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Lemierre Syndrome in Adolescent with Active Ulcerative Colitis
Unic, Josipa,Kovacic, Matea,Jakovljevic, Gordana,Batos, Ana Tripalo,Grmoja, Tonci,Hojsak, Iva The Korean Society of Pediatric Gastroenterology 2018 Pediatric gastroenterology, hepatology & nutrition Vol.21 No.3
Inflammatory bowel disease (IBD) is a well-recognized risk factor for thrombotic events in adults but data on children are scarce. In the great majority of adult patients, thrombotic events are usually deep vein thrombosis and pulmonary embolism. Other sites such as jugular veins are extremely rare. We present a case of Lemierre syndrome in an adolescent girl with active ulcerative colitis and discuss possible risk factors. This is the first reported case of severe Lemierre syndrome with thrombus extension to cranial veins in a patient with ulcerative colitis. Early recognition of Lemierre syndrome in patients who present with rapidly worsening symptoms of neck pain, fever and signs of pharyngitis is imperative because it increases a chance of favorable prognosis. It is important for pediatricians treating IBD patients not to underestimate possible thrombotic events in children with IBD. Recognition of additional risk factors is crucial for prompt diagnosis and adequate treatment.
Basis for the design of lateral reinforcement for high-strength concrete columns
Mendis, P.A.,Kovacic, D.,Setunge, S. Techno-Press 2000 Structural Engineering and Mechanics, An Int'l Jou Vol.9 No.6
This paper attempts to provide a theoretical basis for the design of high-strength concrete columns in terms of the spacing of lateral reinforcement. In order to achieve this, important concepts had to be addressed such as the choice of a measure of ductile behaviour and a realistic high-strength concrete stress-strain model, as well as limiting factors such as longitudinal steel buckling and lateral steel fracture. A design method incorporating above factors are suggested in the paper. It is shown that both buckling of longitudinal steel and hoop fracture will not demand a reduction in spacing of lateral ties with increase in compressive strength of concrete.
Stat5 is indispensable for the maintenance of <i>bcr/abl</i> -positive leukaemia
Hoelbl, Andrea,Schuster, Christian,Kovacic, Boris,Zhu, Bingmei,Wickre, Mark,Hoelzl, Maria A,Fajmann, Sabine,Grebien, Florian,Warsch, Wolfgang,Stengl, Gabriele,Hennighausen, Lothar,Poli, Valeria,Beug, WILEY-VCH Verlag 2010 EMBO molecular medicine Vol.2 No.3
<P>Tumourigenesis caused by the Bcr/Abl oncoprotein is a multi-step process proceeding from initial to tumour-maintaining events and finally results in a complex tumour-supporting network. A key to successful cancer therapy is the identification of critical functional nodes in an oncogenic network required for disease maintenance. So far, the transcription factors Stat3 and Stat5a/b have been implicated in <I>bcr/abl</I>-induced initial transformation. However, to qualify as a potential drug target, a signalling pathway must be required for the maintenance of the leukaemic state. Data on the roles of Stat3 or Stat5a/b in leukaemia maintenance are elusive. Here, we show that both, Stat3 and Stat5 are necessary for initial transformation. However, Stat5- but not Stat3-deletion induces G<SUB>0</SUB>/G<SUB>1</SUB> cell cycle arrest and apoptosis of imatinib-sensitive and imatinib-resistant stable leukaemic cells <I>in vitro</I>. Accordingly, Stat5-abrogation led to effective elimination of myeloid and lymphoid leukaemia maintenance <I>in vivo</I>. Hence, we identified Stat5 as a vulnerable point in the oncogenic network downstream of Bcr/Abl representing a case of non-oncogene addiction (NOA).</P>
Shadi Taheri,Nils Peters,Annaelle Zietz,Berthold Abel,Gordian Hubert,Filip Barinka,Hanni Wiestler,Irena Kovacic,Ralf Linker,Felix Schlachetzki,Roland Backhaus 대한신경과학회 2023 Journal of Clinical Neurology Vol.19 No.6
