Antinociceptive and anti-inflammatory activities of Pandanus fascicularis Lamk. leaves in animal models

Panda, Prabhudutta,Panda, DP,Panda, PK,Nayak, SS Kyung Hee Oriental Medicine Research Center 2008 Oriental pharmacy and experimental medicine Vol.7 No.5

The present study was carried out to elucidate the potential of, chloroform extract of Pandanus (P.) fascicularis Lamk (Family-Pandanaceae) leaves on antinociceptive, behavioral study and anti-inflammatory effects using various animal models The dried, powdered leaves of, P. fascicularis were extracted successively with petroleum ether ($60\;-\;80^{\circ}C$) and chloroform in soxhlet apparatus. The chloroform extract (yield 21.6% w/w with respected to dry powdered plant material) was selected for all experimental procedure. Two models were employed to investigate the effects on nociception, the tail immersion and hot plate method in Swiss albino mice and anti inflammatory effect were investigated by employing the carrageenan induced rat paw edema test in. adult Wister albino rats. Behavioral study was investigated by elevated plus maze method in Swiss albino mice. Results were revealed that the PFCE was found significant antinociceptive effect (P < 0.001) at the dose levels of 100, 200 and 400 mg/kg, orally in mice and produced remarkable antiinflammatory effect (P < 0.001) at the same dose levels used in the rats. Behavioral study of the PFCE has no significant anxiolysis effect when used orally. It concludes that, PFCE possessed remarkable antinociceptive effect and anti-inflammatory effect but no anxiolytic effect on animal models.

Numerical modeling and prediction of adhesion failure of adhesively bonded composite T-Joint structure

Subhransu K Panda,Pradeep K Mishra,Subrata K. Panda 국제구조공학회 2020 Structural Engineering and Mechanics, An Int'l Jou Vol.74 No.6

This study is reported the adhesion failure in adhesive bonded composite and specifically for the T-joint structure. Three-dimensional finite element analysis has been performed using a commercial tool and the necessary outcomes are obtained via an eight noded solid element (Solid 185-element) from the library of ANSYS. The structural analysis input has been incurred through ANSYS parametric design language (APDL) code. The normal and shear stress distributions along different layers of the joint structure have been evaluated as the final outcomes. Based on the stress distributions, failure location in the composite joint structure has been identified by using the Tsai-Wu stress failure criterion. It has been found that the failure index is maximum at the interface between flange and web part of the joint (top layer) which indicates the probable location of failure initiation. This kind of failures are considered as adhesion failure and the failure propagation is governed by strain energy release rate (SERR) of fracture mechanics. The different adhesion failure lengths are also considered at the failure location to calculate the SERR values i.e. mode I fracture (opening), mode II fracture (sliding) and mode III fracture (tearing) along the failure front. Also, virtual crack closure technique (VCCT) principle of fracture mechanics steps is used to calculate the above said SERRs. It is found that the mode I SERR is more dominating compared to other two modes of failure for the joint considered. Finally, the influences of various parametric (geometrical and material) effect on SERR of the joint structure are evaluated and discussed in details.

Synergistic interactions of Aegle marmelos leaf, Emblica officinalis fruit and Ocimum sanctum leaf extracts in the regulation of hyperthyroidism and / or hyperglycaemia

Panda, Sunanda,Kar, Anand Kyung Hee Oriental Medicine Research Center 2004 Oriental pharmacy and experimental medicine Vol.4 No.1

The effects of Aegle marmelos (Rutaceae) leaf, Emblica officinalis (Euphorbiaceae) fruit and Ocimum sanctum. (Labiateae) leaf extracts were studied in L-thyroxine (0.5 mg/kg) induced hyperthyroidic mice. Separately combined effects of these three plant extracts and of a commonly used antithyroidic drug, Propyl thiouracil (PTU) were investigated for comparison. Serum concentration of thyroxine $(T_4)$, triiodothyronine $(T_3)$, glucose and the activity of hepatic Glucose 6-Phosphatase (G-6-Pase) were considered as main parameters. Hepatic lipid peroxidation (LPO), superoxide dismutase (SOD) and Catalase (CAT) activities were also studied to reveal the toxic effect of the plant extracts, if any. While exogenous $T_4$ enhanced serum concentration of $T_4$, $T_3$, glucose and the activity of hepatic G-6-Pase, a simultaneous administration of either A. marmelos leaf (1.0 mg/kg), E. officinalis fruit( 30 mg/kg) and O. sanctum leaf (50 mg/kg) extracts, to hyperthyroidic animals decreased all these parameters. However, the effects were more pronounced, as nearly normal thyroid function and serum glucose concentration were exhibited when all three plant extracts were administered together. A decrease in LPO and a concomitant increase in SOD and the CAT activities indicated the safe and antiperoxidative nature of the plant extracts, administered either alone or in combination. Our findings reveal that the three test plant materials exhibit synergistic effects without any hepatotoxicity, suggesting their potential use in the amelioration of hyperthyroidism and/ or hyperglycaemia.

