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로지 케리건(Lodge Kerrigan)의 〈클린, 쉐이븐 Clean, Shaven〉은 정신 분열증 환자가 투옥되고 아내가 사망 후 입양된 딸을 찾으려고 노력한다. 환각과 편집증은 피터를 휩쓸고 그를 주류 사회로부터 멀어지게 만드는 자해와 분노로 가득 찬다. 이 소외는 영화 에서 계속 악화된다. 피터의 어머니는 적대감으로 그를 대우하고 입양 기관은 딸에 대한 정보를 제공하기를 거부하며, 경찰은 그를 두 명의 소녀를 살해 한 것으로 의심한다. 이 일련의 불쾌한 만남을 통해 케리건은 정신분열병이 본질적으로 폭력적이고 사교적이지 않다는 전제를 드러낸다. 케리건은 정신 분열증에 대한 의학적 또는 정신 의학적 관점을 제외하고는 피터의 박해와 폭력적인 사망이 임상적 현실이 아니라 질병의 사회적 구성에서 비롯된 것이라고 규정한다. 케리건은 그러한 잘못된 신념이 가족 관계와 법적 절차 모두에 부정적인 영향을 미친다는 것을 보여주려 하지만 피터의 죽음에 대한 책임은 주류 언론에까지 확장시킨다. 왜냐하면 전통적인 가정에 대한 표현은 정신 분열병 환자가 가족 생활에 참여할 수 없거나 참여해서는 안된다는 것을 암시하기 때문이다. 〈클린, 쉐이번〉에서 행복하고 놀기 좋은 아버지의 이미지는 예측할 수 없는 피터와 크게 대조된다. 이러한 미디어 표현은 정신분열병 환자가 반사회적이라는 고정 관념을 강화함으로써 가족 생활에서 그를 제외시키는 피터의 장애 구성에 기여한다. Lodge Kerrigan's Clean, Shaven chronicles a schizophrenic man's attempts to find his daughter who is put up for adoption after his wife dies during his incarceration. Hallucinations and paranoia haunt Peter and lead him into outbursts and acts of self-harm that alienate him from mainstream society. This alienation worsens throughout the film: Peter's mother treats him with hostility, the adoption agency refuses to offer any information about his daughter, and the police suspect him of murdering two young girls. Through this series of unpleasant encounters, Kerrigan exposes the presupposition that schizophrenics are innately violent and unsociable. To the contrary, Peter finds vindication when Nicole chooses to leave her adopted home to live with him and when the police's case against him falls apart. Tragically, the lead detective only realizes the tenuousness of his case after he shoots and kills Peter in front of his daughter under the mistaken assumption that he had planned to abuse her. Through the exclusion of the medical or psychiatric perspectives on schizophrenia, Kerrigan establishes that Peter's persecution and violent death result from the social construction of the disease, rather than its clinical reality. While Kerrigan demonstrates that such false beliefs negatively impact both family relations and legal procedures, he extends the responsibility for Peter's death to the mainstream media because its representations of traditional families implicitly suggest that schizophrenics cannot or should not participate in family life. Throughout Clean, Shaven, media images of happy, playful fathers sharply contrast with the unpredictable Peter. These media representations contribute to the construction of Peter's disability, which excludes him from family life by reinforcing the stereotype that schizophrenics are antisocial. Peter's refusal to accept the limitations that accompany the social construction of schizophrenia necessitates his death by police, the institution responsible for maintaining and reinforcing social order and expectations.
Over the past decade, Peter J. Katzenstein has made enormous contributions to our theoretical and empirical understanding of Asian economic and security regionalism, which has been manifested by the proliferation of intra- and extra-regional free trade agreements, regional financial institutions, and cooperative regional security dialogues. Katzensteins scholarly works on Asian regionalism and the changing role of Japan have set the pace for research in the field. In this article, a group of distinguished scholars in the field of Asian regionalismVinod K. Aggarwal, Min Gyo Koo, Amitave Acharya, Richard Higgott, and John Ravenhillcritically evaluate Katzensteins approach to the links among Japan, Asian regionalism, and global politics. In response, Katzenstein argues that Asian (and European) regionalism is linked to the American imperium and to core regional states and that regionalism is best studied with an eclectic approach. For him, regionalism is a force that defines security, economic, and cultural dimensions of world politics, thus bringing about a modicum of order therein.