Background and Purpose While the clinical hallmarks of transient global amnesia (TGA) are well defined, its pathophysiological causes are poorly understood. Specifically, risk factors for recurrences are yet to be determined. Methods This retrospective study analyzed TGA cases diagnosed and treated within the TEMPiS telestroke network and a university stroke center in Germany. Demographic and clinical data were assessed and characteristics of TGA episodes were recorded, such as season of occurrence, trigger factors, duration, and concomitant symptoms. Follow-up of the potential recurrence of TGA was performed using a standardized questionnaire. Results Overall 109 patients were included (age 64±8 years [mean±SD], 59.6% female). The most common vascular risk factor was arterial hypertension (60.6%), and other concomitant conditions included migraine (11.9%), hypothyroidism (22.9%), and atrial fibrillation (4.6%). The most frequent concomitant clinical feature accompanying the TGA episode at admission was elevated blood pressure (48.6%). Nineteen patients experienced at least one recurrent TGA episode. Migraine and hypothyroidism were only observed in subjects with a single TGA episode without recurrence (migraine: 14.4% without recurrence vs. none in the recurrence group, p=0.02; hypothyroidism: 27.8% without recurrence vs. none in the recurrence group, p=0.009). In contrast, atrial fibrillation was more common in subjects with TGA recurrence (p<0.001). Conclusions Arterial hypertension is prevalent in TGA patients, with elevated blood pressure being the most-frequent concomitant condition. In our cohort, recurrence of TGA occurred in approximately one-fifth of patients. Concomitant conditions such as migraine, hypothyroidism, and atrial fibrillation occurred at different frequencies in the two groups.
Standards-Based Worldwide Semantic Interoperability for IoT
Kovacs, Erno,Bauer, Martin,Jaeho Kim,Jaeseok Yun,Le Gall, Franck,Mengxuan Zhao Institute of Electrical and Electronics Engineers 2016 IEEE communications magazine Vol.54 No.12
<P>Global IoT services (GIoTS) are combining locally available IoT resources with cloud-based services. They are targeting worldwide services. GIoTS require interoperability between the locally installed heterogeneous IoT systems. Semantic processing is an important technology to enable data mediation as well as knowledge-based processing. This article explains a system architecture for achieving worldwide semantic interoperability using international standards such as oneM2M and the OMA NGSI-9/10 context interfaces (as used in the European Future Internet Platform FIWARE). Semantics also enables the use of knowledge-based semantic processing agents. Furthermore, we explain how semantic verification enables the testing of such complex systems.</P>
BIFURCATIONS IN A HUMAN MIGRATION MODEL OF SCHEURLE-SEYDEL TYPE-II: ROTATING WAVES
Kovacs, Sandor 한국전산응용수학회 2004 Journal of applied mathematics & informatics Vol.16 No.1
This paper treats the conditions for the existence of rotating wave solutions of a system modelling the behavior of students in graduate programs at neighbouring universities near each other which is a modified form of the model proposed by Scheurle and Seydel. We assume that both types of individuals are continuously distributed throughout a bounded two-dimension spatial domain of two types (circle and annulus), across whose boundaries there is no migration, and which simultaneously undergo simple (Fickian) diffusion. We will show that at a critical value of a system-parameter bifurcation takes place: a rotating wave solution arises.
Evaluation of the Middle Part of the Nuclear Fuel Cycle
Kovac, Michal Korean Nuclear Society 2016 Nuclear Engineering and Technology Vol.48 No.1
This article describes a comprehensive methodology for the evaluation of the middle part of nuclear fuel cycles. Evaluation of fuel cycles is basically divided into two parts. The first comprises nuclear calculation, i.e., creation of the strategy for nuclear fuel reloading and core design calculations. The second part is the business-economic evaluation of the selected reloading strategy, which can be done either by financial analysis or economic analysis. The financial analysis incorporates the perspectives of a company while the economic analysis can be used primarily by national economists or politicians. This methodology was applied to a case study that is focused on impacts of switching from a 12-month to an 18-month fuel cycle strategy for Water-Water Energetic Reactor (VVER)-1000 reactors.