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Nakahira, Katsuya,Kobayashi, Kiyoshi,Ohata, Kohei,Ueba, Masazumi 통신위성우주산업연구회 2004 Joint Conference on Satellite Communications Vol.2004 No.-
To yield a large communication capacity in future mobile satellite communication systems, a multi-beam system must be employed that has extremely high levels of frequency reuse. This paper proposes a novel resource allocation algorithm for multi-beam satellite communication systems that can dynamically offer the virtually maximum communication capacity. The algorithm optimizes frequency bandwidth, satellite transmission power, modulation level and coding rate to each beam to deal with the ever changing traffic distribution considering interference between beams. First, the optimal resource allocation is found by evaluating capacities for all possible resource allocation patterns. Although, this primitive search takes a huge amount of computer calculation power, the achieved communication capacities are higher than with conventional ones such as fixed resource system. In addition, the results of analysis clarify the the optimal condition by which all clusters have the same bandwidth allocation ratio. Second, we propose an optimal resource allocation algorithm utilizing the aforementioned condition as a constraint. By using our algorithm, which is based on sequential quadratic programming, the calculation amount can be drastically reduced. It is confirmed that the algorithm allocate the same bandwidth as that by the amount can be drastically reduced. It is confirmed that the algorithm allocate the same bandwidth as that by the primitive search method for varieties of traffic model. This means that the preposed algorithm is applicable for multi-beam satellite resource allocation.
Circulating Mitochondrial DNA as a Predictor of Mortality in Critically ill Patients
( Sun Young Kyung ),( Kiichi Nakahira ),( Augustine Mk Choi ) 대한결핵 및 호흡기학회 2012 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.114 No.-
Background: Multiple scoring systems based on commonly measured clinical parameters help to predict of prognosis of patients admitted to intensive care units. Despite these scoring systems it is needed to develop biomarkers that improve risk prediction in critically ill patients. Mitochondrial DNA (mtDNA) is a critical activator of the inflammasome-dependent inflammation. We evaluated the predictive value of mtDNA level on mortality in critically ill patients. Methods: Circulating cell-free mtDNA levels were measured in plasma from observational cohort study (the Brigham and Women`s Hospital registry of Critical Illness, BWH RoCI, n=200). MtDNA levels in plasma were assessed by measuring copy number of the NADH dehydrogenase 1 (mt-ND1) gene by quantitative real-time PCR. Results: The levels of mt-ND1 were significantly higher in patients with sepsis, and in patients who died. For every 100 copy increase of mt-ND1, there is a 0.09 unit increase in APACHE II score (p=0.0004). The elevated mt-ND1 level (≥400 copies/μL plasma) was associated with increased in-hospital mortality (p=0.0001). Conclusions: Increased levels of circulating mtDNA are associated with sepsis, and in-hospital mortality. The mtDNA could be a plasma biomarker as a predictor of mortality in critically ill patients.
NOX4-dependent fatty acid oxidation promotes NLRP3 inflammasome activation in macrophages
Moon, Jong-Seok,Nakahira, Kiichi,Chung, Kuei-Pin,DeNicola, Gina M,Koo, Michael Jakun,Pabó,n, Maria A,Rooney, Kristen T,Yoon, Joo-Heon,Ryter, Stefan W,Stout-Delgado, Heather,Choi, Augustine M K Nature Publishing Group, a division of Macmillan P 2016 Nature medicine Vol.22 No.9
<P>Altered metabolism has been implicated in the pathogenesis of inflammatory diseases. NADPH oxidase 4 (NOX4), a source of cellular superoxide anions, has multiple biological functions that may be of importance in inflammation and in the pathogenesis of human metabolic diseases, including diabetes. However, the mechanisms by which NOX4-dependent metabolic regulation affect the innate immune response remain unclear. Here we show that deficiency of NOX4 resulted in reduced expression of carnitine palmitoyltransferase 1A (CPT1A), which is a key mitochondrial enzyme in the fatty acid oxidation (FAO) pathway. The reduced FAO resulted in less activation of the nucleotide-binding domain, leucine-rich-repeat-containing receptor (NLR), pyrin-domain-containing 3 (NLRP3) inflammasome in human and mouse macrophages. In contrast, NOX4 deficiency did not inhibit the activation of the NLR family, CARD-domain-containing 4 (NLRC4), the NLRP1 or the absent in melanoma 2 (AIM2) inflammasomes. We also found that inhibition of FAO by etomoxir treatment suppressed NLRP3 inflammasome activation. Furthermore, Nox4-deficient mice showed substantial reduction in caspase-1 activation and in interleukin (IL)-1b and IL-18 production, and there was improved survival in a mouse model of NLRP3-mediated Streptococcus pneumoniae infection. The pharmacologic inhibition of NOX4 by either GKT137831, which is currently in phase 2 clinical trials, or VAS-2870 attenuated NLRP3 inflammasome activation. Our results suggest that NOX4-mediated FAO promotes NLRP3 inflammasome activation.</P>
