Higher energy consumption in the evening is associated with increased odds of obesity and metabolic syndrome: findings from the 2016-2018 Korea National Health and Nutrition Examination Survey (7th KNHANES)

Sarang Jeong(Sarang Jeong),Hajoung Lee(Hajoung Lee),Sukyoung Jung(Sukyoung Jung),Jee Young Kim(Jee Young Kim),Sohyun Park(Sohyun Park) 한국역학회 2023 Epidemiology and Health Vol.45 No.-

OBJECTIVES: Chrono-nutrition emphasizes meal timing in preventing obesity and metabolic disorders. This study explores the impact of temporal dietary patterns (TDPs) on obesity and metabolic syndrome (MetS) in Korean adults aged 20 years to 65 years. METHODS: We utilized dynamic time warping method and Kernel k-means clustering to investigate diet quality and the odds ratios (ORs) of obesity and MetS with different TDPs using data from the 7th Korea National Health and Nutrition Examination Survey. RESULTS: Participants were divided into three groups based on relative energy intake over 24 hours. After adjusting for age and gender, Cluster 3 (with the highest proportion of energy intake in the evening) had the lowest Healthy Eating Index scores compared to other clusters. Following adjustment for key covariates, Cluster 3 showed the highest values for body mass index, waist circumference, blood pressure, total cholesterol, and triglycerides. Compared to Cluster 1 (with a lower proportion of energy intake in the evening), Cluster 2 and Cluster 3 had ORs for obesity of 1.12 (95% confidence interval [CI], 0.97 to 1.30) and 1.19 (95% CI, 1.03 to 1.37), respectively. For MetS, the ORs were 1.26 (95% CI, 1.08 to 1.48) and 1.37 (95% CI, 1.17 to 1.61) when comparing Cluster 2 and Cluster 3 to Cluster 1. CONCLUSIONS: This study reveals that individuals with higher energy intake in the evening have increased odds of obesity and MetS, even after adjusting for major covariates, including age and total energy intake.

Survival, Prognosis, and Clinical Feature of Refractory Myasthenia Gravis: a 15-year Nationwide Cohort Study

Jeong Sohyun,Noh Yunha,Oh In-Sun,Hong Yoon-Ho,Shin Ju-Young 대한의학회 2021 Journal of Korean medical science Vol.36 No.39

Background: Myasthenia gravis (MG) is a rare classic autoimmune disease where immunosuppressant therapies have been successful to reduce MG attributable mortality fairly well. However, patients with refractory MG (rMG) among the actively treated MG (aMG) are nonresponsive to conventional therapy and display high disease severity, which calls for further research. We aimed to determine survival, prognosis, and clinical feature of patients with rMG compared to non-rMG. Methods: Retrospective nationwide cohort study using Korea's healthcare database between 2002 and 2017 was conducted. Patients with rMG (n = 47) and non-rMG (n = 4,251) who were aged > 18 years, followed-up for ≥ 1 year, and prescribed immunosuppressants within 2 years after incident MG diagnosis were included. Patients with rMG were defined as administered plasma exchange or intravenous immunoglobulin at least 3 times per year after receiving ≥ 2 immunosuppressants. All-cause mortality, myasthenic crisis, hospitalization, pneumonia/ sepsis, and emergency department (ED) visits were measured using Cox proportional hazard models and pharmacotherapy patterns for rMG were assessed. Results: The rMG cohort included a preponderance of younger patients and women. The adjusted hazard ratio was 2.49 (95% confidence interval, 1.26–4.94) for mortality, 3.14 (2.25–4.38) for myasthenic crisis, 1.54 (1.15–2.06) for hospitalization, 2.69 (1.74–4.15) for pneumonia/sepsis, and 1.81 (1.28–2.56) for ED visits for rMG versus non-rMG. The immunosuppressant prescriptions were more prevalent in patients with rMG, while the difference was more remarkable before rMG onset rather than after rMG onset. Conclusion: Despite the severe prognosis of rMG, the strategies for pharmacotherapeutic regimens were similar in those two groups, suggesting that intensive monitoring and introduction of timely treatment options in the early phase of MG are required.

