG-1, 2, 3, 4, and 6) also showed the high content of more than 0.2% in protopanaxadiol. B. natto inoculation or open culture fermentation with soybean transformed ginseng saponin glycosides into saponin aglycon.

Change of electrical properties of (K0.5Na0.5) (Mn0.005Nb0.995)O3 thin films induced by gamma-ray irradiation

Byung Hoon Kim,Sun A Yang,Sin Wook Kang,Gi Ppeum Choi,Sam Yeon Cho,한진규,Gyoung Ja Lee,이민구,Hae Jin Seog,Ill Won Kim,Sang Don Bu 한국물리학회 2016 Current Applied Physics Vol.16 No.5

We investigated the effects of gamma-ray (g) irradiation on the electrical properties of (K0.5Na0.5) (Mn0.005Nb0.995)O3 (KNMN) thin films. The KNMN thin films were prepared on Pt/Ti/SiO2/Si substrate using a chemical solution deposition method through a spin-coating process and were subject to g radiation at various total doses from 0 to 3000 kGy. The structural properties as well as the ferroelectric and dielectric properties of the prepared films were examined before and after g irradiation. We found that their crystalline quality did not vary significantly with an increase in the total dose. It was also observed that the remnant polarization value of the films decreased by ~10%, but the films maintained ferroelectricity even after irradiation up to 3000 kGy. In addition, the dielectric constant of the films decreased with the total dose. The observed variation of the electrical properties on the total dose might be mainly associated with the mobile defects in Mn-doped KNN thin films such oxygen vacancy and the stored energy gained from gamma-rays.

An Analysis of Technological Convergence Using Industry Data : Catch-Up or Leapfrogging Path

Sang-Sup Cho,Yeong-Seok Yang,Byung-Sun Cho 한국산업경제학회 2008 산업경제연구 Vol.21 No.4

본 연구는 국가경제성장에서 중요한 역할을 하는 생산성과 기술모방의 관계를 DEA 방법론과 패널 단위근 방법론을 사용하여 기술수렴가설을 검증하는 데 있다. 한 나라 또는 산업성장요인으로 기술모방과 총 요소생산성 수준차이가 장기적으로 이 서로 정상적인 관계를 나타낸다면, 기술수렴을 뒷받침한다고 볼 수 있다. 기술수렴성이 기술모방요인에 의하여 성립된다면, 기술 Catch-up메커니즘작동은 경제 및 산업성장요인으로 매우 중요한 역할을 수행다고 볼 수 있다. 본 연구에서는 2단계분석을 실시하여 기술수렴을 검증하였다. 먼저 기술모방수준을 추출하고 총 기술요소수준과 기술모방수준의 차이에 대하여 패널 단위근 검증을 통하여 기술수렴의 존재를 검증하였다. 1970년부터 2003년 동안 우리나라 9개 산업에 대한 본 연구결과는 다음과 같이 나타났다. 첫째, 패널 단위근 검정에 의한 기술모방수준과 총 요소생산성수준에 대한 기술수렴 가설은 기각할 수 없었다. 둘째, 그러나 우리나라 산업별로 절대적 기술수렴보다는 조건부 기술수렴가설이 뒷받침되었다. 따라서 산업성장을 위한 산업별 동질적 정책 및 제도보다는 산업의 특성을 고려한 성장전략이 유효했다고 볼 수 있다. This study tests the hypothesis of technological convergence in the Korean industry by analyzing the relationship between productivity and technological imitation, using the DEA methodology and panel unit root techniques. Technological convergence is generally achieved through technological imitation factors, and the mechanism of technology catch-up has a determining influence on economic and industrial growth. In this study, we test the existence of technological convergence through a two-stage analysis. We first determine the degree of technological imitation and then conduct a panel unit root test to establish the relationship between total technological capacity and technological imitation. Our findings, from analyzing nine Korean industries over a period ranging from 1970 to 2003, were as follows: first, based on our results, we could not reject the hypothesis of technological convergence, with regard to the relationship between technological imitation and total factor productivity. This study result suggests the catch-up rather than leapfrogging growth path in Korea industry. Second, our results support the hypothesis of a conditional technological convergence rather than an absolute technological convergence. Our results, therefore, suggest that diversified strategies are more effective than homeogenous strategies for promoting industrial growth in Korea.

Long-term survival in primary CNS lymphoma treated by high-dose methotrexate monochemotherapy: role of STAT6 activation as prognostic determinant

Yang, Seung-Ho,Lee, Kun Soo,Kim, Il Sup,Hong, Jae Taek,Sung, Jae Hoon,Son, Byung Chul,Lee, Sang Won,Hong, Yong-Kil Springer-Verlag 2009 Journal of neuro-oncology Vol.92 No.1

Integrated devices based on networks of nanotubes and nanowires

Yang Lee, Byung,Gyu Sung, Moon,Lee, Hyungwoo,Namgung, Seon,Young Park, Sung,Shin Choi, Dong,Hong, Seunghun Nature Publishing Group 2010 NPG Asia Materials Vol.2 No.3

Effectiveness of Non-invasive Brain Stimulation in Dysphagia Subsequent to Stroke: A Systemic Review and Meta-analysis.

