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( Sung Bum Cho ),( Young Lan Park ),( Nuri Kim ),( Cho Yun Chung ),( Hyung Chul Park ),( Jong Sun Kim ),( Dae Seong Myung ),( Kyung Hwa Lee ),( Jae Hyuk Lee ),( Sung Kyu Choi ),( Young Eun Joo ) 대한간학회 2013 춘·추계 학술대회 (KASL) Vol.2013 No.1
Background: Livin, a member of the inhibitors of apoptosis proteins, has been found to be expressed in variable cancers, where its expression is considered to be a poor prognostic marker. The purposes of this study were to observe the effect of Livin on tumor cell behaviors of human hepatocellular carcinoma (HCC) cells and to evaluate its expression in human HCC tissues and its relation to prognosis. Methods: We investigated the biologic role of Livin on tumor cell behaviors by using the small interfering RNA (siRNA) in human HCC cell line, HepG2. The migration, invasion and proliferation assays were performed. To evaluate the impact of Livin on apoptosis and cell cycle, we performed flow cytometric analyses and Western blotting. The expression of Livin by western blotting and immunohistochemistry was investigated in human HCC tissues. Results: Knockdown of Livin suppressed tumor cell migration, invasion and proliferation in human HCC cells. The proportion of apoptotic cells induced by knockdown of Livin was greater than that induced by the scramble siRNA-transfected cells in human HCC cells. Knockdown of Livin activated cleaved caspase-3, -7, -9 and PARP, leading to induction of apoptosis in human HCC cells. Knockdown of Livin induced the G2/M phase arrest by decreasing cyclin D1, CDK4 and CDK6, and by increasing p16, p21, p27 and p57 expression in human HCC cells. The expression of Livin was significantly elevated in human HCC tissues compared to normal hepatic tissues. But Livin expression is not associated with various clinicopa- thological parameters including survival. Conclusions: These results suggest that Livin is associated with the alteration of invasive and oncogenic phenotypes such as tumor cell migration, invasion, proliferation, resistance to apoptosis and cell cycle arrest in human HCC cells.
Sung-In Cho,Seung-Jae Yoo,Eun-Ho Kim,In Lee,Il-Bum Kwon,Dong-Jin Yoon 한국비파괴검사학회 2010 한국비파괴검사학회지 Vol.30 No.3
Fiber Bragg grating(FBG) sensor arrays can be used to monitor the mechanical behavior of the large composite structures such as wind turbine rotor blades and aircrafts. However, brittle FBG sensors, especially multiplexed FBG sensors are easily damaged when they are installed in the flexible structures. As a protection of brittle FBG sensors, epoxy packaged FBG sensors have been presented in this paper. Finite element analysis and experiments were performed to evaluate the effects of adhesives, packaging materials and the bonding layer thickness on the strain transmission. Two types of epoxy were used for packaging FBG sensors and the sensor probes were attached with various bonding layer thickness. It was observed that thin bonding layer with high elastic modulus ratio of the adhesive to packaging provided good strain transmission. However, the strain transmission was significantly decreased when elastic modulus of the adhesive was much lower than the packaged FBG sensor probe’s one.
