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Activity Guided Isolation of Antioxidant Tannoid Principles from Anogeissus latifolia
Raghavan Govindarajan1*,Madhavan Vijayakumar1,,Annie Shirwaikar2,,Ajay Kumar Singh Rawat1,,Shanta Mehrotra1,,Palpu Pushpangadan1 한국생약학회 2005 Natural Product Sciences Vol.11 No.3
Oxidative stress is an important causative factor in several human chronic diseases, such asatherosclerosis, cardiovascular disorders, mutagenesis, cancer, several neurodegenerative disorders, and the agingprocess. Phenolics and tannins are reported to be good antioxidants. Anogeissus latifolia (Combretaceae) bark hasnot available till date. Hence the present study was undertaken to isolate antioxidant compounds by activity-guided isolation. Inhibtion of diphenyl picryl hydrazyl (DPH) and Xanthine oxidase along with photoc-hemiluminescence assay were used as bioassay for antioxidant activity. Activity guided isolation was carried outusing silica column and the compounds were quantified using HPLC. Ethyl acetate and butanol fraction exhibitedpotent antioxidant activity. Bioassay-guided isolation led to isolation of ellagic acid (1) and dimethyl ellagic acid(2these three major tannoid principles present in A. latifolia, are responsible for the antioxidant potential andpossibly their therapeutic potential.
I.S.R.Punitha1,,Nalini Bhat3,,K.Rajendran1,,Arun Shirwaikar2,,Annie Shirwaikar1 한국생약학회 2005 Natural Product Sciences Vol.11 No.3
The aqueous extract of Coscinium fenestratum was studied for its antioxidant status in STZ-nicotinamide induced type 2 diabetic rats at two dose levels of 250 mg/kg and 500 mg/kg. At the end of theexperimental period, diabetic rats treated with aqueous extract at both dose levels showed a significant increase insuperoxide dismutase and catalase as compared to the untreated control. Similarly, a significant increase was alsoobserved in the levels of the non enzymatic antioxidants ceruloplasmin, ascorbic acid and tocopherol. The resultssuggest that the aqueous stem extract of C. fenestratum prevents type 2 diabetes mellitus induced oxidative stress.