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한승주 ( Han¸ Seungjoo ),최흥석 ( Choi¸ Heungsuk ),이철주 ( Lee¸ Cheouljoo ) 한국행정학회 2021 韓國行政學報 Vol.55 No.3
대통령의 입장에서 행정관료 조직은 자신의 정책을 집행하고, 정책목표를 구현하기 위한 수단적 존재이다. 많은 전문성으로 무장한 관료조직이 지나친 자율성으로 대통령 리더십을 빛바래게 하지 못하도록 정치적으로 통제할 대상이기도 하다. 본 연구의 목적은 대통령의 관료 통제가 그의 정책공간에 결과적으로 무슨 영향을 주는지를 분석하는 것이다. 여기서 정책공간이란 대통령이 현실적으로 추구할 수 있는 정책 실현의 범위를 의미한다. 대통령은 관료에 대한 통제를 통해 관료조직의 자율성을 어느 정도 제한하고 자신의 정책공간을 확장시키려할 것이다. 그런데 대통령의 관료 통제가 늘 정책공간의 확대로 이어질 것인가? 이와 관련하여 본 연구는 대통령의 통제가 의도와는 다른 방향으로 관료조직의 행태를 변화시켜 대통령의 정책공간을 오히려 수축시키는 결과를 낳을 가능성을 탐색한다. 중상위직 공무원의 인식을 통해서 실증 분석한 결과는 다음과 같다. 첫째, 관료에 대한 대통령의 통제는 관료조직의 자의적, 폐쇄적 행태를 억제하고 대통령의 정책에 대한 대응성을 높여 대통령의 정책공간을 확장시킨다. 둘째, 그러나 동시에 대통령의 정치적 통제는 소극적 묵종, 책임회피 등 관료의 소위 도구적 행태를 강화시켜 대통령의 정책공간을 축소시킬 수 있다. 그리고 셋째, 대통령의 정치적 통제와 정책공간 사이의 긍정적 상관관계에서 관료의 도구적 행태가 부정적 매개 작용을 하고 있음을 발견하였다. Government bureaucracy is a vehicle with which the president implements policies and tries to achieve his or her political goals. It is a subject of the president’s political control, as its expertise-based political powers could possibly overshadow the presidential executive leadership. This study analyzes the effects of the president’s control of government bureaucracy in his or her policy space. The policy space of the president stands for the scope of public policies that he or she could pursue while taking into account their implementational feasibility. The president would try to control bureaucracy so as to delimit its autonomy and concurrently expand his or her policy space. However, would the presidential control of bureaucracy be necessarily conducive to the expansion of the policy space? This study also focuses on the possibility of contraction of the policy space, as the attempt to control could result in unexpected behavioral responses on the part of bureaucracy. The empirical analysis using a survey of mid- and high-ranking public officials reveals, first, that the presidential control of bureaucracy is positively associated with the expansion of the policy space, as it suppresses bureaucracy’s arbitrary and bigoted behaviors. Second, at the same time, however, presidential control would result in contraction of the policy space, as it reinforces the instrumentality behavior of bureaucracy in the forms of passive and lukewarm compliance, as well as avoidance of responsibility. And third, the instrumentality behavior of bureaucracy negatively mediates the association between presidential control of bureaucracy and presidential policy space.
균열발생시기 결정을 위한 항공기 엔진 구성품의 비파괴검사 결과에 대한 통계적 분석
최재만(Jaeman Choi),권영한(Younghan Kwon),최환서(Hwanseo Choi),양승효(Seunghyo Yang),우상욱(Sangwook Woo),조순미(Soonmi Cho),이승주(Seungjoo Lee) 대한기계학회 2009 大韓機械學會論文集A Vol.33 No.12
In this study statistical analysis was performed for NDI(Non-Destructive Inspection) results of F100 engine front seal support assembly. NDI results can be statistically considered as Quantal Response Data. It is found that the suitable probability distribution to the failure data is normal distribution through MLE(Maximum Likelihood Estimation) of the Quantal Response Data. Moreover, Cumulative Distribution Function, failure rate function and B-Life are calculated on the supposed distribution.