Synthesis of Regioselectively Diiodinated Porphyrins; 5,20-Diaryl-12,13-diiodoporphyrins

Panda, Pradeepta K.,Padhy, Sasmita,Ha, Kwon-Soo,Lee, Chang-Hee Korean Chemical Society 2004 Bulletin of the Korean Chemical Society Vol.25 No.9

Perception and Practices of Physicians in Addressing the Smokeless Tobacco Epidemic: Findings from Two States in India

Panda, Rajmohan,Persai, Divya,Mathur, Manu,Sarkar, Bidyut Kanti Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.12

Background: Smokeless tobacco use in South Asia is believed to be a significant contributor to morbidity and mortality. In India, only a few studies involving health educational intervention by health care providers have demonstrated reduction in smokeless tobacco usage. In the present study we assessed the cessation efforts towards smokeless tobacco by physicians in two high tobacco prevalence states of India. The study also identified opportunities and barriers for integration of tobacco cessation services in routine practices of physicians. Materials and Methods: This mixed method study involved qualitative (phase I) and quantitative research study (phase II). In phase I, 59 in-depth interviews with physicians were conducted. In phase II, a quantitative study conducted among 238 physicians. An inductive approach was followed to analyze qualitative data using ATLAS. Ti software. The Chi-square test was employed to test the association between different variables of interest using SPSS version 17. Results: The majority of physicians related only respiratory problems and cancer with smokeless tobacco. Other major health effects like cardio-vascular problems, oral diseases, and effects on reproductive and neonatal health were recognized only by a few physicians. The age-group of 10-19 years was identified as most vulnerable to smokeless tobacco use. Less than one-third of physicians reported recording smokeless tobacco history of all patients. Findings indicated that less than half of physicians provided information on harmful health effects of smokeless tobacco with regard to specific diseases. Conclusions: The study revealed a low level of knowledge of physicians about harmful effects of tobacco and their suboptimal engagement in tobacco control practices. The study indicates the need of capacity building initiatives to equip physicians with skills in tobacco cessation.

A Benzodipyrrole-Derived Sapphyrin

Panda, Pradeepta K,Kang, Young-Jin,Lee, Chang-Hee WILEY-VCH Verlag 2005 Angewandte Chemie. international edition Vol.44 No.26

<B>Graphic Abstract</B> <P>Within the framework: The fused benzodipyrrole unit within the sapphyrin 1 has a significant influence on its structure as compared to those of usual sapphyrins. The fused benzene ring partly inhibits distortion of the macrocycle about the dipyrrole unit (see structure of 1⋅2 H<SUP>+</SUP> 2 (p-CH<SUB>3</SUB>C<SUB>6</SUB>H<SUB>4</SUB>SO<SUB>3</SUB><SUP>−</SUP>); C gray, N blue, O red, S yellow) and contributes to the significant red-shift of Q-bands. <img src='wiley_img/14337851-2005-44-26-ANIE200500944-content.gif' alt='wiley_img/14337851-2005-44-26-ANIE200500944-content'> </P>

A behavioral reasoning theory of nonprofit competition for grant acquisition

Panda Debadutta Kumar 한국행정학회 2023 International Review of Public Administration Vol.28 No.2

This study examines nonprofit competition for grant acquisition from the behavioral reasoning theory. The study was conducted in 2 phases. Personal interviews were conducted with the senior managers of 44 Nonprofit Organizations (NPOs), and information was processed using a coding technique to find out the ‘reason for’ and the ‘reason against’ nonprofit competition for grant acquisition (study 1). Post that, responses were collected from 377 senior NPO managers and the information was processed using confirmatory factor analysis and structural equation model-ing (study 2). The ‘reason for’ nonprofit competition was the reputational benefit and sustainability benefit, and the ‘reason against’ nonprofit competition was the organizational barrier, knowledge barrier, and image barrier. The ‘reason for’ positively impacted and the ‘reason against’ negatively impacted the motive and intention of nonprofit leaders for grant acquisition. The motive for grant acquisition positively impacted the inten-tion for grant acquisition in nonprofit leaders.

