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      • KCI등재

        Angiogenesis-Targeted 68Ga-DOTA-RGD2 PET/CT Imaging: a Potential Theranostic Application in the Case of Chondrosarcoma

        Venkata Subramanian Krishnaraju,Kumar Rajender,Sood Ashwani,Jaya Shukla,Karthikeyan Subramanian,Nandita Kakkar,Naresh Panda,Mittal Bhagwant Rai 대한핵의학회 2021 핵의학 분자영상 Vol.55 No.3

        Chondrosarcoma is a cartilaginous tumor of mesenchymal origin. The histology and grade of the tumor determine the chances of relapse and survival. These tumors usually respond poorly to chemo-radiotherapy in cases of non-resectable and recurrent disease. 18F-FDG PET/CT has been used in evaluation of recurrence. However, these tumors show only mild to moderate FDG avidity due to their lower mitotic activity and large acellular matrix. These tumors are known to have a high degree of angiogenesis, especially in those of higher grade. We present a case of a 53-year-old man with grade II chondrosarcoma of the left femur showing only mild avidity on 18F-FDG PET/CT but showing moderate to intense tracer avidity on 68Ga-DOTA-RGD2 PET/CT. This may enable the use of angiogenesis-targeted positron and beta-emitting radiopharmaceuticals as a potentially new theranostic alternative treatment in cases of refractory metastatic chondrosarcoma.

      • KCI등재

        Optimization of machining parameters for EDM operations based on central composite design and desirability approach

        Subramanian Gopalakannan,Thiagarajan Senthilvelan 대한기계학회 2014 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.28 No.3

        A novel aluminium metal matrix composite reinforced with SiC particles were prepared by liquid metallurgy route. Recent developmentsin composites are not only focused on the improvement of mechanical properties, but also on machinability for difficult-tomachineshapes. Electrical discharge machining (EDM) was employed to machine MMC with copper electrode. using EDM. Experimentswere conducted using pulse current, gap voltage, pulse on time and pulse off time as typical process parameters. The experimentplan adopts face centered central composite design of response surface methodology. Analysis of variance was applied to investigate theinfluence of process parameters and their interactions viz., pulse current, gap voltage, pulse on time and pulse off time on material removalrate (MRR), electrode wear ratio (EWR) and surface roughness (SR). The objective was to identify the significant process parametersthat affect the output characteristics. Further a mathematical model has been formulated by applying response surface method inorder to estimate the machining characteristics such as MRR, EWR and SR.

      • KCI등재후보

        State of the Art in Liquid Crystals Nanophysiochemical Properties at Surfaces and Interfaces, and Frontier for Posterity

        Subramanian Kumar,노재근,장창현 한국바이오칩학회 2009 BioChip Journal Vol.3 No.3

        Liquid crystals (LC) have been drastically protracted in recent years, due to the ferret out of novel nanophysiochemical properties at surfaces. Physiochemical characteristics, such as weak intermolecular forces manifested like odd-even effect, hydrogen bonding, and electric double layers make them ideal for variety of applications. Furthermore, the orientation of LC exploits the conventional and novel detectionmethod for protein binding event on nanostructured surfaces and protein crystallization on lipid monolayers. These explorations include the detection of parts per billion (ppb) chemical warfare agents on surfaces as well as new mechanisms for driving the orientation of liquid crystals. The scope of the present review attempts the recent progress on using LC to amplify a wide range of engineered surface chemistry progressed from liquid-solid and liquid-aqueous interfaces. The distinct features of LC role in imaging and biosensing have been discussed. From these studies, it is clear that the LC has the enormous potential as a promising material for the biomedical applications. Liquid crystals (LC) have been drastically protracted in recent years, due to the ferret out of novel nanophysiochemical properties at surfaces. Physiochemical characteristics, such as weak intermolecular forces manifested like odd-even effect, hydrogen bonding, and electric double layers make them ideal for variety of applications. Furthermore, the orientation of LC exploits the conventional and novel detectionmethod for protein binding event on nanostructured surfaces and protein crystallization on lipid monolayers. These explorations include the detection of parts per billion (ppb) chemical warfare agents on surfaces as well as new mechanisms for driving the orientation of liquid crystals. The scope of the present review attempts the recent progress on using LC to amplify a wide range of engineered surface chemistry progressed from liquid-solid and liquid-aqueous interfaces. The distinct features of LC role in imaging and biosensing have been discussed. From these studies, it is clear that the LC has the enormous potential as a promising material for the biomedical applications.

