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MUSTAFAYEV, SHAHIN Academia Via Serica 2018 Acta Via Serica Vol.3 No.2
The Silk Road usually implies a network of trade and communications that stretched from east to west and connected China and the countries of the Far East via Central Asia and the Middle East to the eastern Mediterranean, or through the northern coast of the Caspian Sea and the Volga basin to the Black Sea coast. However, at certain historical stages, a network of maritime and overland routes stretching from north to south, commonly called the Volga-Caspian trade route, also played a significant role in international trade and cultural contacts. The geopolitical realities of the early Middle Ages relating to the relationship of Byzantium, the Sassanid Empire, and the West Turkic Khaganate, the advance of the Arab Caliphate to the north, the spread of Islam in the Volga region, the glories and fall of the Khazar State, and the Scandinavian campaigns in the Caucasus, closely intertwined with the history of transport and communications connecting the north and south through the Volga-Caspian route. In a later era, the interests of the Mongolian Uluses, and then the political and economic aspirations of the Ottoman Empire, the Safavid State, and Russia, collided or combined on these routes. The article discusses trade contacts existing between the north and the south in the 15th and first half of the 17th century along the routes on the western coast of the Caspian Sea.
THE SILK TRADE FROM ILKHANIDS TO AQQOYUNLU
MUSTAFAYEV, SHAHIN Academia Via Serica 2016 Acta Via Serica Vol.1 No.1
The initial phase of the Mongol invasion resulted in the establishment of relative political stability in the vast expanses of Eurasia, which came under the control of a single political entity - the Mongol realm. This contributed to a fairly rapid restoration of the commercial links and trade routes between the East and the West. During this period, Chinese silk again became available in large quantities in the Western markets. At the same time, the beginning of silk production and manufacturing of silk fabrics in Italy and the fashion flash for these goods in Western countries affected trade between Europe and the Muslim world. The centers of silk production in the Ilkhanid Empire were some provinces of Azerbaijan and Persia, where from it was exported in large numbers along the trade routes of Anatolia and Syria to the Mediterranean ports and further to the west. There are numerous testimonies of European travelers, and Muslim authors related the international silk trade in 13th-15th centuries, ie in the era from the Mongol Ilkhanid Empire till the reign of the Turkman Aqqoyunlu dynasty. One of the most informative documentary sources on this issue are the legislative codes (kanuname) of sultan Uzun Hasan from the Aqqoyunlu dynasty regarding the eastern provinces of the Asia Minor. This article presents and analyzes the information from these documents concerning the whole range of goods related to silk and silk fabrics trade in the period under the consideration.
Evaluation of response to stereotactic radiosurgery in patients with radioresistant brain metastases
Sayan, Mutlay,Mustafayev, Teuta Zoto,Sahin, Bilgehan,Kefelioglu, Erva Seyma Sare,Wang, Shang-Jui,Kurup, Varsha,Balmuk, Aykut,Gungor, Gorkem,Ohri, Nisha,Weiner, Joseph,Ozyar, Enis,Atalar, Banu The Korean Society for Radiation Oncology 2019 Radiation Oncology Journal Vol.37 No.4
Purpose: Renal cell carcinoma (RCC) and melanoma have been considered 'radioresistant' due to the fact that they do not respond to conventionally fractionated radiation therapy. Stereotactic radiosurgery (SRS) provides high-dose radiation to a defined target volume and a limited number of studies have suggested the potential effectiveness of SRS in radioresistant histologies. We sought to determine the effectiveness of SRS for the treatment of patients with radioresistant brain metastases. Materials and Methods: We performed a retrospective review of our institutional database to identify patients with RCC or melanoma brain metastases treated with SRS. Treatment response were determined in accordance with the Response Evaluation Criteria in Solid Tumors. Results: We identified 53 radioresistant brain metastases (28% RCC and 72% melanoma) treated in 18 patients. The mean target volume and coverage was 6.2 ± 9.5 mL and 95.5% ± 2.9%, respectively. The mean prescription dose was 20 ± 4.9 Gy. Forty lesions (75%) demonstrated a complete/partial response and 13 lesions (24%) with progressive/stable disease. Smaller target volume (p < 0.001), larger SRS dose (p < 0.001), and coverage (p = 0.008) were found to be positive predictors of complete response to SRS. Conclusion: SRS is an effective management option with up to 75% response rate for radioresistant brain metastases. Tumor volume and radiation dose are predictors of response and can be used to guide the decision-making for patients with radioresistant brain metastases.
Gamze Ugurluer,Teuta Zoto Mustafayev,Gorkem Gungor,Banu Atalar,Ufuk Abacioglu,Meric Sengoz,Fulya Agaoglu,Gokhan Demir,Enis Ozyar 대한방사선종양학회 2021 Radiation Oncology Journal Vol.39 No.1
Purpose: We aimed to present our initial clinical experience on the implementation of a stereotactic M2021-04-26methods for treatment of liver metastases in oligometastatic disease with the advantages of better visualization of soft tissue, real-time tumor tracking and potentially reduced toxicity to organs at risk.
Mutlay Sayan,Teuta Zoto Mustafayev,Aykut Balmuk,Swati Mamidanna,Erva Seyma Sare Kefelioglu,Gorkem Gungor,Anupama Chundury,Nisha Ohri,Ercan Karaarslan,Enis Ozyar,Banu Atalar 대한방사선종양학회 2020 Radiation Oncology Journal Vol.38 No.3
Purpose: Approximately 10% of patients who received brain stereotactic radiosurgery (SRS) develop symptomatic radiation necrosis (RN). We sought to determine the effectiveness of treatment options for symptomatic RN, based on patient-reported outcomes. Materials and Methods: We conducted a retrospective review of 217 patients with 414 brain metastases treated with SRS from 2009 to 2018 at our institution. Symptomatic RN was determined by appearance on serial magnetic resonance images (MRIs), MR spectroscopy, requirement of therapy, and development of new neurological complaints without evidence of disease progression. Therapeutic interventions for symptomatic RN included corticosteroids, bevacizumab and/or surgical resection. Patient-reported therapeutic outcomes were graded as complete response (CR), partial response (PR), and no response. Results: Twenty-six patients experienced symptomatic RN after treatment of 50 separate lesions. The mean prescription dose was 22 Gy (range, 15 to 30 Gy) in 1 to 5 fractions (median, 1 fraction). Of the 12 patients managed with corticosteroids, 6 patients (50%) reported CR and 4 patients (33%) PR. Of the 6 patients managed with bevacizumab, 3 patients (50%) reported CR and 1 patient (18%) PR. Of the 8 patients treated with surgical resection, all reported CR (100%). Other than surgical resection, age ≥54 years (median, 54 years; range, 35 to 81 years) was associated with CR (odds ratio = 8.40; 95% confidence interval, 1.27-15.39; p = 0.027). Conclusion: Corticosteroids and bevacizumab are commonly utilized treatment modalities with excellent response rate. Our results suggest that patient’s age is associated with response rate and could help guide treatment decisions for unresectable symptomatic RN.