http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
( Su Hyun Park ),( Seo Yeon Hwang ),( So Hee Kang ),( Se Ra Yang ),( Seo Hyun Shin ),( Jonghwa Kim ),( Yong Han Paik ) 대한간학회 2016 춘·추계 학술대회 (KASL) Vol.2016 No.1
Aims: Liver disease is the fifth biggest killer in Korea. Currently, two major treatments of severe liver disease, liver transplant (LT) and antitumor agent, are limited due to availability of donor and side-effects. Therefore, liver regeneration is an important component of the reparative process following liver injury and surgical resection. In this study, we investigated the possibility of using induced hepatocyte (iHep) that were generated by direct reprogramming from fibroblast to promote liver regeneration in mouse model of acute liver failure. Methods: Acute liver failure model was generated in 8weeks of BALB/C nude mouse by intraperitoneal injection of CCl4 (tetra-chloride, 0.5μl/g mix with Corn oil 1:3). After 24hr CCl4 injection, GFP-iHep(GI) and GFP-MEF(GM) were administered by intrasplenic injection. Serum and livers were collected at specified time points (0, 4, 24, 48, 72hr post cell injection). Serum ALT and AST were measured by ELISA. Degree of liver injury is confirmed by Hematoxylin-Eosin (H&E) staining. Immnunofluorescence (IF) staining was performed on slices of formalin tissues. Tissue proteins were extracted by Tissue homogenizer and used for Western Blot analysis. Results: Hematoxylin-Eosin (H&E) staining confirmed CCl4-induced acute liver injury. Consistent with previous reports, serum ALT/AST levels were peaked at 24hr after CCl4 injection. Besides, iHep injection significantly lowered serum ALT/AST levels than MEF injection did. Through IF staining, we found that intrinsic GFP fluorescence and alpha-GFP were co-localized nearby damaged portal vein area, indicating that the injected iHep has been successfully migrated to the damaged area of liver. Moreover, Albumin also co-localized with intrinsic GFP fluorescence. Also, western blot showed that iHep were stay still in liver upto 72hours post cell injection. These results indicate that iHep was migrated to liver and functioned as primary hepatocyte. Conclusions: We confirmed that liver injury were occurred by CCl4 and cells were migrated to liver through intrasplenic injection and keep condition in a few days. Moreover, Cells were function as primary Hepatocyte by co-staining with liver function marker such as Albumin. These result suggested that iHep may support liver repair, promote liver regeneration, fibrosis resolution or new blood vessel formation.
Al-Li-Cu-Mg-Zr 계 합금분말 압출재의 기계적 성질에 미치는 석출물의 영향
나형용,이동수,이성의 대한금속재료학회(대한금속학회) 1994 대한금속·재료학회지 Vol.32 No.12
The changes of microstructures and mechanical properties of Al-Li-Cu-Mg-Zr P/M alloy with various composition and extrusion variables were observed. Increasing Li content, yield stress increases but tensile stress decreases because of increasing intermetallic phases and δ phase formation. As the extrusion temperature get higher from 573K to 773K, the larger size of subgrain is obtained. Besides in case of extrustion at 773K, composite precipitates are precipitated in the matrix. The mechanical properties of extruded bars-Y.S. (570MPa), E.L. (2.6%)-were obtained by the finer microstructure. The reason is considered that composite precipitates derived cross slip or Orowan by pass of dislocation and Zr acted as grain refiner to suppress recrystallization.
Al-Li-Cu-Mg-Zr 계 합금분말의 응고조직과 압출재에서의 석출물에 대한 고찰
나형용,이동수,이성의 대한금속재료학회(대한금속학회) 1993 대한금속·재료학회지 Vol.31 No.9
AL-Li-Cu-Mg-Zr alloy powders were manufactured by gas atomizer and then extruded. The microstructures and mechanical properties of alloy powders and extruded bars were studied. The microstructures were typical cellular structure and icosahedral phases were crystallized out on the cell boundaries in Al-3Li-3Cu-1Mg-0.3Zr, Al-3Li-3Cu-1Mg-0.1Zr and Al-4Li-3Cu-1Mg-0.1Zr alloy powders. But increasing Li/Cu ratio, icosahedral phase and T_B, phase were crystallized out simultaneously. In Al-3Li-3Cu-Mg-Zr alloy extruded bars, almost the precipitates were icosahedral phase and Type 1 phase appeared. In Al-3Li-1.5Cu-Mg-Zr alloy extruded bars, the precipitates were almost R phase. In Al-3Li-1Cu-Mg-Zr alloy extruded bars, the precipitates were almost C phase. Therefore, In AI-Li-Cu-Mg-Zr alloy extruded bars, precipitation mode is Icosahedral phase → Type 1 → Type 2 → R → C phase appeared according to increasing Li/Cu ratio.
