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Measurement of the refractive index of the LAB-based liquid scintillator and acrylic at RENO
Yeo, I S,Jang, J H,Kim, M S,Ahn, J K,Baik, S R,Choi, E I,Choi, Seonho,Choi, Y,Jang, H I,Jang, J S,Jeon, E J,Jeong, I S,Joo, K K,Kim, B C,Kim, H S,Kim, J Y,Kim, S B,Kim, S H,Kim, W,Kim, Y D,Lee, J,Lim, Royal Swedish Academy of Sciences 2010 Physica scripta Vol.82 No.6
<P>In this paper, we describe the first measurement of the refractive index of the linear alkyl benzene (LAB)-based liquid scintillator and acrylic used at the Reactor Experiment for Neutrino Oscillation (RENO). The refractive index of a material is an important optical property and the prism spectrometer is the most common device for measuring the refractive index. Using the minimum deviation technique, which requires an exact measurement of the apex angle, we determined the refractive indices at six different wavelengths and then fitted them. We also compared the refractive index of the LAB-based liquid scintillator with the refractive indices of other liquid scintillator solvents commonly used in reactor neutrino experiments.</P>
Kim, Seonhoe,Lee, Ui Jin,Kim, Mi Na,Lee, Eun-Ju,Kim, Ji Young,Lee, Mi Young,Choung, Sorim,Kim, Young Joo,Choi, Young-Chul American Society for Biochemistry and Molecular Bi 2008 The Journal of biological chemistry Vol.283 No.26
<P>MicroRNAs (miRNAs) constitute a class of small noncoding RNAs that play important roles in a variety of biological processes including development, apoptosis, proliferation, and differentiation. Here we show that the expression of miR-199a and miR-199a* (miR-199a/a*), which are processed from the same precursor, is confined to fibroblast cells among cultured cell lines. The fibroblast-specific expression pattern correlated well with methylation patterns: gene loci on chromosome 1 and 19 were fully methylated in all examined cell lines but unmethylated in fibroblasts. Transfection of miR-199a and/or -199a* mimetics into several cancer cell lines caused prominent apoptosis with miR-199a* being more pro-apoptotic. The mechanism underlying apoptosis induced by miR-199a was caspase-dependent, whereas a caspase-independent pathway was involved in apoptosis induced by miR-199a* in A549 cells. By employing microarray and immunoblotting analyses, we identified the MET proto-oncogene as a target of miR-199a*. Studies with a luciferase reporter fused to the 3'-untranslated region of the MET gene demonstrated miR-199a*-mediated down-regulation of luciferase activity through a binding site of miR-199a*. Interestingly, extracellular signal-regulated kinase 2 (ERK2) was also down-regulated by miR-199a*. Coordinated down-regulation of both MET and its downstream effector ERK2 by miR-199a* may be effective in inhibiting not only cell proliferation but also motility and invasive capabilities of tumor cells.</P>
Kim, Seonhoe,Moon, Aree 德成女子大學校 藥學硏究所 2004 藥學論文誌 Vol.15 No.1
Many studies have focused on the anticarcinogenic, antimutagenic or chemopreventive activities of capsaicin (trans-8-methyl-N-vanillyl-6-nonenamide) which is a major pungent ingredient in red pepper. We have previously shown that capsaicin selectively induces apoptosis in H-ras-transformed MCF10A human breast epithelial cells but not in their normal cell counter-parts (Int. J. Cancer, 103, 475-482, 2003). In this study, we investigated the possible roles of reactive oxygen species (ROS) and Racl in capsaicin-induced apoptosis of H-ras MCF10A cells. Selective induction of ROS generation by capsaicin treatment was observed only in H-ras MCF10A cells. Pretreatment of H-ras MCF10A cells with an antioxidant N-acetylcysteine (NAC) significantly reversed capsaicin-induced growth inhibition, suggesting that ROS may mediate the apoptosis of H-ras-transformed cells induced by capsaicin. Racl was prominently activated by H-ras in MCF10A cells. Based on the studies using a wild type Racl and a dominant negative Racl constructs, we propose that Racl activity is critical for inhibitory effect of capsaicin on growth of H-ras-transformed MCF10A cells possibly through ROS generation.