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Antioxidant Flavonoids from the Twigs of Stewartia koreana
Lee, Sa-Im,Yang, Jae-Heon,Kim, Dae-Keun The Korean Society of Applied Pharmacology 2010 Biomolecules & Therapeutics(구 응용약물학회지) Vol.22 No.4
In the course of screening for antioxidant compounds by measuring the radical scavenging effect on 1,1-diphenyl- 2-picrylhydrazyl (DPPH), a total extract of the twigs of Stewartia koreana (Theaceae) was found to show potent antioxidant activity. Subsequent activity-guided fractionation of the methanolic extract led to the isolation of six phenolic compounds, ampelopsin (1), catechin (2), proanthocyanidin-A2 (3), fraxin (4), (2R, 3R)-taxifolin-3-${\beta}$-D-glucopyranoside (5), and (2S, 3S)-taxifolin-3-${\beta}$-D-glucopyranoside (6), as active principles. Their structures were elucidated by spectroscopic studies. Compounds 1-6 were isolated for the first time from this plant. Among them, three compounds 1-3 showed the significant antioxidative effects on DPPH, and riboflavin originated superoxide quenching activity. In riboflavin-nitrobluetetrazolium (NBT)-light system, compound 1 showed better superoxide quenching activity than vitamin C.
이종문,전임기,민광식,심두생 한국어병학회 1990 한국어병학회지 Vol.3 No.1
1. 1990年 4月 7日부터 1990年 5月 8日까지 對照區와 海上가두리 施設別로 養殖넙치의 血淸化學指數 및 電解質指數를 測定하였다. 2. 對照區의 血淸化學指數는 總蛋白 5.74±0.83g/㎗, 알부민 0.94±0.22g/㎗ 및 血糖 62±29㎎/㎗를 나타내었으며, 電解質의 境遇, 포타슘이 2.5±1.1mmol/ℓ, 소디움이 169±17mmol/ℓ, 칼슘이 5.0±1.7㎎/ℓ이었다. 3. 試驗區別 血淸化學指數에 있어서 對照區와 比較하여 總蛋白의 경우 네트론의 試驗區만이 移送後 27日만에 對照區의 數値와 거의 같은 5.72±1.11g/㎗을 나타내었으며 調査期間 中 다른 試驗區에 比해 安定된 狀態를 維持하였다. 그 다음으로 安定된 狀態를 보인 PVC 試驗區는 27日만에 5.34±0.81g/㎗ 漸次對照區의 水準으로 回復하는 趨勢를 보였다. 알부민의 경우 가장 變動이 적고 安定된 狀態를 維持한 PVC 試驗區의 경우 移送 後 27日 만에 對照區 水準과 거의 같은 1.00±0.18g/㎗을 나타내었고 血糖의 경우는 移送 後에는 全 試驗區가 對照區와 比較하여 2倍 가량 增加하였으며 對照區의 水準으로 回復한 試驗區는 PVC 試驗區와 네트론 試驗區였다. 그러나 네트론의 試驗區는 그 後에 49±15㎎/㎗로 低下하였다가 다시 對照區 水準을 回復하였으나 PVC 試驗區는 큰 變動이 없이 安定된 狀態를 維持하였다. 4. 試驗區別 電解質指數에 있어서 對照區와 比較하여 포타슘의 경우 移送 直後부터 9日째까지는 全 試驗區가 3倍 以上 增加하였으며 그 後에는 低下되었으나 PVC 試驗區와 네트론支柱 試驗區를 除外하고는 低下의 幅이 너무 컸다. 調査期間 중 가장 變動의 幅이 적은 試驗區는 PVC 試驗區였다. 소디움의 경우는 移送後 9日째에는 對照區의 水準을 回復하는 試驗區들과 큰 幅으로 低下하는 試驗區로 大別되었다. 그리고 移送後 16日째는 全般的으로 上昇하였으나 變動이 적은 PVC 試驗區는 調査期間 中 169±17 - 178±10mmol/ℓ이고 그 다음 變動이 적은 PVC支柱 試驗區는 173±10 - 179±9mmol/ℓ를 나타내었다. 5. 海上가두리의 各 施設別 血淸化學 指數 및 電解質指數의 分析結果를 綜合한 結果 指數의 變動이 安定된 試驗區는 PVC 試驗區, 네트론, PVC支柱試驗區順이었으며 그외 試驗區들은 變動의 幅이 컸었다. Chemical constituents in blood serum and electrolytes were mearsured to the cultured flounder. Paralichthys olivaceus classified by control group and establishments of mari-netcages from April 7, 1990 to May 8, 1990. The total protein, albumin and glucose were 5.74 ±0.83g/㎗, 0.94 ± 0.22g/㎗ and 62 ±29㎎/㎗, respectively in the blood serum constituents of control group. The potassium, sodium and calcium were 2.5±1.1 mmol/ℓ, 169±17 mmol/ℓ and 5.0±1.7 ㎎/ℓ, respectively in the electrolytes of control group. In the variation of chemical constituents and electrolytes in blood serum, glucose of PVC group was alone represented 66±19 ㎎/㎗ as control level on the 9th after locomotion to mari-floating netcages, and was stable within period of experiment in comparision with the other group. Subsequently stable netron group was decreased 49±15 ㎎/㎗ on the 12th. Total protein of netron group was alone represented 5.72±1.11 g/㎗ as control level on the 27th. Albumin of PVC group was stable, and was retruned 1.00±0.18 g/㎗ as control level on the 27th. Potassium of PVC and netron group were stable within priod of experiment. Sodium of PVC, pole-PVC group were stable, and were 169±17∼178±10 mmol/ℓ, 173±10 ∼ 179±9 mmol/ℓ respectively in blood serum with in priod of experiment. According to the combined results of chemical constituents in blood serum and electrolytes classified by establishment of mari-floating netcages, the experiment group that were stabilized variation were in order of PVC, netron and pole-PVC group. But the other groups were extended the range of variation.
