Development of Polymer-based Nanodiscs for Broad Spectrum Antivirals

Suhyun KIM,Mi Soo KIM,Jaehyeon HWANG,Wonbeom PARK,Hwanju KIM,SeungJoo KIM,Eunkhang PARK 한국생물공학회 2023 한국생물공학회 학술대회 Vol.2023 No.4

RESEARCH ON CONSILIENCE IN FASHION PRODUCTS AND CUSTOMER ADOPTION INTENTION

Suhyun Park,Liyan Hung,Heeju Chae,Eunju Ko 글로벌지식마케팅경영학회 2015 Global Fashion Management Conference Vol.2015 No.06

In a period of crisis and uncertainty as the current, heritage marketing is a suitable strategic opportunity because it associates values and meanings to products and services by using corporate heritage or brand heritage in order to communicate identity, continuity and stability. Heritage marketing seems particularly appropriate for high symbolic fashion brand that require the ability to transmit identity and to generate symbolic meanings. In relation to high symbolic fashion brand, an opportunity for heritage marketing strategies is to narrate the myths associated with the brand. In fact, literature has highlighted that fashion brand can be associate to the concept of myth thanks to the presence of symbolic values and meanings. Heritage and myth are concepts linked to time and progression. Therefore, they should continually innovate and evolve in relation to the community of reference in order to find a balance between continuity and renewal. However, a risk of heritage marketing strategies is to merely celebrating the past thus losing the ability to generate and regenerate myths and symbolic values. This paper aims to provide a critical contribution to heritage marketing literature highlighting the risk of obsessive fixation in the celebration of the past. In order to avoid this risk, the paper proposes that a possible solution might be the integration of mythopoesis which is the ability to generate and regenerate myths in order to create and perpetuate sense and meaning through narrative.

Enhancement of peri-implant bone formation via parathyroid hormone administration in a rat model at risk for medication-related osteonecrosis of the jaw

Park, Ji Young,Heo, Hyun A,Park, Suhyun,Pyo, Sung Woon Korean Academy of Periodontology 2020 Journal of Periodontal & Implant Science Vol.50 No.2

Purpose: Dental implant-associated medication-related osteonecrosis of the jaw has been frequently reported in patients administered bisphosphonates (BPs) to prevent osteoporosis. The aim of this study was to investigate the effect of intermittent administration of parathyroid hormone (PTH) on peri-implant bone in the maxillae of ovariectomized rats systemically administered BPs. Methods: Thirty 8-week-old female Sprague-Dawley rats were randomly divided into 3 groups. The OVX-ZP group included ovariectomized rats administered 60 ㎍/kg of zoledronate once a week for 6 weeks and 30 ㎍/kg PTH after implant installation. The OVX-Z group included ovariectomized rats administered 60 ㎍/kg of zoledronate once a week for 6 weeks and saline after implant installation, and the control group included rats that underwent a sham operation and were then administered saline. Rats were sacrificed 4 weeks after implant placement for histomorphometric and micro-computed tomography (CT) analyses. Results: The average bone area percentage was greater in the OVX-ZP group than in the OVX-Z group (53.4%±4.0% vs. 28.9%±9.5%, P=0.01). The bone-to-implant contact ratio was 50.8%±1.4% in the OVX-ZP group and 16.9%±2.4% in the OVX-Z group (P=0.012). The average bone volume ratio as shown on micro-CT was 31.3%±19.8% in the OVX-ZP group and 19.4%±9.3% in the OVX-Z group (P=0.045). The OVX-ZP and OVX-Z groups displayed similar trabecular thickness (0.06±0.004 mm vs. 0.06±0.002 mm) (P>0.05) and trabecular separation (0.21±0.02 mm vs. 0.29±0.13 mm) (P>0.05). However, the number of trabeculae in the OVX-ZP group was significantly higher than that in the OVX-Z group (4.3±1.33/㎣ vs. 2.2±0.19/㎣) (P=0.024). Conclusions: The present findings indicate that intermittently-administered PTH can promote peri-implant bone formation and suggest that PTH administration may aid in effective treatment for medication-related osteonecrosis of the jaw after dental implantation.

