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Kim, Sung-Eun,Jang, Eun Sun,Ki, Moran,Gwak, Geum-Youn,Kim, Kyung-Ah,Kim, Gi-Ae,Kim, Do Young,Kim, Dong Joon,Kim, Man Woo,Kim, Yun Soo,Kim, Young Seok,Kim, In Hee,Kim, Chang Wook,Kim, Ho Dong,Kim, Hyun The Korean Academy of Medical Sciences 2018 JOURNAL OF KOREAN MEDICAL SCIENCE Vol.33 No.42
<P><B>Background</B></P><P>Hepatitis B virus (HBV) infection leads to hepatic and extrahepatic manifestations including chronic kidney disease (CKD). However, the association between HBV and CKD is not clear. This study investigated the association between chronic HBV infection and CKD in a nationwide multicenter study.</P><P><B>Methods</B></P><P>A total of 265,086 subjects who underwent health-check examinations in 33 hospitals from January 2015 to December 2015 were enrolled. HBV surface antigen (HBsAg) positive cases (n = 10,048), and age- and gender-matched HBsAg negative controls (n = 40,192) were identified. CKD was defined as a glomerular filtration rate (GFR) < 60 mL/min/1.73 m<SUP>2</SUP> or proteinuria as at least grade 2+ of urine protein.</P><P><B>Results</B></P><P>HBsAg positive cases showed a significantly higher prevalence of GFR < 60 mL/min/1.73 m<SUP>2</SUP> (3.3%), and proteinuria (18.9%) than that of the controls (2.6%, <I>P</I> < 0.001, and 14.1%, <I>P</I> < 0.001, respectively). In the multivariate analysis, HBsAg positivity was an independent factor associated with GFR < 60 mL/min/1.73 m<SUP>2</SUP> along with age, blood levels of albumin, bilirubin, anemia, and hemoglobin A1c (HbA1c). Likewise, HBsAg positivity was an independent factor for proteinuria along with age, male, blood levels of bilirubin, protein, albumin, and HbA1c. A subgroup analysis showed that HBsAg positive men but not women had a significantly increased risk for GFR < 60 mL/min/1.73 m<SUP>2</SUP>.</P><P><B>Conclusion</B></P><P>Chronic HBV infection was significantly associated with a GFR < 60 mL/min/1.73 m<SUP>2</SUP> and proteinuria (≥ 2+). Therefore, clinical concern about CKD in chronic HBV infected patients, especially in male, is warranted.</P>
( Sung Eun Kim ),( Eun Sun Jang ),( Moran Ki ),( Geum-Youn Gwak ),( Kyung-Ah Kim ),( Gi-Ae Kim ),( Do Young Kim ),( Dong Joon Kim ),( Man Woo Kim ),( Yun Soo Kim ),( Young Seok Kim ),( In Hee Kim ),( 대한간학회 2017 춘·추계 학술대회 (KASL) Vol.2017 No.1
Aims: Hepatitis C virus (HCV) entry and replication is associated with interruption of lipid metabolism. We aimed to investigate the association between anti-HCV positivity and serum lipid profiles in a nationwide, multicenter study. Methods: A total of 268,422 subjects who underwent health-check examination in nationwide 33 hospitals from Jan 2015 to Dec 2015 were enrolled. Data on the anti-HCV positivity, and biochemical laboratory results including serum levels of total cholesterol, triglyceride, LDL-cholesterol, and HDL-cholesterol were obtained and analyzed. Among the subjects, 1,360 anti-HCV antibody positive cases (0.6%), and 5,440 anti-HCV negative controls matched for age and sex to the cases were identified in same dataset. Results: Though body mass index (BMI) was not different between case and control group, the mean serum levels of total cholesterol (185 mg/dL), triglyceride (111.8 mg/dL), LDL cholesterol (117.4 mg/dL), and HDL cholesterol (54.5 mg/dL) were all significantly lower in anti-HCV positive group than in controls (192.5, 119.1, 125.1, and 55.8 mg/dL, respectively). By multivariable analyses using logistic regression, the independent factors associated with elevated serum total cholesterol (≥200 mg/dL) were age, male sex, anti-HCV positivity or HCV-RNA positivity. In addition, the independent factors associated with elevated serum triglyceride(≥150 mg/dL) were age, male sex, BMI (≥25kg/m2) HbA1C (≥5.5%), ALT (≥40IU/L), anti-HCV positivity or HCV-RNA positivity. Moreover, the independent factors associated with elevated LDL-cholesterol (≥130 mg/dL) were age, male sex, and anti-HCV positivity or HCV-RNA positivity. Conclusions: In this large population-based data, HCV infection independently associated with lower serum total cholesterol level, lower triglyceride level and lower LDL cholesterol level.
