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- 저자 : Michael Strupp (검색결과 4 건)
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Michael Strupp,Katharina Feil,Stanislavs Bardins,Raphaela Waidelich 대한배뇨장애요실금학회 2014 International Neurourology Journal Vol.18 No.4
Aminopyridines are potassium channel blockers that increase the excitability of nerve cells and axons; therefore, they arewidely used to treat different neurological disorders. Here we present a patient with idiopathic downbeat nystagmus and lowerurinary tract symptoms (LUTS) due to benign prostatic hyperplasia who was treated with the sustained-release form of4-aminopyridine (4-AP). During treatment with 4-AP, the LUTS improved. This improvement was monitored by using uroflowmetryand the International Prostate Symptom Score. A significant improvement of symptoms was observed in relationto the voided volume. This included an improved emptying of the bladder without an increase in residual urine. In animalstudies, both nonselective K+ channel blockade and selective voltage-sensitive potassium blockade by 4-AP resulted in increasedcontraction on rat detrusor strips. To our knowledge, this is the first clinical observation of the mode of action of 4-APin urological symptoms in humans.
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Conjugate Eye Deviation in Unilateral Lateral Medullary Infarction
Julian Teufel,Michael Strupp,Jennifer Linn,Roger Kalla,Katharina Feil 대한신경과학회 2019 Journal of Clinical Neurology Vol.15 No.2
Background and Purpose The initial diagnosis of medullary infarction can be challenging since CT and even MRI results in the very acute phase are often negative. Methods A retrospective, observer-blinded study of horizontal conjugate eye deviation was performed in 1) 50 consecutive patients [age 58±15 years (mean±SD), 74% male, National Institutes of Health Stroke Scale 2±1] with acute unilateral lateral medullary infarction as seen in MRI (infarction group), 2) 54 patients with transient brainstem symptoms [transient ischemic attack of brainstem (TIA) group; age 69±16 years, 59% male], and 3) 53 patients (age 59±20 years, 49% male) with diagnoses other than stroke (control group). Results Conjugate eye deviation was found in all patients in the infarction group [n=47 (94%) with ipsilesional deviation and n=3 (6%) with contralesional deviation] compared to 41% (n=22) in the brainstem TIA group and 15% (n=8) in the control group (p<0.0001). Within all groups mean deviation and range were similar for both sides (to the right vs. to the left side 26.6°±12.3 vs. 26.1°±12.3 in the infarction group, 10.5°±5.8 vs. 8.4°±6.3 in the brainstem TIA group and 4.5°±3.2 vs. 7.5°±3.2 in the control group). The extent of eye deviation was significantly greater in the infarction group (p<0.05). Conclusions All patients with MRI-demonstrated unilateral medullary infarction showed conjugate eye deviation. Therefore, conjugate eye deviation in patients with suspected acute lateral medullary infarction is a helpful sensitive sign for supporting the diagnosis, particularly if the deviation is >20°.
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Nicolina Goldschagg,Tatiana Bremova-Ertl,Stanislav Bardins,Nora Dinca,Katharina Feil,Siegbert Krafczyk,Stefan Lorenzl,Michael Strupp 대한신경과학회 2019 Journal of Clinical Neurology Vol.15 No.3
Background and Purpose Conflicting results about vestibular function in progressive supranuclear palsy (PSP) prompted a systematic examination of the semicircular canal function, otolith function, and postural stability. Methods Sixteen patients with probable PSP [9 females, age=72±6 years (mean±SD), mean disease duration=3.6 years, and mean PSP Rating Scale score=31] and 17 age-matched controls were examined using the video head impulse test, caloric testing, ocular and cervical vestibular evoked myogenic potentials (o- and cVEMPs), video-oculography, and posturography. Results There was no evidence of impaired function of the angular vestibulo-ocular reflex (gain=1.0±0.1), and caloric testing also produced normal findings. In terms of otolith function, there was no significant difference between PSP patients and controls in the absolute peakto- peak amplitude of the oVEMP (13.5±7.2 μV and 12.5±5.6 μV, respectively; p=0.8) or the corrected peak-to-peak amplitude of the cVEMP (0.6±0.3 μV and 0.5±0.2 μV, p=0.3). The total root-mean-square body sway was significantly increased in patients with PSP compared to controls (eyes open/head straight/hard platform: 9.3±3.7 m/min and 6.9±2.1 m/min, respectively; p=0.032). As expected, the saccade velocities were significantly lower in PSP patients than in controls: horizontal, 234±92°/sec and 442±66°/sec, respectively; downward, 109±105°/sec and 344±72°/sec; and upward, 121±110°/sec and 348±78°/sec (all p<0.01). Conclusions We found no evidence of impairment of either high- or low-frequency semicircular function or otolith organ function in the examined PSP patients. It therefore appears that other causes such as degeneration of supratentorial pathways lead to postural imbalance and falls in patients with PSP.
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Jose A. Lopez-Escamez,John Careyb,Won-Ho Chung,Joel A. Goebeld,Måns Magnusson,Marco Mandalà,David E. Newman-Tokerg,Michael Strupp,Mamoru Suzuki,Franco Trabalzini,Alexandre Bisdorff 대한평형의학회 2015 Research in Vestibular Science Vol.14 No.3
This paper presents diagnostic criteria for Ménierè’s disease jointly formulated by the Classification Committee of the Bárány Society, The Japan Society for Equilibrium Research, the European Academy of Otology and Neurotology, the Equilibrium Committee of the American Academy of Otolaryngology-Head and Neck Surgery, and the Korean Balance Society. The classification includes two categories: definite Ménière's disease and probable Menière's disease. The diagnosis of definite Ménière's disease is based on clinical criteria and requires the observation of an episodic vertigo syndrome associated with low- to me-dium-frequency sensorineural hearing loss and fluctuating aural symptoms (hearing, tinnitus and/or fullness) in the affected ear. Duration of vertigo episodes is limited to a period between 20 minutes and 12 hours. Probable Ménierè's disease is a broader concept defined by episodic vestibular symptoms (vertigo or dizziness) associated with fluctuating aural symptoms occurring in a period from 20 minutes to 24 hours. Res Vestib Sci 2015;14(3):67-74
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