Radially Phase Segregated PtCu@PtCuNi Dendrite@Frame Nanocatalyst for the Oxygen Reduction Reaction

Park, Jongsik,Kanti Kabiraz, Mrinal,Kwon, Hyukbu,Park, Suhyun,Baik, Hionsuck,Choi, Sang-Il,Lee, Kwangyeol American Chemical Society 2017 ACS NANO Vol.11 No.11

<P>Pt-based alloy nanoframes have shown great potential as electrocatalysts toward the oxygen reduction reaction (ORR) in fuel cells. However, the intrinsically infirm nanoframes could be severely deformed during extended electro-cyclings, which eventually leads to the loss of the initial catalytic activity. Therefore, the structurally robust nanoframe is a worthy synthetic target. Furthermore, ternary alloy phase electrocatalysts offer more opportunities in optimizing the stability and activity than binary alloy ones. Herein, we report a robust PtCuNi ternary nanoframe, structurally fortified with an inner-lying PtCu dendrite, which shows a highly active and stable catalytic performance toward ORR. Remarkably, the PtCu@PtCuNi catalyst exhibited 11 and 16 times higher mass and specific activities than those of commercial Pt/C.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/ancac3/2017/ancac3.2017.11.issue-11/acsnano.7b04097/production/images/medium/nn-2017-04097w_0008.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/nn7b04097'>ACS Electronic Supporting Info</A></P>

Identification of the Phenalamide Biosynthetic Gene Cluster in Myxococcus stipitatus DSM 14675

( Suhyun Park ),( Hyesook Hyun ),( Jong Suk Lee ),( Kyungyun Cho ) 한국미생물 · 생명공학회 2016 Journal of microbiology and biotechnology Vol.26 No.9

Phenalamide is a bioactive secondary metabolite produced by Myxococcus stipitatus. We identified a 56 kb phenalamide biosynthetic gene cluster from M. stipitatus DSM 14675 by genomic sequence analysis and mutational analysis. The cluster is comprised of 12 genes (MYSTI_04318- MYSTI_04329) encoding three pyruvate dehydrogenase subunits, eight polyketide synthase modules, a non-ribosomal peptide synthase module, a hypothetical protein, and a putative flavin adenine dinucleotide-binding protein. Disruption of the MYSTI_04324 or MYSTI_04325 genes by plasmid insertion resulted in a defect in phenalamide production. The organization of the phenalamide biosynthetic modules encoded by the fifth to tenth genes (MYSTI_04320- MYSTI_04325) was very similar to that of the myxalamid biosynthetic gene cluster from Stigmatella aurantiaca Sg a15, as expected from similar backbone structures of the two substances. However, the loading module and the first extension module of the phenalamide synthase encoded by the first to fourth genes (MYSTI_04326-MYSTI_04329) were found only in the phenalamide biosynthetic gene cluster from M. stipitatus DSM 14675.

Development of HIFU-sensitive Nanomedicine-Microbubbles Complex for Cancer Therapy

Suhyun PARK,Hyejin JANG,Minkyu SEO,Hyunchul KIM 한국생물공학회 2018 한국생물공학회 학술대회 Vol.2018 No.4

Palladium(II) complexes containing <i>N</i>,<i>N</i>′-bidentate imine ligands derived from picolinaldehyde and substituted anilines: Synthesis, structure and polymerisation of methyl methacrylate

Park, Suhyun,Lee, Jaegyeong,Jeong, Jong Hwa,Lee, Hyosun,Nayab, Saira Elsevier 2018 Polyhedron Vol.151 No.-

<P><B>Abstract</B></P> <P>Palladium(II) complexes, <B>L<SUB>n</SUB>PdCl<SUB>2</SUB> </B> (L<SUB>n</SUB> = L<SUB>A</SUB>–L<SUB>I</SUB>), with <I>N</I>,<I>N</I>′-bidentate imine ligands derived from picolinaldehyde and substituted anilines have been synthesized and structurally characterized. Molecular structures revealed a distorted square plane geometry around Pd(II) centre in <B>L<SUB>n</SUB>PdCl<SUB>2</SUB> </B> (L<SUB>n</SUB> = L<SUB>A</SUB>–L<SUB>C</SUB>) obtained <I>via</I> coordination with pyridine and imine nitrogens and two chloro ligands. Pd(II) complexes <B>L<SUB>n</SUB>PdCl<SUB>2</SUB> </B> (L<SUB>n</SUB> = L<SUB>A</SUB>–L<SUB>I</SUB>) initiate polymerisation of methylmethacrylate (MMA) in the presence of modified methylaluminoxane (MMAO). The complex <B>L<SUB>I</SUB>PdCl<SUB>2</SUB> </B> (of which the ligand was <I>N</I>-furfuryl substituted) showed the highest catalytic activity for the polymerisation of MMA with an activity of 7.08 × 10<SUP>4</SUP> g PMMA/mol·Pd·h at 60 °C. All the complexes yielded syndio-rich poly(methyl methacrylate) (PMMA) ([<I>rr</I>] = 0.70). Notably, the substituents on the imine moiety of the iminopyridine fragments affects the activities towards MMA polymerization, whereas the stereoselectivities remained unchanged.</P> <P><B>Graphical abstract</B></P> <P>Palladium(II) complexes <B>L<SUB>n</SUB>PdCl<SUB>2</SUB> </B> (L<SUB>n</SUB> = L<SUB>A</SUB>–L<SUB>I</SUB>) with <I>N</I>,<I>N</I>′-bidentate imine ligands derived from picolinaldehyde and substituted anilines have been synthesized and characterized. Pd(II) complexes effectively initiate MMA polymerisation in the presence of MMAO yielding syndio-enriched PMMA. The substituent at imine moiety of iminopyridine framework significantly affect the catalytic activity. Substituents at imine moiety in <B>L<SUB>n</SUB>PdCl<SUB>2</SUB> </B> (L<SUB>n</SUB> = L<SUB>A</SUB>–L<SUB>I</SUB>) play a vital role in controlling their activities toward MMA polymerization.</P> <P>[DISPLAY OMISSION]</P>

