The effect of spin reorientation transition of antiferromagnetic NiO on the Py magnetic anisotropy in Py/NiO/CoO/MgO(0 0 1)

Yang, M.,Li, Q.,N'Diaye, A.T.,Dong, Q.Y.,Gao, N.,Arenholz, E.,Hwang, C.,Wu, Y.Z.,Qiu, Z.Q. Elsevier 2018 Journal of magnetism and magnetic materials Vol.460 No.-

<P><B>Abstract</B></P> <P>Using X-ray Magnetic Linear Dichroism (XMLD) measurement, we investigate the antiferromagnetic (AFM) NiO spin reorientation transition (SRT) in epitaxial NiO/CoO/MgO(0 0 1) system at room temperature and constructed a complete NiO spin phase diagram. Then utilizing Magneto-Optic Kerr Effect (MOKE) combined with a rotation magnetic field (ROTMOKE), we investigated the effect of NiO SRT on the magnetic anisotropy of a ferromagnetic (FM) Py overlayer in Py/NiO/CoO/MgO(0 0 1) system. We find that the Py coercivity and anisotropy only slightly enhanced for Py on top of out-of-plane NiO spins but greatly enhanced for Py on top of in-plane NiO spins. Both the uniaxial and fourfold anisotropies of the Py showed a clear dependence on the NiO spin orientation.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Spin reorientation transition (SRT) of antiferromagnetic NiO. </LI> <LI> Direct measurement of antiferromagnetic spins using XMLD. </LI> <LI> Quantitative determination of Py magnetic anisotropy using ROTMOKE. </LI> <LI> Demonstration of the effect of the NiO SRT on the Py magnetic anisotropy. </LI> </UL> </P>

Responsiveness to reduced dosage of rituximab in Chinese patients with neuromyelitis optica

Yang, C.-S.,Yang, L.,Li, T.,Zhang, D.-Q.,Jin, W.-N.,Li, M.-S.,Su, N.,Zhangning, N.,Liu, Q.,Shao, Z.-H.,Yu, C.,Shi, F.-D. Ovid Technologies (Wolters Kluwer) - American Acad 2013 Neurology Vol.81 No.8

Thermal analysis and optimization of the new ICRH antenna Faraday Screen in EAST

Q.C. Liang,L.N. Liu,W. Zhang,X.J. Zhang,S. Yuan,Y.Z. Mao,C.M. Qin,Y.S. Wang,H. Yang Korean Nuclear Society 2023 Nuclear Engineering and Technology Vol.55 No.7

In Experimental Advanced Superconducting Tokamak (EAST) experiments, to achieve long pulse and high-power ICRH system operation, a new kind of ICRH antenna has been designed. One of the most critical factors in limiting the operation of long pulse and high power is the intense heat load in the front face of the ICRH antenna, especially the Faraday Screen (FS). Therefore, the cooling channels of FS need to be designed. According to thermal-hydraulic analysis, the FS tubes are divided into several groups to achieve more excellent water cooling capability. The number of series and parallel tubes in one group is chosen as six. This antenna went into service in the spring of 2021, and it is delightful that the temperature distribution of the FS tube is below 400 ℃ in 14.5 s and 1.8 MW ICRH system operation. However, the active water-cooling design was not carried out on the upper and lower plates of FS, which led to severe ablations on that region under long pulse and high power operation, and the temperature is up to 800. Therefore, the upper and lower side plates of the FS were designed with water cooling based on thermal-hydraulic analysis. During the 2022 winter experiments, the temperature of ICRH antenna FS was lower than 400 in the pulse of 200s and the power of 1 MW operation.

Ni and CoO spin cantings induced by Fe layer in Ni/CoO/Fe/vicinal MgO(001)

Li, Q.,Yang, M.,N'Diaye, A. T.,Dong, Q. Y.,Scholl, A.,Young, A. T.,Gao, N.,Arenholz, E.,Hwang, C.,Li, J.,Qiu, Z. Q. American Physical Society 2017 Physical Review B Vol.96 No.21

<P>Using element-resolved x-raymagnetic circular dichroism and x-raymagnetic linear dichroism measurements, we studied Ni/CoO/vicinal MgO(001) and Ni/CoO/Fe/vicinal MgO(001) systems at 350 and 78 K. Above the CoO Neel temperature, the Ni magnetization is fully in plane and parallel to the atomic steps in both systems due to step-induced magnetic anisotropy. Below the CoO Neel temperature, the CoO spins in Ni/CoO/vicinal MgO(001) are fully in plane and parallel to the atomic steps and the Ni magnetization is fully in plane and perpendicular to the atomic steps due to the 90 degrees Ni/CoO magnetic coupling. The CoO spins in Ni/CoO/Fe/vicinal MgO(001), however, develop an out-of-plane canted spin component in addition to the in-plane component parallel to the atomic steps. Consequently, the Ni magnetization is canted towards the out-of-plane direction by an appreciable angle. Photoemission electron microscopy imaging shows a 90 degrees interfacial magnetic coupling at both the Ni/CoO and the CoO/Fe interfaces and an absence of a direct interlayer coupling, showing that the Ni spin canting is due to its coupling to the canted CoO spin components which is caused by the underlying ferromagnetic Fe layer in Ni/CoO/Fe/vicinal MgO(001).</P>

