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상향류 생물막공법을 이용한 양어장 순환수의 질산화특성에 관한 연구
오선경,김정숙,강임석,이병헌 ( Sun Kyoung Oh,Jeong Sook Kim,Im Suk Kang,Byung Hun Lee ) 한국물환경학회 1997 한국물환경학회지 Vol.13 No.1
The purpose of this study was to investigate the efficiency of water treatment processes using the biofilm in recirculating aquaculture system, to find out the optimum treatment conditions for ammonia removing in recirculating water, and to estimate possibility of reduction the water treatment unit volume in the aquaculture system as maintaining an efficient treatment process. The upflow biofilm process was equipped with two different types of media, such as Saran media and Ceramic media. This study scaled down to the 20% of the original water treatment unit volume, was compared biofilm process using Saran media with using Ceramic media over conditions of 10 cycle and 20 cycle ratio. The experimental results showed that upflow biofilm process using the Ceramic media was appeared to be better for organic removal, whereas, the biofilm process with Saran media was found to be better for ammonia removal. The biofilm process with the Saran media showed above 90% ammonia removal efficiency. When the volume ratio of recirculating water treatment unit to rearing unit was scaled down to the 20% of the original ratio, the ammonia removal efficiency could be maintained to be similar. Therefore, it can be suggested that the treatment unit of the aquaculture recirculating system can be reduced if the upflow biofilm process with the Saran media is used.
황시목 ( Si Mok Hwang ),권경훈 ( Kyoung Hun Kwon ),오선경 ( Sun Kyung Oh ) 서울대학교 인구의학연구소 2012 人口醫學硏究論集 Vol.25 No.-
This study was performed to analyze the indications and to evaluate the recent ftequency of karyotypes in different sex chromosome abnormalities. We investigated 26 cases(amniotic fluid 8 cases, peripheral blood 12 cases, abortus tissue 5 cases, chorionic villus sampling 1 case) in which sex chromosome abnormalities has been found in cytogenetic analysis. The frequencies of different sex chromosome abnormalities were Turner syndrome 61.6%(16/26), Klinefelter syndrome 30.8%(8/26), XYY syndrome 3.8% and XX male 3.8%. We have to pay careful attention in diagnoses of Turner syndrome because of the high proportion of mosaicism. In this study, we will be provided information in sex chromosome abnormalities analysis, its diagnostic problems and make possible genetic counseling.
황시목 ( Si Mok Hwang ),권경훈 ( Kyoung Hun Kwon ),오선경 ( Sun Kyung Oh ) 서울대학교 인구의학연구소 2011 人口醫學硏究論集 Vol.24 No.-
Invasive prenatal diagnosis is the most commonly used method for detection of chromosomal aneuploidy or other generic disorders. We performed this study to analyze the indications, distributions of maternal age and cytogenetic results of prenatal cytogenetic examinations, and to evaluate the usefulness of prenatal diagnosis. A cytogenetic analysis of 712 cases (698 amniotic fluid samples, 14 chorionic villi samples) was performed at the GenDix, Inc. from January to December, 2010. The overall rate of chromosomal abnormalities was 7.6% (54 out of 712 cases). The average maternal age of coral subjects was 35.94.2 years, and the most common age group was from 35 to 39 (47.9%). The most frequent indication for prenatal cytogenetic diagnosis was advanced maternal age (>35yr) (42.1%) and positive maternal serum screening (41.0%). Among the 54 cases of chromosomal abnormalities, it contains 28 cases (51.9%) of numerical abnormalities and 26 cases (48.1%) of structural abnormalities. The most frequent structural aberrations were inversion with 69.2% (18 our of 26 cases). Advanced maternal age and positive maternal serum screening must be important screening methods for prenatal diagnosis which is considered to the most effective diagnostic procedure for prenatal cytogenetic studies. Cytogenetic analysis is efficacious method for detection of chromosomal aberration and genetic counseling for parents.
