http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Park, Duk-Woo,Kim, Young-Hak,Song, Hae Geun,Ahn, Jung-Min,Kim, Won-Jang,Lee, Jong-Young,Kang, Soo-Jin,Lee, Seung-Whan,Lee, Cheol Whan,Park, Seong-Wook,Yun, Sung-Cheol,Chung, Sung-Ho,Choo, Suk Jung,Chu Ovid Technologies Wolters Kluwer -American Heart A 2012 Circulation. Cardiovascular interventions Vol.5 No.4
Clinical Results of Drug-Coated Balloon Treatment in a Large-Scale Multicenter Korean Registry Study
Sang Yeub Lee,Yun-Kyeong Cho,Sang-Wook Kim,Young-Joon Hong,Bon-Kwon Koo,Jang-Whan Bae,Seung-Hwan Lee,Tae Hyun Yang,Hun Sik Park,Si Wan Choi,Do-Sun Lim,Soo-Joong Kim,Young Hoon Jeong,Hyun-Jong Lee,Kwan 대한심장학회 2022 Korean Circulation Journal Vol.52 No.6
Background and Objectives: The aim of this study was to demonstrate the efficacy and safety of treatment with drug-coated balloon (DCB) in a large real-world population. Methods: Patients treated with DCBs were included in a multicenter observational registry that enrolled patients from 18 hospitals in Korea between January 2009 and December 2017. The primary outcome was target lesion failure (TLF) defined as a composite of cardiovascular death, target vessel myocardial infarction, and clinically indicated target lesion revascularization at 12 months. Results: The study included 2,509 patients with 2,666 DCB-treated coronary artery lesions (1,688 [63.3%] with in-stent restenosis [ISR] lesions vs. 978 [36.7%] with de novo lesions). The mean age with standard deviation was 65.7±11.3 years; 65.7% of the patients were men. At 12 months, the primary outcome, TLF, occurred in 179 (6.7%), 151 (8.9%), 28 (2.9%) patients among the total, ISR, and de novo lesion populations, respectively. A history of hypertension, diabetes, acute coronary syndrome, previous coronary artery bypass graft, reduced left ventricular ejection fraction, B2C lesion and ISR lesion were independent predictors of 12 months TLF in the overall study population. Conclusions: This large multicenter DCB registry study revealed the favorable clinical outcome of DCB treatment in real-world practice in patient with ISR lesion as well as small de novo coronary lesion.
Epidemiological features of Kawasaki disease in Korea, 2006–2008
Park, Yong Won,Han, Ji Whan,Hong, Young Mi,Ma, Jae Sook,Cha, Sung Ho,Kwon, Tae Chan,Lee, Sang Bum,Kim, Chul Ho,Lee, Joon Sung,Kim, Chang Hwi Blackwell Publishing Asia 2011 PEDIATRICS INTERNATIONAL Vol.53 No.1
<P><B>Abstract</B></P><P><B>Background: </B> The aim of this study was to estimate the incidence and describe the epidemiological characteristics of Kawasaki disease among children in Korea.</P><P><B>Methods: </B> Questionnaires for surveying the epidemiology of Kawasaki disease were distributed to a total of 101 hospitals that conduct pediatric residency programs. Then, we retrospectively obtained the data, which covered a three‐year period (2006–2008) and analyzed them.</P><P><B>Results: </B> During the three‐year study period, a total of 9039 cases of Kawasaki disease were reported from 84 hospitals (response rate, 83.2%), comprising 5375 boys and 3664 girls (male : female ratio, 1.47:1). The outbreak rate per 100 000 children <5 years old was 108.7 in 2006, 118.3 in 2007 and 112.5 in 2008 (average rate, 113.1). The seasonal distribution showed a slightly higher incidence rate in winter and summer. The patients’ mean age of onset was 32.6 months, while the proportions of sibling cases and recurrent cases were 0.17% and 2.2%, respectively. Coronary arterial abnormalities were detected during follow up by echocardiogram in 17.5% of all cases including dilatations (16.4%) and aneurysms (2.1%).</P><P><B>Conclusions: </B> The average annual incidence rate of Kawasaki disease in Korea has been continuously increasing, and reached 113.1/100 000 children <5 years old, which is the second highest rate in the world.</P>
