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( Chaiyoung Lee ),( Sun Hye Shin ),( Noeul Kang ),( Yeonseok Choi ),( Hyun Kyu Cho ),( Jun Hyeok Lim ),( Hye Yun Park ) 대한결핵 및 호흡기학회 2020 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.128 No.-
Background Vitamin D deficiency is prevalent in patients with chronic obstructive pulmonary disease (COPD). The relationship between vitamin D and clinical symptoms in stable COPD has not been fully investigated. We aimed to explore the association between vitamin D sufficiency and clinical symptoms in stable COPD patients. Methods We performed a cross-sectional study using data between October 2015 and March 2019 from the COPD Lung Evolution (CLUE) Registry in Samsung Medical Center. Serum 25-hydroxy (25-OH) vitamin D levels measured at diagnosis with concurrent spirometry. Vitamin D sufficiency was defined as serum level ≥ 30ng/mL of 25-OH vitamin D. Results Of the 330 COPD patients, mean age was 70.8±8.5 years and 305 (92.4%) were male. Current or ex-smokers were 296 (89.7%) and 281 (85.2%) did not have vitamin D sufficiency. Patients without vitamin D sufficiency showed higher COPD assessment test (CAT) score compared to those with vitamin D sufficiency (17.14±8.56 vs. 13.08±8.15, p = 0.002 and 80.4% vs. 63.3% for CAT ≥ 10, p =0.008). Among CAT items, the patients without vitamin D sufficiency showed higher scores in sputum (p = 0.005), chest tightness (p = 0.014), dyspnea (p = <0.001), activity (p = 0.006) and energy (p = 0.010) than those with vitamin D sufficiency. The modified Medical Research Council ≥2 was more common in patients without vitamin D sufficiency than those with vitamin D sufficiency (37.4% versus 22.4%, p = 0.044). Conclusions COPD patients without vitamin D sufficiency had worse clinical symptom than those with vitamin D sufficiency.
β-Difluoro-α-trimethylsilyl-γ-lactam 유도체의 합성
채규윤,곽경철,문재정,최장호 圓光大學校 基礎自然科學硏究所 2000 基礎科學硏究誌 Vol.18 No.1
α-위치만 선택적으로 difluoromethylene기가 도입된 α.α-difluoro-γ-trimethylsilyl-γ-lactam 유도체(6)들은 ethyl α.α-difluoro-γ-trimethylsilyl-γ-iodopentanoate(4)는 일차아민 유도체와의 반응으로부터 비교적 편리한 작용조건과 비교적 좋은 수득률로 합성하였다. The target of α.α-difluoro-γ-trimethylsilyl-γ-lactam derivatives(6) with selectively in corporated difluoromethylene on α-position were readily prepared form reaction ethyl α.α-difluoro-γ-trimethylsilyl-γ-iodopentanoate(4) and primary derivatives in moderate yields.
鄭起源,蔡奎允,李英行 圓光大學校 1993 論文集 Vol.27 No.2
새로운 축합시약인 (3-nitropyridyl) dialkyl phosphate (3a,3b)를 2-hydroxy-3-nitropyridine (1), dialkyl chlorophosphate (2a,2b) 그리고 triethylamine을 dichloromethane 용액중에서 1시간동안 상온에서 반응시켜 쉽게 얻을 수 있었다. 축합시약인 3a와 3b는 온화한 반응 조건에서 아미드와 디펩티드를 합성하는데 있어서 유용한 시약임을 알 수 있었다. A new coupling reagents,(3-nitropyridyl) diallkyl phosphate (3a,3b), were readily prepared by the reaction of 2-hydroxy-3-nitropyridine (1), dialkyl chlorophosphate (2a,2b), and triethylamine in dichloromethane at room temperature for 1h. The coupling reagents, 3a and 3b, were found to be very useful for the preparation of amides and dipeptides under mild conditions.