Cho, Jae Yong,Kim, Jihoon,Kim, Kyung-Bum,Ryu, Chul Hee,Hwang, Wonseop,Lee, Tae Hee,Sung, Tae Hyun ELSEVIER 2019 Applied Energy Vol.254 No.-
<P><B>Abstract</B></P> <P>Unlike previous piezoelectric energy harvesters that generate electrical energy from a magnetic field according to the magnetic strength or magnetostrictive material, the proposed method achieves significant power enhancement using directional optimization of magnetization. This method can serve as a ubiquitous autonomous energy source that converts a magnetic field into usable electrical energy in a wireless sensor network for an (Industrial) Internet of Things (IIoT). The key approach in the proposed model is to increase of the Lorentz force by vertically adjusting the magnetic flux direction of a power cable and the magnetic direction of a tip magnet. In the simulation, a 3592 times higher y-axis Lorentz force was obtained in the vertical pole array, which resulted in about a 1.6 times higher output voltage. Then, we experimentally compared the electrical output performance of six different types of pole array according to the size and direction of the tip magnet. In a one-tip magnet (10 × 10 × 10 mm<SUP>3</SUP>), the output power values were 2.34 mW (Vertical) and 1.23 mW (Horizontal) at 8 kΩ matching impedance. For two-tip magnets (20 × 10 × 10 mm<SUP>3</SUP>), the output power values of the harvester were 39.2 mW (Planar-Vertical), 18.4 mW (Orthogonal-Vertical), 8.64 mW (Planar-Horizontal), and 0.05 mW (Orthogonal-Horizontal) at 5 kΩ matching impedance. It was found that the power generation differed by 2.13 to 784 times. With this method of power enhancement using multi-disciplinary research, we successfully constructed autonomous IoT and IIoT sensor systems for smart homes, smart buildings and smart factories.</P> <P><B>Highlights</B></P> <P> <UL> <LI> The directional optimization of magnetization was considered to enhance output power. </LI> <LI> The harvester generated 39.2 mW as 2.13 to 784 times enhanced power. </LI> <LI> The autonomous IoT and IIoT sensor systems were successfully constructed. </LI> <LI> This method can significantly improve the energy harvesting using a magnetic field. </LI> </UL> </P>
( Sung Bum Cho ),( Yen Joo Kim ),( Won Hyung Choi ),( Chung Hwan Cheon ),( Ki Hoon Lee ),( Nam Kyu Zang ),( Jin Woong Kim ),( Young Eun Joo ),( Sung Kyu Cho ) 대한간학회 2012 춘·추계 학술대회 (KASL) Vol.2012 No.-
Background: Liver abscess was very rare but serious complication lead to liver failure and fatal outcomes after transarterial chemoembolization (TACE) for hepatocellular carcinoma (HCC). This study was evaluated to clinical features of TACE related liver abscess and predicting risk factors among HCC patients who developed postembolization syndrome after TACE. Methods: From January 2008 to December 2010, 13 patients of liver abscess which was undergone percutanous drainage developed in 2582 sessions of TACE. There was retrospectively analyzed to clinical features and predicting risk factors of liver abscess compared with control group who was selected 181 patients with fever after TACE. Results: The incidence of liver abscess was 0.5%. The etiologic types were necrosis related abscess (7 cases, 54%), biloma related abscess (4 cases, 31%), indirect abscess (2 cases, 15%). The mean interval time between percutanous drainage and TACE was 51±38 days. The positive culture rate was 69 % (9 cases) and organisms were enterococcus (4), Klebsiella pnemumoniae (2), Escherichia coli (1), Citrobacter (1) and Clostridium difficile (1). Abscess group was more higher peak AST level, peak bilirubin level, single nodular type HCC, Choledocholithiasis, air forming tumoral necrosis than control group. Independent predicting risk factors to abscess was only large air forming tumoral necrosis. The overall mortality rate of abscess was 61%. 6 patients were died caused by directly related to abscess. Conclusions: TACE related liver abscess was fatal infectious complication related to extensive air forming tumoral necrosis. The clinician should be considered to possibility of developing abscess in HCC patient with high risk factors after TACE.
