결합조직형성 모종 1예

이병진,노진혁,조옥자,박시룡 대한피부과학회 2003 大韓皮膚科學會誌 Vol.41 No.1

Desmoplastic trichilemmoma is a rare variant of trichilemmoma characterized by typical features of trichilemmoma with abundant desmoplastic stroma. We report herein a 54-year-old man presented with 2-year history of a solitary bean sized verrucous nodule on the occipital scalp. Histologically, the tumor showed a well-defined lobular growth extending from the epidermis into the dermis with abundant central desmoplastic stroma. Epithelial lobules at the margins of the neoplasm showed the typical features of trichilemmoma composed of glycogen-rich clear cells and peripheral palisading columnar cells. In contrast, at the center the cells assume a more random pattern of cords and strands traversed by the hyaline stroma, mimicking invasive carcinoma. It was diagnosed desmoplastic trichilemmoma by the distinctive histologic appearance and totally excised. (Korean J Dermatol 2003;41(1) : 120∼122)

두피에 발생한 유상피 혈관육종 1예

노진혁,이병진,조옥자,박시룡 대한피부과학회 2003 大韓皮膚科學會誌 Vol.41 No.7

Angiosarcoma is a rare malignant tumor of endothelial cell origin. Histopathologically, varied differentiation may be observed even within the same tumor. Epithelioid angiosarcoma is one subset of poorly differentiated angiosarcoma which is a rare variant. We report a case of epithelioid angiosarcoma of the scalp in a 59-year-old man. The patient had a painful solitary, 2×3 cm sized, dome-shaped, firm, erythematous to purplish nodule with crust on the vertex of the scalp. Histopathologically, the tumor was chiefly composed of solid sheets of atypical epithelioid cells with prominent eosinophilic cytoplasm, a large vesicular nuclei, and occasional intracytoplasmic vacuoles. Well to moderately differentiated areas with irregular vascular channel-like structures lined by atypical hyperchromatic endothelial cells were also seen in the peripheral areas of the tumor. Immunohistochemically, the tumor cells were positive with CD31 which is sensitive marker of endothelial cell. (Korean J Dermatol 2003;41(7) : 971~973)

神經稜起原細胞의 皮膚腫瘍에서 S-100 蛋白, Neuron-Specific Enolase 및 Myelin Basic Protein의 免疫組織化學的 硏究

朴時龍,金秀男,金仁仙 고려대학교 의과대학 1987 고려대 의대 잡지 Vol.24 No.1

Immunohistochemical techniques for the demonstration of neural markers are useful diagnostic tools in providing important information which cannot be obtained by use of conventional histologic methods. We examined the presence of S-100 protein, neuron specific enolase (NSE) and myelin basic protein (MBP) in 53 cases of skin tumors derived from cells of neural crest origin by indirect immunoperoxidase method. The results obtained are as follows: 1. Of 53 cases of skin tumors derived from cells of neural crest origin, 46 were positively stained for 2. S-100 protein, 12 for NSE and 29 for MBP. 2. S-100 protein was found in most of tumors derived from Schwann cells and melanocytes, but blue nevi, Ota nevi and malignant Schwannomas contained little or no S-100 protein. 3. NSE was found only in proliferative nerve fibers of neuromas, but was not found in a variety of melanocytic and Schwann cell tumors. 4. MBP was found in most of neuromas and neurofibromas, but was not found in a variety of melanocytic tumors. 5. These results indicate that S-100 protein is an useful diagnostic marker for skin tumors derived from cells of neural crest origin, especially for malignant melanoma and that NSE and MBP are useful in understanding the histogenesis of neural and Schwannian differentiation.

수포성 병변을 보인 피부백혈병 1예

박종일,박시룡,오진욱 대한피부과학회 2000 大韓皮膚科學會誌 Vol.38 No.11

Leukemia cutis has been said to occur in 13% of cases of AML(Acute myelogenous leukemia). Patients with AML have the highest incidence of both specific and nonspecific skin lesions, but leukemia cutis presenting with vesicobullous lesion are relatively rare. We report a case of a 50-year-old woman who showed leukemia cutis presenting with vesicobullous lesion.

금속작업자의 피부질환에 관한 연구 ( II . 알레르기성 접촉피부염 )

박종일 ( Jong Il Park ),김희옥 ( Hee Ok Kim ),박시룡 ( See Ryong Park ),오칠환 ( Chil Hwan Oh ),김순덕 ( Soon Duck Kim ),염용태 ( Yong Tae Yeum ) 대한피부과학회 1998 대한피부과학회지 Vol.36 No.2

