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Study on the Lethal Reason of Overwintering Weedy Rice Seed in Cold Rice Production Area in China
Ming-gen Wu,Jie Yang,De-liang Yang,Feng Xu,Min-jie Fu 한국잡초학회 2011 한국잡초학회 별책(학술대회 초록집) Vol.31 No.2
The outdoor trails were carried out to investigate overwintering survival rate of different weedy rice seeds in two latitude areas including Longjing city located in Jilin province and Donggang city located in Liaoning province in China, respectively. The survival rates of all weedy rice seeds which were frozen under the condition of saturated soil for 3 months are about 0%. The germination rates of weedy rice seeds overwintering in air-dried soil are more than 50%. The death of overwintering weedy rice seed in the two production areas was positively related to its dormancy characteristic, seed water content and temperature during seed frozen period.
MicroRNA-3200-5p Promotes Osteosarcoma Cell Invasion via Suppression of BRMS1
Li, Gen,Li, Li,Sun, Qi,Wu, Jiezhou,Ge, Wei,Lu, Guanghua,Cai, Ming Korean Society for Molecular and Cellular Biology 2018 Molecules and cells Vol.41 No.6
Tumour metastasis is one of the most serious challenges of cancer as it is the major cause of mortality in patients with solid tumours, including osteosarcoma (OS). In this regard, anti-metastatic genes have potential for metastasis inhibition strategies. Recent evidence showed the importance of breast cancer metastasis suppressor 1 (BRMS1) in control of OS invasiveness, but the regulation of BRMS1 in OS remains largely unknown. Here, we used bioinformatics analyses to predict BRMS1-targeting microRNAs (miRNAs), and the functional binding of miRNAs to BRMS1 mRNA was evaluated using a dual luciferase reporter assay. Among all BRMS1-targeting miRNAs, only miR-151b, miR-7-5p and miR-3200-5p showed significant expression in OS specimens. Specifically, we found that only miR-3200-5p significantly inhibited protein translation of BRMS1 via pairing to the 3'-UTR of the BRMS1 mRNA. Moreover, we detected significantly lower BRMS1 and significantly higher miR-3200-5p in the OS specimens compared to the paired adjacent non-tumour bone tissues. Furthermore, BRMS1 and miR-3200-5p levels were inversely correlated to each other. Low BRMS1 was correlated with metastasis and poor patient survival. In vitro, overexpression of miR-3200-5p significantly decreased BRMS1 levels and promoted OS cell invasion and migration, while depletion of miR-3200-5p significantly increased BRMS1 levels and inhibited OS cell invasion and migration. Thus, our study revealed that miR-3200-5p may be a critical regulator of OS cell invasiveness.
오명근,김길웅,신동현,Wu, Ming-Gen,Kim, Kil-Ung,Shin, Dong-Hyun 한국잡초학회 1998 Weed&Turfgrass Science Vol.18 No.2
