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Li Shuang,Guo Dongyang,Sun Qiang,Zhang Lu,Cui Yun,Liu Min,Ma Xixi,Liu Yiman,Cui Wenyu,Sun Leimin,Teng Lisong,Wang Liangjing,Lin Aifu,Liu Wei,Zhuo Wei,Zhou Tianhua 생화학분자생물학회 2023 Experimental and molecular medicine Vol.55 No.-
Liver metastasis is a major cause of death in gastric cancer patients, but the underlying mechanisms are poorly understood. Through a combination of in vivo screening and transcriptome profiling followed by quantitative RT-PCR and tissue array analyses, we found that mitogen-activated protein kinase 4 (MAPK4) downregulation in gastric cancer tissues from patients is significantly associated with liver metastasis and poor prognosis. The knockdown of MAPK4 in gastric cancer cells promotes liver metastasis in orthotopic mouse models. MAPK4 depletion in gastric cancer cells induces the secretion of macrophage migration inhibitory factor (MIF) to polarize tumor-associated macrophages (TAMs) in orthotopic xenograft tumors. Moreover, TAMs activate epithelial–mesenchymal transition of gastric cancer cells to suppress MAPK4 expression, which further increases MIF secretion to polarize TAMs. Taken together, our results suggest a previously undescribed positive feedback loop between cancer cells and macrophages mediated by MAPK4 silencing that facilitates gastric cancer liver metastasis.
Development of High-Current Sheet Beam Cathodes for Terahertz Sources
Lili Li,Yiman Wang,Wei Liu,Yanchun Wang,Jinshu Wang,Srivastava, A.,Jin-Kyu So,Gun-Sik Park IEEE 2009 IEEE transactions on electron devices Vol.56 No.5
<P>Generation of a sheet beam directly from a scandia-doped dispenser cathode has been investigated and optimized by means of beam-profile simulations and measurements. Rectangular beams 600 mum wide and 100 mum thick with current densities over 50 A/cm<SUP>2</SUP> have been generated. The beams are stable for at least several hundred hours with the cathodes operating at 950degC<SUB>b</SUB>, making them promising candidates for application in the next generation of terahertz vacuum electron devices such as a 0.5-THz superradiant Smith-Purcell radiation source.</P>
Characteristics of La_2O_3―Y_2O_3―Mo cermet cathode with RE_2O_3 nano particles
Jinshu Wang,Wei Liu,Zhiyuan Ren,Fan Yang,Yiman Wang,Yucheng Du,Meiling Zhou 한국물리학회 2011 Current Applied Physics Vol.11 No.3
The secondary electron emission property and microstructure of La_2O_3―Y_2O_3―Mo cermet cathode have been studied. It shows that the cathode prepared by Sol―Gel doping method has fine microstructure containing rare earth oxide (RE_2O_3) nanoparticles and uniform distribution of different substances. Auger Electron Spectroscopy (AES) depth profile result shows that an RE_2O_3 layer about 28 nm in thickness could be formed on the cathode surface, which plays an important role in the emission. Pre-activation of the cathode is favorable for the improvement of emission property. La_2O_3―Y_2O_3―Mo cathode preactivated exhibits good secondary emission property. The secondary emission yield could reach 5.24,about 1.8 times higher than that of original cathode. The enhancement on the conductivity of materials resulting from the pre-activation is favorable for the replenishment and transport of electrons, thus the secondary emission property of the cathode could be improved.
Advances in High Emission Sc<sub>2</sub>O<sub>3</sub>-W Matrix Cathode Materials
Wang, Jinshu,Yang, Yunfei,Liu, Wei,Wang, Yiman Korean Society of Microscopy 2016 Applied microscopy Vol.46 No.1
Our work on $Sc_2O_3-W$ matrix dispenser cathodes had been reviewed in this paper. The cathode with uniform distribution of $Sc_2O_3$ had been obtained using liquid-liquid doping method. The cathode had excellent emission property, i.e., the emission current density in pulse condition could reach over $35A/cm^2$. It was found that the cathode surface was covered by a Ba-Sc-O active substance multilayer with a thickness of about 100 nm, which was different from the monolayer and semiconducting layer in thickness. Furthermore, the observation results displayed that nanoparticles appeared at the growth steps and the surface of tungsten grains of the fully activated cathode. The calculation result indicated that the nanoparticles could cause the increase of local electric field strengths. We proposed the emission model that both the Ba-Sc-O multilayer and the nanoparticles distributing mainly on the growth steps of the W grains contributed to the emission. The future work on this cathode has been discussed.