A New Estimation Method by Utilizing On-Line Tracking Simulator

Makoto Nakaya,Akio Nakabayashi,Tetsuya Ohtani,Yoshihiro Ikegaya,Satoshi Asawa,Nobuhiko Terashima,Yuji Izawa,Marina Gravina Ogata 제어로봇시스템학회 2009 제어로봇시스템학회 국제학술대회 논문집 Vol.2009 No.8

In the chemical process, it is hard to describe the polymer property by a rigorous model based on the physical and chemical theory. The soft sensor with the statistical data processing is often used for modeling to monitor and to control the polymer quality. We confirmed regarding the estimation accuracy that using data from the on-line tracking simulator is better than using data from the conventional use of the soft sensor. The on-line tracking simulatorperfectly simulates the target and provides the virtual input data which can not be measured by the soft sensor on the real time. We propose the application of the rigorous and the statistical model to the plant operation.

Recent trends in diagnostic techniques for inflammatory bowel disease

Makoto Naganuma,Naoki Hosoe,Takanori Kanai,Haruhiko Ogata 대한내과학회 2015 The Korean Journal of Internal Medicine Vol.30 No.3

Although ileocolonoscopy is the gold standard for diagnosis of inflammatory bowel disease and is useful for assessing the disease severity in the colon and terminal ileum, several alternative diagnostic techniques have been developed recently. For ulcerative colitis (UC), magnification colonoscopy, endocytoscopy, and confocal laser endomicroscopy enable assessment of histological inflammation without the need for biopsy. Capsule endoscopy is useful for detection of small intestinal and colonic lesions in both female and male patients. For UC, capsule endoscopy may be useful for evaluating colonic inflammation in patients with a previous poor colonoscopy experience, while it should be used only in Crohn’s disease (CD) patients with unexplained symptoms when other examinations are negative. Magnetic resonance enterography (MRE) is particularly useful for detecting transmural inflammation, stenosis, and extraintestinal lesions, including abscesses and fistulas. MRE is also useful when evaluating small and large intestinal lesions, even in cases with severe strictures in which full evaluation of the small bowel would be virtually impossible using other devices. Therefore, the appropriate diagnostic devices for detecting CD lesions in the small and large intestine should be used.

Development of a walking assist machine using crutches (Composition and basic experiments)

Masaru HIGUCHI,Makoto OGATA,Shuta SATO,Yukio TAKEDA 대한기계학회 2010 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.24 No.1

This paper proposes a walking assist machine for people with walking difficulties. It has crutches operated by the user and a wearable mechanism generates motion of the leg and foot relative to the upper body. First, a healthy person’s swing-through walking using axillary crutches was measured and kinematically analyzed. Based on the results, a composition of a walking assist machine using crutches (WAMC) was proposed. An Experimental apparatus of WAMC was designed and built. It realized walking with desired constant step length. And it was clarified that error of the step length decreases its walking stability. Then we investigated the relationship between walking stability and parameters of walking motion by dynamic simulations. The desired parameters were determined through the simulations Sensors and switches which convey user’s intentions to WAMC were also designed and attached to the WAMC.

Improvement of Slow Wave Sleep Continuity by Mattress with Better Body Pressure Dispersal

Momoko Kayaba,Hitomi Ogata,Insung Park,Asuka Ishihara,Fusae Kawana,Toshio Kokubo,Shoji Fukusumi,Michiko Hayashi,Kumpei Tokuyama,Masashi Yanagisawa,Makoto Satoh 대한수면학회 2019 sleep medicine research Vol.10 No.2