Park, Hayng-Mi,Shin, Sang-Hyun,Ko, Jong-Min,Yi, Gi-Hwan,Nam, Min-Hee,Chung, Young-Soo,Chung, Won-Bok,Lee, Jai-Heon,Park, Seong-Whan Korean Society of Life Science 2004 생명과학회지 Vol.14 No.1
이소플라본의 함량이 매우 높은 것으로 알려진 국내 콩품종 신팔달로부터 2개의 유전자 IFS1 (SinIFS1)과 IFS2(SinIFS2)가 클로닝되었다. 유전자의 염기서열을 밝힌 후, 기존에 알려진 콩과의 다른 IFS 유전자들과 유전자 염기서열의 유사성을 비교 분석하였다. 유전자 SinIFS1은 전체 1,828bp의 nucleotide와 521개의 아미노산으로 이루어져 있었고 SinIFS2의 경우, 1912bp의 nucleotide와 521의 아미노산으로 이루어져 있었다. 두 유전자 모두 cytochrome P45O superfamily의 일원이었고, 상응하는 conserve된 motif들을 가지고 있었다. 콩과의 다른 식물에서 클로닝된 IFS들과의 염기서열비교에서는 매우 높은 염기서열 유사성(98% 이상)이 관측되었다. 유전자의 발현과 유발에 관한 노던분석 실험 결과, 무처리구로 사용한 암처리보다 모두 유발된 유전자의 발현을 나타났는데, 특히 곰팡이 elicitor 처리구의 경우, 무처리보다 6배 이상의 유전자 유발을 보였다. 그 다음으로는 자외선 처리가 높은 유전자 발현 유발효과를 나타내었고, 그 다음으로 저온과 명처리순으로 유발효과를 나타내었다. Two genes, SinIFS1 and SinIFS2 from Korean soybean cultivar, Sinpaldalkong known as one of isoflavonerich cultivars, were cloned with PCR and degenerate primers. The sequences of two genes were analyzed with previously reported IFS genes of leguminous plants and their expression pattern in various environmental conditions was surveyed. The genomic clone of SinIFS1 contained 1,828bp nucleotides and encoded a polypeptide of 521 amino acids, and 1912bp nucleotides and a polypeptide of 521 amino acids for SinIFS2. Both genes included several conserved motifs, oxygen binding and activation (A/G-G-X-E/D-T-T/S), ERR triad (E...R....R), and heme binding (F-X-X-G-X-R-X-C-X-G) domain, which are typical in any member of cytochrome P45O superfamily. Very high sequence homology (>98%) was observed in the comparison with other IFSs of legumes. In the northern blot analysis to check the expression and increase of SinIFS1 to various environmental renditions (low temperature, light, dark, UV, and fungal elicitor), the most significant induction, more than 6 times of transcript level compared to the dark treatment as a control, was observed from the fungal elicitor treatment. The next up-regulated expression was from UV treatment (4${\times}$), low temperature and light conditions.
Immunoglobulin Can Be Functionally Regulated by Protein Carboxylmethylation in Fc Region
Park Jong-Sun,Cho Jae-Youl,Kim Sung-Soo,Bae Hyun-Jin,Han Jeung-Whan,Lee Hyang-Woo,Hong Sung-Youl The Pharmaceutical Society of Korea 2006 Archives of Pharmacal Research Vol.29 No.5
Protein carboxylmethylation methylates the free carboxyl groups in various substrate proteins by protein carboxyl O-methyltransferase (PCMT) and is one of the post-translational modifications. There have been many studies on protein carboxylmethylation. However, the precise functional role in mammalian systems is unclear. In this study, immunoglobulin, a specific form of $\gamma-globulin$, which is a well-known substrate for PCMT, was chosen to investigate the regulatory roles of protein carboxylmethylation in the immune system. It was found that the anti-BSA antibody could be carboxylmethylated via spleen PCMT to a level similar to $\gamma-globulin$. This carboxylmethylation increased the hydrophobicity of the anti-BSA antibody up to 11.4%, and enhanced the antigen-binding activity of this antibody up to 24.6%. In particular, the Fc region showed a higher methyl accepting capacity with 80% of the whole structure level. According to the amino acid sequence alignment, indeed, 7 aspartic acids and 5 glutamic acids, as potential carboxylmethylation sites, were found to be conserved in the Fc portion in the human, mouse and rabbit. The carboxylmethylation of the anti-BSA antibody was reversibly demethylated under a higher pH and long incubation time. Therefore, these results suggest that protein carboxylmethylation may reversibly regulate the antibody-mediated immunological events via the Fc region.