( Sa Ik Hong ),( Seung Hwan Kwon ),( Min Jung Kim ),( Shi Xun Ma ),( Je Won Kwon ),( Seung Min Choi ),( Soo Im Choi ),( Sun Yeou Kim ),( Seok Yong Lee ),( Choon Gon Jang ) 한국응용약물학회 2012 Biomolecules & Therapeutics(구 응용약물학회지) Vol.20 No.4
Chrysanthemum indicum Linne is an ancient herbal medicine used to treat bone and muscle deterioration, ocular infl ammation, headache, and anxiety in Korea, China, and Japan. Furthermore, tea derived from Chrysanthemum indicum Linne has been used to treat anxiety by facilitating relaxation and curing insomnia. However, no reports exist on the anxiolytic-like effects of Chrysanthemum indicum Linne water extract (CWE) in mice. In the present study, we investigated the anxiolytic-like effects of CWE using the elevated plus-maze (EPM) test in mice. CWE, at a dose of 500 mg/kg (p.o.), signifi cantly increased the time spent in the open arms of the EPM compared to a vehicle-injected control group. Moreover, the effect of CWE (500 mg/kg) was blocked by bicuculline (a selective GABAA receptor antagonist) and WAY 100635 (a selective 5-HT1A receptor antagonist). Taken together, these fi ndings suggest that the anxiolytic-like effects of CWE might be mediated by the GABAA receptor and the 5-HT1A receptor.
Chami Im,Young Suk Park,Sa-Hong Min,So Hyun Kang,Eunju Lee,Mira Yoo,Duyeong Hwang,Sang-Hoon Ahn,Yun Suhk Suh,Sangjun Lee,Do Joong Park,Hyung-Ho Kim 대한외과학회 2023 Annals of Surgical Treatment and Research(ASRT) Vol.104 No.2
Purpose: The use of antiplatelet and/or anticoagulant therapies has become common. In rare cases, these therapies may increase the risk of dangerous postoperative bleeding. We investigated the association of antiplatelets and/or anticoagulants with postoperative major bleeding risk in laparoscopic gastric cancer surgery. Methods: We retrospectively enrolled 3,663 gastric cancer patients (antiplatelet/anticoagulant group, 518; control group, 3,145) who had undergone laparoscopic surgery between January 2012 and December 2017. To minimize selection bias, 508 patients in each group were matched using propensity score matching (PSM) method. The primary outcome was postoperative major bleeding. Secondary outcomes were intraoperative, postoperative transfusion and early complications. Results: After PSM, postoperative major bleeding occurred in 10 (2.0%) and 3 cases (0.6%) in the antiplatelets/ anticoagulants and control groups, respectively (P = 0.090). Intraoperative and postoperative transfusions were not significantly different between 2 groups (2.4% vs. 1.4%, P = 0.355 and 5.5% vs. 4.3%, P = 0.469). Early complications developed in 58 (11.4%) and 43 patients (8.5%) in the antiplatelets/anticoagulants and control groups, respectively (P = 0.142). The mean amounts of intraoperative and postoperative transfusions were not significantly different between the groups (366.67 ± 238.68 mL vs. 371.43 ± 138.01 mL, P = 0.962; 728.57 ± 642.25 mL vs. 508.09 ± 468.95 mL, P = 0.185). In multivariable analysis, male (P = 0.008) and advanced stage (III, IV) (P = 0.024) were independent significant risk factors for postoperative major bleeding. Conclusion: Preoperative antiplatelets and/or anticoagulants administration did not significantly increase the risk of postoperative major bleeding after laparoscopic gastric cancer surgery.