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- 저자 : Stanislav Bardins (검색결과 2 건)
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Michael Strupp,Katharina Feil,Stanislavs Bardins,Raphaela Waidelich 대한배뇨장애요실금학회 2014 International Neurourology Journal Vol.18 No.4
Aminopyridines are potassium channel blockers that increase the excitability of nerve cells and axons; therefore, they arewidely used to treat different neurological disorders. Here we present a patient with idiopathic downbeat nystagmus and lowerurinary tract symptoms (LUTS) due to benign prostatic hyperplasia who was treated with the sustained-release form of4-aminopyridine (4-AP). During treatment with 4-AP, the LUTS improved. This improvement was monitored by using uroflowmetryand the International Prostate Symptom Score. A significant improvement of symptoms was observed in relationto the voided volume. This included an improved emptying of the bladder without an increase in residual urine. In animalstudies, both nonselective K+ channel blockade and selective voltage-sensitive potassium blockade by 4-AP resulted in increasedcontraction on rat detrusor strips. To our knowledge, this is the first clinical observation of the mode of action of 4-APin urological symptoms in humans.
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Nicolina Goldschagg,Tatiana Bremova-Ertl,Stanislav Bardins,Nora Dinca,Katharina Feil,Siegbert Krafczyk,Stefan Lorenzl,Michael Strupp 대한신경과학회 2019 Journal of Clinical Neurology Vol.15 No.3
Background and Purpose Conflicting results about vestibular function in progressive supranuclear palsy (PSP) prompted a systematic examination of the semicircular canal function, otolith function, and postural stability. Methods Sixteen patients with probable PSP [9 females, age=72±6 years (mean±SD), mean disease duration=3.6 years, and mean PSP Rating Scale score=31] and 17 age-matched controls were examined using the video head impulse test, caloric testing, ocular and cervical vestibular evoked myogenic potentials (o- and cVEMPs), video-oculography, and posturography. Results There was no evidence of impaired function of the angular vestibulo-ocular reflex (gain=1.0±0.1), and caloric testing also produced normal findings. In terms of otolith function, there was no significant difference between PSP patients and controls in the absolute peakto- peak amplitude of the oVEMP (13.5±7.2 μV and 12.5±5.6 μV, respectively; p=0.8) or the corrected peak-to-peak amplitude of the cVEMP (0.6±0.3 μV and 0.5±0.2 μV, p=0.3). The total root-mean-square body sway was significantly increased in patients with PSP compared to controls (eyes open/head straight/hard platform: 9.3±3.7 m/min and 6.9±2.1 m/min, respectively; p=0.032). As expected, the saccade velocities were significantly lower in PSP patients than in controls: horizontal, 234±92°/sec and 442±66°/sec, respectively; downward, 109±105°/sec and 344±72°/sec; and upward, 121±110°/sec and 348±78°/sec (all p<0.01). Conclusions We found no evidence of impairment of either high- or low-frequency semicircular function or otolith organ function in the examined PSP patients. It therefore appears that other causes such as degeneration of supratentorial pathways lead to postural imbalance and falls in patients with PSP.
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