Production of Iron-Binding Peptides from Colostral Whey by Enzymatic Hydrolysis
Sang Bum Kim,Myoung Soo Nam,Kwang Seok Ki,Hyeon Shup Kim,Min Jung Ku,Won Mo Cho 한국축산식품학회 2010 한국축산식품학회지 Vol.30 No.6
Colostral whey prepared from colostrum (pooled from first six post-partum milkings) was heated for 10 min at 100oC. Heated colostral whey was incubated with 1% enzymes (protein equivalent basis) for 15, 30, 60, 90, and 120 min at 50oC. Papain, pepsin, trypsin, and alcalase produced different degrees of hydrolysis (DH), 10.66%, 12.42%, 10.83%, and 25.31%, respectively, at an incubation time of 120 min. The SDS-PAGE reveals that significant amounts of bovine serum albumin (BSA), β-lactoglobulin (β-LG), and α-lactalbumin (α-LA) survived papain digestion. In contrast, pepsin completely removed BSA but not β-LG present in heated colostral whey. Alcalase completely eliminated BSA, β-LG, and α-LA. This differential hydrolysis was confirmed by reversed-phase HPLC analysis. Using ion-exchange chromatography, fraction-1 (F-1) was obtained from alcalase hydrolysate at a NaCl gradient concentration of 0.25 M. Reversed-phase HPLC chromatograms of alcalase F-1 showed numerous small peaks, which probably indicate that a variety of new peptides were produced. Iron content of alcalase F-1 was 28.94 ppm, which was the highest among all enzyme fractions, whereas iron content of colostral whey was 36.56 ppm. Main amino acids contained in alcalase F-1 were Thr (15.45%), Glu (14.12%), and Ser (10.39%). Therefore, alcalase can be used to generate good iron-binding peptides in heated colostral whey, and the resulting iron-binding peptides could be suitable as a value-added food ingredient for food supplements.
Post-Thaw Cryosurvival of Bovine Embryos Produced In Vitro and In Vivo after Controlled Freezing
Cho, Sang-Rae,Choi, Sun-Ho,Choe, Chang-Yong,Lee, Poong-Yeon,Son, Jun-Kyu,Kim, Jae-Bum,Kim, Sung-Jae,Kim, Hyun-Jong,Shin, Seung-Oh,Son, Dong-Soo 韓國受精卵移植學會 2009 한국동물생명공학회지 Vol.24 No.4
To enhance the embryo preservation technology and better application of embryo transfer technique to the field (dairy science or animal reproduction. etc.), we examined the viabilities of bovine embryos produced in vitro and in vivo after cryopreservation according to their developmental stage and thawing temperature. Bovine embryos from in vivo/vitro fertilization (Hanwoo) were examined at day 7, 8, and 9. Survival rates and total cell numbers of in vivo fertilized embryos were as follows: morulae 68.8% and ; blastocysts 80.5% and ; expanded blastocysts 77.4% and , respectively. Rates of embryo development for blastocysts and expanded blastocysts after thawing were significantly higher than that of morula stage embryos (p<0.05). While survival rates of in vitro fertilized embryos according to developmental stage showed no significant difference among groups (morula 67.9%; blastocyst 74.3%; and expanded blastocyst 79.4%), total cell numbers were significantly lower than those of other groups (morula ; blastocyst ; and expanded blastocyst ) For the viability according to thawing temperature, survival rate was higher in .
Si 도핑이 InAs 자기조립 양자점 적외선 소자 특성에 미치는 효과
서동범,황제환,오보람,김준오,이상준,김의태,Seo, Dong-Bum,Hwang, Je-hwan,Oh, Boram,Kim, Jun Oh,Lee, Sang Jun,Kim, Eui-Tae 한국재료학회 2019 한국재료학회지 Vol.29 No.9
We investigate the characteristics of self-assembled quantum dot infrared photodetectors(QDIPs) based on doping level. Two kinds of QDIP samples are prepared using molecular beam epitaxy : $n^+-i(QD)-n^+$ QDIP with undoped quantum dot(QD) active region and $n^+-n^-(QD)-n^+$ QDIP containing Si direct doped QDs. InAs QDIPs were grown on semi-insulating GaAs (100) wafers by molecular-beam epitaxy. Both top and bottom contact GaAs layer are Si doped at $2{\times}10^{18}/cm^3$. The QD layers are grown by two-monolayer of InAs deposition and capped by InGaAs layer. For the $n^+-n^-(QD)-n^+$ structure, Si dopant is directly doped in InAs QD at $2{\times}10^{17}/cm^3$. Undoped and doped QDIPs show a photoresponse peak at about $8.3{\mu}m$, ranging from $6{\sim}10{\mu}m$ at 10 K. The intensity of the doped QDIP photoresponse is higher than that of the undoped QDIP on same temperature. Undoped QDIP yields a photoresponse of up to 50 K, whereas doped QDIP has a response of up to 30 K only. This result suggests that the doping level of QDs should be appropriately determined by compromising between photoresponsivity and operating temperature.