본(本) 연구(硏究)는 벼 건답직파재배(乾畓直播栽培) 잡초방제(雜草防除)에 우수한 경엽처리형(莖葉處理型) 혼합제초제(混合除草劑)를 선발(選拔)하기 위해 3원(元) 2차(次) UPCCD계획법(計劃法)을 이용(利用)하여 건답직파재배(乾畓直播栽培)에서 문제(問題)가 되고 있는 피, 너도방동사니 등의 잡초(雜草)를 방제대상(防除對象)으로 cyhalofop, bispyribenzoxim, pyrazosulfuron 간(間)의 상호작용(相互作用) 및 혼합효과(混合效果)를 구명(究明)함과 아울러 제초제분야(除草劑分野)에서 UPCCD계획법(計劃法)의 활용가능성(活用可能性)을 검토(檢討)하였다. (1)제초제분야(除草劑分野)에서 직선(直線) 및 2차곡선(次曲線) 관계(關係)를 나타내는 반응(反應)또는 비수식(指數式), 대수식(對數式) 관계(關係)를 나타내는 반응(反應)이라도 혼합제초제(混合除草劑)의 처리량(處理量) 범위(範圍)를 적당(適當)히 선정(選定)하면 UPCC계획법(計劃法)을 응용(應用)하여 제초제간(除草劑間)의 상호작용(相互作用) 및 혼합제(混合劑)의 혼합효과(混合效果) 분석(分析)은 가능(可能)하였다. (2) 제초제(除草劑) cyhalofop, bispyribenzoxim 및 pyrazosulfuron 혼합처리시(混合處理時) 피에 대한 억제효과(抑制效果)는 cyhalofop, bispyribenzoxim, pyrazosulfuron 순(順)이었고 제초제간(除草劑間)에 상가작용(相加作用)이 존재하는 동시(同時)에 cyhalofop와 bispyribenzoxim 간(間)에 역상호작용(逆相互作用)이 존재하여 "부분적 상가작용(相加作用)"이 검정(檢定)되었다. (3) 너도방동사니에 대한 억제효과(抑制效果)는 pyrazosulfuron, bispyribenzoxim 순(順)이었고 cyhalofop의 억제효과(抑制效果)는 인정되지 않았으며, pyrazosulfuron과 bispyribenzoxim 간(間)에는 상가작용(相加作用)이 있었다. (4) 사마귀풀에 대한 억제효과(抑制效果)는 bispyribenzoxim, pyrazosulfuron 순(順)이었고 cyhalofop의 억제효과(抑制效果)는 인정되지 않았으며 bispyribenzoxim과 pyrazosulfuron 간(間)에 상가적작용(相加的作用)이 있었다. 피, 너도방동사니 및 사마귀풀 등의 3종(種) 잡초(雜草)의 $ED_{90}$을 나타내는 cyhalofop+bispyribenzoxim+pyrazosulfuron 적정혼합(適正混合) 처리량(處理量)은 100+12+10g ai/ha 이었다. This study was conducted to develop a foliar applied herbicide mixture covering wide spectrum weeds in dry direct seeded rice. Uniform precision central composite design(UPCCD) was employed to evaluate the effect of herbicide mixture among cyhalofop-butyl(cyhalofop), bispyribenzoxim and pyrazosulfuron-ethyl(pyrazosulfuron) having different weed control spectrum and to determine the best application rates of the three herbicide mixtures. The partial additive effect was observed in the mixture of cyhalofop and bispyribenzoxim with pyrazosulfron against Echinochloa crus-galli Beauv var crus-galli L., attributed to the negative interaction between cyhalofop and bispyribenzoxim system. Additive effect was observed in the mixture of bispyribenzoxim and pyrazosulfuron against Cyperus serotinus R. and Aneilema keisak H. but cyhalofop had no effect on these weeds. The most appropriate rate of the mixture of cyhalofop with bispyribenzoxim and pyrazosulfuron was 100 : 12 : 10g ai/ha exhibiting $ED_{90}$ against three weeds such as E. crus-galli, C. serotinus and A. keisak.
Qing-Hua Tian,Chun-Gen Wu,Quan-Ping Xiao,Cheng-Jian He,Yi-Feng Gu,Tao Wang,Ming-Hua Li 대한영상의학회 2014 Korean Journal of Radiology Vol.15 No.6
Glucocorticosteroid-induced osteoporosis is the most frequent of all secondary types of osteoporosis, and can increase the risk of vertebral compression fractures (VCFs). There are promising additions to current medical treatment for appropriately selected osteoporotic patients. Few studies have reported on the efficiency of percutaneous vertebroplasty (PVP) or kyphoplasty for whole thoracic and lumbar glucocorticosteroid-induced osteoporotic vertebral compression fractures. We report a case of a 67-year-old man with intractable pain caused by successional VCFs treated by PVP.
