자기 센서를 이용한 자율주행 차량의 경로인식 시스템

김명준,김의선,손석준,오승열,류영재,임영철 경북대학교 센서기술연구소 2002 센서技術學術大會論文集 Vol.13 No.1

柔道技術 중 허벅다리걸기의 運動學的 特性

신성휴,손명성,김원섭,최승필 한국운동역학회 1998 한국운동역학회지 Vol.8 No.2

This study has been aimed to analyze UCHIMATE technique of Judo gymnastically. The following are the results and the proposition obtained through an image analysis method 3 men half heavy weight champions of the national Judo standing team(85-95kg) were used as subjects for the study. 1. CONCLUSION The following are the conclusion obtained through the discussion of analysis results of the Uchimata technique using 3 men, half heavy weight(85-95kg) champions of the National standing Judo team. 1) The time performing total technique were 1.48-seconds which was performinglonger than the light heavy weight class of 1.28-seconds by 0.20-seconds, this showed that the heavy weight class players demonstrated the technique later than the light heavy weight class palyers. 2) The average length of moving 1-step leg for attacking was 24.27cm, and 2-step leg moving was 92.87cm on average. Therefore, the shorter the moving distance, the more the technique performing hour could be shortened. 3) In the hanging phase, the moving displacement of the center of gravity of the body weight showed in horizontal, vertical, right and left direction 28.97cm, 21.59cm and 13.57cm respectively. Each of which were longer than the phase of KUZUSHI and TSUKURI. Such results show that the center of gravity of the body in move lift the opponent. This reducing the displacement of body weight from the center toward the right and left direction in the phase of KAKE is considered to be effective in demonstrationg the technique. 4)The central speed of the body was 0.8cm per second on average and the average vertical speed was 0.74cm per second. The speed of right and left movement was 0.51cm per second on average which showed the horizontal speed was the fastest while it is preferred that the vertical speed should be faster than that of the horizontal. 5) Angle of the Trunk showed 98.13 ˚ on average in the hanging phase and the larger the trunk angle, the shorter the needed time to demonstrate the technique, thus making the throw of the opponent over shoulder more advantageous. 2. PROPOSTION The following propositions are suggested through this analysis for further study : 1) It is to be considered that the kinetics in hanging the thigh and the degree of every segment of the body be studied in a more detailed fashion. 2) A study on the technique of thigh hanging in an actual game situation (rather than during mere exercises) is necessary. 3) It is necessary to study the TORI and UKE techniques together. 4) The study of each weight class ought to be performed.

Bowling 투구 動作分析

신성휴,위승두,손명성,구희성 조선대학교 스포츠과학연구소 1998 스포츠科學硏究 Vol.9 No.-

The Purpose of this study is the provide basic data for bowlers by analyzing the kinematical variables of throwing motion to the male pro bowler using 3-dimensional image analysis method. This researcher took the pictures with a video camera, analyzed them using the Kwon 3D program. 1×4×2m control object installed to get a 3 dimensional space coordinates. Results were as follows. 1. It was indicated that the trunk angle did not change left and right. Back and forth from stance to release motions of three subjects, and the average angle of trunk angle at the stance and that at the tabular side were 19.5˚ and 14.6˚ respectively, which showed they did not deviated from well-known range of forward direction, 15-20˚ and lateral direction 10-15˚. Also the trunk angle of release motion was average 17.1˚ for thalamus side, 41.3˚ for tabular side. 2. It was indicated that the knee angle repeated the increase and decrease to a small degree from the first to the fourth phase, the average angle of left knee at the release motion, the sixth phase was 110.8˚, which was higher than generally known 90˚.

Diagnostic performance of CD66c in lung adenocarcinoma-associated malignant pleural effusion: comparison with CEA, CA 19-9, and CYFRA 21-1.

