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Nguyen Ngoc-Viet,Van Manh Hoang,Van Hieu Nguyen 한국유변학회 2022 Korea-Australia rheology journal Vol.34 No.4
Circulating tumor cells (CTCs) detection has become one of the promising solutions for the early diagnosis of cancers. Thus, the separation of CTCs is of great importance in biomedical applications. In addition, microfluidic technology has been an attractive approach to the manipulation of biological cells. This study presents the parametric investigations relevant to the volumetric throughput of a microfluidic platform with the dielectrophoresis (DEP)-based cell manipulation technique for the continuous CTCs separation. A low potential voltage at an appropriate frequency was applied to slanted planar electrodes to separate CTCs from normal cells in blood samples due to mainly the cell size difference. The performance of the separation process was analyzed by evaluating the cell trajectories, purity, and recovery rates. Several inlet flow rates of buff er and cell sample fluid streams were examined. Various channel configurations with different outlet and height dimensions were also investigated to enhance the isolation of CTCs. During the simulation, the size and shape of cells were assumed as fixed-sized, solid spheres. The results showed that CTCs could be separated from blood cells, including white blood cells (WBCs), red blood cells (RBCs), and platelets (PLTs) with recovery and purity factors up to 100% at the cell sample throughput of 10 μL/ min by utilizing a suitable microchannel design. The current study significantly contributes valuable insights into the design of the microchip devices to effectively and selectively isolate different cancerous cells in biofluids.
Acute Myocardial Infarction in Patients With Single Coronary Artery: A Case Report
Nguyen Thi Huyen,Nguyen Ngoc Trang,Nguyen Khoi Viet,Le Thi Thuy Lien,Hoang Thi Van Hoa,Phung Bao Ngoc,Vu Dang Luu 아시아심장혈관영상의학회 2022 Cardiovascular Imaging Asia Vol.6 No.2
A single coronary artery (SCA) is a rare congenital anomaly. In most cases, it is an incidental finding on coronary angiography and has no clinical significance. However, it can cause angina, myocardial infarction, or even sudden death. Reports of SCA with acute myocardial infarction are very rare in the medical literature. This case study presents a patient with SCA from the right aortic sinus with severe stenosis in the proximal and distal part of the right coronary artery, which was detected using cardiac angiography and cardiac multidetector computed tomography (MDCT) with acute myocardial infarction.
Nguyen Van Hieu,Le Thi Ngoc Loan,Nguyen Duc Khoang,Nguyen Tuan Minh,Do Thanh Viet,Do Cong Minh,Tran Trung,Nguyen Duc Chien 한국물리학회 2010 Current Applied Physics Vol.10 No.2
In this paper, a very simple procedure was presented for the reproducible synthesis of large-area SnO2nanowires (NWs) on a silicon substrate by evaporating Sn powders at temperatures of 700, 750, and 800 ℃. As-obtained SnO2 NWs were characterized by field emission scanning electron microscopy (FESEM),transmission electron microscopy (TEM), X-ray diffraction (XRD), and Raman spectroscopy. They revealed that the morphology of the NWs is affected by growth temperature and the SnO2 NWs are single-crystalline tetragonal. The band gap of the NWs is in the range of 4.2–4.3 eV as determined from UV/visible absorption. The NWs show stable photoluminescence with an emission peak centered at around 620 nm at room-temperature. The sensors fabricated from the SnO2 NWs synthesized at 700 ℃ exhibited good response to LPG (liquefied petroleum gas) at an operating temperature of 400 ℃.
Nguyen Ngoc Duy,Latsamy Xayavong,Nguyen Kim Uyen,Vinh Nguyen Thanh Pham,Tran Viet Nhan Hao 한국물리학회 2019 새물리 Vol.69 No.10
Nuclear physics is an obligatory subject for the general physics program of undergraduates in most of the natural science universities worldwide. In nuclear physics, the shell model is one of the most important models, and is well used to determine the spin-parity and the magnetic moment of a nucleus. Over ten years of teaching general physics, we have realize that most undergraduate students find calculating these parameters by using this shell model to be difficult due to the classification of the subshells and the intrinsic spin of nucleons. With the hope to help these students, in the present study, we introduce a graphical-user-interface (GUI) program to execute our selfdeveloped Shell Model Calculator (SMC) code written in the Visual Basic 6.0 (VB6) programming language. Our SMC validation results for the quantum quantities in a series of nuclei Z = 1 - 20 were compared with experimental data and found to be in good agreement. In general, we successfully developed an SMC program that can be used for teaching, learning, and researching nuclear physics in universities.
