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Stem cell-based therapy for inflammatory bowel disease
Hiromichi Shimizu,Kohei Suzuki,Mamoru Watanabe,Ryuichi Okamoto 대한장연구학회 2019 Intestinal Research Vol.17 No.3
Inflammatory bowel disease (IBD) is an idiopathic, multi-etiological disease characterized by inflammation and mucosal destruction of the gastrointestinal tract. Despite the remarkable advance in immunomodulating therapies, there still remains a certain population of patients who are refractory to conventional as well as biologic therapies and fail to achieve mucosal healing. To improve the prognosis of those patients, at least 2 types of stem cells have been tested for their potential therapeutic use. Transplantation of hematopoietic stem cells or mesenchymal stem cells have been tested in several clinical studies, but their beneficial effect still remains controversial. In this review, we would like to overview the recent clinical challenges of stem cell-based therapies in IBD and also introduce our new therapeutic plan of intestinal stem cell transplantation for IBD, based on our ex vivo intestinal organoid culture technique.
( Tadakazu Hisamatsu ),( Yasuo Suzuki ),( Mariko Kobayashi ),( Takashi Hagiwara ),( Takeshi Kawaberi ),( Haruhiko Ogata ),( Toshiyuki Matsui ),( Mamoru Watanabe ),( Toshifumi Hibi ) 대한장연구학회 2021 Intestinal Research Vol.19 No.4
Background/Aims: Crohn’s disease is a chronic disorder; therefore, it is essential to investigate long-term safety and efficacy of treatments. This study assessed the safety and effectiveness of adalimumab for up to 3 years in Japanese patients with Crohn’s disease in real-world settings. Methods: This was a multicenter, single-cohort, observational study of patients with Crohn’s disease. Safety assessments included incidence of adverse drug reactions. Effectiveness assessments included clinical remis-sion, mucosal healing, and Work Productivity and Activity Impairment (WPAI). Results: The safety and effectiveness analysis populations comprised 389 and 310 patients, respectively. Mean (standard deviation) exposure to adalimumab in the safety analysis population was 793.4 (402.8) days, with a 58.1% retention rate. A total of 105 patients (27.0%) and 43 patients (11.1%) experienced adverse drug reactions and serious adverse drug reactions, respectively, with no patient reporting tuberculosis or hepatitis B. Infections and serious infections were reported in 37 patients (9.5%) and 17 patients (4.4%), respectively. Malig-nancy was reported as an adverse drug reaction in 2 patients (0.5%). Remission rate increased from 37.8% (98/259) at baseline to 73.9% (167/226) at week 4 and remained >70% over 3 years. Proportion of patients without mucosal ulcerations increased from 2.7% (2/73) at baseline to 42.3% (11/26) between years >2 to ≤3. WPAI improvement started at 4 weeks, with the overall work impairment score improving from 42.7 (n=102) at baseline to 26.9 (n=84) at 4 weeks. Conclusions: Results from this study confirm the long-term safety and effectiveness of adalimumab treatment in Japanese patients with Crohn’s disease in the real-world setting. (Intest Res 2021;19:408-418)
Grease matrix as a versatile carrier of proteins for serial crystallography
Sugahara, Michihiro,Mizohata, Eiichi,Nango, Eriko,Suzuki, Mamoru,Tanaka, Tomoyuki,Masuda, Tetsuya,Tanaka, Rie,Shimamura, Tatsuro,Tanaka, Yoshiki,Suno, Chiyo,Ihara, Kentaro,Pan, Dongqing,Kakinouchi, Ke Nature Publishing Group 2015 NATURE METHODS Vol. No.
Serial femtosecond X-ray crystallography (SFX) has revolutionized atomic-resolution structural investigation by expanding applicability to micrometer-sized protein crystals, even at room temperature, and by enabling dynamics studies. However, reliable crystal-carrying media for SFX are lacking. Here we introduce a grease-matrix carrier for protein microcrystals and obtain the structures of lysozyme, glucose isomerase, thaumatin and fatty acid–binding protein type 3 under ambient conditions at a resolution of or finer than 2 Å.