Pharmacogenetic analysis of cinacalcet response in secondary hyperparathyroidism patients

Jeong, Sohyun,Kim, In-Wha,Oh, Kook-Hwan,Han, Nayoung,Joo, Kwon Wook,Kim, Hyo Jin,Oh, Jung Mi Dove Medical Press 2016 Drug design, development and therapy Vol.10 No.-

<P><B>Background</B></P><P>Secondary hyperparathyroidism (SHPT) is one of the major risk factors of morbidity and mortality in end-stage renal disease. Cinacalcet effectively controls SHPT without causing hypercalcemia and hyperphosphatemia. However, there is significant inter-individual response variance to cinacalcet treatment. Therefore, we aimed to evaluate the genetic effects related with parathyroid hormone regulation as factors for cinacalcet response variance.</P><P><B>Methods</B></P><P>Patients with a diagnosis of SHPT based on intact parathyroid hormone (iPTH) >300 pg/mL on dialysis were included in this study. They were over 18 years and have been treated by cinacalcet for more than 3 months. Responders and nonresponders were grouped by the serum iPTH changes. Twenty-four single nucleotide polymorphisms of <I>CASR</I>, <I>VDR</I>, <I>FGFR1</I>, <I>KL</I>, <I>ALPL</I>, <I>RGS14</I>, <I>NR4A2</I>, and <I>PTHLH</I> genes were selected for the pharmacogenetic analysis.</P><P><B>Results</B></P><P>After adjusting for age, sex, and calcium level, <I>CASR</I> rs1042636 (odds ratio [OR]: 0.066, <I>P</I>=0.027) and rs1802757 (OR: 10.532, <I>P</I>=0.042) were associated with cinacalcet response. The association of haplotypes of <I>CASR</I> rs1042636, rs10190, and rs1802757; GCC (OR: 0.355, <I>P</I>=0.015); and ATT (OR: 2.769, <I>P</I>=0.014) with cinacalcet response was also significant.</P><P><B>Conclusion</B></P><P>We obtained supporting information of the associations between cinacalcet response and <I>CASR</I> polymorphisms. <I>CASR</I> single nucleotide polymorphisms (SNPs) rs1802757, rs1042636, and haplotypes of rs1042636, rs10190, and rs1802757 were significantly associated with cinacalcet response variance.</P>

Global perspectives on ensuring the safety of pharmaceutical products in the distribution process

Jeong, Sohyun,Ji, Eunhee Dustri-Verlag Dr. Karl Feistle 2018 International Journal of Clinical Pharmacology and Vol.56 No.1

TRP14 Inhibits Osteoclast Differentiation via Its Catalytic Activity

Hong, Sohyun,Huh, Jeong-Eun,Lee, Soo Young,Shim, Jae-Kyung,Rhee, Sue Goo,Jeong, Woojin American Society for Microbiology 2014 Molecular and cellular biology Vol.34 No.18

<P>We previously reported the inhibitory role of thioredoxin-related protein of 14 kDa (TRP14), a novel disulfide reductase, in nuclear factor-κB (NF-κB) activation, but its biological function has remained to be explored. Here, we evaluated the role of TRP14 in the differentiation and function of osteoclasts (OCs), for which NF-κB and cellular redox regulation have been known to be crucial, using RAW 264.7 macrophage cells expressing wild-type TRP14 or a catalytically inactive mutant, as well as its small interfering RNA. TRP14 depletion enhanced OC differentiation, actin ring formation, and bone resorption, as well as the accumulation of reactive oxygen species (ROS). TRP14 depletion promoted the activation of NF-κB, c-Jun NH<SUB>2</SUB>-terminal kinase, and p38, the expression of c-Fos, and the consequent induction of nuclear factor of activated T cell, cytoplasmic 1 (NFATc1), a key determinant of osteoclastogenesis. However, pretreatment with <I>N</I>-acetylcysteine or diphenylene iodonium significantly reduced the OC differentiation, as well as the ROS accumulation and NF-κB activation, that were enhanced by TRP14 depletion. Furthermore, receptor activator of NF-κB ligand (RANKL)-induced ROS accumulation, NF-κB activation, and OC differentiation were inhibited by the ectopic expression of wild-type TRP14 but not by its catalytically inactive mutant. These results suggest that TRP14 regulates OC differentiation and bone resorption through its catalytic activity and that enhancing TRP14 may present a new strategy for preventing bone resorption diseases.</P>

