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Epinephrine 첨가 Lidocaine 에 의한 액와신경차단시 발생한 Potassium 감소에 대한 Propranolol 의 영향
윤재승,이강창,김태요,임홍섭 대한마취과학회 1989 Korean Journal of Anesthesiology Vol.22 No.3
Recently, interest has been increased on the role of catecholamines in extrarenal potassium homeostasis. This study has undertaken to investigate the effects of epinephrine added to lidocaine for axillary block in HR, MAP, ABG, blood sugar and electrolytes (Na+, K+), and the effects of propranolol, β-adrenergic blocker, on the data. The patients admitted to our hospital for operation of upper extremities were divided into three groups. Group I was 10 patients blocked with lidocaine 30 ml. Group II was 14 patients blocked with lidocaine 30 ml with epinephrine 0.3 mg(1:100,000). Group III was 10 patients pretreated with propranolol (10μ/kg) and blocked with lidocaine 30 ml with epinephrine. After block, the results were as follows. 1) MAP decreased in all group and group III decreased more than group I. 2) HR increased all group and group III decreased more than group I. 3) ABG showed hypoventilatory pattern due to sedative effect by diazepam (0.15mg/kg). 4) Blood sugar value was increased in group I and IIshowed increasing tendency in group III, but this tendency was not significant. 5) Blood K+ concentration decreased significantly and the maximal decrease was 0.5 mEq/L in 30 min after block, but there was not significant decrease in group III. This results indicate that clinical dose of epinephrine(1;100,000) decrease blood K+ concentration significantly and propranolol (10μ/kg) pretreatment prevent K+ decreasing effect of epinephrine. In clinical practice, it is suggested that much care must be paid to use of local anesthetics with epinephrine to hypokalemic patients.
Diabetic Retinopathy and Endothelial Dysfunction in Patients with Type 2 Diabetes Mellitus
윤재승,고승현,김지훈,문건웅,박용문,유기동,안유배 대한당뇨병학회 2013 Diabetes and Metabolism Journal Vol.37 No.4
Background: We investigated the relationship between endothelial dysfunction and diabetic retinopathy (DR) in patients with type 2 diabetes. Methods: We used a cross-sectional design to examine 167 patients with type 2 diabetes mellitus. All patients underwent biochemical and ophthalmological examination. We assessed endothelial dysfunction by a flow-mediated vasodilation method of the brachial artery. Changes in vasodilation (flow-mediated vasodilatation, %FMD) were expressed as percent change over baseline values. Results: The mean±standard deviation of patient age was 54.1±8.6 years. The %FMD was significantly lower in patients with DR than without DR. The prevalence of retinopathy decreased across increasing tertiles of %FMD. After adjusting for patients’age, sex, diabetes duration, use of insulin, use of antihypertensive, antiplatelet, and lipid lowering medications, systolic blood pressure, fasting plasma glucose, 2-hour plasma glucose, glycated hemoglobin, and urinary albumin excretion, participants with a reduced %FMD were more likely to have DR (odds ratio, 11.819; 95% confidence interval, 2.201 to 63.461; P=0.004, comparing the lowest and highest tertiles of %FMD). Conclusion: Endothelial dysfunction was associated with DR, which was most apparent when the endothelial dysfunction was severe. Our study provides insights into the possible mechanism of the influence of endothelial dysfunction on the development of DR.
윤재승,송희선 대한마취과학회 1976 Korean Journal of Anesthesiology Vol.9 No.2
Malignant hyperthermia is a well-recognized syndrome of uncertain etiology. The confusing facts are: the variety and different nature of the triggering agents, the variation in time of onset of rigidity and fever coupled with a variation in response to succinylcholine, the lack of family history in some patients, and its occurence in some who have had previously normal general anesthetics. A case is a 23 year old relatively healthy male patient in whom subtotal gastrectomy was performed under N2O-O2-ether and gallamine anesthesia with induction after pentothal sodium and succinylcholine. This was complicated by an abrupt, high rise in body temperature, muscle rigidity, flushing with peripheral cyanosis, disseminated intravascular coagulation and hyperpnea 40 minutes after induction. He died 3 hours after cessation of anesthesia without effective responce to any active antipyretic therapy. The etiologic factors, incidence, clinical feature, prevention, treatment and prognosis of malignant hyperthermia are discussed.
Diabetic Retinopathy and Endothelial Dysfunction in Patients with Type 2 Diabetes Mellitus
윤재승,고승현,김지훈,문건웅,박용문,유기동,안유배 대한당뇨병학회 2013 Diabetes and Metabolism Journal Vol.37 No.6
Background We investigated the relationship between endothelial dysfunction and diabetic retinopathy (DR) in patients with type 2 diabetes. Methods We used a cross-sectional design to examine 167 patients with type 2 diabetes mellitus. All patients underwent biochemical and ophthalmological examination. We assessed endothelial dysfunction by a flow-mediated vasodilation method of the brachial artery. Changes in vasodilation (flow-mediated vasodilatation, %FMD) were expressed as percent change over baseline values. Results The mean±standard deviation of patient age was 54.1±8.6 years. The %FMD was significantly lower in patients with DR than without DR. The prevalence of retinopathy decreased across increasing tertiles of %FMD. After adjusting for patients' age, sex, diabetes duration, use of insulin, use of antihypertensive, antiplatelet, and lipid lowering medications, systolic blood pressure, fasting plasma glucose, 2-hour plasma glucose, glycated hemoglobin, and urinary albumin excretion, participants with a reduced %FMD were more likely to have DR (odds ratio, 11.819; 95% confidence interval, 2.201 to 63.461; P=0.004, comparing the lowest and highest tertiles of %FMD). Conclusion Endothelial dysfunction was associated with DR, which was most apparent when the endothelial dysfunction was severe. Our study provides insights into the possible mechanism of the influence of endothelial dysfunction on the development of DR.
윤재승,전순익,채종석,Yun, Jae-Seung,Jeon, Sun-Ik,Chae, Jong-Seok 통신위성우주산업연구회 2002 Joint Conference on Satellite Communications Vol.2002 No.-
이동위성 인터넷 시스템을 위한 양방향 위상 배열 안테나로 송수신 겸용 마이크로스티립 구조의 안테나를 개발 중에 있다. 기존의 기계식 안테나에 비하여 빔 포밍이 가능한 전자식 안테나를 구현함으로써 이동에 따른 추적 성능을 향상시켜 보다 안정적인 통신 성능을 얻을 수 있다. 이 배열 안테나 모듈의 소자 수는 방위각과 앙각 방향에서의 빔 스캔 각도에 의해 결정되었고, 위성 인터넷의 수신과 DBS 위성 수신을 겸할 수 있도록 수신부는 광대역으로 설계되었다. 적층된 패치 안테나를 사용하여 광대역 특성을 갖고 고 이득의 배열 안테나를 얻었으며, 송수신 급전 층을 분리함으로써 높은 격리도를 얻을 수 있었다. A dual TX/RX microstrip array antenna is under development for a two-way phased array antenna of the mobile satellite internet system. Compared to the conventional mechanical antenna, this approach can achieve a better communication performance as well as stability through enhancement of tracking performance by and electrical beam forming. The element numbers in array antenna module were determined from the beam scan angle requirement in azimuth and elevation. RX antennas are designed wideband to accommodate reception of both Internet data and DBS signal. A wideband return loss characteristics and high gain were obtained by applying stacked patch antenna structure, A good isolation was achieved as well by separating the feed layers of TX and RX.