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STABLE MINIMAL HYPERSURFACES WITH WEIGHTED POINCARÉ INEQUALITY IN A RIEMANNIAN MANIFOLD
Nguyen, Dinh Sang,Nguyen, Thi Thanh Korean Mathematical Society 2014 대한수학회논문집 Vol.29 No.1
In this note, we investigate stable minimal hypersurfaces with weighted Poincar$\acute{e}$ inequality. We show that we still get the vanishing property without assuming that the hypersurfaces is non-totally geodesic. This generalizes a result in [2].
Mitochondria-associated programmed cell death as a therapeutic target for age-related disease
Nguyen Thanh T.,Wei Shibo,Nguyen Thu Ha,Jo Yunju,Zhang Yan,Park Wonyoung,Gariani Karim,Oh Chang-Myung,Kim Hyeon Ho,Ha Ki-Tae,Park Kyu-Sang,Park Raekil,Lee In-Kyu,Shong Minho,Houtkooper Riekelt H.,Ryu 생화학분자생물학회 2023 Experimental and molecular medicine Vol.55 No.-
Mitochondria, ubiquitous double-membrane-bound organelles, regulate energy production, support cellular activities, harbor metabolic pathways, and, paradoxically, mediate cell fate. Evidence has shown mitochondria as points of convergence for diverse cell death-inducing pathways that trigger the various mechanisms underlying apoptotic and nonapoptotic programmed cell death. Thus, dysfunctional cellular pathways eventually lead or contribute to various age-related diseases, such as neurodegenerative, cardiovascular and metabolic diseases. Thus, mitochondrion-associated programmed cell death-based treatments show great therapeutic potential, providing novel insights in clinical trials. This review discusses mitochondrial quality control networks with activity triggered by stimuli and that maintain cellular homeostasis via mitohormesis, the mitochondrial unfolded protein response, and mitophagy. The review also presents details on various forms of mitochondria-associated programmed cell death, including apoptosis, necroptosis, ferroptosis, pyroptosis, parthanatos, and paraptosis, and highlights their involvement in age-related disease pathogenesis, collectively suggesting therapeutic directions for further research.
Anti-inflammatory Asterosaponins from the Starfish <i>Astropecten monacanthus</i>
Thao, Nguyen Phuong,Cuong, Nguyen Xuan,Luyen, Bui Thi Thuy,Thanh, Nguyen Van,Nhiem, Nguyen Xuan,Koh, Young-Sang,Ly, Bui Minh,Nam, Nguyen Hoai,Kiem, Phan Van,Minh, Chau Van,Kim, Young Ho American Chemical Society and American Society of 2013 Journal of natural products Vol.76 No.9
<P>Four new asterosaponins, astrosteriosides A–D (<B>1</B>–<B>3</B> and <B>5</B>), and two known compounds, psilasteroside (<B>4</B>) and marthasteroside B (<B>6</B>), were isolated from the MeOH extract of the edible Vietnamese starfish <I>Astropecten monacanthus</I>. Their structures were elucidated by chemical and spectroscopic methods including FTICRMS and 1D and 2D NMR experiments. The effects of the extracts and isolated compounds on pro-inflammatory cytokines were evaluated by measuring the production of IL-12 p40, IL-6, and TNF-α in LPS-stimulated bone marrow-derived dendritic cells. Compounds <B>1</B>, <B>5</B>, and <B>6</B> exhibited potent anti-inflammatory activity comparable to that of the positive control. Further studies are required to confirm efficacy <I>in vivo</I> and the mechanism of effects. Such potent anti-inflammatory activities render compounds <B>1</B>, <B>5</B>, and <B>6</B> important materials for further applications including complementary inflammation remedies and/or functional foods and nutraceuticals.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jnprdf/2013/jnprdf.2013.76.issue-9/np400492a/production/images/medium/np-2013-00492a_0005.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/np400492a'>ACS Electronic Supporting Info</A></P>
Anti-inflammatory tirucallane saponins from Paramignya scandens.
