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I.S.R.Punitha1,,Nalini Bhat3,,K.Rajendran1,,Arun Shirwaikar2,,Annie Shirwaikar1 한국생약학회 2005 Natural Product Sciences Vol.11 No.3
The aqueous extract of Coscinium fenestratum was studied for its antioxidant status in STZ-nicotinamide induced type 2 diabetic rats at two dose levels of 250 mg/kg and 500 mg/kg. At the end of theexperimental period, diabetic rats treated with aqueous extract at both dose levels showed a significant increase insuperoxide dismutase and catalase as compared to the untreated control. Similarly, a significant increase was alsoobserved in the levels of the non enzymatic antioxidants ceruloplasmin, ascorbic acid and tocopherol. The resultssuggest that the aqueous stem extract of C. fenestratum prevents type 2 diabetes mellitus induced oxidative stress.
Rajendran, Senthilnathan,Muthupalani, Rajendran Shanmugam,Ramanathan, Arvind Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.2
Background: In normal cells, activated epidermal growth factor receptor (EGFR) molecules are subjected to ubiquitination-mediated proteasome degradation pathway by c-Cbl, an ubiquitin ligase that checks uncontrolled proliferation. Hence expression of wild type c-Cbl molecule is essential to keep this degradation machinery in a functional state. Loss of expression or function of c-Cbl may consequently lead to sustained activation of EGFR and promote carcinogenesis, loss of function mutations in the c-Cbl gene already being reported in lung and hematopoietic cancers. However, the genetic status of c-Cbl in oral squamous cell carcinoma (OSCC) is not known. Hence in the present study we investigated the genomic DNA isolated from OSCC tissue biopsy samples for mutations in the RING finger domain coding region of c-Cbl gene, which has also been reported to be most frequently mutated in other cancers. Materials and Methods: Total genomic DNA isolated from thirty two post surgical OSCC tissue samples were amplified using primers flanking the exon 8 of c-Cbl gene that codes for the RING finger domain. The PCR amplicons were then resolved in a 1.2% agarose gel, purified and subjected to direct sequencing to screen for mutations. Results: The sequencing data of the thirty two OSCC samples did not identify mutations in the RING finger domain coding region of c-Cbl gene. Conclusions: To the best of our knowledge, this is the first time that the genetic status of c-Cbl gene in OSCC samples has been investigated. The present data indicates that genetic alteration of RING finger domain coding region of c-Cbl gene is relatively infrequent in OSCC samples.
Meconium Peritonitis: A Rare Treatable Cause of Non-Immune Hydrops
Rajendran, Usha Devi,Govindarajan, Jeyanthi,Balakrishnan, Umamaheswari,Chandrasekaran, Ashok,Amboiram, Prakash The Korean Society of Pediatric Gastroenterology 2019 Pediatric gastroenterology, hepatology & nutrition Vol.22 No.6
Meconium peritonitis as a cause of non-immune hydrops in neonates is rarely reported. Here we report such a rare occurrence. In our case, a routine antenatal scan at 25 weeks revealed isolated ascites. By 31 weeks of gestation, all features of hydrops were observed in scans. However, antenatal workup for immune and non-immune hydrops was negative. Subsequently, a preterm hydropic female baby was delivered at 32 weeks. She required intubation and ventilator support. An X-ray revealed calcification in the abdomen suggestive of meconium peritonitis. Ultrasound showed gross ascites, a giant cyst compressing the inferior vena cava, and minimal bilateral pleural effusion. Emergency laparotomy revealed meconium pellets and perforation of the ileum. Double-barrel ileostomy was performed, and the edema resolved and activity improved. The baby was discharged after 3 weeks. Ileostomy closure was done at follow-up. The baby is growing well.
Completeness requirements of shape functions for higher order finite elements
Rajendran, S.,Liew, K.M. Techno-Press 2000 Structural Engineering and Mechanics, An Int'l Jou Vol.10 No.2
An alternative interpretation of the completeness requirements for the higher order elements is presented. Apart from the familiar condition, $\sum_iN_i=1$, some additional conditions to be satisfied by the shape functions of higher order elements are identified. Elements with their geometry in the natural form, i.e., without any geometrical distortion, satisfy most of these additional conditions inherently. However, the geometrically distorted elements satisfy only fewer conditions. The practical implications of the satisfaction or non-satisfaction of these additional conditions are investigated with respect to a 3-node bar element, and 8- and 9-node quadrilateral elements. The results suggest that non-satisfaction of these additional conditions results in poorer performance of the element when the element is geometrically distorted. Based on the new interpretation of completeness requirements, a 3-node element and an 8-node rectangular element that are insensitive to mid-node distortion under a quadratic displacement field have been developed.
User Perception on E-resources at University Libraries in India: A Case Study of SRM University
Rajendran, P.,Ganesh, P. Korean Library and Information Science Society 2015 한국도서관정보학회지 Vol.47 No.2
이 논문은 인도의 대학도서관에서 전자자료에 대한 이용자의 지각을 연구하였다. SRM 대학교 도서관을 사례로 하여 전자자료에 대한 이용자의 지각과 이용자 만족도를 조사하였다. 1,724명의 직원과 연구자들에게 설문을 배포하여 수거된 1,205건의 설문지를 분석하여 연구를 수행하였으며 조사결과를 토대로 전자자료이용과 관련한 장애물과 이용을 개선하기 위한 방안을 모색하였다. The researcher conducts the survey through questioner method and analyzed the data in detail about E-resources available at SRM University library. The objectives of the study are to find out the awareness of use and purposes and their level of satisfaction of users. Further the researcher identifies the barrier and the ways and means of improvement of the use of E-resources. A total of 1,205 respondent was participating in this survey.
Rajendran Selvamani,Hepzibah Christinal,Farzad Ebrahimi Techno-Press 2023 Advances in materials research Vol.12 No.4
The humid thermal vibration characteristics of a nonhomogeneous thermopiezoelectric nonlocal plate of polygonal shape are addressed in the purview of generalized nonlocal thermoelasticity. The plate is initially stressed, and the three-dimensional linear elasticity equations are taken to form motion equations. The problem is solved using the Fourier expansion collocation method along the irregular boundary conditions. The numerical results of physical variables have been discussed for the triangle, square, pentagon, and hexagon shapes of the plates and are given as dispersion curves. The amplitude of non-dimensional frequencies is tabulated for the longitudinal and flexural symmetric modes of the thermopiezoelectric plate via moisture and thermal constants. Also, a comparison of numerical results is made with existing literature, and good agreement is reached.