( Peter Buggisch ), ( Jorg Peterson ), ( Stefan Mauss ), ( Kris Kowdley ), ( Micheal Curry ), ( Peter Ruane ), ( Dani Ain ), ( Naoky Tsai ), ( Yoori Lee ), ( Edward Eggleton ), ( Macky Natha ), ( Bruce Kreter ), ) 대한간학회 2016 춘·추계 학술대회 (KASL) Vol.2016 No.1
Aims: The optimal duration of therapy to achieve SVR depends on multiple factors. In a post-hoc analysis of the Phase 3 ION-3 (treatment-naive (TN), non-cirrhotic (NC) patients) 8 week of LDV/SOF data, a viral load (VL) <6M was shown to be the best predictor of SVR. Real world effectiveness (RWE) is often different from Phase III trials and there is a need to understand real-world 8 week regimens in a broader spectrum of patients. Methods: RWE 8 week LDV/SOF data is emerging from multiple single- center and multicenter retrospective and prospective cohorts. In this analysis, the phase-3 ION-3 data is compared with data from several diverse real world populations and one post-marketing investigator sponsored HIV/HCV trial. Patient demographics, characteristics, SVR12 and discontinuation data has been compared. Results: The ION-3 post-hoc analysis reported 123 patients who were TN, NC and VL<6M and treated with 8 weeks of LDV/SOF. Mean age was 52, 22% black, 72% GT1a; the SVR12 was 97% (119/123). The overall SVR12 rate from six diverse real world and post marketing cohorts was also 97% (638/658). There was no significant impact of HCV genotypes or subtypes (GT1a, 1b versus GT4), prior treatment history, presence or absence of cirrhosis, high viral load (HCV VL>6M), or HIV/HCV co-infection. All response rates are detailed in Figure1. Conclusions: LDV/SOF for 8 weeks yielded high SVR rates in ION-3. Analysis of RWE data from several diverse and heterogeneous cohorts from the US & EU show SVR outcomes that were consistent with the ION-3 results and supports the use of 8 weeks LDV/SOF in treatment- naive, non-cirrhotic GT1 patients with a baseline HCV VL <6M and possibly in other populations including HIV/HCV co-infected patients. Discontinuation rates were low despite diverse patients and clinical settings. Data from the TARGET and TRIO cohorts also suggests that the 8-week regimen is underutilized.
In this contribution we'll introduce a new control structure for mechatronic drives. Such a drive combines motor, gear-box, electronics as well as control to one module. In light-weight applications like robotics as well as in general automation industry, the end-effector prone to oscillate due to a relatively low system damping. For ”transient”- effects methods like input shaping or posicast-control can reduce or even eliminate an unwanted oscillation. Additionally ”semi-stead-state”-effects can arise an oscillation two. Therefor the relatively new method of harmonic modulation can be applied. We now focus on a control structure where these techniques are joined together. In many applications the set-point generation is done by a host system (e.g. PLC) and transfered to the drive. Hence, we seek a control structure for the mechatronic drive without affecting the set-point generation process. Further, the advantage of this new structure will be shown along measurement results.
( Peter Buggisch ), ( Ana Moreno ), ( Vasily Isakov ), ( Lisa Backus ), ( Dani Ain ), ( Peter Ruane ), ( Juan Gonzalez ), ( Sooji Lee ), ( Sarjita Naik ), ( Swarup Mehta ), ( Jina Lee ), ( Michael Mertens ), ( Ma) 대한간학회 2017 춘·추계 학술대회 (KASL) Vol.2017 No.1
Aims: The AASLD/IDSA/IAS-USA Guidance and EASL Recommendations on Treatment of Hepatitis C state that HIV/HCV coinfection should be treated the same as HCV monoinfection with careful monitoring of antiretrovirals. Real world cohorts (RWC) have demonstrated excellent efficacy of LDV/SOF for 8weeks in HCV monoinfected patients. The aim of this study was to describe the effectiveness of the STR of LDV/SOF for 8 weeks in HCV GT 1 patients with HIV/HCV coinfection in RWC. Methods: Real world effectiveness data of LDV/SOF for 8weeks in HIV/HCV coinfection is emerging from multiple cohorts. In this descriptive analysis, data from two prospective studies, one investigator- sponsored, 1 registrational trial, and three retrospective RWC of LDV/SOF for 8weeks in HIV/HCV co-infected patients were compared. The prospective trials include data from Ain et al (investigator sponsored) and Isakov et al (registrational trial). The RWC include the Deutsches Hepatitis C-Register, Madrid Coinfection Registry (Madrid-CoRe), and Veterans Affairs HCV Registry. Baseline characteristics and efficacy were analyzed. Results: The majority of the 279 patients included in this descriptive analysis were GT1, treatment naive (TN), noncirrhotic (NC), and had a HCV viral load <6million. The prospective cohorts enrolled 79 patients with the following baseline characteristics: mean age (43 years), male (74%), white (78%), and GT1a (55%). The RWC studies assessed enrolled 200 patients with the following overall baseline characteristics: mean age (53 years) male (79%), white (98%), and GT1a (82%) in those that reported demographics. The overall SVR12 from five diverse real world and post-marketing cohorts was 94% (263/279). The individual study results are presented in Table 1. Conclusions: This analysis of diverse cohorts from the EU and US yielded high SVR rates similar to SVR rates seen in multiple RW moninfected cohorts and supports the use of 8 weeks of LDV/SOF in TN, NC GT 1 HIV/HCV coinfected patients with a baseline HCV viral load <6 million.