Synthesis of 6-Alkyloxyl-3,4-dihydro-2(1H)-quinoliones and Their Anticonvulsant Activities
Kyu-Yun Chai,Jun-Min Wang,노정래,Kyung-Chell Kwak,Hee-Cheol Kang,Chang-Soo Jun,Zhe-Shan Quan 대한화학회 2005 Bulletin of the Korean Chemical Society Vol.26 No.11
A series of 6-alkyloxyl-3,4-dihydro-2(1H)-quinoliones (5a-5n) were synthesized through nitration, reduction, diazotization, hydrolysis and alkylation from 3,4-dihydro-2(1H)-quinolione. Their structures were characterized by IR, 1H-NMR and MS. The anticonvulsant activity was evaluated by the Maximal electroshock test (MES) and the subcutaneous pentylenetetrazole (Metrazole) test (sc-Met). The neurotoxicity was measured by the Rotarod test (Tox). The result showed that 6-hexyloxy-3,4-dihydro-2 (1H)-quinolinone (5c) was potent in anti-MES and anti-scMet test with ED50 of 24.0 mg/kg and 21.2 mg/kg, respectively, albeit its TD50 (67.6 mg/kg) revealed the high neurotoxicity. 6-Benzyloxy-3,4-dihydro-2(1H)-quinolinone (5f) was less effective against MES induced seizure with ED50 of 29.6 mg/kg, but no neurotoxicity was observed even under 300 mg/kg. Its Protective index (PI) was greater than 10 preferable to Phenytoin, Carbamazepin, Phenobarbital and Valproate.
Scutellaria baicalensis Inhibits Mast Cell-Mediated Anaphylactic Reactions
Yun Ho Choi(최윤호),Eui-Hyeog Han(한의혁),Ok Hee Chai(채옥희),Yun-Kyu Kim(김윤규),Hyoung Tae Kim(김형태),Chang Ho Song(송창호) 대한체질인류학회 2010 대한체질인류학회지 Vol.23 No.4
비만세포는 즉시형 과민반응과 알레르기성 질환의 발현에 중요한 역할을 한다. 황금은 동양의학에서 전통적으로 널리 사용된 약초로, 약리작용에는 항암, 항바이러스, 항박테리아, 항염증 효과 등이 있다. 그러나, 황금이 비만세포를 매개로 한 아나필락틱 반응에 미치는 영향을 다룬 연구가 거의 없는 실정이다. 본 연구에서 우리는 황금의 메탄올 추출물이 compound 48/80 혹은 anti-DNP IgE에 의한 쥐 모델 아나필락시에 미치는 영향을 관찰하였다. 이러한 결과를 보다 확실히 입증하고자, 비만세포의 히스타민 유리에 초점을 맞춰서 황금이 이들 세포에 대해 억제효과를 보이는지 확인하였다. 황금은 compound 48/80에 의한 전신성 아나필락시양 반응과 그에 따른 혈장 내 히스타민 유리 그리고 귀의 부종반응을 억제하였다. 황금은 또한 anti-DNP IgE에 의해 수동적으로 유도된 전신 및 피부 아나필락시 반응을 억제하였다. 시험관 내 실험에서, 황금은 compound 48/80에 의해 유도된 비만세포의 탈과립을 억제하였으며, compound 48/80 혹은 anti-DNP IgE로 활성화된 비만세포로부터의 히스타민 유리를 감소시켰다. 이외에도 compound 48/80에 의해 유도된 세포 내 칼슘 유입이 황금에 의해 농도의존적으로 억제되었다. 아울러 황금은 일시적으로 비만세포 내 cAMP의 양을 증가시켰다. 이상의 결과들은 황금이 효과적인 항 아나필락틱 활성을 가지고 있음을 제시한다. Mast cells play a critical role in the effector phase of immediate hypersensitivity and allergic diseases. Scutellaria baicalensis is a widely used herb in traditional oriental medicine with anticancer, antiviral, antibacterial and anti-inflammatory properties. However, the roles of Scutellaria baicalensis in mast cell-mediated anaphylactic reactions have not fully been investigated. In this study, we examined the influences of the methanol extract of Scutellaria baicalensis (MESB) on compound 48/80- or anti-dinitrophenyl (DNP) IgE-induced anaphylaxis-like response in vivo. To further prove these in vivo results, the inhibitory effect of MESB on mast cell activation was evaluated, focusing on the histamine release from rat peritoneal mast cells (RPMC). MESB inhibited compound 48/80-induced systemic anaphylaxis-like reaction, plasma histamine release and ear swelling response in mice. MESB also attenuated passive systemic and cutaneous anaphylaxis evoked by anti-DNP IgE. In in vitro experiments, MESB dose-dependently reduced histamine release from RPMC activated by compound 48/80 or anti-DNP IgE. Moreover, compound 48/80-elicited calcium uptake was suppressed in a concentration-dependent manner of MESB. Furthermore, MESB transiently increased the level of intracellular cAMP. From these results, it is suggested that MESB possesses effective anti-anaphylactic activity.
