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- 저자 : Shengwen Chen (검색결과 3 건)
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In situ monitoring of pore structure of magnesium oxysulfate cement paste: Effect of MgSO4/H2O ratio
Shengwen Tang,Changrong Wei,Rongjin Cai,Jiasheng Huang,E. Chen,Junhui Yuan 한국공업화학회 2020 Journal of Industrial and Engineering Chemistry Vol.83 No.-
This work systematically presented the pore structure evolution of different magnesium oxysulfate(MOS) cement pastes by non-contact impedance measurement (NCIM), fractal theory and othermicrostructural experiments. According to the evolution of electrical impedance response, threehydration stages (dissolution, acceleration and hardened stages) can be identified in the pastes. Furthermore, based on the results obtained from NCIM and fractal theory, the porosity, incremental porevolume, pore tortuosity, average pore diameter and maximal pore diameter of MOS cement pastes areinvestigated. The influence of MgSO4/H2O ratio on pore structure of MOS cement paste is primarilyexplained. It can be inferred from predicted and experimental results that NCIM is a good method toanalyze the microstructure evolution of MOS cement pastes in-situ.
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Huang Bao,He Yongqing,Li Shengwen,Wei Xiaoan,Liu Junhui,Shan Zhi,Huang Yue,Chen Jiang,Zhao Fengdong 생화학분자생물학회 2020 Experimental and molecular medicine Vol.52 No.-
Calcipressin-1, also known as regulator of calcineurin 1 (RCAN1), can specifically bind calcineurin at or near the calcineurin A catalytic domain and downregulate calcineurin activity. However, whether RCAN1 affects the hypoxic intervertebral disc (IVD) phenotype through the calcineurin/NFAT signaling pathway remains unclear. First, we confirmed the characteristics of the degenerative nucleus pulposus (NP) by H&E, safranin O/fast green and Alcian blue staining, and detected increased RCAN1 levels in the degenerative NP by immunohistochemistry. Then, we demonstrated that the protein level of RCAN1.4 was higher than that of RCAN1.1 and progressively elevated from the control group to the Pfirrmann grade V group. In vitro, both hypoxia (1% O2) and overexpression of HIF-1α reduced the protein level of RCAN1.4 in rat NP cells in a dose- and time-dependent manner. We further found that miRNA-124, through a nondegradative pathway (without the proteasome or lysosome), suppressed the expression of RCAN1.4. As expected, calcineurin in NP cells was activated and primarily promoted nuclear translocation of NFATc1 under hypoxia or RCAN1.4 siRNA transfection. Furthermore, SOX9, type II collagen and MMP13 were elevated under hypoxia, RCAN1.4 siRNA transfection or NFATc1 overexpression. Using chromatin immunoprecipitation (ChIP) and a luciferase reporter assay (with mutation), we clarified that NFATc1 increasingly bound the SOX9 promotor region (bp −367~−357). Interaction of HIF-1α and NFATc1 promoted MMP13 transcription. Finally, we found that FK506 reversed hypoxia-induced activation of the calcineurin/NFAT signaling pathway in NP cells and an ex vivo model. Together, these findings show that the RCAN1.4-calcineurin/ NFAT signaling pathway has a vital role in the hypoxic phenotype of NP cells. RCAN1.4 might be a therapeutic target for degenerative disc diseases.
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Shubin Zhang,Tianxiao Wang,Xin Guo,Shengwen Chen,Lijun Wang 대한환경공학회 2023 Environmental Engineering Research Vol.28 No.4
Sulfidated and bimetal modification can improve the reactivity and selectivity of zero-valent iron in contaminant removal. However, previous studies were focused on unilateral material approaches. In this article, a new hybrid composite Ag/S-ZVI was prepared by doping elemental silver on surface of sulfidated nanoscale zerovalent iron (S-nZVI). The results of X-Ray Diffraction (XRD), energy dispersive spectrometer (EDS) and X-ray Photoelectron Spectroscopy (XPS) indicated Ag was dispersed on the surface of S-nZVI. Scanning electron microscope (SEM) images displayed Ag/S-ZVI was irregular clusters with rough surfaces, small agglomeration, and quasi-spherical in shape. The removal of TCE by Ag/S-ZVI was 90.4% within 20 min. The reaction rate constant Kobs of Ag/S-ZVI was 2.59 times or 1.85 times of nZVI or S-nZVI, respectively. Cycling experiments showed that Ag/S-ZVI had good recycling ability, and the removal rate of TCE reached 72.6% at the third cycle. The addition of Ag+ makes S-nZVI as an abundant and efficient source of reducing electrons. The Fe<SUP>0</SUP> core can break C-Cl bonds by releasing electrons and the surface layer of Ag favors the transfer efficiency of electrons. Such study provides an efficient and robust ternary system for the remediation of TCE in groundwater.
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