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- 저자 : MALLICKSUDIPTA (검색결과 3 건)
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Silica coated gold nanorods for imaging and photo-thermal therapy of cancer cells.
Mallick, Sudipta,Sun, In-Cheol,Kim, Kwangmeyung,Yil, Dong Kee American Scientific Publishers 2013 Journal of Nanoscience and Nanotechnology Vol.13 No.5
<P>Due to their efficient conversion of absorbed light energy to heat gold nanorods have been proved to be an amazing tool for minimally invasive photo-thermal cancer therapy. The present in vitro study demonstrates the ability of silica coated Au nanorods to function as a dual probe for cancer-cell therapy and imaging without any toxic side-effects. HeLa cells were incubated with silica coated Au nanorods and imaged inside the cell just after 1 hour of incubation by a dark field set up due to strong surface enhanced Raman scattering. To induce hyperthermia, silica coated Au nanorod incubated HeLa cells were illuminated with a diode laser (671 nm, 200 mW, 10 min). Cell destruction was observed even at a very low dose of nanorods, whereas none was observed in the absence of nanorods. Silica coated Au nanorods thus offer a promising, novel class of selective photo-thermal agents for cancer therapy and diagnosis.</P>
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Mallick, Sudipta,Thuy, Le Thi,Lee, Seulgi,Park, Jong-II,Choi, Joon Sig Elsevier 2018 Colloids and surfaces. B, Biointerfaces Vol.161 No.-
<P><B>Abstract</B></P> <P> <UL> <LI> Mitochondria are exclusively employed to produce energy required for the vital metabolic functions of the cell. However, mitochondria also play a key role in mammalian cell death. Dissipation in the mitochondria membrane potential causes cell death. Therefore, in cancer therapy, mitochondria are a novel target. Herein, we developed a nano-formulation of Antimycin A specifically targeted towards mitochondria and lung cancer; A549 cell. The liposomes were prepared using cholesterol and a mitochondria-penetrating peptide (MPP) having a phenylalanine-arginine-phenylalanine-lysine (FRFK) peptide sequence. The FRFK peptide was synthesized using solid phase peptide synthesis (SPPS) and contained cholesterol in the N-terminal end of the phenylalanine (Chol-FRFK). The synthesized material was confirmed using <SUP>1</SUP>H NMR, Fourier transform infrared spectroscopy (FT-IR) and matrix-assisted laser desorption/ionization time of flight mass spectrometry (MALDI TOF/MS). 1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine (DOPE) and Chol-FRFK, at a molar ratio of 1:1, were used for liposomal (Chol-FRFK/D) formulations; the sizes of the liposomes were confirmed using dynamic light scattering (DLS). Cytotoxicity was evaluated in A549 cells. Cellular uptake and mitochondria targeting were confirmed by flow cytometry and confocal microscopy, respectively. Antimycin A, a hydrophobic and mitochondrial electron transporter inhibitor was encapsulated into the Chol-FRFK/D liposomes. Our results indicate that Chol-FRFK/D liposomes may potentially be used for the nano-formulation of cytotoxic drugs and enhancing their bioavailability in cancer therapy. </LI> </UL> </P> <P><B>Highlights</B></P> <P> <UL> <LI> Idea of mitochondria targeting carrier to deliver mitochondria-specific drug, is proposed. </LI> <LI> Chol-FRFK was synthesized as a liposomal component. </LI> <LI> Chol-FRFK/D liposomes were prepared for delivery of Antimycin A to the mitochondria. </LI> <LI> Nano-formulation of Antimycin A showed higher toxicity in A549 cells. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
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오혜민,강은애,Zhengzheng Li,조익성,김다은,MALLICKSUDIPTA,강선웅,노경호,허강무 한국공업화학회 2019 Journal of Industrial and Engineering Chemistry Vol.80 No.-
Thermogels have been extensively utilized as one of representative in situ forming hydrogel systems forbiomedical applications. However, most thermogels often suffer from a weak mechanical strength andlow physical stability. To overcome these intrinsic weaknesses of conventional thermogels, wedeveloped a new in situ crosslinkable thermogel system with enhanced and tunable physicochemicalproperties. Thermosensitive N-hexanoyl glycol chitosans (HGCs) were synthesized by N-hexanoylationof glycol chitosan and further modified to yield methacrylated HGCs (M-HGCs) and thiolated HGCs (SHHGCs). A mixture of M-HGCs and SH-HGCs (M/SH-HGCs) retained not only their thermogellingproperties but also their reactive functionalities for chemical crosslinking at physiological temperature. Compared to conventional thermogels, the M/SH-HGC thermogels showed enhanced mechanicalproperties due to physical and chemical crosslinking mechanisms. The physicochemical properties of theM/SH-HGC thermogels were characterized in terms of the sol–gel transition temperature, gelation time,mechanical strength, and biodegradability. They showed negligible toxicity in cells, and the in situcrosslinking step did not affect cell viability. These results suggest that our crosslinkable thermogelsystem is useful not only as a new in situ forming hydrogel but also as a biomaterial for variousbiomedical applications due to its thermogelling characteristics and enhanced and tunablephysicochemical properties.
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