Background and Objective This study evaluated the effects of a mattress with better body pressure dispersal in comparison to a control mattress on sleep quality. Methods In this randomized crossover study, 10 healthy young men slept in an experimental sleep room on either a functional mattress made from polyurethane, with a special four-layer three-dimensional structure, or a control mattress made from solid polyester wadding, which is a mattress commercially available in Japan. Polysomnography recordings were used to characterize sleep architecture, and the length of slow wave sleep (SWS) episodes and delta power density were calculated from the electroencephalography data and subjective sleep quality was evaluated by questionnaire they answered after waking. Results There were no significant differences in sleep latency, the total duration of each sleep stages, total sleep time, or sleep efficiency. Although the difference was subtle, delta power density significantly increased with the functional mattress. There was no difference in the total duration of SWS, but there were significantly fewer SWS episodes with the functional mattress (10.3 ± 1.8) than with the control mattress (16.9 ± 1.2) and longer SWS episode duration (10.9 ± 1.7 min) with the functional mattress than with the control mattress (5.6 ± 0.5 min). Conclusions It was suggested that the functional mattress lengthened SWS episode duration, and its fragmentation was effective in evaluating the sleep quality of healthy young individuals.

5-Aminosalicylic acid aggravates colitis mimicking exacerbation of ulcerative colitis

( Jun Miyoshi ),( Katsuyoshi Matsuoka ),( Atsushi Yoshida ),( Makoto Naganuma ),( Tadakazu Hisamatsu ),( Tomoharu Yajima ),( Nagamu Inoue ),( Susumu Okamoto ),( Yasushi Iwao ),( Haruhiko Ogata ),( Fum 대한장연구학회 2018 Intestinal Research Vol.16 No.4

Ulcerative colitis (UC) is one of the major clinical phenotypes of inflammatory bowel diseases. Although 5-aminosalicylic acid (5-ASA) is widely used for UC and its efficacy and safety have been demonstrated, a few patients paradoxically develop a severe exacerbation of colitis by 5-ASA administration. It is crucial to know clinical features including endoscopic findings in this condition for making a correct diagnosis and a prompt decision to withdraw the medication. Here, we report case series with UC exacerbated by 5-ASA. Medical records of 8 UC patients experiencing an exacerbation of colitis after induction of 5-ASA that was improved by the withdrawal of 5-ASA but also re-aggravated by dose increase or re-administration of 5-ASA were reviewed. The patients were newly diagnosed with UC, started 5-ASA and developed an exacerbation in approximately 2 to 3 weeks. They did not appear to have systemic allergic reactions. Seven of the 8 patients had a high fever. Three of 5 patients who undertook total colonoscopy showed right-side-dominant colitis. These findings suggest clinical characteristics in this condition. Further assessment of clinical and endoscopic features in more cases is necessary for establishing diagnostic criteria and understanding underlying mechanisms in those cases where 5-ASA aggravates the colitis. (Intest Res 2018;16:635-640)

Effects of the Oral Administration of Mosapride Citrate on Capsule Endoscopy Completion Rate

( Yosuke Ida ),( Naoki Hosoe ),( Hiroyuki Imaeda ),( Rieko Bessho ),( Riko Ichikawa ),( Makoto Naganuma ),( Takanori Kanai ),( Toshifumi Hibi ),( Haruhiko Ogata ) 대한소화기학회 2012 Gut and Liver Vol.6 No.3

Background/Aims: In capsule endoscopy (CE), the capsule does not always reach the cecum within its battery life, which may reduce its diagnostic yield. We evaluated the effect of mosapride citrate, a 5-hydroxytryptamine-4 agonist that increases gastrointestinal motility, on CE completion. Meth-ods: In a retrospective study, we performed univariate and multivariate analyses for 232 CE procedures performed at our hospital. To identify factors that affect CE completion, the following data were systematically collected: gender, age, gastric transit time (GTT), nonsteroidal anti-inflammatory drug administration, previous abdominal surgery, hospitaliza-tion, use of a polyethylene glycol solution, use of mosapride citrate (10 mg), body mass index (BMI), and total recording time. Results: The univariate analysis showed that oral mo-sapride citrate, GTT, and BMI were associated with improved CE completion. Multivariate analyses showed that oral mo-sapride citrate (odds ratio [OR], 1.99; 95% confidence inter-val [CI], 1.01 to 3.91) and GTT (OR, 2.34; 95% CI, 1.13 to 4.87) were significant factors for improving the CE completion. Oral mosapride citrate significantly shortened the GTT and small bowel transit time (SBTT). Conclusions: Oral mosapride ci-trate reduced the GTT and SBTT during CE and improved the CE completion rate. (Gut Liver 2012;6:339-343)