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Open Channel Block of Kv3.1 Currents by Fluoxetine
Sung, Min Ji,Ahn, Hye Sook,Hahn, Sang June,Choi, Bok Hee The Japanese Pharmacological Society 2008 Journal of pharmacological sciences Vol.106 No.1
<P>The action of fluoxetine, a serotonin reuptake inhibitor, on the cloned neuronal rat Kv3.1 channels stably expressed in Chinese hamster ovary cells was investigated using the whole-cell patch-clamp technique. Fluoxetine reduced Kv3.1 whole-cell currents in a reversible, concentration-dependent manner, with an IC<SUB>50</SUB> value and a Hill coefficient of 13.4 μM and 1.4, respectively. Fluoxetine accelerated the decay rate of inactivation of Kv3.1 currents without modifying the kinetics of current activation. The inhibition increased steeply between 0 and +30 mV, which corresponded with the voltage range for channel opening. In the voltage range positive to +30 mV, inhibition displayed a weak voltage dependence, consistent with an electrical distance δ of 0.38. The binding (k<SUB>+1</SUB>) and dissociation (k<SUB>−</SUB><SUB>1</SUB>) rate constants for fluoxetine-induced block of Kv3.1 were 5.7 μM<SUP>−</SUP><SUP>1</SUP>s<SUP>−</SUP><SUP>1</SUP> and 53.5 s<SUP>−</SUP><SUP>1</SUP>, respectively. The theoretical K<SUB>D</SUB> value derived by k<SUB>−</SUB><SUB>1</SUB>/k<SUB>+1</SUB> yielded 9.3 μM. Fluoxetine did not affect the ion selectivity of Kv3.1. Fluoxetine slowed the deactivation time course, resulting in a tail crossover phenomenon when the tail currents, recorded in the presence and absence of fluoxetine, were superimposed. Inhibition of Kv3.1 by fluoxetine was use-dependent. The present results suggest that fluoxetine acts on Kv3.1 currents as an open-channel blocker.</P>
Vaccination and Complementary and Alternative Medicine in Patients with Inflammatory Bowel Disease
( Sung Bae Kim ),( Soo Jung Park ),( Sook Hee Chung ),( Kyu Yeon Hahn ),( Do Chang Moon ),( Sung Pil Hong ),( Jae Hee Cheon ),( Tae Il Kim ),( Won Ho Kim ) 대한장연구학회 2014 Intestinal Research Vol.12 No.2
Background/Aims: Vaccinations in patients with inflammatory bowel disease (IBD) are recommended to prevent infectiousdiseases. However, there are few reports of vaccination in IBD patients in Korea. The frequency of complementary and alternativemedicine (CAM) use is high despite its uncertain effectiveness. This study aimed to identify the rates of vaccination anduse of CAM in patients with IBD. Methods: A total of 219 patients attended an education session for IBD patients held at SeveranceHospital on March 23, 2013. We conducted a survey on vaccination and CAM use in IBD patients; 120 patients completedthe questionnaire. Results: The influenza vaccination rate was 44.2% and pneumococcal vaccination rate was 4.2%. Thirtyone(66%) patients were aware of the importance of vaccination. The vaccination rate was higher in patients who were awareof the importance of vaccination compared with that in patients who were unaware of the importance of vaccination (70.1%vs. 41.7%, P =0.004). The rate of CAM use was 30.0%. The most commonly used CAMs were oral products: vitamins (33.3%),red ginseng (25.0%), and probiotics (19.4%). Conclusions: Awareness of the importance of vaccination and actual vaccinationrates were low in IBD patients. Despite insufficient evidence on the effectiveness of CAMs in IBD patients, many patients usedCAMs. We believe that repeated education and promotion of vaccination are important. Further large-scale studies to investigatethe efficacy and safety of CAMs are warranted in patients with IBD. (Intest Res 2014;12:124-130)
Multitracing Capability of Double-Scattering Compton Imager With NaI(Tl) Scintillator Absorber
Hee Seo,Chan Hyeong Kim,Jin Hyung Park,Jong Kyung Kim,Ju Hahn Lee,Chun Sik Lee,Soo Mee Kim,Jae Sung Lee IEEE 2010 IEEE transactions on nuclear science Vol.57 No.3
<P>The Compton camera can provide 3-D images of radioactive material distribution based on a single measurement at a fixed position. The Compton camera also can image several different kinds of radioactive materials simultaneously, by means of the “multitracing” capability. In the present study, this multitracing capability was tested for a double-scattering-type Compton camera, or Double-Scattering Compton Imager (DOCI), which utilizes two double-sided silicon strip detectors (DSSDs) and one NaI(Tl) scintillation detector. Our experimental result shows that the <SUP>137</SUP>Cs and <SUP>60</SUP>Co gamma sources can be clearly distinguished in 2-D and 3-D Compton images, and that there is no significant interference between the two gamma sources. The imaging resolutions were determined to be 6.2 and 4.7 mm FWHM for the <SUP>137</SUP>Cs (662 keV) and <SUP>60</SUP>Co (1332 keV) point sources at 4 cm, respectively. The angular resolutions, determined from the angular resolution measure (ARM) distributions, were 7.3° and 6.5° for the source energies of 662 and 1332 keV, respectively. The DOCI remains under development; its imaging resolution will be further improved with the incorporation of more sophisticated detectors and the related electronics, including a faster scintillation detector (LYSO) and higher-spatial-resolution position-sensitive detectors.</P>