Lee, Chai Ho,Chai, Kyu Yun,Lee, Man Koo,Chung, Bong Young 圓光大學校 基礎自然科學硏究所 1988 基礎科學硏究誌 Vol.7 No.3
Racemic N-benzylaspartic acid (4) was prepared from maleic anhydride and used to modify and develop some efficient methods for the preparation of N-benzylaspartic anhydride hydrobromide (5). Thus, successive treatment of the compound 4 with 30% HBr in acetic acid and acetic anhydride afforded the title compound 5 in 75% yield. From this compound 5. α-benzyl and α-methyl N-benzylaspartates were also prepared.
Trimellitic anhydride에 의한 접촉성피부염에서 인터루킨 10의 역할
김윤규(Yun-Kyu Kim),채옥희(Ok Hee Chai),송창호(Chang Ho Song) 대한체질인류학회 2013 해부·생물인류학 (Anat Biol Anthropol) Vol.26 No.2
Trimellitic anhydride (TMA)는 에폭시와 알킬 레진, 플라스틱, 계면활성제를 생산하는 재료로 널리 사용한다. 이 연구의 목적은 반복적인 TMA의 도포로 접촉성피부염이 유발되는지와 TMA에 의한 접촉성피부염에서 인터루킨-10의 역할을 밝히기 위한 것이다. TMA에 의한 반복적인 야기(challenge)로 정상 마우스와 인터루킨-10 결핍 마우스에서 접촉성피부염이 유발되었다. 특히 TMA에 의한 접촉피부염의 귀부종은 1회 야기 후 12시간에 최고로 증가하였으며, 반복적인 야기에서는 마지막 야기 후 8시간에 귀부종이 최고로 증가하였다. 인터루킨-10 결핍 마우스에서 TMA에 의한 접촉성 피부염은 정상마우스에 비해 감소하였다. 이상의 결과로 접촉성피부염의 기작 연구를 위한 동물모델로 TMA에 의한 접촉성피부염 동물모델을 사용할 수 있으며, TMA에 의한 접촉성피부염에서 인터루킨-10이 중요한 역할을 할 것으로 생각된다. 접촉성피부염의 치료에 인터루킨-10의 조절물질을 사용할 수 있을 것으로 기대한다. Trimellitic anhydride (TMA) is widely used industrially to make epoxy and alkyd resins, plasticizers and surfactants. The purpose of this study was to investigate whether contact dermatitis is induced by repeated TMA challenge and the role of interleukin (IL)-10 in the TMA-induced contact dermatitis. The repetition of the challenge enlarged the extent of an early and a late phase of contact dermatitis in IL-10<SUP>+/+</SUP> and IL-10<SUP>-/-</SUP> mice. In the late phase of TMA-induced contact dermatitis, the peak of ear swelling responses by single challenge showed at 12 h after challenge, but the peak was observed at 8 h after repeated challenge. In the IL-10<SUP>-/-</SUP> mice, the repetition of the TMA challenges enlarged the extent of the contact dermatitis, but less than those in IL-10<SUP>+/+</SUP> mice. These results indicate that mice sensitized by TMA could possibly offer a useful model to study the mechanism of contact dermatitis, and IL-10 may act as potential modulators in the TMA-induced contact dermatitis. IL-10 may provide therapeutic tools for the treatment of TMA-induced contact dermatitis.