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Identification of Specific Gene Modules in Mouse Lung Tissue Exposed to Cigarette Smoke
Xing, Yong-Hua,Zhang, Jun-Ling,Lu, Lu,Li, De-Guan,Wang, Yue-Ying,Huang, Song,Li, Cheng-Cheng,Zhang, Zhu-Bo,Li, Jian-Guo,Xu, Guo-Shun,Meng, Ai-Min Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.10
Background: Exposure to cigarette may affect human health and increase risk of a wide range of diseases including pulmonary diseases, such as chronic obstructive pulmonary disease (COPD), asthma, lung fibrosis and lung cancer. However, the molecular mechanisms of pathogenesis induced by cigarettes still remain obscure even with extensive studies. With systemic view, we attempted to identify the specific gene modules that might relate to injury caused by cigarette smoke and identify hub genes for potential therapeutic targets or biomarkers from specific gene modules. Materials and Methods: The dataset GSE18344 was downloaded from the Gene Expression Omnibus (GEO) and divided into mouse cigarette smoke exposure and control groups. Subsequently, weighted gene co-expression network analysis (WGCNA) was used to construct a gene co-expression network for each group and detected specific gene modules of cigarette smoke exposure by comparison. Results: A total of ten specific gene modules were identified only in the cigarette smoke exposure group but not in the control group. Seven hub genes were identified as well, including Fip1l1, Anp32a, Acsl4, Evl, Sdc1, Arap3 and Cd52. Conclusions: Specific gene modules may provide better understanding of molecular mechanisms, and hub genes are potential candidates of therapeutic targets that may possible improve development of novel treatment approaches.
Zhang Ni,Jiang Jia,Song Yue-Hua 한국응용곤충학회 2022 Journal of Asia-Pacific Entomology Vol.25 No.3
Two new species: A. (Arboridia) xiaotungensis sp. nov. and A. (Arboridia) luojiashangensis sp. nov. from Guizhou Province, China are described and illustrated. In addition, the appearances of A. reniformis Song & Li (2013a) and A. anteoculara Song & Li (2013a) are supplementarily described. A key to distinguish all known species of the genus from China is provided. LSID: https://www.zoobank.org/urn:lsid:zoobank.org:pub:3DD14108-ED08-430D-AE8D-CD0 FCC215A4E
Jiang Jia,Li Can,Song Yue-Hua 한국응용곤충학회 2020 Journal of Asia-Pacific Entomology Vol.23 No.2
The Oriental leafhopper genus Cassianeura Ramakrishnan & Menon is reviewed with two new species records from Thailand: C. cassiae (Ahmed, 1970) and C. bimaculata Dworakowska, 1984. The three species of the genus are redescribed and illustrated including details of the female ovipositor for the first time. A key to distinguish the three species of the genus is provided.
Synchronous Ectopic Pancreatoblastoma in a Child: A Case Report
Zhi-Hao Yang,Jian-Bo Gao,Song-Wei Yue,Xue-Hua Yang,Hua Guo 대한의학회 2011 Journal of Korean medical science Vol.26 No.6
Pancreatoblastoma is a rare primary pancreatic neoplasm of children that may arise in any portion of the pancreas. We report a case of a 3-yr-old boy who presented to with abdominal pain our hospital and a progressive bulge in his right abdomen. Biochemical evaluation and serum levels of tumoral markers were within reference limits. On the computed tomography, two tumors were found. One located in the head of the pancreas;however, a laparotomy revealed that the head of pancreas was compressed but normal. The other was in the left abdomen near the spleen and the tail of the pancreas. The diagnosis of two synchronous pancreatoblastoma originating from the omentum was confirmed by pathology. Therefore, a pancreatoblastoma should be considered when a large well-defined, lobulated, and heterogeneous mass is identified in the pancreas of children. In addition, an ectopic pancreatoblastoma should be considered when identified within or near the ectopic pancreatic tissue.
Jiang Jia,Tan Wei-Wen,Song Yue-Hua 한국응용곤충학회 2021 Journal of Asia-Pacific Entomology Vol.24 No.3
In this paper, one new species of the leafhopper genus Thaioneura Song, Li & Dietrich, 2016 from Guizhou Province, China are described and illustrated: Thaioneura huajiangensis sp. nov. And the female ovipositors are photographed and described. A key to distinguish all known species of the genus is provided. The hind wing venation of the new species are the same as the T. suphanburia and T. sinuata, and not common in the tribe Erythroneurini.
Caspase-3 inhibitor inhibits enterovirus D68 production
Wenbo Huo,Jinghua Yu,Chunyu Liu,Ting Wu,Yue Wang,Xiangling Meng,Fengmei Song,Shuxia Zhang,Ying Su,Yumeng Liu,Jinming Liu,Xiaoyan Yu,Shucheng Hua 한국미생물학회 2020 The journal of microbiology Vol.58 No.9
Enterovirus D68 (EVD68) is an emerging pathogen that recently caused a large worldwide outbreak of severe respiratory disease in children. However, the relationship between EVD68 and host cells remains unclear. Caspases are involved in cell death, immune response, and even viral production. We found that caspase-3 was activated during EVD68 replication to induce apoptosis. Caspase-3 inhibitor (Z-DEVDFMK) inhibited viral production, protected host cells from the cytopathic effects of EVD68 infection, and prevented EVD68 from regulating the host cell cycle at G0/G1. Meanwhile, caspase-3 activator (PAC-1) increased EVD68 production. EVD68 infection therefore activates caspase-3 for virus production. This knowledge provides a potential direction for the prevention and treatment of disease related to EVD68.
Luo Guimei,Zhao Yuanqi,Yuan Zhouwei,Zhang Ni,Song Yue-Hua 한국응용곤충학회 2023 Journal of Asia-Pacific Entomology Vol.26 No.4
Kapsa arca and Alnetoidia dujuanensis, which belong to erythroneurine leafhoppers (Cicadellidae and Typhlo cybinae), are economic pests with the characteristics of a large number of small individuals and wide distri bution. Analysis of the complete mitochondrial genome sequence and phylogenetic relationships of the leafhopper will help not only in its identification but also in its control. In this work, two mitochondrial gene sequences from K. arca and A. dujuanensis were sequenced, analyzed, and used to explore the phylogenetic re lationships of the tribe. The lengths of the K. arca and A. dujuanensis genomes were 15,594 bp and 15,375 bp, respectively, and all contained a noncoding control region, two ribosomal RNAs (rRNAs), 22 transfer RNAs (tRNAs), and 13 PCGs. Most protein-coding genes end with TAA or TAG and start with ATN, with AT skew exhibiting a positive skew and GC skew exhibiting a negative skew. The mitotic genomes of K. arca and A. dujuanensis are similar in structure to those of other leafhoppers and are conserved. Phylogenetic analysis revealed that K. arca forms a sister group with Elbelus tripunctatus, and A. dujuanensis forms a sister group with Kaukania anser, but Zyginellini and Typhlocybini, which should branch separately, are interrelated and cannot form separate branches. The result differs from previous studies. The results indicated that the two species, K. arca and A. dujuanensis, should belong to the same tribe, the Erythroneurini leafhoppers, but should be grouped into different genera. A time-calibrated phylogeny estimated the earliest divergence time of Eryth roneurini, Empoascini, Typhlocybini, and Zyginellini.