Reduced graphene oxide modified smart conducting paper for cancer biosensor

Kumar, Saurabh,Kumar, Suveen,Srivastava, Saurabh,Yadav, Birendra K.,Lee, Seung H.,Sharma, Jai G.,Doval, Dinesh C.,Malhotra, Bansi D. Elsevier 2015 Biosensors & bioelectronics Vol.73 No.-

<P><B>Abstract</B></P> <P>We report results of the studies relating to the fabrication of a paper based sensor comprising of poly (3,4-ethylenedioxythiophene):poly(styrenesulfonate) (PEDOT:PSS) and reduced graphene oxide (RGO) composite. The effect of various solvents like methanol, ethylene glycol and H<SUB>2</SUB>SO<SUB>4</SUB> on the electrical conductivity of PEDOT:PSS coated Whatman paper has been investigated. The conductivity of this solution processed conducting paper significantly increases from ~1.16×10<SUP>−4</SUP> Scm<SUP>−1</SUP> up to ~3.57×10<SUP>−2</SUP> Scm<SUP>−1</SUP> (~300 times) on treatment with ethylene glycol. The observed significant increase in electrical conductivity is due to conformational rearrangement in the polymer and is due to strong non-covalent cooperative interaction between PEDOT and the cellulose molecules. Further, incorporation of RGO into the conducting paper results in improved electrochemical performance and signal stability. This paper electrode is a promising alternative over the expensive conventional electrodes (ITO, gold and glassy carbon), that are known to have limited application in smart point-of-care (POC) devices. This low cost, flexible and environment friendly conducting paper based biosensor utilized for cancer biomarker (carcinoembryonic antigen, CEA) detection reveals high sensitivity of 25.8µAng<SUP>−1</SUP> mLcm<SUP>−2</SUP> in the physiological range, 1–10ngmL<SUP>−1</SUP>.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Solution processed reduced graphene oxide modified conducting paper sensor is reported for cancer detection. </LI> <LI> This paper sensor is exceptionally low cost, flexible and disposable. </LI> <LI> It exhibits high sensitivity of 25.8µAng<SUP>−1</SUP> mLcm<SUP>−2</SUP> in the detection range of 1–10ngmL<SUP>−1</SUP> for cancer biomarker (carcinoembryonic antigen, CEA) detection. </LI> <LI> This conducting paper electrode is a promising alternative over the expensive conventional electrodes (ITO, gold and glassy carbon) for application to POC devices. </LI> </UL> </P>

An Efficient Trademark Image Retrieval using Combination of Shape Descriptor and Salience Features

Saurabh Agarwal,Nikhil Chaturvedi,Punit Kumar Johari 보안공학연구지원센터(IJSIP) 2014 International Journal of Signal Processing, Image Vol.7 No.4

Thermal characteristics of thermoelectric generator for waste heat recovery from a billet casting cooling process

Saurabh Yadav,Jie Liu,Man Sik Kong,Young Gyoon Yoon,Sung Chul Kim 대한설비공학회 2021 대한설비공학회 학술발표대회논문집 Vol.2021 No.6

In the present investigation, experiments were performed to recover waste heat in a billet casting cooling process utilizing bismuth telluride based thermoelectric generators (TEGs). Four d-type absorber plates made of copper material, were mounted over manufactured billet. Three sides of each absorber plate were attached with three thermoelectric units to generate a total power of 339 W. Power density was achieved to be 981 W/㎡ at operating voltage of (58 V) of battery energy storage system. Numerical results obtained using 1-D simulation through FloMASTER<SUP>TM</SUP> software are found to exhibit a good agreement with the experimental results. Further, one-dimensional numerical simulation has been carried out to obtain the heat transfer characteristics at varying flow rates of cold water(Reynolds number = 2540 - 16943) at inlet temperatures of 20 °C for the cold side of TEG. Results indicate that the thermoelectric generators performance increases with the increase of cold water flow rate and the decrease in the inlet temperature of cold water.