      • Layer by layer approach to enhance capacitance using metal sulfides for supercapacitor applications

        Subramanian, Archana,Punnoose, Dinah,Raman, Vivekanandan,Gopi, Chandu V.V. Muralee,Rao, Sunkara Srinivasa,Khan, Muhammad Adil,Kim, Hee-Je Elsevier 2018 Materials letters Vol.231 No.-

        <P><B>Abstract</B></P> <P>Layer-by-layer approach for NiS, CoS and PEDOT:PSS (poly(3,4-ethylenedioxythiophene) polystyrene sulfonate) is being fabricated. Metal sulfides have always been chosen for their remarkable electrochemical characteristics and wide beneficial domains, such as electrochemical energy conversion and storage. This work presents the preparation of cost-effective metal sulfides (NiS, NiS/CoS, NiS/CoS/PEDOT:PSS) developed on nickel foam sheets for supercapacitor (SC) applications. The assembled NiS/CoS/PEDOT:PSS array SC device exhibits an utmost energy density of 30.3 W h kg<SUP>−1</SUP> and specific capacitance of 353 F g<SUP>−1</SUP>. All wet processing methods of fabrication accompanied with superior performance characteristics make these SCs very attractive for the next generation flexible energy storage systems.</P> <P><B>Highlights</B></P> <P> <UL> <LI> NiS/CoS/PEDOT:PSS on nickel foam is coated by Chemical Bath Deposition method. </LI> <LI> Metal sulfides extend active area due to low electronegativity of sulfur over oxygen. </LI> <LI> PEDOT:PSS on NiS/CoS is coated to increase surface area and conductivity. </LI> <LI> NiS/CoS/PEDOT:PSS showed maximal specific capacitance of 353 F g<SUP>−1</SUP> at 15 mA cm<SUP>−2</SUP>. </LI> </UL> </P>

      • Surface Modification of Droplet Polymeric Microfluidic Devices for the Stable and Continuous Generation of Aqueous Droplets

        Subramanian, Balamurugan,Kim, Namwon,Lee, Wonbae,Spivak, David A.,Nikitopoulos, Dimitris E.,McCarley, Robin L.,Soper, Steven A. American Chemical Society 2011 Langmuir Vol.27 No.12

        <P>Droplet microfluidics performed in poly(methyl methacrylate) (PMMA) microfluidic devices resulted in significant wall wetting by water droplets formed in a liquid–liquid segmented flow when using a hydrophobic carrier fluid such as perfluorotripropylamine (FC-3283). This wall wetting led to water droplets with nonuniform sizes that were often trapped on the wall surfaces, leading to unstable and poorly controlled liquid–liquid segmented flow. To circumvent this problem, we developed a two-step procedure to hydrophobically modify the surfaces of PMMA and other thermoplastic materials commonly used to make microfluidic devices. The surface-modification route involved the introduction of hydroxyl groups by oxygen plasma treatment of the polymer surface followed by a solution-phase reaction with heptadecafluoro-1,1,2,2-tetrahydrodecyl trichlorosilane dissolved in fluorocarbon solvent FC-3283. This procedure was found to be useful for the modification of PMMA and other thermoplastic surfaces, including polycyclic olefin copolymer (COC) and polycarbonate (PC). Angle-resolved X-ray photoelectron spectroscopy indicated that the fluorination of these polymers took place with high surface selectivity. This procedure was used to modify the surface of a PMMA droplet microfluidic device (DMFD) and was shown to be useful in reducing the wetting problem during the generation of aqueous droplets in a perfluorotripropylamine (FC-3283) carrier fluid and could generate stable segmented flows for hours of operation. In the case of PMMA DMFD, oxygen plasma treatment was carried out after the PMMA cover plate was thermally fusion bonded to the PMMA microfluidic chip. Because the appended chemistry to the channel wall created a hydrophobic surface, it will accommodate the use of other carrier fluids that are hydrophobic as well, such as hexadecane or mineral oils.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/langd5/2011/langd5.2011.27.issue-12/la200298n/production/images/medium/la-2011-00298n_0005.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/la200298n'>ACS Electronic Supporting Info</A></P>