Shin Jin-Sup,Lee Jung-Min,Suzuki Kiyoshi,Nomura Mamoru,Cheong In-Woo,Kim Jung-Hyun The Polymer Society of Korea 2006 Macromolecular Research Vol.14 No.4
The kinetic behavior of emulsion polymerizations of styrene in the presence of sulfonated N-hydroxy ethyl aniline (SHEA) was investigated with two initiators: 2,2'-azobisisobutyronitrile (AIBN) and potassium persulfate (KPS). SHEA was synthesized using a stepwise polyurethane reaction method from 3-hydroxy-1-propane sulfonic acid sodium salt, isophorone diisocyanate (IPDI), and N-(2-hydroxyethyl) aniline. Stable core-shell poly(styrene/sulfonated N-hydroxy ethyl aniline, St/SHEA) latex particles were successfully prepared by using an appropriate amount of AIBN, in which SHEA plays the role of 'surfmer', i.e., acting as both a surfactant in the emulsion polymerization and a monomer in the chemical oxidative polymerization. The kinetic behavior was dissimilar to that of typical emulsion polymerization systems. A long inhibition period and low rate of polymerization were observed due to radical loss by the oxidative polymerization of SHEA. It was concluded, due to the low water-solubility of AIBN and retardation reaction by SHEA, that the initial loci of polymerization were monomer droplets. However, growing polymer particles as polymerization loci became predominant as polymerization proceeded. It was suggested that AIBN was more effective than KPS in the preparation of the core-shell type poly(St/SHEA) latex particles. With KPS, no substantial polymerization was observed in any of the samples.
경기육괴 북동부 고성-간성 지역 선캠브리아 암석의 CHIME 연대와 그 지체구조적 의의
조등룡(Deung-Lyong Cho),Kazuhiro Suzuki,최위찬(Ueechan Chwae),Mamoru Adachi 한국암석학회 2007 암석학회지 Vol.16 No.1
경기육괴 북동부 고성-간성 지역에 분포하는 선캠브리아 암석의 CHIME 연대를 측정하였다. 정편마암류의 모나자이트 및 저어콘은 1672±69Ma 내지 1414±36Ma이고, 준편마암류의 모나자이트는 1703±70Ma 내지 1395±97Ma로서 약 1.7-1.4 Ga 사이의 화성활동과 수반한 변성작용을 나타낸다. 이를 전 지구적인 지체구조운동에 대비하변 경기육괴에서 광범위하게 보고되는 1.9-1.8 Ga의 열적사건은 콜롬비아 초대륙의 형성과 관련된 조산운동으로, 이 연구의 1.7-1.4 Ga 심성암의 관입과 변성작용은 콜롬비아 초대륙 형성 후의 대륙연변부의 성장과 관련된 결과로 해석할 수 있다. 그러나 이는 주로 연대측정 자료에 의존한 것으로서 추후 자세한 암석학 및 지화학적 연구를 통한 검정이 필요하다. CHIME (chemical Th-U-total Pb isochron) geochronology were made for Precambrian rocks from Goseong-Ganseong area, northeastern part of the Gyeonggi massif. Zircon and/or monazite grains from orthogneisses give 1672 ± 69 to 1414 ± 36 Ma ages, and monazite grains from paragneisses yield similar ages ranging from 1703 ± 70 to 1395 ± 97 Ma suggesting that 1.7-1.4 Ga igneous intrusions and coeval metamorphisms were occurred over the area. Together with reported prevailing 1.9-1.8 Ga igneous activities and regional metamorphism from the Gyeonggi massif, our age data from Goseong-Ganseong area would be potentially correlated with long-lived (1.8-1.3 Ga) global tectonothermal events in marginal outgrowth of supercontinent Columbia which was finally assembled by collisional orogenies at -1.8 Ga. Petrological and geochmical studies, however, should be followed to confirm this tectonic interpretation.
Rapid prediction of 1-year efficacy of tofacitinib for treating refractory ulcerative colitis
( Hiromichi Shimizu ),( Toshimitsu Fujii ),( Shuji Hibiya ),( Maiko Motobayashi ),( Kohei Suzuki ),( Kento Takenaka ),( Eiko Saito ),( Masakazu Nagahori ),( Kazuo Ohtsuka ),( Mamoru Watanabe ) 대한장연구학회 2021 Intestinal Research Vol.19 No.1