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Scene-based Nonuniformity Correction Algorithm Based on Temporal Median Filter
Lixiang Geng,Qian Chen,Weixian Qian,Yuzhen Zhang 한국광학회 2013 Current Optics and Photonics Vol.17 No.3
Scene-based nonuniformity correction techniques for infrared focal-plane arrays have been widely considered as a key technology, and various algorithms have been proposed to compensate for fixed-pattern noise. However, the existed algorithms’ capability is always restricted by the problems of convergence speed and ghosting artifacts. In this paper, an effective scene-based nonuniformity correction method is proposed to solve these problems. The algorithm is an improvement over the constant statistics method and a temporal median is utilized with the Gaussian kernel to estimate the nonuniformity parameters. Also theoretical analysis is conducted to demonstrate that effective ghosting artifacts elimination and superior convergence speed can be obtained with the proposed method. Finally, the performance of the proposed technique is tested with infrared image sequences with simulated nonuniformity and with infrared imagery with real nonuniformity. The results show the proposed method is able to estimate each detector’s gain and to offset reliably and that it performs better in increasing convergence speed and reducing ghosting artifacts compared with the conventional techniques.
Immunosuppression and Neuroinflammation in Stroke Pathobiology
Qian Jiang,Christopher R. Stone,Kenneth Elkin,Xiaokun Geng,Yuchuan Ding 한국뇌신경과학회 2021 Experimental Neurobiology Vol.30 No.2
Over the preceding decades, there have been substantial advances in our knowledge of the pathophysiology of stroke. One such advance has been an increased understanding of the multifarious crosstalk in which the nervous and immune systems engage in order to maintain homeostasis. By interrupting the immune-nervous nexus, it is thought that stroke induces change in both systems. Additionally, it has been found that both innate and adaptive immunosuppression play protective roles against the effects of stroke. The release of danger-/damage-associated molecular patterns (DAMPs) activates Toll-like receptors (TLRs), contributing to the harmful inflammatory effects of ischemia/reperfusion injury after stroke; the Tyro3, Axl, and MerTK (TAM)/Gas6 system, however, has been shown to suppress inflammation via downstream signaling molecules that inhibit TLR signaling. Anti-inflammatory cytokines have also been found to promote neuroprotection following stroke. Additionally, adaptive immunosuppression merits further consideration as a potential endogenous protective mechanism. In this review, we highlight recent studies regarding the effects and mechanism of immunosuppression on the pathophysiology of stroke, with the hope that a better understanding of the function of both of innate and adaptive immunity in this setting will facilitate the development of effective therapies for post-stroke inflammation.
Kou, Geng,Gao, Jie,Wang, Hao,Chen, Huaiwen,Li, Bohua,Zhang, Dapeng,Wang, Shuhui,Hou, Sheng,Qian, Weizhu,Dai, Jianxin,Zhong, Yanqiang,Guo, Yajun Korean Society for Biochemistry and Molecular Biol 2007 Journal of biochemistry and molecular biology Vol.40 No.5
The purpose of this study was to develop paclitaxel-loaded poly(lactide-co-glycolide) (PLGA) nanoparticles coated with cationic SM5-1 single-chain antibody (scFv) containing a polylysine (SMFv-polylys). SM5-1 scFv (SMFv) is derived from SM5-1 monoclonal antibody, which binds to a 230 kDa membrane protein specifically expressed on melanoma, hepatocellular carcinoma and breast cancer cells. SMFv-polylys was expressed in Escherichia coli and purified by cation-exchange chromatography. Purified SMFv-polylys was fixed to paclitaxel-loaded PLGA nanoparticles to form paclitaxel-loaded PLGA nanoparticles coated with SMFv-polylys (Ptx-NP-S). Ptx-NP-S was shown to retain the specific antigen-binding affinity of SMFv-polylys to SM5-1 binding protein-positive Ch-hep-3 cells. Finally, the cytotoxicity of Ptx-NP-S was evaluated by a non-radioactive cell proliferation assay. It was demonstrated that Ptx-NP-S had significantly enhanced in vitro cytotoxicity against Ch-hep-3 cells as compared with non-targeted paclitaxel-loaded PLGA nanoparticles. In conclusion, our results suggest that cationic SMFv-polylys has been successfully generated and may be used as targeted ligand for preparing cancer-targeted nanoparticles.
Huizhi Wu,Qian Geng,Yonghan Li,Yuqian Song,Jiaqi Chu,Rong Zhou,Xin Ning,Senjie Dong,Ding Yuan 한국공업화학회 2022 Journal of Industrial and Engineering Chemistry Vol.114 No.-
Here, a multifunctional poly (lactic acid)/copper-based metal–organic framework (PLA/CuMOF) degradablecomposite membrane featuring superior antibacterial and self-cleaning properties was fabricated viaa simple electrospinning process for high- efficiency filtration/separation. Benefiting from the decrease offiber diameter, the improved surface roughness and the surface charge of CuMOF, PLA/CuMOF fibrousmembrane achieved excellent capture ability for ultra-fine particles and superb purification capabilityfor real PM2.5 smoke. The differences of filtration capacity between PLA membrane and PLA/CuMOF membranewas further explored using analogue simulation with dynamic particle capture and airflow fielddistribution. Impressively, PLA/CuMOF fibrous membrane combines robust self-cleaning ability, effectiveantibacterial effect, and thermal management capability. Moreover, owing to the special selective wettabilityand chemical stability, PLA/CuMOF membrane possessed the stable oil–water separation performanceunder harsh environment (e.g., high acid, alkali, and salt). This degradable multifunctionalfiltration/separation fibrous membrane emerges a broad application prospect ranging from environmentalgovernance, industrial security to personal protection.
