http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
이문용,김성윤,최정선,최윤식,Mi-HeeJeon,이정희,김인경,이정화 생화학분자생물학회 2002 Experimental and molecular medicine Vol.34 No.2
The expression of Bis (also called Bag-3), a Bcl-2-binding protein, was investigated in the rat kainicacid (KA) model of temporal lobe epilepsy. Westernblot analysis showed a significant increase in theexpression levels of Bis protein in the hippocampusfollowing the systemic administration of KA. Bisimmunoreactivity increased preferentially in the CA1and CA3 regions, as well as in the hilar region of thedentate gyrus. Experiments with double immunofluorescencerevealed that, in KA-administered rats,the cells expressing Bis were GFAP-expressingreactive astrocytes. The increase in Bis immunoreactivitywas accompanied by increased Bcl-2 inreactive astrocytes in the striatum radiatum,whereas Bcl-2 immunoreactivity in pyramidal neuronswas not affected. These results of the coexpressionof Bis and Bcl-2 in reactive astrocytes inthis seizure model suggest that Bis might modulatethe glial reaction under excitotoxic brain injury,probably by interacting with Bcl-2.