국내외 의약품 유익성-위해성 평가 기법에 대한 고찰

정소현(Sohyun Jeong),장선미(Sunmee Jang) 대한약학회 2019 약학회지 Vol.63 No.2

The development of systematic and structural tool evaluating drug Benefit-Risk Assessment (BRA) has long been a hot issue in pharmaceutical and regulatory division worldwide. It has been proposed to conduct drug BRA during the whole drug life due to the unknown adverse events by long term drug use or unconfirmed drug efficacy and safety in specific groups of people by the golden rule of drug approval evidence, randomized controlled trials being widely comprehended. We aimed to collect and review BRA tools and strategies in the advanced countries, international organizations, and Korea in order to get the trends and knowledges of BRA to advance the BRA system in Korea. ICH and WHO did not support a specific BRA model but stated the basic principles and formats. EMA & IMI conducted a rigorous project to present and suggest quantitative and qualitative BRA methods. They highlighted using ProACT-URL and Effects Table in regulatory decision process and suggested to utilize quantitative Multiple Criteria Decision Analysis in BRA. FDA suggested simple and qualitative approach of Benefit Risk Framework (BRF), in the concern of potential bias induced by quantitative approach. Korea also has been following up the advanced BRA tools consistently but requires establishment of localized BRA strategy satisfying its own perspectives. From these contexts, Korea needs to build up a task force or tangible environment to actively discuss and implement BRA tools.

Signaling pathways underlying nitrogen transport and metabolism in plants

Su Jeong Choi,Zion Lee,Eui-Jeong Han,Sohyun Kim,Jun Sung Seo,Taeyoung Um,Jae Sung Shim 생화학분자생물학회 2023 BMB Reports Vol.56 No.2

Nitrogen (N) is an essential macronutrient required for plantgrowth and crop production. However, N in soil is usuallyinsufficient for plant growth. Thus, chemical N fertilizer hasbeen extensively used to increase crop production. Due tonegative effects of N rich fertilizer on the environment, improvingN usage has been a major issue in the field of plantscience to achieve sustainable production of crops. For thatreason, many efforts have been made to elucidate how plantsregulate N uptake and utilization according to their surroundinghabitat over the last 30 years. Here, we provide recent advancesfocusing on regulation of N uptake, allocation of N byN transporting system, and signaling pathway controlling Nresponses in plants.

도시 규모 BIM 모델링 자동화를 위한 건축물의 3D 모델 생성 기술 비교

정준호(Jeong, Joonho),오경석(Oh, Kyungseok),김소현(Kim, Sohyun),정광복(Jeong, Kwangbok),이재욱(Lee, Jaewook) 한국생태환경건축학회 2023 한국생태환경건축학회 학술발표대회 논문집 Vol.23 No.1

DACUM 방법을 활용한 초등학교 진로전담교사의 직무분석 연구

정진철(Jinchul, Jeong),김재호(Jaeho, Kim),남중수(Jung-Soo, Nam)임소현(Sohyun, Im),정성지(Seongji, Jeong),조홍용(Hongyoug, Jo) 학습자중심교과교육학회 2017 학습자중심교과교육연구 Vol.17 No.22