( Sung Eun Kim ),( Eun Sun Jang ),( Moran Ki ),( Geum-youn Gwak ),( Kyung-ah Kim ),( Gi-ae Kim ),( Do Young Kim ),( Dong Joon Kim ),( Man Woo Kim ),( Yun Soo Kim ),( Young Seok Kim ),( In Hee Kim ),( 대한간학회 2017 춘·추계 학술대회 (KASL) Vol.2017 No.1
Aims: Hepatitis B virus (HBV) infection leads to hepatic and extrahepatic manifestations including chronic kidney disease (CKD). However, the association between HBV and CKD is not clear. This study aimed to investigate the association between CKD and HBV infection in a population-based, nationwide multicenter study. Methods: A total of 268,422 subjects who underwent health-check examination in nationwide 33 hospitals from Jan 2015 to Dec 2015, were enrolled. We identified 10,473 adults who had chronic HBV infection by hepatitis B surface antigen (HBsAg) positivity (cases), and 41,892 age-and sex-matched HBsAg negative people (controls) in the same dataset. CKD is defined as GFR<60ml/min/1.73<sup>2</sup> (GFR categories G3a-G5), according to KDIGO 2010 clinical practice guideline. Proteinuria was defined as the presence of urine protein of at least grade 2+. Results: HBsAg positive cases showed significantly higher frequency of CKD (3.3%) than in controls (2.7%) (P=0.006). Also, the prevalence of proteinuria in HBV cases (18.4%) was significantly higher than in controls (13.9%) (P<0.001). Multivariable logistic regression analysis for associated factors of CKD revealed that age, serum protein, serum albumin, hemoglobin, hemoglobinA1c and HBsAg positivity were independent predictors (P<0.05). Also, age, sex, HBsAg positivity, serum protein, hemoglobin, hemoglobinA1c and platelet were independent predictors of the proteinuria (P <0.05). Conclusions: HBV infection was significantly associated with GFR<60 ml/min/1.73<sup>2</sup> and proteinuria (≥2+). Therefore, in the era of effective antiviral therapy, clinical concern on the extrahepatic manifestations including kidney disease is warranted.
Kim, Jong Woo,Kang, Won Sub,Lee, Sang Min,Kim, Su Kang,Park, Hae Jeong,Gwak, Geum-Hee,Baik, Hyung Hwan 대한독성유전단백체학회 2012 Molecular & cellular toxicology Vol.8 No.3
Extracellular matrix (ECM) abnormality is implicated in the pathogenesis of schizophrenia. Matrix metalloproteinases (MMPs) mediate the proteolysis of ECM and may play a crucial role in neuronal plasticity. We investigated whether single nucleotide polymorphisms (SNPs) of MMP1 and MMP8 are associated with the development of schizophrenia. We also assessed the relationships between MMP1, MMP8 SNPs and the core symptoms of schizophrenia such as persecutory delusion, auditory hallucinations, affective disturbances, and poor concentration according to the Operation Criteria Checklist for Psychotic Illness (OPCRIT). Three coding SNPs (rs470558, Ala216Ala in MMP1; rs3740938, Leu291Leu and rs1940475, Lys87Glu in MMP8) were selected, and 263 patients and 283 controls were evaluated. SNPStats was used to obtain the odds ratio (OR), 95% confidence intervals (CI), and P value adjusted for age and gender as covariables. Multiple logistic regression models (codominant1, codominant2, dominant, recessive, and log-additive) were employed to analyze genetic data. As a result, the three examined SNPs were not associated with the development of schizophrenia. In the analysis of clinical symptoms, the genotype frequency of rs470558 in MMP1 was associated with auditory hallucinations (P=0.04 in the codominant1 model, P=0.014 in the dominant1 model, and P=0.0066 in the log-additive model). The allele frequency of rs470558 also showed a significant difference between schizophrenia without auditory hallucinations [the auditory hallucination (-) group] and schizophrenia with auditory hallucinations [the auditory hallucination (+) group] (P=0.009, OR=1.94, 95% CI=1.19-3.28). The A allele frequency of rs470558 was higher in the auditory hallucination (+) group (19.2%) than that in the auditory hallucination (-) group (10.8%). Two MMP8 SNPs (rs3740938 and rs1940475) were not associated with the development and core symptoms of schizophrenia, respectively. These results suggest that the A allele of rs470558 (Ala216Ala) in MMP1 may contribute to the susceptibility to auditory hallucinations of schizophrenia.