Ra, Ho Jong,Oh, Mi Young,Kim, Hee Ju,Lee, Seung Yong,Eom, Dae Woon,Lee, Suk Kyu,Kim, Su-Nam,Chung, Kyu Sung,Jang, Hyuk Jai The Korean Society of Pharmacology 2018 The Korean Journal of Physiology & Pharmacology Vol.22 No.2
PRF001 is a fragmented DNA polymer extracted from the testes of salmon. The purpose of this study was to assess the anti-inflammatory effect of PRF001 in vitro as well as the protective effect of PRF001 intake against arthritis in a rat model. In vitro, cell survival and inflammatory markers after $H_2O_2$ treatment to induce cell damage were investigated in CHON-001 cells treated with different concentrations of PRF001. In vivo, osteoarthritis was induced by intra-articular injection of monosodium iodoacetate (MIA) into the knee joints of rats. After consumption of PRF001 (10, 50, or 100 mg/kg) for 4 weeks, inflammatory mediators and cytokines in articular cartilage were investigated. In vitro, the levels of inflammatory markers, $IL-1{\beta}$, $TNF-{\alpha}$, COX-2, iNOS, and PGE2, were significantly suppressed by PRF001 treatment. In vivo, the inflammatory mediators and cytokines, $IL-1{\beta}$, p-Erk1/2, $NF-{\kappa}B$, $TNF-{\alpha}$, COX-2, and PGE2, as well as MMP3 and MMP7, which have catabolic activity in chondrocytes, were decreased in the MIA-induced osteoarthritic rats following intake of PRF001. Histological analysis revealed that PRF001 had a protective effect on the articular cartilage. Altogether, these results demonstrated that the anti-inflammatory property of PRF001 contributes to its protective effects in osteoarthritis through deregulating $IL-1{\beta}$, $TNF-{\alpha}$, and subsequent signals, such as p-Erk1/2, $NF-{\kappa}B$, COX-2, PGE2, and MMPs.
Reversing the weak quantum measurement for a photonic qubit
Kim, Yong-Su,Cho, Young-Wook,Ra, Young-Sik,Kim, Yoon-Ho The Optical Society 2009 Optics express Vol.17 No.14
<P>We demonstrate the conditional reversal of a weak (partial-collapse) quantum measurement on a photonic qubit. The weak quantum measurement causes a nonunitary transformation of a qubit which is subsequently reversed to the original state after a successful reversing operation. Both the weak measurement and the reversal operation are implemented linear optically. The state recovery fidelity, determined by quantum process tomography, is shown to be over 94% for partial-collapse strength up to 0.9. We also experimentally study information gain due to the weak measurement and discuss the role of the reversing operation as an information erasure.</P>
Kim, Su-Ji,Lee, Jae Yong,Yoon, So-Ra,Lee, Hae-Won,Ha, Ji-Hyoung Elsevier 2019 Journal of food engineering Vol.240 No.-
<P><B>Abstract</B></P> <P>The application of a colorimetric indicator for monitoring the degree of fermentation in Kimchi was studied. Changes in total color difference (TCD) occurred continuously from the initial to final fermentation stage with a maximum TCD value of 36.08 ± 0.72 after 28 days. The experimental data for the converted color response function, <I>F(Xc)</I> were demonstrated to be more linear (<I>R</I> <SUP>2</SUP> = 0.986) than for TCD values. The coefficients of determination of pH: <I>F(Xc)</I> (<I>R</I> <SUP>2</SUP> = 0.9583) and titratable acidity: <I>F(Xc)</I> (<I>R</I> <SUP>2</SUP> = 0.9828) were sufficient to meet the zero-order reaction. Results of standardized residuals evidenced their normal distribution, indicating that 95% of the residuals of predicted pH or titratable acidity were in the range of −1.96 to 1.96. The coefficients of determination between predicted- and observed data were 0.841 (pH) and 0.912 (titratable acidity). Based on regression analysis, the colorimetric indicator could thus be applied as a Kimchi fermentation indicator.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Assessing Kimchi fermentation state attests quality and aids consumer satisfaction. </LI> <LI> Color development of colorimetric indicators can measure pH and titratable acidity. </LI> <LI> A linear regression model was designed for color response vs fermentation changes. </LI> <LI> Commercial indicator color correlated well with pH and titratable acidity changes. </LI> <LI> Predicted vs observed value comparison showed accuracy of the linear model. </LI> </UL> </P>
Woo-Yong Shin,Min-Ji An,Nam-Gyu Im,Kyung-Rok Oh,Yuri Choe,Seo-Ra Yoon,Su-Ra Ryu 대한재활의학회 2020 Annals of Rehabilitation Medicine Vol.44 No.2
Objective To investigate changes in blood glucose level after steroid injection in patients with type 2 diabetes mellitus (DM) and factors affecting those changes. Methods We retrospectively studied 51 patients with type 2 DM who underwent steroid injection for shoulder and back pain. Mean fasting blood sugar (FBS) levels for 7 days before steroid injection was used as the baseline blood glucose level, which was compared with FBS levels for 14 days after steroid injection. We compared the differences in blood glucose changes between HbA1c >7% and HbA1c ≤7% groups and those between insulin and non-insulin treated groups. Demographic data, injection site, and steroid dose were analyzed. Results Compared to baseline, blood glucose significantly (p=0.012) elevated 1 day after steroid injection but not 2 days after injection. In the HbA1c >7% and insulin groups, blood glucose was significantly increased 1 day after injection compared to that in the HbA1c ≤7% (p=0.011) and non-insulin (p=0.024) groups, respectively. Higher HbA1c level before injection was significantly (p=0.003) associated with the degree of blood glucose increase 1 day after injection. No significant differences were noted in the degree of blood glucose increase according to injection site or steroid dose. Conclusion Higher HbA1c level was associated with greater elevation in blood glucose 1 day after steroid injection. Careful monitoring of blood glucose is required on the first day after steroid injection in patients with poorly controlled DM.