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RISS 인기검색어
- 검색키워드
- 저자 : N. Rajendran (검색결과 5 건)
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Anti-tumor Activity of Acanthospermum hispidum DCon Dalton Ascites Lymphoma in Mice
N. Deepa,N.N. Rajendran 한국생약학회 2007 Natural Product Sciences Vol.13 No.3
present study investigated the anti-tumor activity of ethyl acetate extract of Acanthospermumhispidum DC against daltons ascites lymphoma in mice. The extract was prepared by cold maceration with ethylacetate for 3 - 7 days and evaporated in vacuum to dry. (Yield : 14.2 g, 1.42% w/w). The extract was fractionatedby column chromatography by using gradient elution technique and the diterpenes fraction isolated (0.649 g).Both extract and the fraction were administered as oral suspension with tween 20 in water to tumor bearing mice(DAL) and changes in dead cell count, histopathology of tumor cells, hematological parameters and mediansurvival time (MST) were examined and compared with that of tumor control or 5-Fluorouracil (5-FU). Theresults indicate that both ethyl acetate extract and fraction posses anti-tumor activity. The study suggests thatAcanthospermum hispidum DC sems promising as a source of diterpenes for potential anti-tumor activity.KeywordsAcanthospermum hispidum DC, anti-tumor activity, Daltons ascites lymphoma, ethyl acetate extract,diterpenes
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Design of a Smart Safety Vest Incorporated With Metal Detector Kits for Enhanced Personal Protection
Rajendran, Salini D.,Wahab, Siti N.,Yeap, Swee P. Occupational Safety and Health Research Institute 2020 Safety and health at work Vol.11 No.4
Background: Personal protective equipment (PPE) has been designed in such a way to reduce accident rates. Unfortunately, existing PPE is rather ineffective as it is not able to provide warning signals when hazard is around. The integration of intelligent systems is envisaged to increase the efficiency of existing PPE. Methods: This project designed a safety vest incorporated with metal detectors which can provide immediate warning to the field workers when there is metal hazard around. This product has greater freedom of design via smart manufacturing as it involves the assembly of few commercially available parts into a single entity. Briefly, the metal detector is a do it yourself (DIY) kit, and the safety vest is purchasable from any local market. The DIY kit was connected to a copper coil and being sewed into the safety vest. Results: The metal detector induces beeping sound when there is metal hazard around. A total of 121 engineering students were introduced to the prototype before being requested to answer a survey associated with the design. Respondents have rated >3.00/5.00 for the design simplicity, ease of usage, and light weight. Meanwhile, respondents suggested that the design should be further improved by increasing the metal detection range. Conclusion: It is envisaged that the introduction of this smart safety vest will allow the workers to carry out their duties securely by reducing the accident rates. Particularly, such design is expected to reduce workplace accident especially during night time at construction sites where the visibility is low.
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Targeting Epigenetic ‘Readers’ with Natural Compounds for Cancer Interception
Elisabetta Damian,Munevver N. Duran,Nivedhitha Mohan,Praveen Rajendran,Roderick H. Dashwood 대한암예방학회 2020 Journal of cancer prevention Vol.25 No.4
Natural compounds from diverse sources, including botanicals and commonly consumed foods and beverages, exert beneficial health effects via mechanisms that impact the epigenome and gene expression during disease pathogenesis. By targeting the socalled epigenetic ‘readers’, ‘writers’, and ‘erasers’, dietary phytochemicals can reverse abnormal epigenome signatures in cancer cells and preneoplastic stages. Thus, such agents provide avenues for cancer interception via prevention or treatment/therapeutic strategies. To date, much of the focus on dietary agents has been directed towards writers (e.g., histone acetyltransferases) and erasers (e.g., histone deacetylases), with less attention given to epigenetic readers (e.g., BRD proteins). The drug JQ1 was developed as a prototype epigenetic reader inhibitor, selectively targeting members of the bromodomain and extraterminal domain (BET) family, such as BRD4. Clinical trials with JQ1 as a single agent, or in combination with standard of care therapy, revealed antitumor efficacy but not without toxicity or resistance. In pursuit of second-generation epigenetic reader inhibitors, attention has shifted to natural sources, including dietary agents that might be repurposed as ‘JQ1-like’ bioactives. This review summarizes the current status of nascent research activity focused on natural compounds as inhibitors of BET and other epigenetic ‘reader’ proteins, with a perspective on future directions and opportunities. Key Words Bromodomains, Chromodomains, Cancer prevention, Epigenetics, Natural compounds
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A. Madhankumar,S. Nagarajan,N. Rajendran,T. Nishimura 대한금속·재료학회 2012 METALS AND MATERIALS International Vol.18 No.6
This work examines the effect of silicon (Si) nanoparticles on the corrosion protection performance of epoxy coating over carbon steel by Electrochemical Impedance Spectroscopy (EIS) and Transmission Electron Microscopy. The EIS was performed in a 0.1 M NaCl solution after a wet/dry cyclic corrosion and continuous immersion test. The addition of Si nanoparticles increased the film resistance (Rf) and the charge transfer resistance (Rct) of the coated steel. The surface analysis showed that uniform and fine Si-Fe complex oxides layers were formed acting as barrier layers that enhanced the corrosion protection of the coated steel in the wet/dry cyclic corrosion test. The results of the EIS of the coated steel with Si nanoparticles suggested that Si nanoparticles play a beneficial role in enhancing the corrosion resistance of organic coated steel.
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Kirupa Sankar Muthuvelu,Baranitharan Ethiraj,Shreyasi Pramnik,N. Keerthish Raj,Swethaa Venkataraman,Devi Sri Rajendran,Priyadharshini Bharathi,Elakiya Palanisamy,Anusri Sathiya Narayanan,Vinoth Kumar 한국식품과학회 2023 Food Science and Biotechnology Vol.32 No.10
Despite centuries of developing strategies to prevent food-associated illnesses, food safety remains a significant concern, even with multiple technological advancements. Consumers increasingly seek less processed and naturally preserved food options. One promising approach is food biopreservation, which uses natural antimicrobials found in food with a long history of safe consumption and can help reduce the reliance on chemically synthesized food preservatives. The hurdle technology method that combines multiple antimicrobial strategies is often used to improve the effectiveness of food biopreservation. This review attempts to provide a research summary on the utilization of lactic acid bacteria, bacteriocins, endolysins, bacteriophages, and biopolymers helps in the improvement of the shelf-life of food and lower the risk of food-borne pathogens throughout the food supply chain. This review also aims to evaluate current technologies that successfully employ the aforementioned preservatives to address obstacles in food biopreservation.
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