Development of a matrix metalloproteinase-2 (MMP-2) biosensing system by integrating an enzyme-mediated color development reaction into a common electronics components setup

Zhang, C. Q.,Park, Y. M.,Yang, D.,Yoo, T. H.,Yoon, H. C. Springer Science + Business Media 2016 BioChip Journal Vol.10 No.3

<P>Matrix metalloproteinase-2 (MMP-2) is closely related to the proliferation and invasion of various types of cancers. The protease is secreted by malignant tumor cells, thus allowing the enzyme to serve as a biomarker for cancer diagnosis. Methods have been developed to analyze MMP-2 activities; however, their applications to disease diagnosis have not been widely demonstrated yet because of the need for high-end analytical equipment and labor-intensive processes. In this study, we developed an MMP-2 activity assay system by integrating an engineered autoinhibited beta-lactamase which can be activated by MMP-2 in an optical sensing system consisting of reassembled common electronic components, such as a laser diode, a solar cell, and a multimeter. The autoinhibited beta-lactamase was immobilized on a polymeric biosensing channel by a polydopamine coating and self-assembled monolayer methods. In the presence of MMP-2, the immobilized autoinhibited beta-lactamase was converted to an active form that hydrolyzed the chromogenic cephalosporin CENTA, thereby changing the substrate color from pale yellow (lambda(max) = 340 nm) to highly discernible chrome yellow (lambda(max) = 405 nm). By reading the interfered laser-light intensity, we were able to analyze MMP-2 activities precisely both with the samples prepared in a buffer solution and also those in urine. These results suggested that the developed system can be used for the quantitative analysis of enzyme activity related to cancer diagnosis.</P>

Direct and quantitative understanding of the non-Ohmic contact resistance in organic and oxide thin-film transistors

Liu, C.,Minari, T.,Xu, Y.,Yang, B.r.,Chen, H.X.,Ke, Q.,Liu, X.,Hsiao, H.C.,Lee, C.Y.,Noh, Y.Y. Elsevier Science 2015 ORGANIC ELECTRONICS Vol.27 No.-

We explore the device physics of thin film transistors (TFTs) with non-Ohmic contacts and develop a simple and fast method for evaluating the contact properties TFTs through output characteristics. Using one single output scan, the quantitative relationship between contact resistances and drain voltage were evaluated, revealing the property of interfacial injection at non-Ohmic contacts. This is demonstrated and validated in both TFT simulations and experiments employing inorganic and organic TFTs. The approach can be applied to general TFTs with arbitrary materials and configurations conveniently and enables faster and improved understanding of TFT operation and device physics.

MicroRNA-221 governs tumor suppressor HDAC6 to potentiate malignant progression of liver cancer

Bae, H.J.,Jung, K.H.,Eun, J.W.,Shen, Q.,Kim, H.S.,Park, S.J.,Shin, W.C.,Yang, H.D.,Park, W.S.,Lee, J.Y.,Nam, S.W. Elsevier Science Publishers 2015 Journal of hepatology Vol.63 No.2

Background & Aims: Most common reason behind changes in histone deacetylase (HDAC) function is its overexpression in cancer. However, among HDACs in liver cancer, HDAC6 is uniquely endowed with a tumor suppressor, but the mechanism underlying HDAC6 inactivation has yet to be uncovered. Methods: Microarray profiling and target prediction programs were used to identify miRNAs targeting HDAC6. A series of inhibitors, activators and siRNAs was introduced to validate regulatory mechanisms for microRNA-221-3p (miR-221) governing HDAC6 in hepatocarcinogenesis. Results: Comprehensive miRNA profiling analysis identified seven putative endogenous miRNAs that are significantly upregulated in hepatocellular carcinoma (HCC). While miR-221 was identified as a suppressor of HDAC6 by ectopic expression of miRNA mimics in Dicer knockdown cells, targeted-disruption of miR-221 repressed cancer cell growth through derepressing HDAC6 expression. Suppression of HDAC6 via miR-221 was induced by JNK/c-Jun signaling in liver cancer cells but not in normal hepatic cells. Additionally, cytokine-induced NF-κBp65 independently regulated miR-221, thereby suppressing HDAC6 expression in HCC cells. HCC tissues derived from chemical-induced rat and H-ras12V transgenic mice liver cancer models validated that JNK/c-Jun activation and NF-κBp65 nuclear translocation are essential for the transcription of miR-221 leading to repression of HDAC6 in HCC. Conclusions: Our findings suggest that the functional loss or suppression of the tumor suppressor HDAC6 is caused by induction of miR-221 through coordinated JNK/c-Jun- and NF-κB-signaling pathways during liver tumorigenesis, providing a novel target for the molecular treatment of liver malignancies.