Son, Seung-Myoung,Han, Hye-Suk,An, Jin Young,Choe, Kang Hyeon,Lee, Ki Man,Lee, Ki Hyeong,Kim, So-Seul,Lee, Yong-Moon,Lee, Ho-Chang,Song, Hyung Geun,Lee, Ok-Jun Modern Medicine, etc.] 2015 Pathology Vol.47 No.2

<P>Various tumour markers have been evaluated in malignant pleural effusions, but not CD66c. This study evaluated the diagnostic ability of CD66c in lung adenocarcinoma-associated malignant pleural effusions (LA-MPEs) and compared it with other known tumour markers. Forty-seven cases of LA-MPE and 52 cases of benign pleural effusions were collected. The levels of CD66c, CEA, CA 19-9, and CYFRA 21-1 were measured by enzyme immunoassay. The expression of CD66c, CEA, and CA 19-9 in cell blocks was measured by immunocytochemistry. CEA had the best diagnostic values, with a sensitivity of 87.2% and specificity of 92.3%. Both CD66c and CA 19-9 showed the highest specificity of 98.1%, with sensitivities of 63.8% and 55.3%, respectively. CYFRA 21-1 had a sensitivity of 83.0% and specificity of 76.9%. CEA combined with CA 19-9 reached a sensitivity of 91.5% and a specificity of 98.1%. The sensitivities of immunocytochemical staining for CD66c, CEA, and CA 19-9 were 72.5%, 75%, and 40%, respectively. CD66c showed a diagnostic performance comparable to CYFRA 21-1 and CA 19-9 by enzyme immunoassay. Immunocytochemical study showed that CD66c and CEA were more sensitive than CA19-9. Both studies support CD66c as a potential tumour marker to differentiate LA-MPE from benign effusions.</P>

Sarcomatoid Carcinoma Arising from Mature Cystic Teratoma

Seung-Myoung Son,Yong Moon Lee,Ji Hae Koo,Song-Yi Choi,이옥준,정은환,이호창 충북대학교 동물의학연구소 2012 Journal of Biomedical and Translational Research Vol.13 No.2

Malignant transformation of mature cystic teratoma (MCT) is rare. Sarcomatoid carcinoma is a neoplasm comprising malignant mesenchymal cells and a conventional carcinomatous area. Here, we report a case of sarcomatoid carcinoma arising from an MCT in the left ovary of a 45-year-old woman. A unilocular cyst consistent with MCT but a nodule within the cyst was confirmed from the resected ovary. Microscopically, the nodule showed both squamous cell carcinoma and pleomorphic sarcomatous components admixing with each other. Lining epithelial cells at the periphery of the main tumor showed squamous metaplasia. It is important to find a squamous cell component, either benign or malignant, when a sarcomatous component was present in the ovary tumor.

Prognostic impact of MYC protein expression in central nervous system diffuse large B-cell lymphoma: comparison with MYC rearrangement and MYC mRNA expression

Son, Seung-Myoung,Ha, Sang-Yun,Yoo, Hae-Yong,Oh, Dongryul,Kim, Seok-Jin,Kim, Won-Seog,Ko, Young-Hyeh Springer Science and Business Media LLC 2017 Modern pathology Vol.30 No.1

<P>The prognostic role of MYC has been well documented in non-central nervous system diffuse large B-cell lymphoma; however, it remains controversial in central nervous system diffuse large B-cell lymphoma. To investigate the prognostic value of MYC, we analyzed the MYC protein expression by immunohistochemistry, mRNA expression by RNA in situ hybridization, and gene status by fluorescence in situ hybridization in 74 cases of central nervous system diffuse large B-cell lymphoma. Moreover, we examined the correlation between MYC translocation, mRNA expression, and protein expression. The mean percentage of MYC immunopositive cells was 49%. Using a 44% cutoff value, 49 (66%) cases showed MYC protein overexpression. The result of mRNA in situ hybridization using the RNA scope technology was obtained using the H-scoring system; the median value was 34.2. Using the cutoff value of 63.5, 16 (22%) cases showed MYC mRNA overexpression. MYC gene rearrangement was detected in five out of 68 (7%) cases. MYC translocation showed no statistically significant correlation with mRNA expression; however, all MYC translocation-positive cases showed MYC protein overexpression, with a higher mean percentage of MYC protein expression than that of translocation-negative cases (78 vs 48%, P=0.001). The level of MYC mRNA expression was moderately correlated with the level of MYC protein expression (P < 0.001). The mean percentage of MYC protein expression in the high MYC mRNA group was higher than that in the low MYC mRNA group (70 vs 47%, P<0.001). A univariate analysis showed that age over 60 years, Eastern Cooperative Oncology Group (ECOG) performance status >= 2 and MYC protein overexpression were significantly associated with an increased risk of death. MYC translocation and MYC mRNA expression had no prognostic significance. On multivariate analysis, MYC protein overexpression and ECOG score retained prognostic significance.</P>