( Geum-youn Gwak ),( Young-suk Lim ),( Kwan Soo Byun ),( Yoon Jun Kim ),( Byung Chul Yoo ),( So Young Kwon ),( Jonggi Choi ),( Jihyun An ),( Han Chu Lee ),( Yung Sang Lee ) 대한간학회 2017 춘·추계 학술대회 (KASL) Vol.2017 No.1
Aims: Tenofovir disoproxil fumarate (TDF) monotherapy for 48 weeks displayed non-inferior efficacy to TDF plus entecavir (ETV) combination therapy in hepatitis B virus (HBV) patients resistant to ETV and lamivudine (LAM). However, whether prolonged TDF monotherapy would be safe and increase the virologic response rate in these patients is unclear. Methods: Among 90 patients with HBV resistant to ETV and LAM who were randomized to receive TDF monotherapy (n=45) or TDF/ETV combination therapy (n=45) for 48 weeks, 89 agreed to continue the study on TDF monotherapy, and 84 (93.3%) completed 144 weeks. Results: At baseline, all patients had various HBV mutations resistant to ETV and LAM (rtT184A/C/F/G/I/L/S, rtS202G, and rtM250L/V, in addition to rtM204V/I). By intention-to-treat analysis, 71.1% in the TDF-TDF group and 73.3% in the TDF/ETV-TDF group had serum HBV DNA <15 IU/mL at week 48 (P=0.81). At week 144, the proportion increased to 82.2% and 88.9%, respectively (P=0.37). By on-treatment analysis, 95.1% and 93.0%, respectively, had HBV DNA < 60 IU/mL at week 144 (P=0.68). Virologic breakthrough occurred in 2 patients in TDF-TDF group at week 48 and 120 due to poor drug adherence. At week 144, 5 patients who had HBV DNA >60 IU/mL qualified for HBV genotypic resistance tests, and 2 patients retained some of their baseline resistance mutations. No patients developed additional resistance mutations throughout the study period. Treatment was generally well tolerated. The mean change in estimated GFR from baseline was not significant at week 144 (2.07 mL/min/1.73 m2, P=0.18). The mean change in bone mineral density from baseline at week 144 was 0.32% at spine (P=0.59) and -0.92% at femur (P=0.02). Conclusions: TDF monotherapy was safe and efficacious in patients with ETV-resistant HBV for up to 144 weeks.
Kim, Jung Mo,Moon, Sung-Hwan,Lee, Sung Geum,Cho, Youn Jeong,Hong, Ki Sung,Lee, Jae Ho,Lee, Hey Jin,Chung, Hyung-Min Mary Ann Liebert, Inc 2011 STEM CELLS AND DEVELOPMENT Vol.20 No.11
<P>In general, the formation of embryoid bodies (EBs) is a commonly known method for initial induction of human embryonic stem cells (hESCs) into their derivatives in vitro. Despite the ability of EBs to mimic developmental processing, the specification and classifications of EBs are not yet well known. Because EBs show various differentiation potentials depending on the size and morphology of the aggregated cells, specification is difficult to attain. Here, we sought to classify the differentiation potentials of EBs by morphologies to enable one to control the differentiation of specific lineages from hESCs with high efficiency. To induce the differentiation of EB formation, we established floating cultures of undifferentiated hESCs in Petri dishes with hESC medium lacking basic fibroblast growth factor. Cells first aggregated into balls; 10 days after suspension culture, some different types of EB morphology were present, which we classified as cystic-, bright cavity-, and dark cavity-type EBs. Next, we analyzed the characteristics of each type of EB for its capacity to differentiate into the 3 germ layers via multiplex polymerase chain reaction (PCR), real-time PCR, and immunocytochemistry. Our results indicated that most cells within the cystic EBs were composed of endoderm lineage populations, and both of the cavity EB types were well organized with 3 germ-layer cells. However, the differentiation capacity of the bright cavity EBs was faster than that of the dark cavity EBs. Thus, the bright cavity EBs in this study, which showed equal differentiation tendencies compared with other types of EBs, may serve as the standard for in vitro engineering of EBs. These results indicate that the classification of EB morphologies allows the estimation of the differentiation status of the EBs and may allow the delineation of subsets of conditions necessary for EBs to differentiate into specific cell types.</P>
Geum Su Cheon(천금수),Chae Hoon Paik(백채훈),Sang Soo Kim(김상수) 한국농약과학회 2008 농약과학회지 Vol.12 No.3
The comparative toxicity of recommended rates of three acaricides, fluacrypyrim, cyflumetofen and spiromesifen to the predatory mite, Neoseiulus womersleyi and its prey, Tetranychus urticae was bioassayed in the laboratory. Fluacrypyrim and cyflumetofen were much less toxic to adult females of N. womersleyi than to those of T. urticae. Adult female predators treated with these two acaricides produced 88~93% as many eggs as did control females. Fluacrypyrim and cytlumetofen did not affect the hatch of N. womersleyi eggs or the development of surviving immature predators, and 92~96% of immature predators reached adulthood. Spiromesifen at its treated concentration did not significantly affect the survival and reproduction of adult female predators but caused 100% mortality in larvae of N. womersleyi. Adult female predators survived on a diet of spider mites treated with tluacrypyrim and cytlumetofen, and their fecundity was not significantly affected. Moreover, immature predators developed normally on prey treated with these two acaricides. The results indicate that fluacrypyrim and cyflumetofen are promising candidates for use in integrated mite management programs where N. womersleyi is the major natural enemy.