Observation of the topological surface state in the nonsymmorphic topological insulator KHgSb

Liang, A. J.,Jiang, J.,Wang, M. X.,Sun, Y.,Kumar, N.,Shekhar, C.,Chen, C.,Peng, H.,Wang, C. W.,Xu, X.,Yang, H. F.,Cui, S. T.,Hong, G. H.,Xia, Y.-Y.,Mo, S.-K.,Gao, Q.,Zhou, X. J.,Yang, L. X.,Felser, C. American Physical Society 2017 Physical review. B Vol.96 No.16

<P>Topological insulators represent unusual topological quantum states, typically with gapped bulk band structure but gapless surface Dirac fermions protected by time-reversal symmetry. Recently, a distinct kind of topological insulator resulting from nonsymmorphic crystalline symmetry was proposed in the KHgX (X = As, Sb, Bi) compounds. Unlike regular topological crystalline insulators, the nonsymmorphic glide-reflection symmetry in KHgX guarantees the appearance of an exotic surface fermion with hourglass shape dispersion (where two pairs of branches switch their partners) residing on its (010) side surface, contrasting to the usual two-dimensional Dirac fermion form. Here, by using high-resolution angle-resolved photoemission spectroscopy, we systematically investigate the electronic structures of KHgSb on both (001) and (010) surfaces and reveal the unique in-gap surface states on the (010) surface with delicate dispersion consistent with the 'hourglass Fermion' recently proposed. Our experiment strongly supports that KHgSb is a nonsymmorphic topological crystalline insulator with hourglass fermions, which serves as an important step to the discovery of unique topological quantum materials and exotic fermions protected by nonsymmorphic crystalline symmetry.</P>

Study on Intuitive Configuration of Joystick for Operator in Flattening Task of Excavator

Q. H. Le(레광환),Y. M. Jeong(정영만),C. T. Nguyen(웬치탄),S. Y. Yang(양순용) 유공압건설기계학회 2013 유공압건설기계학회 학술대회논문집 Vol.2013 No.10

Hydraulic excavators are among the most versatile earthmoving equipment: these machines are used in civil engineering, hydraulic engineering, grading and landscaping, pipeline construction and mining. Especially, to flattening the ground these, the excavator operator actuates the machine controls (joysticks, pedals and switches) in an organized form to achieve the desired straight motion; the actuation of these controls is a complex and not intuitive task, and therefore it requires long and costly training periods. This paper present a intuitive configuration of joystick for operator in flattening task of excavator. This method control lets each joystick perform independent horizontal and vertical motions of the end of bucket. The proposed method allows an user to control the excavator intuitively and operate complex motions smoothly with no constraints. For this, a virtual excavator scheme with a joystick control has been developed. Besides, the virtual reality interface is designed to allow the use be able to observe the motion of the attachment of this model.

Electric modulation of conduction in multiferroic Ca-doped BiFeO₃ films

Yang, C.-H.,Seidel, J.,Kim, S. Y.,Rossen, P. B.,Yu, P.,Gajek, M.,Chu, Y. H.,Martin, L. W.,Holcomb, M. B.,He, Q.,Maksymovych, P.,Balke, N.,Kalinin, S. V.,Baddorf, A. P.,Basu, S. R.,Scullin, M. L.,Rames Nature Publishing Group 2009 Nature materials Vol.8 No.6

Many interesting materials phenomena such as the emergence of high-Tc superconductivity in the cuprates and colossal magnetoresistance in the manganites arise out of a doping-driven competition between energetically similar ground states. Doped multiferroics present a tantalizing evolution of this generic concept of phase competition. Here, we present the observation of an electronic conductor–insulator transition by control of band-filling in the model antiferromagnetic ferroelectric BiFeO<SUB>3</SUB> through Ca doping. Application of electric field enables us to control and manipulate this electronic transition to the extent that a p–n junction can be created, erased and inverted in this material. A ‘dome-like’ feature in the doping dependence of the ferroelectric transition is observed around a Ca concentration of ∼1/8, where a new pseudo-tetragonal phase appears and the electric modulation of conduction is optimized. Possible mechanisms for the observed effects are discussed on the basis of the interplay of ionic and electronic conduction. This observation opens the door to merging magnetoelectrics and magnetoelectronics at room temperature by combining electronic conduction with electric and magnetic degrees of freedom already present in the multiferroic BiFeO<SUB>3</SUB>.