Percutaneous Osteoplasty for the Management of a Femoral Head Metastasis: a Case Report
Wei-Guo Wang,Chun-Gen Wu,Yi-Feng Gu,Ming-Hua Li 대한영상의학회 2009 Korean Journal of Radiology Vol.10 No.6
Percutaneous osteoplasty (POP) as a technical extension of percutaneous vertebroplasty (PVP) has been used to treat malignant disease that affects the skeletal system. POP has demonstrated good outcome for pain relief and functional improvement. Few studies have reported on the efficiency of POP to treat malignancies located in the femoral head. We designed a pilot study with the use of POP to treat intractable pain caused by a femoral head metastatic tumor in a 43-year-old man. During the follow-up period, the patient experienced sustained pain relief and improvement of quality of life that persisted for more than three months.
Percutaneous Sacroplasty for Sacral Metastatic Tumors Under Fluoroscopic Guidance Only
Ji Zhang,Chun-gen Wu,Yi-feng Gu,Ming-hua Li 대한영상의학회 2008 Korean Journal of Radiology Vol.9 No.6
Percutaneous sacroplasty is a safe and effective procedure for sacral insufficient fractures under CT or fluoroscopic guidance; although, few reports exist about sacral metastatic tumors. We designed a pilot study to treat intractable pain caused by a sacral metastatic tumor with sacroplasty. A 62-year-old man and a 38-year-old woman with medically intractable pain due to metastatic tumors of S1 from lymphoma and lung cancer, respectively, underwent percutaneous sacroplasty. Over the course of the follow-up period, the two patients experienced substantial and immediate pain relief that persisted over a 3-month and beyond. The woman had deposition of PMMA (polymethyl methacrylate) in the needle track, but did not experience significant symptoms. No other peri-procedural complications were observed for either patient.
Chyong-Huey Lai,Elizabeth Vallikad,Hao Lin,Lan-Yan Yang,Shih-Ming Jung,Hsueh-Erh Liu,Yu-Che Ou,Hung-Hsueh Chou,Cheng-Tao Lin,Huei-Jean Huang,Kuan-Gen Huang,Jiantai Qiu,Yao-Ching Hung,Tzu-I Wu,Wei-Yang 대한부인종양학회 2020 Journal of Gynecologic Oncology Vol.31 No.1
Objectives: An Asian Gynecologic Oncology Group phase III randomized trial was conducted to determine whether maintenance chemotherapy could improve progression-free survival (PFS) in stages III/IV ovarian cancer. Methods: Between 2007 and 2014, 45 newly-diagnosed ovarian cancer patients were enrolled after complete remission and randomized (1:1) to arm A (4-weekly carboplatin area under the curve 4 and pegylated liposomal doxorubicin [PLD] 30 mg/m2, n=24) for 6 cycles or arm B (observation, n=21). The primary end-point was PFS. A post hoc translational study was conducted to deep sequence BRCA/homologous recombination deficiency (HRD) genes, because BRCA/HRD mutations (BRCA/HRDm) are known to be associated with better prognosis. Results: Enrollment was slow, accrual was closed when 7+ years had passed. With a median follow-up of 88.9 months, the median PFS was significantly better in arm A (55.5 months) than arm B (9.2 months) (hazard ratio [HR]=0.40; 95% confidence interval [CI]=0.19–0.87; p=0.020), yet the median overall survival was not significantly different in arm A (not reached) than arm B (95.1 months) (p=0.148). Overall grade 3/4 adverse events were more frequent in arm A than arm B (60.9% vs 0.0%) (p<0.001). Quality of life was generally not significantly different. Distribution of BRCA1/2m or BRCA/HRDm was not significantly biased between the two arms. Wild-type BRCA/non-HRD subgroup seemed to fare better with maintenance therapy (HR=0.35; 95% CI=0.11–1.18; p=0.091). Conclusions: Despite limitations in small sample size, it suggests that maintenance carboplatin-PLD chemotherapy could improve PFS in advanced ovarian cancer.