Sequential Combination of FIB-4 Followed by M2BPGi Enhanced Diagnostic Performance for Advanced Hepatic Fibrosis in an Average Risk Population

( Suhyun Park ),( Dae Won Jun ),( Seungmin Lee ),( Jihyun An ),( Joo Hyun Sohn ) 대한간학회 2020 춘·추계 학술대회 (KASL) Vol.2020 No.1

Aims: The fibrosis-4 (FIB-4) index is the most widely used estimated formula to screen for advanced hepatic fibrosis; however, it has a considerable intermediate zone. Here, we propose an algorithm to reduce the intermediate zone and improve the diagnostic performance of screening for advanced liver fibrosis by incorporating Mac-2-binding protein glycan isomer (M2BPGi) into a FIB-4 based screening strategy in an average risk group. Methods: Four-hundred eighty-eight healthy and chronic liver disease subjects were analyzed using a 1:1 propensity score matched for age and sex. Advanced liver fibrosis (≥F3) was defined by magnetic resonance elastography (MRE, ≥3.6 kPa). Classification tree analysis was employed to improve diagnostic performance using a combination of the FIB-4 index and M2BPGi. Results: The median serum M2BPGi levels of healthy subjects, patients without advanced fibrosis, and those with the condition were 0.48, 0.94, and 2.93, respectively. The area under the receiver operating characteristic (AUROC) curve of M2BPGi (0.918) for advanced fibrosis was the highest compared to those of the FIB-4 index (0.887), APRI (0.873), and AST/ALT ratio (0.794). When M2BPGi was incorporated following the FIB- 4 index, the sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) were 87.1%, 82.5%, 54.0%, and 96.4%, respectively Moreover, 74.3% (133/179) of cases in the intermediate zone of the FIB-4 index avoided unnecessary referrals. Conclusions: Two-step pathway (FIB-4 followed by M2BPGi) could reduce unnecessary referrals and/or liver biopsies in an average-risk population.

A subepithelial lesion in a patient with long-standing ulcerative colitis

Suhyun Park,Jihun Kim,Dong-Hoon Yang 대한소화기내시경학회 2022 Clinical Endoscopy Vol.55 No.5

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Effects of Macro-Encapsulated Mesenchymal Stem Cells Using Poly Lactic-Co-Glycolic Acid (PLGA) on Liver Disease: A Proof of Concept Study

( Suhyun Park ),( Dae Won Jun ),( Hyeyoung Kim ),( Jihyun An ),( Joo Hyun Sohn ) 대한간학회 2020 춘·추계 학술대회 (KASL) Vol.2020 No.1

Aims: Macro-encapsulation of human mesenchymal stem cells (MSCs) for treatment of liver diseases has not been studied. Here, we conducted a proof of concept study by macro-encapsulated MSCs using poly lactic-co-glycolic acid (PLGA) in liver disease models. Methods: Acute liver injury was induced using thioacetamide (TAA) i.p. injection three times for a week. For chronic liver fibrosis model, TAA dose was gradually increased, starting from 100mg/kg to 400mg/kg over the duration of 16 weeks. Results: In acute liver injury model, macro-encapsulated groups showed decreased liver inflammation and necrosis compared to control group. In chronic liver fibrosis model, compared to control group, hepatic fibrosis was reduced in macro-encapsulated group. Encapsulated MSCs implant in mice also showed increased periodic acid-Schiff staining and CYP2E1 expression. Moreover, in encapsulation group, MSCs migration and homing into liver, kidney and lungs was not observed. Encapsulated MSCs secreted more growth hormones under hypoxic condition including vascular endothelial growth factor, platelet-derived growth factor, angiopoietin-2 and, placental growth factor compared to monolayered MSCs. MSCs survival was assessed for 28 days. The results suggested that MSCs survived within macro-capsule for 28 days. Conclusions: macro-encapsulated MSCs attenuated hepatic inflammation and fibrosis via upregulating hypoxia-induced growth hormone secretion in liver disease models.