Epithelioid Malignant Intracerebral Nerve Sheath Tumor: A Case Report and a Comparison with Conventional Type

Seung-Myoung Son,Young Seok Park,Ok-Jun Lee 충북대학교 동물의학연구소 2016 Journal of Biomedical and Translational Research Vol.17 No.2

Chondroid tenosynovial giant cell tumor of the toe: A case report

Seung-Myoung Son, Yong-Moon Lee, Hyang-Mi Shin, Jae-Gul Chung, JongWon Chung, Ok-Jun Lee 충북대학교 동물의학연구소 2014 Journal of Biomedical and Translational Research Vol.15 No.1

Localized tenosynovial giant cell tumor (TGCT) usually occurs in the hand and foot regions. However, localized TGCT with extensive cartilaginous metaplasia is rare, especially in the tendon sheath of the toe. Here, we report a case of localized TGCT with cartilaginous metaplasia in a 57-year-old man. The tumor presented as a lobular mass measuring 2.2 cm in its greatest dimension and arose in the flexor digitorum tendon sheath of the right 2nd toe. Clinically, the mass was palpable 1 year ago and brought pain during walking. Microscopically, the mass was composed of focal conventional TGCT and cartilaginous components. The conventional TGCT areas consisted of mononuclear cells, multinucleated giant cells, and hemosiderin deposition. The chondroid areas were extensive and comprised more than 90% of the whole tumor. In this case, the mononuclear cells in the conventional TGCT areas showed focal immunohistochemical staining for podoplanin and S100 protein as well as diffuse staining for CD68, which is consistent with the staining pattern of conventional TGCT. The mononuclear cells in the chondroid areas were focal positive for podoplanin and diffuse positive for S100 protein. Chondroid metaplasia in diffuse TGCT has been reported in 10 cases involving the temporomandibular, elbow, and hip joints. However, there has been no report of a localized form of chondroid TGCT involving an extra-articular region.

Evaluation of p16INk4a, pRb, p53 and Ki-67 expression in cervical squamous neoplasia

Seung-Myoung Son,Kwon-Il Noh,이호창,Yeon-Jin Park,정은환,Hak-Soon Kim,송형근 충북대학교 동물의학연구소 2012 Journal of Biomedical and Translational Research Vol.13 No.3

Prior studies of p16INK4a, pRb, p53 and Ki-67 expression have suggested that these markers may be preferentially expressed in cervical neoplasms. The purpose of this study was to assess the expression and the clinical significance of p16INK4a, pRb, p53 and Ki-67 proteins in the cervical lesions. We obtained 106 cases with various categories of cervical squamous mucosa including squamous cell carcinoma (n=35), cervical intraepithelial neoplasia (CIN) II/III (n=26), CIN I (n=10), squamous metaplasia (n=15) and normal squamous mucosa (n=20). Immunohistochemical staining was performed for p16INK4a, pRb, p53 and Ki-67 proteins in formalin-fixed and paraffin-embedded tissue sections of the uterine cervix. The evaluation of the immunohistochemical staining based on the frequencies of the expression and the mean immunoreactivity scores (IS) in each diagnostic category. p16INK4a staining was detected in 26 of 35 cases (74.3%) of squamous cell carcinoma, in 16 of 26 cases (61.5%) of CIN II/III, in 6 of 10 cases (60%) of CIN I, in 9 of 15 cases (60%) of squamous metaplasia and negative in normal squamous mucosa. pRb expression was detected in all diagnostic categories; however, the proportion of pRb positive cells was relatively decreased in CIN II/III (38.5%) and squamous cell carcinomas (51.4%) compared to normal squamous epithelium (90%) and squamous metaplasia (73.3%). There were no significant differences in the expression of p53 in all diagnostic categories. Ki-67 expression was increased in squamous cell carcinoma (37.1%), CIN II/III (42.3%), CIN I (40%), but negative in squamous metaplasia and normal mucosa. In 35 cases of squamous cell carcinomas, multivariate analysis revealed no differences in p16INK4a, pRb, p53, and Ki-67 expression according to the age of the patient, lymph node metastasis and the clinical stage. In conclusion, the combined use of p16INK4a and Ki-67 immunoreactivity could improve the diagnostic specificity of squamous cell carcinoma of uterine cervix.

