http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Park, SeonJu,Kim, Nanyoung,Yoo, Guijae,Kim, Sang-Nam,Kwon, Hyun-Jung,Jung, Kiwon,Oh, Dong-Chan,Lee, Yun-Hee,Kim, Seung Hyun Elsevier 2017 Phytochemistry Vol.137 No.-
<P><B>Abstract</B></P> <P> <I>Juglans mandshurica</I> Maxim. (Juglandaceae) is a traditional folk medicine used for treatment of dermatosis and to relieve aches in Korea and China. In this study, eight compounds, along with six known compounds, were isolated from the fruit of <I>J. mandshurica</I>. Among the six known compounds, the absolute configuration of two compounds were determined. The structures of compounds were determined on the basis of extensive spectroscopic methods, including 1D and 2D NMR and CD spectroscopic data. All isolated compounds were tested for their lipolytic activities in differentiated adipocytes using C3H10T1/2 mouse embryonic fibroblasts. Among them, 2-(4-formyl-2-methoxyphenoxy)-propan-1,3-diol and 2-[4-(3-hydroxypropyl)-2-methoxyphenoxy]-1,3-propanediol exhibited the most potent lipolytic activities.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Eight compounds were isolated from the fruit of <I>Juglans mandshurica</I>. </LI> <LI> All compounds were tested for their lipolytic activities in C3H10T1/2. </LI> <LI> 2-(4-Formyl-2-methoxyphenoxy)-propan-1,3-diol showed the best activity compared to the positive control. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>Eight compounds, along with six known compounds, were isolated from the fruit of <I>J. mandshurica</I>. 2-(4-Formyl-2-methoxyphenoxy)-propan-1,3-diol and 2-[4-(3-hydroxypropyl)-2-methoxyphenoxy]-1,3-propanediol exhibited the most potent lipolytic activities in differentiated adipocytes using C3H10T1/2 mouse embryonic fibroblasts.</P> <P>[DISPLAY OMISSION]</P>
Identification of new major histocompatibility complex-B Haplotypes in Bangladesh native chickens
Ediriweera Thisarani Kalhari,Manjula Prabuddha,Kim Jaewon,Kim Jin Hyung,Nam Seonju,Kim Minjun,Cho Eunjin,Bhuiyan Mohammad Shamsul Alam,Rashid Md. Abdur,이준헌 아세아·태평양축산학회 2024 Animal Bioscience Vol.37 No.5
Objective: The major histocompatibility complex in chicken demonstrates a great range of variations within varities, breeds, populations and that can eventually influence their immuneresponses. The preset study was conducted to understand the major histocompatibility complex-B (MHC-B) variability in five major populations of Bangladesh native chicken: Aseel, Hilly, Junglefowl, Non-descript Deshi, and Naked Neck. Methods: These five major populations of Bangladesh native chicken were analyzed with a subset of 89 single nucleotide polymorphisms (SNPs) in the high-density MHC-B SNP panel and Kompetitive Allele-Specific polymerase chain reaction genotyping was applied. To explore haplotype diversity within these populations, the results were analyzed both manually and computationally using PHASE 2.1 program. The phylogenetic investigations were also performed using MrBayes program. Results: A total of 136 unique haplotypes were identified within these five Bangladesh chicken populations, and only one was shared (between Hilly and Naked Neck). Phylogenetic analysis showed no distinct haplotype clustering among the five populations, although they were shared in distinct clades; notably, the first clade lacked Naked Neck haplotypes. Conclusion: The present study discovered a set of unique MHC-B haplotypes in Bangladesh chickens that could possibly cause varied immune reponses. However, further investigations are required to evaluate their relationships with global chicken populations.
Minjun Kim,Thisarani Kalhari Ediriweera,Eunjin Cho,Yoonji Chung,Prabuddha Manjula,Myunghwan Yu,John Kariuki Macharia,Seonju Nam,Jun Heon Lee Asian Australasian Association of Animal Productio 2024 Animal Bioscience Vol.37 No.6
Objective: This study was conducted to investigate the differential expression of the major histocompatibility complex (MHC) gene region in Eimeria-infected broiler. Methods: We profiled gene expression of Eimeria-infected and uninfected ceca of broilers sampled at 4, 7, and 21 days post-infection (dpi) using RNA sequencing. Differentially expressed genes (DEGs) between two sample groups were identified at each time point. DEGs located on chicken chromosome 16 were used for further analysis. Kyoto encyclopedia of genes and genomes (KEGG) pathway analysis was conducted for the functional annotation of DEGs. Results: Fourteen significant (false discovery rate <0.1) DEGs were identified at 4 and 7 dpi and categorized into three groups: MHC-Y class I genes, MHC-B region genes, and non-MHC genes. In Eimeria-infected broilers, MHC-Y class I genes were upregulated at 4 dpi but downregulated at 7 dpi. This result implies that MHC-Y class I genes initially activated an immune response, which was then suppressed by Eimeria. Of the MHC-B region genes, the DMB1 gene was upregulated, and TAP-related genes significantly implemented antigen processing for MHC class I at 4 dpi, which was supported by KEGG pathway analysis. Conclusion: This study is the first to investigate MHC gene responses to coccidia infection in chickens using RNA sequencing. MHC-B and MHC-Y genes showed their immune responses in reaction to Eimeria infection. These findings are valuable for understanding chicken MHC gene function.