황시목 ( Si Mok Hwang ),권경훈 ( Kyoung Hyun Kwon ),오선경 ( Sun Kyung Oh ) 서울대학교 인구의학연구소 2010 人口醫學硏究論集 Vol.23 No.-
Chromosomal aberration of the parents can lead to recurrent miscarriage and fetal chromosomal abnormalities. We have evaluated the outcomes of chromosomal analyses performed on the parents with recurrent spontaneous abortions. A cytogenetic analysis of 156 peripheral blood was performed at the GenDix, Inc. from January, 2008 to December, 2009. The average maternal age was 35.1±4.5 and husband average age was 37.9±4.1. The frequency of chromosome abnormalities in parents was 12.8 percent. Among the chromosomal abnormalities (20 cases), translocation was 30 percent, inversion was 25 percent and mosaicism was 20 percent. Cytogenetic analysis of parents with recurrent spontaneous abortions is imporrant for diagnosis and genetic counseling for patients with spontaneous abortion.
김숙령(Sook Ryung Kim),최은정(Eun Jung Choi),김태윤(Tae Yoon Kim),권경훈(Kyoung Hun Kwon),송남희(Nam Hee Song),오선경(Sun Kyung Oh),지희준(Hee Jun Chi) 대한의학유전학회 2008 대한의학유전학회지 Vol.5 No.2
목적: 양수 천자를 이용한 세포 유전학적 결과와 산전 유전 진단의 적응증의 변화를 알아보고자 하였다. 대상 및 방법: 지난 2000년부터 2007년까지 8년간 미즈메디 병원 산부인과에 내원한 산모 중 산전 유전 진단의 적응증에 해당되어 양수 천자를 시행한 2,523예에 대하여 세포 유전학적 검사 결과를 종합 분석하였다. 결과: 양수 천자를 시행한 2,523예의 적응증은 고령의 산모가 1159예(45.9%)로 가장 많았으며, 다음으로 양성 산모혈청 표지자가 755예(29.9%)로 많았다. 염색체 핵형 분석 결과로는 정상 핵형이 2,413예(95.6%)였으며, 염색체 이상을 보인 경우가 110예(4.4%)였다. 염색체 이상을 보인 110예에서는 수적 이상이 38예(34.5%), 구조적 이상이 65예(59.1%), 모자이시즘이 7예(6.4%)로 나타났다. 위의 110예의 염색체 이상을 적응증에 따라 분석한 결과에는 고령의 산모로 의뢰된 경우가 40예(36.4%)로 가장 많았으며, 양성 산모 혈청 표지자가 36예(32.7%)로 많았다. 결론: 양수 천자는 산전 진단에 있어서 효과적인 방법이다. 이에 고령 산모, 산모 혈청 표지자 검사 그리고 초음파 소견과 같은 적응증은 태아의 염색체 이상 등을 예측하기 위한 산전 세포 유전학적 진단에 효과적인 요인이 된다. 이에 지난 8년간의 미즈메디에서 시행한 산전 세포 유전학 분석 결과는 산전 진찰 및 유전 상담의 중요한 자료로 활용될 수 있을 것이라 사료된다. Propose: To analyze the indications and cytogenetic results of midtrimester amniocentesis. Material and Methods: This study reviewed 2,523 cases of midtrimester prenatal genetic amniocentesis performed at MizMedi Hospital between January 2000 and December 2007. Results: The most frequent indication for midtrimester amniocentesis was advanced maternal age (45.9%), followed by positive serum markers (29.9%). Chromosomal aberrations were diagnosed in 110 cases (4.4%), for which numerical aberration accounted for 38 cases (34.5%), structural aberration accounted for 65 cases (59.1%), and mosaicism accounted for 7 cases (6.4%). Among the autosomal aberrations, there were 20 cases of trisomy 21 and 8 cases of trisomy 18. With respect to structural aberrations, there were 14 cases of reciprocal translocation and 8 cases of robertsonian translocation. The frequencies of chromosomal aberrations according to the indication were highest in individuals with a family history of chromosome abnormality 14.0% (8/57) followed by previous congenital anomaly 5.9% (2/34). Conclusion: Midtrimester amniocentesis is an effective tool for prenatal diagnosis. Indications such as advanced maternal age, maternal serum markers, and ultrasound are important for predicting abnormal fetal karyotypes.