Tobacco Control Law Enforcement and Compliance in Odisha, India - Implications for Tobacco Control Policy and Practice

Panda, Bhuputra,Rout, Anita,Pati, Sanghamitra,Chauhan, Abhimanyu Singh,Tripathy, Asima,Shrivastava, Radhika,Bassi, Abhinav Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.9

Introduction: Tobacco use is a leading cause of deaths and disabilities in India, killing about 1.2 lakh people in 2010. About 29% of adults use tobacco on a daily basis and an additional 5% use it occasionally. In Odisha, non-smoking forms are more prevalent than smoking forms. The habit has very high opportunity cost as it reduces the capacity to seek better nutrition, medical care and education. In line with the WHO Framework Convention on Tobacco Control (FCTC), the Cigarettes and Other Tobacco Products Act (COTPA) is a powerful Indian national law on tobacco control. The Government of Odisha has shown its commitment towards enforcement and compliance of COTPA provisions. In order to gauge the perceptions and practices related to tobacco control efforts and level of enforcement of COTPA in the State, this cross-sectional study was carried out in seven selected districts. Materials and methods: A semi-structured interview schedule was developed, translated into Odiya and field-tested for data collection. It mainly contained questions related to knowledge on provisions of section 4-7 of COTPA 2003, perception about smoking, chewing tobacco and practices with respect to compliance of selected provisions of the Act. 1414 samples were interviewed. Results: The highest percentage of respondents was from the government departments. 73% of the illiterates consumed tobacco as compared to 34% post graduates. 52.1% of the respondents were aware of Indian tobacco control laws, while 80.8% had knowledge about the provision of the law prohibiting smoking in public places. However, 36.6% of the respondents reported that they had 'very often' seen tobacco products being sold 'to a minor', while 31.2% had seen tobacco products being sold 'by a minor'. In addition, 24.8% had 'very often' seen tobacco products being sold within a radius of 100 yards of educational institutions.

Plasma plume behavior of laser ablated cerium oxide: Effect of oxygen partial pressure

Panda, Arun Kumar,Singh, Akash,Mishra, Maneesha,Thirumurugesan, R.,Kuppusami, P.,Mohandas, E. Cambridge University Press 2014 Laser and particle beams Vol.32 No.3

<B>Abstract</B><P>This paper describes the spatial and temporal investigation of laser ablated plasma plume of cerium oxide target using Langmuir probe. Cerium oxide target was ablated using a KrF (λ ~ 248 nm) gas laser. Experimental studies confirmed that oxygen partial pressure of 2 × 10<SUP>−2</SUP> mbar is sufficient enough to get good quality films of cerium oxide. At this pressure, plume was diagnosed for their spatial and temporal behavior. Spatial distribution was investigated at a distance of 15 mm, 30 mm, and up to a maximum distance of 45 mm from the target, whereas temporal behavior has been recorded in the range of 0 to 50 µS with an interval of 0.5 µS. The average electron densities are found to be maximum at 30 mm from the target position and the plasma current of the laser ablated ceria is found to be maximum at 22 µS.</P>

Bio-inspired self-propelled diatom micromotor by catalytic decomposition of H₂O₂ under low fuel concentration

Panda, Atanu,Reddy, Ankireddy Seshadri,Venkateswarlu, Sada,Yoon, Minyoung The Royal Society of Chemistry 2018 Nanoscale Vol.10 No.34

<P>Recently, active bubble-propelled micromotors have attracted great attention for fuel applications. However, for generating bubble-propelled micromotors, additional catalysts, such as Pt, Ag, and Ru, are required. These catalysts are expensive, toxic, and highly unstable for broad applications. To overcome these issues, in this study, we present an innovative methodology for the preparation of self-propelled motor machines using naturally occurring diatom frustules. This natural diatom motor shows effective motion in the presence of a very low concentration (0.8%) of H2O2 as a fuel at pH 7. Due to the unique 3D anisotropic shape of the diatom, the self-propelled motor exhibited unidirectional motion with a speed of 50 μm s<SUP>−1</SUP> and followed pseudo first-order kinetics. It was found that a trace amount of iron oxide (Fe2O3) in the diatom was converted into Fe3O4, which can act as a catalyst to achieve the facile decomposition of H2O2. Interestingly, “braking” of the unidirectional motion was observed upon treatment with EDTA, which blocked the catalytically active site. These results illustrate that diatom catalytic micromotors have opened a new era in the field of catalysis and bioengineering applications.</P>