RAGAMALA: the visual representation of melody types in Northern India

Saurabh Goswami,Selina Thielemann 아시아음악학회 2005 Asian Musicology Vol.7 No.-

Management of inflammatory bowel disease in older persons: evolving paradigms

( Saurabh Kedia ),( Jimmy K. Limdi ),( Vineet Ahuja ) 대한장연구학회 2018 Intestinal Research Vol.16 No.2

The incidence and prevalence of inflammatory bowel disease (IBD) is increasing, and considering the aging population, this number is set to increase further in the future. The clinical features and natural history of elderly-onset IBD have many similarities with those of IBD in younger patients, but with significant differences including a broader differential diagnosis. The relative lack of data specific to elderly patients with IBD, often stemming from their typical exclusion from clinical trials, has made clinical decision-making somewhat challenging. Treatment decisions in elderly patients with IBD must take into account age-specific concerns such as comorbidities, locomotor and cognitive function, and polypharmacy, to set realistic treatment targets in order to enable personalized treatment and minimize harm. Notwithstanding paucity of clinical data, recent studies have provided valuable insights, which, taken together with information gleaned from previous studies, can broaden our understanding of IBD. These insights may contribute to the development of paradigms for the holistic and, when possible, evidence-based management of this potentially vulnerable population and are the focus of this review. (Intest Res 2018;16:194-208)

Orbital IgG4 Disease: Imaging Findings on 68Ga-DOTANOC PET/CT

Saurabh Arora,Nishikant A. Damle,Rachna Meel,Sanjay Sharma,Seema Sen,Chandrasekar Bal,Kanak Lata,Sneha Prakash,Divya Yadav,Meivel Angamuthu 대한핵의학회 2019 핵의학 분자영상 Vol.53 No.6

Immunoglobulin G4 (IgG4)–related diseases are a spectrum of systemic inflammatory conditions of unknown etiology, which are characterized by infiltration of tissues by IgG4 plasma cells and sclerosing inflammation (Cheuk and Chan Adv Anat Pathol 17:303–32, 2010). Although this condition was initially described in relation to autoimmune pancreatitis, now it has been reported in almost every organ system of body (Zen and Nakanuma Am J Surg Pathol 34:1812–9, 2010, Masaki et al. Ann Rheuma Dis 68:1310–5, 2009). Orbital involvement by IgG4 disease can involve extraocular muscles (EOM), lacrimal glands, conjunctiva, eyelids, infraorbital nerve, orbital fat, and nasolacrimal system (McNab and McKelvie. Ophthal Plast Reconstr Surg 31:167–78, 2015, Katsura et al. Neuroradiology 54:873–82, 2012). The basis of using 68Ga-DOTANOC PET/CT in IgG4 orbital disease is the known expression of somatostatin receptors in chronic inflammatory cells (Cuccurullo et al. Indian J Radiol Imaging 27:509-16, 2017) and also avidity shown previously in other IgG4-related diseases (Cheng et al. Clin Nucl Med 43:773-6, 2018).

Optimum Timing of Laparoscopic Cholecystectomy for Patients of Cholelithiasis with Choledocholithiasis after ERCP: A Randomized Study

Saurabh Galodha,Bhavesh Devakaran 대한외과학회 2021 대한외과학회 학술대회 초록집 Vol.2021 No.11

Experimental Investigations on Spray Characteristics of Potential Fuels for Advance Low Temperature Combustion Engines

( Saurabh Kumar Gupta ),( M. Murugesa Pandian ),( Anand Krishnasamy ) 한국액체미립화학회 2017 한국액체미립화학회 학술강연회 논문집 Vol.2017 No.-

Advanced low temperature combustion (LTC) strategies including Premixed Charge Compression Ignition (PCCI), Reactivity Controlled Compression Ignition (RCCI), Stratified Charge Compression Ignition (SCCI) and High Efficiency Clean Combustion (HECC) are proposed to simultaneously reduce oxides of nitrogen (NOx) and particulate matter (PM) emissions to near zero levels along with higher thermal efficiencies. However, precise control of ignition timings is difficult to achieve in these LTC strategies as it is primarily controlled by the molecular composition of fuel by altering physical and chemical delay period and creating reactivity stratification. Fuel spray characteristics plays a vital role in varying the rate of fuel-air mixing and physical delay period. The potential fuels for advanced LTC modes include fuels with optimal reactivity and better volatility. The effects of physical properties and its impact on spray behavior of potential fuels for LTC are sparsely available. The present work intends to study the effects of changes in properties and injection pressures on the macroscopic spray behavior of potential fuels for advanced LTC engines. The experiments are carried out in a constant volume spray chamber with different potential fuels for advanced combustion engines, viz. Diesel with 10%,20% and 30% gasoline (DG10, DG20 and DG30) and Diesel with 10%,20% and 30% kerosene (DK10, DK20 and DK30). The fuel injection pressures and the injection strategies have been chosen as representative of direct injection diesel engine working conditions. The spray characteristics such as spray tip penetration distance, spray cone angle are obtained by using a high resolution spray visualization system for the different fuel blends. The obtained results show that the changes in physical properties of the fuel blends affect the macroscopic fuel spray behavior. Further, as compared to that of conventional diesel, all the fuel blends show a significant difference in the macroscopic spray characteristics.