Controls on KSTAR Superconducting Poloidal Field (PF) Magnets
Hahn, Sang-Hee,Kim, K.H.,Choi, J.H.,Ahn, H.S.,Lee, D.K.,Park, K.R.,Eidietis, N.W.,Leuer, J.A.,Walker, M.L.,Yang, H.L.,Kim, W.C.,Oh, Y.K. The Korean Society of Superconductivity and Cryoge 2008 한국초전도저온공학회논문지 Vol.10 No.4
As a part of the plasma control system (PCS) for the first plasma campaign of KSTAR, seven sets of fast feedback control loop for the superconducting poloidal field magnet power supply (PF MPS) have been implemented. A special real-time digital communication interface has been developed for the simultaneous exchanges of the current/voltage data from the 7 sets of 12-thyristor power supplies in a 200 microsecond control cycle. Preliminary power supply tests have been performed before actual cooldown of the device. A $29mH/50m{\Omega}$ solenoid dummy has been fabricated for a series of single power supply tests. Connectivity and response speed of the plasma control system have been verified. By changing hardware cabling, this load was also used to estimate mutual inductance coupling effects of two geometrically adjacent solenoid coils on each power supply. After the cooldown was complete, each pair of the up/down symmetric PF coils has been serially connected and tested as part of the device commissioning process. Bipolar operation and longer pulse attempts have been investigated. The responses of the coils and power supplies corresponding to the plasma magnetic controls in plasma discharges are also analyzed for the future upgrades.
Flexible wireless powered drug delivery system for targeted administration on cerebral cortex
Sung, Sang Hyun,Kim, Young Soo,Joe, Daniel J.,Mun, Beom Ho,You, Byoung Kuk,Keum, Do Hee,Hahn, Sei Kwang,Berggren, Magnus,Kim, Daesoo,Lee, Keon Jae Elsevier 2018 Nano energy Vol.51 No.-
<P><B>Abstract</B></P> <P>The controlled drug delivery devices helps timely drug administrations and maintenance of effective dose to maximize curing effects with minimal side effects. Application of this technology to various body parts has been limited, especially in organs with curved surface, such as the brain and the eye. Herein, we report a flexible drug delivery microdevice (f-DDM) for controlled administration on the curved organ surface. The unique structure of the f-DDM consists of freestanding gold membranes over the multireservoir array was implemented by reversing the typical fabrication order of the reservoir and sealing membrane. We optimized the design of the f-DDM by a finite element analysis to prevent thermal damage during the laser transfer and the applying current density for reliable drug release through an electrochemical analysis. The wireless power transfer system was applied to f-DDM, which shows stable wirelessly powered operation. The f-DDM was flexible enough to be implantable on the curved cerebral cortex and successfully adopted for delivery of two different chemicals or prevention of seizure activity using an anti-epileptic drug. Our study opens a new avenue for the controlled, region-specific, and combinatorial application of drugs, the key factors for precision medicine.</P> <P><B>Highlights</B></P> <P> <UL> <LI> The flexible drug delivery microdevice with controlled release was fabricated by laser-lift off technique. </LI> <LI> The f-DDM was able to operate with wireless power transfer system in near-field range. </LI> <LI> The f-DDM was implanted to the brain of live mice for the localized administration to the cerebral cortex. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Intraventricular Vancomycin Therapy for Intractable Bacillus cereus Ventriculitis
Hahn, Jong Woo,Ju, Hee young,Park, Meerim,Yi, Eun Sang,Park, Byung-Kiu,Shin, Sang-Hoon,Lee, Sang-Hyun,Park, Hyeon Jin,Kang, Ji-Man The Korean Society of Pediatric Infectious Disease 2019 Pediatric Infection and Vaccine Vol.26 No.2
Bacillus cereus causes serious central nervous system infections, especially in immunocompromised patients. Successful treatment requires adequate antimicrobial concentrations in the cerebrospinal fluid; however, in some cases, achieving this with systemic treatment alone is difficult. We treated intractable B. cereus ventriculitis with intraventricular vancomycin, with no major adverse events.