LFT Modeling and Robust Stability Analysis of Missiles with Uncertain Parameters
HOU Zhen-qian,LIANG Xiao-geng,WANG Wen-zheng,LI Rui 한국항공우주학회 2014 International Journal of Aeronautical and Space Sc Vol.15 No.2
The structured singular value (μ) analysis based method has many advantages for the robust stability analysis of missiles with uncertain parameters. Nevertheless, the present linear fractional transformation (LFT) modeling process, which is the basis of μ analysis, is complex, and not suitable for automatic implementation; on the other hand, μ analysis requires a large amount of computation, which is a burden for large-scale application. A constructive procedure, which is computationally more efficient, and which may lead to a lower order realization than existing algorithms, is proposed for LFT modeling. To reduce the calculation burden, an analysis method is developed, based on skew μ. On this basis, calculation of the supremum of μ over a fixed frequency range converts into a single skew μ value calculation. Two algorithms are given, to calculate the upper and lower bounds of skew μ, respectively. The validity of the proposed method is verified through robust stability analysis of a missile with real uncertain parameters.
Liu, Mei,Wang, Qian,Geng, Yuanyuan,Wang, Changwei,Lee, Yong-Ill,Hao, Jingcheng,Liu, Hong-Guo American Chemical Society 2014 Langmuir Vol.30 No.34
<P>An aqueous solution of AgNO<SUB>3</SUB> (upper phase) and a DMF/CHCl<SUB>3</SUB> solution of polystyrene-<I>b</I>-poly(acryl acid)-<I>b</I>-polystyrene (PS-<I>b</I>-PAA-<I>b</I>-PS) or PS-<I>b</I>-PAA-<I>b</I>-PS/1,6-diaminohexane (DAH) (lower phase) constituted a planar liquid/liquid interface. The lower phase gradually transformed to a water-in-oil (W/O) emulsion via spontaneous emulsification due to the “ouzo effect”. Polymer molecules, DAH molecules, and Ag<SUP>+</SUP> ions assembled into microcapsules around emulsion droplets that adsorbed at the planar liquid/liquid interface, resulting in formation of a foam film. DAH acted as a cross-linker during this process. Transmission electron microscopic observations indicated that Ag nanoclusters that were generated through reduction of Ag<SUP>+</SUP> ions by DMF were homogeneously dispersed in the walls of the foam structure. X-ray photoelectron spectroscopic investigations revealed that Ag(I) and Ag(0) coexisted in the film, and Ag(I) transformed to Ag(0) after further treatment. The film formed without DAH was not stable, while the film formed with DAH was very stable due to intermolecular attraction between PAA and DAH and formation of amides, as revealed by FTIR spectra. The film formed with DAH exhibited high and durable catalytic activity for hydrogenation of nitro compounds and, very interestingly, exhibited thermoresponsive catalytic behavior.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/langd5/2014/langd5.2014.30.issue-34/la502738j/production/images/medium/la-2014-02738j_0012.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/la502738j'>ACS Electronic Supporting Info</A></P>
A VAR Model Application in the Work Safety of Coal Mines
SUN Yong-bo,GENG Qian-qi,LU Yong-heng 인하대학교 정석물류통상연구원 2009 인하대학교 정석물류통상연구원 학술대회 Vol.2009 No.10
This paper is an analysis of the relationship between the work safety and the safety investment level of coal mines, the coal miners" occupational competence, the unemployment rate, and total coal production. The analysis was performance using a VAR econometric model, Granger causality test, and pulse analysis. The sepcific results show: the indicator of safety investment brought significant impact on the indicator of "fatality rate per million tons of coal production"; in the current period the shock from the safety investment brought negative impact on "fatality rate per million tons of coal production", which would be further strengthened with time going; the improvement of coal miners occupational competence brought positive impact on "fatality rate per million tons of coal production", which tends to be strengthened in long term. Based on the results in this empirical study, this paper suggests to improve Chinese coal mine work safety the following measures be taken; improve supervisin and administration of the employment systems of coal enterprises from the national institutional perspective; introduce and implement competitive employment mechanisms in response to the surplus labour force of unskilled workers; increase coal enterprises" investment into the safety training of coal miners; and further facilitate more cooperation with the coal miners.
Dual-Responsive Shape Memory and Thermally Reconfigurable Reduced Graphene Oxide-Vitrimer Composites
Guo-kang Chen,Kun Wu,Qian Zhang,Yan-cen Shi,Man-geng Lu 한국고분자학회 2019 Macromolecular Research Vol.27 No.6
In this paper, we have prepared shape memory reduced graphene oxidevitrimer composites via in situ reduction of graphene oxide (GO) during the curing reaction. Because of good compatibility between GO and epoxy resin, reduced graphene oxide (rGO) has a good dispersion in the epoxy matrix. Conventional thermoset shape memory polymers can only maintain one permanent shape, while these obtained composites can be randomly reconfigured into other shapes via dynamic covalent transesterification reaction at 200 °C above transesterification temperature (TV). They can recover quickly from fixed shapes to their initial shapes with shape fixity ratio higher than 95% and shape recovery ratio higher than 97%. Besides, the rGO-vitrimers show good mechanical properties and thermal stabilities. In addition, sequent nearinfrared (NIR) irradiation can control the shape recovery, because rGO can serve as an energy convertor to convert NIR irradiation into thermal energy.