      • Isolation, Characterization, Antioxidant, Antimicrobial and Cytotoxic Effect of Marine Actinomycete, Streptomyces Carpaticus MK-01, against Fish Pathogens

        Subramanian, Dharaneedharan,Kim, Min-Sun,Kim, Dong-Hwi,Heo, Moon-Soo SciELO 2017 Brazilian archives of biology and technology Vol.60 No.-

        <P>Present study aim to evaluate the antimicrobial, antioxidant and cytotoxic potential of crude extract of Marine Streptomyces carpaticus MK-01 isolated from seawater collected from Daejeong-cost of Jeju Island. About 24 actinomycetes strains were isolated and subjected to morphological and molecular analysis that confirmed the isolate as S. carpaticus MK-01. Crude ethyl acetate extract of MK-01 strain showed extensive antibacterial activity against Gram-positive fish pathogenic bacteria namely Streptococcus iniae and S. parauberis with a maximum zone of inhibition (0.92 +/- 0.03mm) was recorded against S. parauberis at the minimum extract concentration (3.12 mu g/ml). The MK-01 ethyl acetate extract shows dose dependant significant increase in antioxidant activity. The 50% cytotoxic concentration (CC50) of MK-01 ethyl acetate extract was attained at 53.71 mu g/ml and the effective concentration 50 (EC50) against virus-infected Epithelioma papulosum cyprini cell lines was 8.72 mu g/ml of S. carpaticus MK-01 crude ethyl acetate extract.</P>

      • SCIESCOPUS

        Seismic performance of lateral load resisting systems

        Subramanian, K.,Velayutham, M. Techno-Press 2014 Structural Engineering and Mechanics, An Int'l Jou Vol.51 No.3

        In buildings structures, the flexural stiffness reduction of beams and columns due to concrete cracking plays an important role in the nonlinear load-deformation response of reinforced concrete structures under service loads. Most Seismic Design Codes do not precise effective stiffness to be used in seismic analysis for structures of reinforced concrete elements, therefore uncracked section properties are usually considered in computing structural stiffness. But, uncracked stiffness will never be fully recovered during or after seismic response. In the present study, the effect of concrete cracking on the lateral response of structure has been taken into account. Totally 120 cases of 3 Dimensional Dynamic Analysis which considers the real and accidental torsional effects are performed using ETABS to determine the effective structural system across the height, which ensures the performance and the economic dimensions that achieve the saving in concrete and steel amounts thus achieve lower cost. The result findings exhibits that the dual system was the most efficient lateral load resisting system based on deflection criterion, as they yielded the least values of lateral displacements and inter-storey drifts. The shear wall system was the most economical lateral load resisting compared to moment resisting frame and dual system but they yielded the large values of lateral displacements in top storeys. Wall systems executes tremendous stiffness at the lower levels of the building, while moment frames typically restrain considerable deformations and provide significant energy dissipation under inelastic deformations at the upper levels. Cracking found to be more impact over moment resisting frames compared to the Shear wall systems. The behavior of various lateral load resisting systems with respect to time period, mode shapes, storey drift etc. are discussed in detail.

      • KCI등재

        Study of Multiple Phonon Behavior in Li-doped ZnO Thin Films Fabricated Using the Sol-gel Spin-coating Technique

        Subramanian Kalyanaraman,Rajapandi Vettumperumal,Rajalingam Thangavel 한국물리학회 2013 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.62 No.5

        Undoped and lithium-doped zinc oxide (ZnO) thin films have been deposited on sapphire substrates (0001) using the sol-gel method. The effect of doping with various percentages of Li ata particular annealing temperature of 600 ℃ is studied. The samples are characterized using Xray diffraction (XRD), scanning electron microscopy (SEM), micro-photoluminescence (μ-PL) and Raman and polarized Raman (PR) spectroscopy. The X-ray diffraction and micro-Raman spectroscopy confirm the presence of lithium substitution for zinc. The wurtzite structure of the lattice is retained, and five multiple phonon Raman modes are observed. The values of the depolarization ratios are calculated from polarized Raman data. Photoluminescence shows a strong emission peak in the near UV at 3.276 eV and negligible visible emission. The PL peak positions in the doped samples nearly coincide with each other, suggesting very similar recombination mechanisms in the nanocrystals.

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