이 연구의 목적은 DACUM 직무 분석기법을 적용하여 초등학교 진로전담교사의 직무를 분석하는 것이다. 연구 목적의 달성을 위해 이 연구에서는 먼저, 초등학생의 진로발달 특성과 진로교육 목표를 분석하고 진로전담교사 직무 관련 국내․외 선행 연구를 분석하였다. 그리고 DACUM 직무분석을 통하여 초등학교 진로전담교사의 책무(Duty)와 과업(Task)을 도출하고 각 과업의 중요도를 평정하였다. DACUM 직무분석을 위해 1명의 직무분석가, 9명의 데이컴 위원(내용 전문가), 3명의 서기, 2명의 실무자로 이루어진 DACUM 위원회를 구성하여 2017년 7월 25일에 DACUM 워크숍을 실시하였다. 연구결과는 다음과 같다. 첫째, 초등학교 진로전담교사의 직무를 ‘학생들이 행복한 삶을 사는데 필요한 기초적인 진로개발역량을 기를 수 있도록 하기 위해, 학교 진로교육과정 편성, 운영 및 평가를 총괄하고 교사의 진로교육을 지원 하는 것’으로 정의하였다. 둘째, 초등학교 진로전담교사의 직무를 수행하기 위해 요구되는 8개의 책무(학교 진로교육과정 편성(기획), 진로교육(단위) 프로그램 구안, 진로교육 정보지원, 진로심리검사 실시, 진로상담 지원, 진로체험 운영, 교사/학부모 진로교육 역량 강화, 진로교육과정 운영 결과 평가 및 환류)를 도출하였으며 각 책무 별 과업은 총 48개로 분석되었다. 셋째, 각 과업의 중요도를 평정한 결과 핵심 과업으로 20개가 도출되었다. 넷째, 초등 진로전담교사에게 필요한 지식, 기술, 태도에 대한 의견을 수렴하여 제시하였으며, 9개의 지식과 15개의 기술이 도출되었고, 갖추어 야 할 바람직한 태도로는 12개의 태도가 도출되었다. The purpose of this study is to analyze the duties of the Elementary School Career teacher by applying the DACUM task analysis technique. In order to achieve the goal, we analyzed the development characteristics of elementary school students, the career education objectives of elementary school, and the former research related to career teacher. Based on the analysis of DACUM tasks, we have drawn out the duties and tasks of our career teacher and weighed down the importance of each task. For the DACUM job analysis, we organized one task analyst, nine subject matter expert, three staff members, and two practitioners and hold a DACUM workshop on the 25th of July, 2017. The results of the study are as follows. First, defining the job of an elementary school career teacher as ‘to develop basic career development skills necessary for a happy life, elementary school career teacher is responsible for organizing, operating, and evaluating school career education courses and supporting the career education of teachers’. Second, there are eight duties (organizing/planning school career education curriculum, career education (unit) program design, career education information support, operating psychological examination, career counseling support, career experience management, strengthening teacher/parent career education competency, evaluation and feedback of career course operation results) and the total number of tasks according to eight duties is 48. Third, as a result of evaluating the importance of each task, 20 core tasks were derived. Fourth, the opinions about the general knowledge, skills and attitudes required for elementary school career teachers were collected and presented. Therefore, nine knowledge and fifteen technologies were derived, also a desirable attitude was derived from the recommended attitude.

Genome-Wide Differential Gene Expression Profiling of Human Bone Marrow Stromal Cells

Jeong, Ju Ah,Ko, Kyung-Min,Bae, Sohyun,Jeon, Choon-Ju,Koh, Gou Young,Kim, Hoeon Wiley (John WileySons) 2007 Stem Cells Vol.25 No.4

<P>Bone marrow stromal cells (BMSCs) reside in bone marrow and provide a lifelong source of new cells for various connective tissues. Although human BMSCs are regarded as highly suitable for the development of cell therapeutics and regenerative medicine, the molecular factors and the networks of signaling pathways responsible for their biological properties are as yet unclear. To gain a comprehensive understanding of human BMSCs at the transcriptional level, we have performed DNA microarray-based, genome-wide differential gene expression analysis with the use of peripheral blood-derived mononuclear cells (MNCs) as a baseline. The resulting molecular profile of BMSCs was revealed to share no meaningful overlap with those of other human stem cell types, suggesting that the cells might express a unique set of genes for their stemness. By contrast, the distinct molecular signature, consisting of 92 different genes whose expression strengths are at least 50-fold higher in BMSCs compared with MNCs, was shown to encompass largely a gene subset of umbilical cord blood-derived adherent cells, suggesting that adherent cells derived from bone marrow and umbilical cord blood may be defined by a common set of genes, regardless of their origin. Intriguingly, a large number of these genes, particularly ones for extracellular matrix products, coincide with normal or tumor endothelium-specific markers. Taken together, our results here provide a BMSC-specific genetic catalog that may facilitate future studies on molecular mechanisms governing core properties of these cells.</P>