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LY6D is crucial for lipid accumulation and inflammation in nonalcoholic fatty liver disease
Lee Jibeom,Kim Hyeonhui,Kang Yun-Won,Kim Yumin,Park Moon-young,Song Ji-Hong,Jo Yunju,Dao Tam,Ryu Dongryeol,Lee Junguee,Oh Chang-Myung,Park Sangkyu 생화학분자생물학회 2023 Experimental and molecular medicine Vol.55 No.-
Nonalcoholic fatty liver disease (NAFLD) is a serious metabolic disorder characterized by excess fat accumulation in the liver. Over the past decade, NAFLD prevalence and incidence have risen globally. There are currently no effective licensed drugs for its treatment. Thus, further study is required to identify new targets for NAFLD prevention and treatment. In this study, we fed C57BL6/J mice one of three diets, a standard chow diet, high-sucrose diet, or high-fat diet, and then characterized them. The mice fed a high-sucrose diet had more severely compacted macrovesicular and microvesicular lipid droplets than those in the other groups. Mouse liver transcriptome analysis identified lymphocyte antigen 6 family member D (Ly6d) as a key regulator of hepatic steatosis and the inflammatory response. Data from the Genotype-Tissue Expression project database showed that individuals with high liver Ly6d expression had more severe NAFLD histology than those with low liver Ly6d expression. In AML12 mouse hepatocytes, Ly6d overexpression increased lipid accumulation, while Ly6d knockdown decreased lipid accumulation. Inhibition of Ly6d ameliorated hepatic steatosis in a diet-induced NAFLD mouse model. Western blot analysis showed that Ly6d phosphorylated and activated ATP citrate lyase, which is a key enzyme in de novo lipogenesis. In addition, RNA- and ATAC-sequencing analyses revealed that Ly6d drives NAFLD progression by causing genetic and epigenetic changes. In conclusion, Ly6d is responsible for the regulation of lipid metabolism, and inhibiting Ly6d can prevent diet-induced steatosis in the liver. These findings highlight Ly6d as a novel therapeutic target for NAFLD.
포터의 다이아몬드 모델을 이용한 한국 방위산업 경쟁력 평가 및 향상방안 연구
이지범(Jibeom Lee),최경환(Kyunghwan Choi) 육군사관학교 화랑대연구소 2022 한국군사학논집 Vol.78 No.3
The purpose of this study is to evaluate the competitiveness of the Korean defense industry using Porters Diamond model and to suggest ways to improve it. We evaluate the four main variables of the diamond model based on data published by the National Statistical Office, using them as elements of competitiveness evaluation. As a result of the evaluation, the defense industry was evaluated to be less competitive than the manufacturing industry. As a way to improve competitiveness, it is necessary to foster talent and improve efficiency using the 4th industrial revolution technology. In addition, government policy support is required to expand investment in facilities and expand the defense industry cluster. This study is significant in that it evaluates the competitiveness of the defense industry contributing to the national economy and suggests specific measures to improve it.
Tensorflow를 활용한 야구선수 유형 분석 및 타격 결과 예측에 관한 연구
박채원 ( Chaewon Park ),박지범 ( Jibeom Park ),주영준 ( Yeongjun Joo ),김현석 ( Hyunseok Kim ),이남용 ( Namyong Lee ),김영종 ( Youngjong Kim ) 한국정보처리학회 2019 한국정보처리학회 학술대회논문집 Vol.26 No.1
본 연구는 한국 프로 야구 선수 개인의 수치화된 데이터를 바탕으로 타석의 결과를 예측하고자 하는데 목적을 두고 있다. 연구의 방법은 2015시즌부터 2018시즌에 활약한 한국 프로 야구 소속의 투수와 타자의 유형을 군집화 하여 지도학습 모델을 만든다. 지도학습 모델과 현재까지 진행된 2019시즌의 결과를 비교·대조한다. 본 연구결과는 한국 프로 야구 10개 구단의 감독의 선수 선발 결정에 기여할 것으로 판단된다.