약물유해반응의 인과관계 판정을 위한 Naranjo와 WHO-UMC 지표의 비교

손명균 ( Myoung Kyun Son ),이용원 ( Yong Won Lee ),정한영 ( Han Young Jung ),이승우 ( Seung Woo Yi ),이광훈 ( Kwang Hoon Lee ),김승업 ( Seung Up Kim ),정재헌 ( Jae Heon Jeong ),박재준 ( Jae Jun Park ),박중원 ( Jung Won Park ),홍 대한내과학회 2008 대한내과학회지 Vol.74 No.2

목적: 약물유해반응의 인과관계를 분석함에 있어 그 객관성, 신뢰성 및 타당성을 증대시키기 위해 평가의 기준이 되는 지표들이 개발되어 왔다. 가장 널리 사용되는 평가지표인 Naranjo 지표와 WHO-UMC 지표를 비교 평가하였다. 방법: 세브란스 병원에 입원했던 환자 및 외래 추적관찰하는 환자들 중, 약물유해반응으로 보고된 환자들 100명을 후향적으로 분석하였다. 의무기록들을 검토하여 Naranjo와 WHO-UMC 지표를 적용, 평가하였다. 결과: Naranjo 지표와 WHO-UMC 지표의 평가를 비교 검토한 결과, 동일한 증례에 대해서 평가범주가 다르게 나타나는 경우가 많았다. WHO-UMC 지표와 비교할 때, Naranjo 지표로 평가한 결과는 상당히 관련이 있음(probable)으로 수렴되는 경향이 관찰되었다. Naranjo 지표는 위약투여에 대한 반응, 약물농도, 객관적인 검사, 이전 투약시의 반응, 약물용량조절에 대한 반응을 평가하는 항목들을 포함하고 있는데 실제로 임상에서 이런 검사 및 평가가 가능하거나 시행된 경우는 거의 없었다. 결론: Naranjo 지표는 어느 정도 타당성을 보여주고 있으나 한국의 임상 환경에서 WHO-UMC 지표에 비해 유용성이 제한적임을 알 수 있었다. Background/Aims: Several criteria have been proposed to increase the objectivity, reliability and validity of causality assessment of adverse drug reactions (ADR). We compared the Naranjo probability scale and the World Health Organization-Uppsala Monitoring Centre (WHO-UMC) causality categories to evaluate the validity and clinical usefulness of these criteria. Methods: We evaluated 100 ADR cases with the Naranjo probability scale and the WHO-UMC causality categories. The Spearman rank coefficient was used to determine the correlation of these criteria. The evaluation of the ADR was categorized into four groups for the Naranjo system: definite, probable, possible, and doubtful, and six groups for the WHO-UMC: certain, probable, possible, unlikely, conditional/unclassified, and unassessable. Results: The criteria used form these two systems showed some differences when compared with the same ADR cases. The Spearman rank coefficient was 0.519 (p<0.001) and the agreement was 55% between the Naranjo probability scale and the WHO-UMC causality categories. The Naranjo probability scale includes measurements for drug concentration, objective evidence of ADR, ADR to previous exposures, responses to placebo, and the dose adjustment of drugs. However, few cases were evaluated for all of these measures. Conclusions: The Naranjo probability scale may be helpful for assessing unexpected ADRs and useful for evaluators with little experience. However, some of the items are not utilized and there are discrepancies when compared with the WHO-UMC causality criteria.