Two competing soft modes and an unusual phase transition in the stuffed tridymite-type oxideBaAl2O4
Ishii, Y.,Mori, S.,Nakahira, Y.,Moriyoshi, C.,Park, J.,Kim, B. G.,Moriwake, H.,Taniguchi, H.,Kuroiwa, Y. American Physical Society 2016 Physical Review B Vol.93 No.13
<P>We investigated the structural phase transition of BaAl2O4, which has a network structure with corner-sharing AlO4 tetrahedra, via synchrotron x-ray thermal diffuse scattering measurements and first-principles calculations. BaAl2O4 shows the structural phase transition at T-C = 451.4 K from the P6(3)22 parent crystal structure to the low-temperature superstructure with a cell volume of 2a x 2b x c. This phase transition is unusual, in which two energetically competing phonon modes at M and K points soften simultaneously. When approaching T-C from above, the K-point mode appears first. However, this K-point mode is overcome by the later-developed M-point mode. The thermal diffuse scattering intensities from both modes increase sharply at T-C; therefore, both modes soften simultaneously. The first-principles calculations demonstrate that the M-point mode is electrostatically more preferable than the K-point mode and determines the eventual low-temperature structure, although these two modes are competing energetically. This competition is characteristic of BaAl2O4, which is ascribed to the structurally flexible network structure of this compound.</P>
Kosuke Kumagai,Tetsuo Fujita,Masashi Nakahira,Yoshiki Mizuguchi,Hideki Sonoda 전력전자학회 2015 ICPE(ISPE)논문집 Vol.2015 No.6
To reduce the environmental impact of the DC power system of the East Japan Railway Company (JREAST), it is important to have effective regenerative energy transfer from one train to another. In this paper, a simultaneous measurement between a Yamanote Line Series E231 train and the adjacent substations was conducted. From these measurements, the correlation between squeezing control of regenerative power in the train and behavior of the substations was confirmed. Also, to consider minimizing the total squeezing control of regenerative power we studied the total of squeezing control of regenerative power from the data at the substations.
Mitsuo Tokuhara,Masaaki Shimatani,Kazunari Tominaga,Hiroko Nakahira,Takuya Ohtsu,Katsuyasu Kouda,Makoto Naganuma 대한소화기내시경학회 2023 Clinical Endoscopy Vol.56 No.5
Background/Aims: Endoscopic resection of all colorectal adenomatous lesions with a low complication rate, simplicity, and negativeresiduals is challenging. Hence, we developed a new method called “non-injection resection using bipolar soft coagulation mode(NIRBS)” method, adapted for colorectal lesions. In addition, we evaluated the effectiveness of this method. Methods: We performed NIRBS throughout a 12-month period for all colorectal lesions which snare resection was acceptable withoutcancerous lesions infiltrating deeper than the submucosal layer. Results: A total of 746 resected lesions were included in the study, with a 4.5 mm mean size (range, 1–35 mm). The major pathologicalbreakdowns were as follows: 64.3% (480/746) were adenomas, and 5.0% (37/746) were intraepithelial adenocarcinomas (Tis lesions). Noresiduals were observed in any of the 37 Tis lesions (mean size, 15.3 mm). Adverse events included bleeding (0.4%) but no perforation. Conclusions: NIRBS allowed the resection of multiple lesions with simplicity because of the non-injection and without perforating dueto the minimal burn effect of the bipolar snare set in the soft coagulation mode. Therefore, NIRBS can be used to resect adenomatouslesions easily, including Tis lesions, from small to large lesions without leaving residuals.
Synthesis and electrical conductivity of bulk tetra-valent cerium pyrophosphate
Hiroaki Onoda,Yousuke Inagaki,Akihide Kuwabara,Naoto Kitamura,Koji Amezawa,Atsushi Nakahira,Isao Tanaka 한양대학교 세라믹연구소 2010 Journal of Ceramic Processing Research Vol.11 No.3
Tetra-valent cerium pyrophosphate was synthesized from cerium oxide and phosphoric acid by heating. The sintering processes, pressure-less sintering (PLS), spark plasma sintering (SPS), and hydrothermal hot pressing (HHP), were attempted to form bulk pyrophosphate. Furthermore, the electrical conductivity of bulk cerium pyrophosphate was investigated. Tetravalent cerium pyrophosphate was synthesized by heating at 700 oC for 20 hours. The hydrothermal hot pressing process was a suitable method to synthesize bulk tetra-valent cerium phosphate.