Phan, Nguyen Huu Toan,Thuan, Nguyen Thi Dieu,Ngoc, Ninh Thi,Thao, Nguyen Phuong,Kim, Sohyun,Koh, Young Sang,Thanh, Nguyen Van,Cuong, Nguyen Xuan,Nam, Nguyen Hoai,Kiem, Phan Van,Kim, Young Ho,Minh, Cha Pharmaceutical Society of Japan 2015 Chemical & pharmaceutical bulletin Vol.63 No.7
<P>Five new tirucallane saponins, paramignyosides A-E (1-5), were isolated from the water fraction of the Paramignya scandens stem and leaves. Their structures were elucidated on the basis of spectroscopic evidence including high-resolution electrospray ionization mass spectrometry (HR-ESI-MS) and one dimensional (1D)- and 2D-NMR. The effects of isolated compounds on pro-inflammatory cytokines were evaluated by measuring the production of interleukin (IL)-12 p40, IL-6, and tumor necrosis factor-α (TNF-α) in lipopolysaccharide (LPS)-stimulated bone marrow-derived dendritic cells (BMDCs). Paramignyoside C (3) exhibited selective and potent inhibitory effect (IC50=5.030.19??M) on the production of IL-12 p40 comparable to that of the positive control, SB203580 (IC50=5.000.16??M). Further studies are required to confirm efficacy in vivo and the mechanism of anti-inflammatory effects.</P>
Minh Sang VO,Ngoc Phu TRAN,Thi Kieu Thu NGUYEN,Thi Cam Tien HUYNH,Thi Kim Loi NGUYEN,Le Phuong Nghi THACH,Gia Nhu THAI,Thi Thanh Sang TRAN 한국유통과학회 2022 The Journal of Asian Finance, Economics and Busine Vol.9 No.4
This study intends to analyze the impact of the country of origin on the intention to ingest COVID-19 vaccinations by measuring Vietnamese people’s perceptions of India in the manufacture of COVID-19 vaccines. The research is done using a quantitative method, and primary data was obtained using a conventional manner based on the willingness of the research respondents, who are Vietnamese persons aged 18 and up, to contribute information. The findings revealed that perceived brand association and perceived brand quality directly positively impact the COVID-19 vaccine’s consumption intention and willingness. Meanwhile, while the perceived country image component has no direct effect on consumption intention, it does have a positive indirect effect on consumption intention through perceived brand linkage and perceived brand quality. The findings also emphasize the importance and significance of a country’s image in brand association and quality perception. The study’s findings imply that to increase consumers’ willingness to buy India’s COVID-19 vaccination, the country should develop communication initiatives to improve consumer perceptions of the country’s image, the perceived value of the brand association, and brand quality.
Ly, Nguyen Hoang,Nguyen, Thanh Danh,Bui, Thanh Lam,Lee, Sangyeop,Choo, Jaebum,Joo, Sang-Woo Elsevier 2017 Colloids and surfaces. A, Physicochemical and engi Vol.518 No.-
<P><B>Abstract</B></P> <P>We compared the adsorption and desorption of 1-pyrenecarboxylic acid (PyC), 1-pyreneacetic acid (PyA), and 1-pyrenebutyric acid (PyB) on silver nanoparticles (AgNPs) via interfacial spectroscopic tools to study the role of the aliphatic units between pyrene and carboxylic group. The negative surface charges of AgNPs at ca. −51mV shifted up to −11mV, after adsorbing hydrophobic pyrene compounds. The three pyrene acid compounds appeared to adsorb onto AgNPs via their carboxylate units by referring to the observation of the broad <I>ν</I>(COO<SUP>−</SUP>) bands at 1380–1410cm<SUP>−1</SUP> in the Raman spectra. X-ray photoelectron spectroscopy (XPS) also supported the CO species in the C<SUB>1s</SUB> region. AgNPs were found to efficiently quench the fluorescence of the three pyrene acid adsorbates. The highest Stern–Volmer constant of PyA may be due to the largest overlap integral with the surface Plasmon absorption band of AgNPs. The butyric unit was expected to lead a stronger binding on Ag, as suggested by density functional theory (DFT) calculations. The adsorbed pyrene acid compounds appeared to be released from AgNPs by thiol-containing glutathione (GSH). PyB with the butyric group exhibited larger quenched fluorescence intensities and smaller released amounts than PyC and PyA in aqueous solutions and A549 cancer cells. Our study will be helpful in designing pyrene-based fluorescence sensors in cellular imaging.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Hydrophobic pyrene acids were chemically interacted with Ag nanoparticles. </LI> <LI> 1-Pyrene acids were found to adsorb on silver via the COO<SUP>−</SUP> bonds. </LI> <LI> Fluorescence quenching behaviors of pyrene acids were compared on Ag. </LI> <LI> Glutathione-triggered desorption of pyrene acids were observed in cancer cells. </LI> <LI> 1-Pyrenebutyrate showed stronger binding than 1-pyrenecarboxlyate on Ag. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>