Yang, Seung Nam,Pyun, Sung-Bom,Kim, Hyun Jung,Ahn, Hyeong Sik,Rhyu, Byung Joo Springer-Verlag 2015 Dysphagia Vol.30 No.4

<P>The objective of this study is to assess the efficacy and safety of non-invasive brain stimulation (NIBS) in patients with dysphagia subsequent to stroke. A systematic search of the literature published by Medline (January 1, 1976 through June 21, 2013), EMBASE (January 1, 1985 through June 21, 2013), and the Cochrane Library (January 1, 1987 through June 21, 2013) was conducted for all relevant articles related to NIBS, dysphagia, and cerebrovascular disorders (CVD). Two reviewers (S.N.Y and S.B.P) independently evaluated the eligibility of retrieved data according to the selection criteria and assessed methodological quality of the studies using the 'assessing risk of bias' table recommended in the Cochrane Handbook for Systematic Reviews of Interventions (version 5.0.2). Six randomized controlled trials (59 intervention groups and 55 placebo groups) were identified as addressing the use of NIBS for dysphagia after CVD and were included in the meta-analysis. The function scale score improvement of dysphagia in patients treated with NIBS was statistically significant compared with that of patients who underwent sham stimulation (standardized mean difference = 1.08, 95 % confidence intervals = 0.29-1.88, p = 0.008; I (2) = 72 %). A subgroup analysis based on the type of intervention (three repetitive transcranial magnetic stimulation (rTMS) studies and three transcranial direct current stimulation (tDCS) studies) revealed a statistically significant beneficial effect of NIBS compared with sham stimulation in the rTMS group, but not in the tDCS group. When the results were examined based on intervention site (ipsilesional vs. contralesional site stimulation), no statistically significant difference was noted between two groups. No complications of NIBS were reported in this analysis.</P>

The Relationship between Cognitive Therapeutic Exercises and Basal Ganglia Function in Patients with Basal Ganglia Region Stroke; a Pilot Study

Sang-Mi Joung,Byung-Il Yang 대한신경치료학회 2019 신경치료 Vol.23 No.1

Purpose This study was aimed that the cognitive therapeutic exercises (CTE) benefit on motor function in patients with basal ganglia stroke. Methods The subjects assigned to a right hemiplegia group (RHG) and left hemiplegia group (LHG) and performed the CTE 5 times a week for 4 weeks. Manual functional test (MFT), Korean-Modified Barthel Index (K-MBI) and Sensory Function Test (SFT) were used to assess motor functions of basal ganglia. Results There were significant differences in MFT in non-hemi side (MFT_nh), K-MBI and SFT in the RHG and in K-MBI in the LHG. Conclusion The subjects with the RHG more were improved in most assessments than that of the LHG. As a whole, the CTE influenced the basal ganglia functions.

Pretreatment with low-dose fimasartan ameliorates NLRP3 inflammasome-mediated neuroinflammation and brain injury after intracerebral hemorrhage

Yang, Xiuli,Sun, Jing,Kim, Tae Jung,Kim, Young-Ju,Ko, Sang-Bae,Kim, Chi Kyung,Jia, Xiaofeng,Yoon, Byung-Woo Elsevier 2018 Experimental neurology Vol.310 No.-

<P><B>Abstract</B></P> <P>Nucleotide-binding and oligomerization domain-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome, which is composed of an NLRP3 domain, the adaptor molecule apoptosis-associated speck-like protein containing a CARD (ASC) domain, and procaspase-1, plays an important role in the immune pathophysiology of the secondary damage induced by intracerebral hemorrhage (ICH). This study aims to investigate whether pre-stroke treatment with fimasartan, an angiotensin II receptor blocker, has anti-inflammatory effects on ICH by inhibiting the activation of the NLRP3 inflammasome. Sprague-Dawley rats were divided into five groups: sham, vehicle, low-dose (0.5 mg/kg) and regular-doses (1.0 and 3.0 mg/kg) fimasartan. These rats were treated for 30 days before the induction of collagenase-induced ICH and continuously 3 days after surgery. The mean blood pressure (BP) in the low-dose fimasartan group was not significantly different from that of control, and BP in the regular-dose groups was decreased in a dose-dependent manner. Pretreatment with low-dose fimasartan attenuated ICH-induced edema and improved neurological functions. Activation of the NLRP3/ASC/caspase-1 and the NF-κB pathways after ICH was markedly reduced by low-dose fimasartan. The double immunofluorescence staining of brain cells showed a significant decrease in the co-localization of NLRP3 with Iba1 (microglia marker) positive cells by fimasartan treatment. Cultured microglia cells stimulated by hemolysate demonstrated significant activation of the inflammasome, which was reduced by fimasartan. Pretreatment with a low-dose fimasartan alleviated brain damage after acute ICH by inhibiting the NLRP3 inflammasome without lowering MBP. Our study suggests pre-stroke administration of fimasartan could potentially attenuate ICH-induced secondary brain injury by targeting the inflammasome.</P> <P><B>Highlights</B></P> <P> <UL> <LI> NLRP3 inflammasome activation is involved in the secondary brain damage after ICH. </LI> <LI> Pre-stroke treatment with low-dose fimasartan has favorable effects on acute ICH injury. </LI> <LI> Fimasartan could potentially target the NLRP3 inflammasome to protect ICH injury independent of its effect on BP. </LI> </UL> </P>

Influences of stocking density, fumonisin B1, and mycotoxin binder on growth performance, bone quality, and physiological traits of broiler chickens

Sang Lee,Da-Hye Kim,Moung-Cheul Keum,Eileen Han,Byoung-Ki An,Hong-Hee Chang,Yang-Ho Choi,Byung-Hern Moon,Kyung-Woo Lee 한국가금학회 2017 한국가금학회 정기총회 및 학술발표회 Vol.2017 No.11