Choi, Kyung-Chul,Oh, So-Young,Kang, Hee-Bum,Lee, Yoo-Hyun,Haam, Seungjoo,Kim, Ha-Il,Kim, Kunhong,Ahn, Young-Ho,Kim, Kyung-Sup,Yoon, Ho-Geun Biochemical Society 2008 Biochemical journal Vol.411 No.1
<P>A central issue in mediating repression by nuclear hormone receptors is the distinct or redundant function between co-repressors N-CoR (nuclear receptor co-repressor) and SMRT (silencing mediator of retinoid and thyroid hormone receptor). To address the functional relationship between SMRT and N-CoR in TR (thyroid hormone receptor)-mediated repression, we have identified multiple TR target genes, including BCL3 (B-cell lymphoma 3-encoded protein), Spot14 (thyroid hormone-inducible hepatic protein), FAS (fatty acid synthase), and ADRB2 (beta-adrenergic receptor 2). We demonstrated that siRNA (small interfering RNA) treatment against either N-CoR or SMRT is sufficient for the de-repression of multiple TR target genes. By the combination of sequence mining and physical association as determined by ChIP (chromatin immunoprecipitation) assays, we mapped the putative TREs (thyroid hormone response elements) in BCL3, Spot14, FAS and ADRB2 genes. Our data clearly show that SMRT and N-CoR are independently recruited to various TR target genes. We also present evidence that overexpression of N-CoR can restore repression of endogenous genes after knocking down SMRT. Finally, unliganded, co-repressor-free TR is defective in repression and interacts with a co-activator, p300. Collectively, these results suggest that both SMRT and N-CoR are limited in cells and that knocking down either of them results in co-repressor-free TR and consequently de-repression of TR target genes.</P>
Specific Near‐IR Absorption Imaging of Glioblastomas Using Integrin‐Targeting Gold Nanorods
Choi, Jihye,Yang, Jaemoon,Park, Joseph,Kim, Eunjung,Suh, Jin‐,Suck,Huh, Yong‐,Min,Haam, Seungjoo WILEY‐VCH Verlag 2011 Advanced Functional Materials Vol.21 No.6
<P><B>Abstract</B></P><P>Molecular imaging using nanoprobes with high resolution and low toxicity is essential in early cancer detection. Here we introduce a new class of smart imaging probes employing PEGylated gold nanorods (GNRs) conjugated to cRGD for specific optical imaging of α<SUB>v</SUB>β<SUB>3</SUB> integrins from glioblastoma. GNRs exhibiting an optical resonance peak in the near‐infrared (NIR) region were synthesized using the seed‐mediated growth method. CTAB (cetyl trimethylammonium bromide) bilayer on the GNRs was replaced with a biocompatible stabilizer, heterobifunctional polyethyleneglycol (COOH‐PEG‐SH). Further, the carboxylated GNRs (PGNRs; PEG‐coated GNRs) were functionalized with cRGD using EDC‐NHS chemistry to formulate cRGD‐conjugated GNRs (cRGD‐PGNRs) for α<SUB>v</SUB>β<SUB>3</SUB> integrins. In order to assess the potential of the cRGD‐PGNRs as a targeted imaging probe, we investigated their optical properties, biocompatibility, colloidal stability and in vitro/in vivo binding affinities for cancer cells. Consequently, cRGD‐PGNRs demonstrated excellent tumor targeting ability with no cytotoxicity, as well as sufficient cellular uptake due to stable and prolonged blood circulation of cRGD‐PGNRs.</P>
Choi, Jihye,Kang, Byunghoon,Kim, Hyun-Ouk,Suh, Jin-Suck,Haam, Seungjoo,Yang, Jaemoon The Royal Society of Chemistry 2019 Nanoscale Vol.11 No.5
<P>Herein, we report a <I>de novo</I> synthesis approach to produce bandgap-controlled polyaniline (PAni) nanostructure <I>via</I> Mn-mediated oxidative polymerization at the catalytic nanoreactor. To achieve systemic nanoconfined polymerization, manganese oxide (MnOx) nanoparticles coated with silica were used as the sacrificial nanotemplate. Interestingly, the catalytic nanoreactor simultaneously allowed the nanoconfined oxidative polymerization and controlling of the bandgap. MnOx could be reduced by the addition of aniline monomers and consecutive redox reaction at the nanoreactor. Furthermore, core cavity was generated, and ionized Mn could control the bandgap by coordination at the nanostructures.</P>
Efficient Secure Group Communications for SCADA
Donghyun Choi,Sungjin Lee,Dongho Won,Seungjoo Kim IEEE 2010 IEEE transactions on power delivery Vol.25 No.2
<P>Modern industrial facilities have command and control systems. These industrial command and control systems are commonly called supervisory control and data acquisition (SCADA). In the past, SCADA system has the closed operating environment, so this system were designed without security functionality. These days, as a demand for connecting the SCADA system to the open network increases, the study of SCADA system security is an issue. A key-management scheme is essential for secure SCADA communications. Several key-management schemes for SCADA also have been proposed. Recently, advanced SCADA key-management architecture (ASKMA) was proposed. While previous studies do not support message broadcasting and secure communications, ASKMA supports it. Although the overall performance of ASKMA has many advantages compared to previous studies, it can be less efficient during multicast. In this paper, we propose ASKMA+ which is a more efficient scheme that decreases the computational cost for multicast communication. ASKMA+ reduces the number of keys to be stored in a remote terminal unit and provides multicast and broadcast communications.</P>