Ngoc-Viet Nguyen,Jian-Sheng Wu,Chun-Ping Jen 한국바이오칩학회 2018 BioChip Journal Vol.12 No.4
This paper investigated the effects of ionic strength in the medium on a preconcentrator for a protein sample with low concentration. The preconcentration chip was designed and fabricated using a polydimethylsiloxane replica through standard lithophotography. A glass substrate is silanized prior to functionalizing the nanoparticles for self-assembly at a designed region. Due to the overlap of electrical double layers in a nanofluidic channel, a concentration polarization effect can be achieved using an electric field. A nonlinear electrokinetic flow is induced, resulting in the fast accumulation of proteins in front of the induced ionic depletion zone, so called exclusion-enrichment effect. Thus, the protein sample can be driven by electroosmotic flow and accumulated at a specific location. The chip is used to collect fluorescein isothiocyanate-labeled bovine serum albumin (FITC-BSA) diluted in phosphate- buffered saline (PBS) buffer solution. Different concentrations of the buffer media were studied herein. Fluorescence intensity images show that the buffer concentration of 4 mM is more appropriate than all the other ones. The sample of FITC-BSA with an initial concentration of 10 μM in the 4 mM PBS solution increases its concentration at the desired region by up to 50 times within 30 min, demonstrating the results in this investigation.
Ngoc-Viet Nguyen,Jih-Hao Yeh,Chun-Ping Jen 한국바이오칩학회 2018 BioChip Journal Vol.12 No.3
This study proposes a handheld electronics module integrated with the microchip that utilizes dielectrophoretic (DEP) impedance measurement for characterizing of cancerous cell lines. The microchip consists of circle-on-line-shaped interdigitated microelectrodes, which were used for DEP concentration and impedance sensing of cells within a chamber, patterned by standard microfabrication processes. The handheld electronics module was built for measuring impedance of cancerous cells in the microchip. It can provide sinusoidal electrical signals in a large range of frequencies. The analyzed results demonstrate a high-sensitivity impedance measurement. Meanwhile, the linear relationships between the admittance variation and the number of cell were observed for both two human lung cell lines, namely A549 human lung carcinoma cells and MRC-5 human lung epithelial cells. The difference in the slopes of these characteristic lines could be used to distinguish two stages of lung cells. The proposed device is simple to operate, has high sensitivity, inexpensive and portable.
Enzyme-mediated fabrication of an oxidized chitosan hydrogel as a tissue sealant
Phuong, Nguyen Thi,Anh Ho, Viet,Hai Nguyen, Dai,Khoa, Nguyen Cuu,Quyen, Tran Ngoc,Lee, Yunki,Park, Ki Dong Technomic Pub. Co 2015 Journal of bioactive and compatible polymers Vol.30 No.4
<P>Oxidized polysaccharide-based hydrogels have recently attracted much attention for tissue regeneration because of their biocompatibility and tissue-adhesive property. In this study, we introduce a new type of chitosan-based hydrogel as a tissue sealant, which was prepared by enzymatic mediation from periodate-oxidized chitosan–polyethylene glycol–tyramine. The oxidized chitosan backbone was expected to enhance the interconnection between the hydrogel layer and collagen in the tissues via the Schiff-base reaction. Proton nuclear magnetic resonance spectra indicated that tyramine-functionalized polyethylene glycol-nitrophenyl carbonate ester was conjugated to the oxidized chitosan. The degree of oxidation of the chitosan backbone was around 14% of the glucosamine units by proton nuclear magnetic resonance. The hydrogel was rapidly formed in situ (within a few seconds) in the presence of horseradish peroxidase and hydrogen peroxide. In vitro experiments with live/dead cell assays showed that the oxidized chitosan-based hydrogel was cytobiocompatible. The hydrogel exhibited high tissue adhesion strength on porcine skin models as well as good tissue-adhesive ability and wound healing properties on rabbit skin. These positive results could be promising for the application of oxidized chitosan-based hydrogels as a wound sealant.</P>