Background: Skin contact with metalworking fluid(MWF) remains a frequent cause of occupational dermatitis. However, no precise data is available about sensitization in metalworkers exposed to MWF in Korea. Objectives : The purpose of this study was to evaluate the prevalence of contact sensitivity among metalwokers who handle MWFs and to investigate the suitability of a screening test with MWFs being actually used in metalworkers. Methods: An epidemiological study was performed using a ' questionnaire in 771 workers in 9 derpartments of a motor company. 278 out of 771 workers had actual contact with MWF. Patch tests were performed in 73 metalworkers who had suspected dermatits in relation to exposure of MWF, which was selected via interviews and dermatologic examinations. Patch tests were included with a routine series of common components of MWF(materials obtained from Chemotechnique, Sweden), a solvent series and several dilutions of various crude MWFs(8 species) Results : Contact sensitization was established in 14 metalworkers(5% of 278). Sensitising substances were biocide(6 cases), corrosion inhibitors(2 cases), emulsifiers(2 cases), biostatic substances(1 cses) and others(4 cases). Therefore 10 out of 14 metalworkers had true occupational allergic contact dermatitis. 10 out of 73 screening patch tests showed positive reactions to MWF elements, and 9 people who were positive to MWF elements showed positive reactions to crude MWF, but 1 person did not. Conclusion : The prevalence of occupational allergic contact dermatitis(3.5% of 278) was low. The screening patch test by crude MWFs actually used in metalworkers may give false negatives. Therefore for the purpose of diagnosis of allergic contact dermatitis, we need a process of patch tests with MWF elements. (Korean J Dermatol 1998;36(2) 246-251)

연골양 한관종 1예

오진욱,박종일,박시룡 대한적십자사 2000 적십자병원지 Vol.27 No.1

유방암에서 전이된 종양성 탈모증 1예

김희옥,박시룡,오진욱,박종일 대한피부과학회 1999 大韓皮膚科學會誌 Vol.37 No.2

Breast cancer is a common cancer in women and the most common primary tumor metastatic to the skin. Cutaneous metastasis from breast cancer occurs predominently through lymphatic dissemination. Alopecia neoplastica is rare and probably caused by the hematogenous spread of the internal carcinoma. It has diagnostic importance because it may be the first sign of an undiscovered internal malignancy. We report a case of a 40-year-old female who showed alopecia neoplastia secondary to an invasive intraductal carcinoma of the breast.

급성 백혈병이 동반된 괴저성 농피증

박진주(Jin Joo Park),정은정(Eun Chyung Jung),박시룡(See Ryong Park) 대한피부과학회 1987 대한피부과학회지 Vol.25 No.6

A 16-year-old girl developed pyoderma gangrenosum without underlying disease at first. She was treated with local cutaneous dressing and systemic oral prednisolone and minocycline for 10 months, imtermittently. After that, acute leukemia, which was undeterminated type, was developed 4 years after first onset. Since pyoderma gangrenosum may be a preindication of underlying disease, continual follow up check for systemic disease is required.

담마진 환자의 문진 및 일반 검사 성적 고찰

박진주(Jin Joo Park),정은정(Eun Jung Chyung),박시룡(See Ryong Park) 대한피부과학회 1988 대한피부과학회지 Vol.26 No.1

Any type of urticaria may affect as many as 20% person during their lifetimes, yet the causes of this disorder is established in no more than 20% of cases. So, 308 patients with urticaria(acute ; 73, factitial; 120, chronic;115) were evaluated for results of historical and laboratory tests. The results were summerized as follows,' 1. The disesse primarily affected 2nd % 3rd decade(46.2%) with predominance of woman than man (M: F=1: 1.4). 2. Ninety-seven(31.5%) had at least one abnormal finding in the laboratory tests but, may be twenty-three(7.5%) would have causal relationship. 3. We sought serologic markers of Hepatitis B virus infection in serum from 8(14%) of 57 patients with urticaria. Of these, 4 were found to have abnormal liver function. 4. Sixty-five had taken at least one sort of drug previously or just before urticaria developed, but, may be forty-six(14.9%) would have a causal relationship and the predisposing drugs were analgesics, antibiotics, common cold medication & vitamin etc. 5. The predisposing conditions were as follows ; pulmory tuberculosis, viral hepatitis, hyperthyroidism, tonsillitis & ascariasis, etc. Of these, eleven(3.6%) of this patients were newly found to have underlying diseases. 6. This study showed inciting factors of urticaria in 27.2%(84/308).

편평 황색종 , 건 황색종 , 결절성 황색종을 동반한 제 IIa형 과지질단백혈증

박종일,허광회,김희옥,박시룡 ( Jong Il Park,Kwang Hoi Hur,Hee Ok Kim,See Ryong Park ) 대한피부과학회 1997 대한피부과학회지 Vol.35 No.1

We report a case of a 59 year-old female with hyperlipoproteinernia who had xanthoma tuberosum, xanthoma tendinosurn and xanthoma planum. Yellowish nodules appeared on the right elbow 26 years ago and the lesions gradually increased in size and spread to the elbow, hand, knee, foot and achilles tendon. Except for the skin lesion, she was normal on physical examination. The laboratory findings showed that the serum cholesterol, beta lipoprotein and total lipid were increased. The beta band was rnarkedly elevated on electrophoresis, which suggested type IIa hyperlipoproteinemia. Histopathological findings shc wed many aggregates of foam cells and foreign body giant cells were seen in the dermis. (Kor J Dermatol 1997;35(1): 144-149)