Accuracy of computed tomographic features in differentiating intestinal tuberculosis from Crohn`s disease: a systematic review with meta-analysis

( Saurabh Kedia ),( Raju Sharma ),( Vishnubhatla Sreenivas ),( Kumble Seetharama Madhusudhan ),( Vishal Sharma ),( Sawan Bopanna ),( Venigalla Pratap Mouli ),( Rajan Dhingra ),( Dawesh Prakash Yadav ) 대한장연구학회 2017 Intestinal Research Vol.15 No.2

Abdominal computed tomography (CT) can noninvasively image the entire gastrointestinal tract and assess extraintestinal features that are important in differentiating Crohn`s disease (CD) and intestinal tuberculosis (ITB). The present meta-analysis pooled the results of all studies on the role of CT abdomen in differentiating between CD and ITB. We searched PubMed and Embase for all publications in English that analyzed the features differentiating between CD and ITB on abdominal CT. The features included comb sign, necrotic lymph nodes, asymmetric bowel wall thickening, skip lesions, fibrofatty proliferation, mural stratification, ileocaecal area, long segment, and left colonic involvements. Sensitivity, specificity, positive and negative likelihood ratios, and diagnostic odds ratio (DOR) were calculated for all the features. Symmetric receiver operating characteristic curve was plotted for features present in >3 studies. Heterogeneity and publication bias was assessed and sensitivity analysis was performed by excluding studies that compared features on conventional abdominal CT instead of CT enterography (CTE). We included 6 studies (4 CTE, 1 conventional abdominal CT, and 1 CTE+conventional abdominal CT) involving 417 and 195 patients with CD and ITB, respectively. Necrotic lymph nodes had the highest diagnostic accuracy (sensitivity, 23%; specificity, 100%; DOR, 30.2) for ITB diagnosis, and comb sign (sensitivity, 82%; specificity, 81%; DOR, 21.5) followed by skip lesions (sensitivity, 86%; specificity, 74%; DOR, 16.5) had the highest diagnostic accuracy for CD diagnosis. On sensitivity analysis, the diagnostic accuracy of other features excluding asymmetric bowel wall thickening remained similar. Necrotic lymph nodes and comb sign on abdominal CT had the best diagnostic accuracy in differentiating CD and ITB. (Intest Res 2017;15:149-159)

Forgery Detection Scheme Using Enhanced Markov Model and LBP Texture Operator in Low Quality Images

Saurabh Agarwal(아가왈 사우랍),Ki-Hyun Jung(정기현) 한국정보보호학회 2021 정보보호학회논문지 Vol.31 No.6

본 논문에서는 저품질 이미지에 적용된 미디언 필터링를 검출하는 기법을 제안하고자 한다. 이러한 미디언 필터링 검출은 이미지 포렌식 기법에 사용되고 있는 것으로 제안된 방법에서는 원본 이미지와 미디언 필터링된 이미지를 구분하기 위하여 공간 영역에서 통계적 특징 정보를 추출하고 확장시킨다. 확장된 특징 정보는 마르코프 모델을 사용하고 강인한 특징 집합을 생성하기 위하여 다중 방향 배열을 사용한다. 제안된 방법에서는 검출 정확도를 높이기 위하여 텍스처 연산자를 사용하고 SVM 분류기를 통하여 분류 모델을 훈련시킨다. 실험 결과에서는 JPEG 압축을 사용한 저품질 이미지에서 제안한 방법의 우수함을 보인다. Image forensic is performed to check image limpidness. In this paper, a robust scheme is discussed to detect median filtering in low quality images. Detection of median filtering assists in overall image forensic. Improved spatial statistical features are extracted from the image to classify pristine and median filtered images. Image array data is rescaled to enhance the spatial statistical information. Features are extracted using Markov model on enhanced spatial statistics. Multiple difference arrays are considered in different directions for robust feature set. Further, texture operator features are combined to increase the detection accuracy and SVM binary classifier is applied to train the classification model. Experimental results are promising for images of low quality JPEG compression.